Real-time Image Feedback Research Articles

Processes for Quality Improvements in Radiation Oncology Clinical Trials

Quality assurance in radiotherapy (RT) has been an integral aspect of cooperative group clinical trials since 1970. In early clinical trials, data acquisition was nonuniform and inconsistent and computational models for radiation dose calculation varied significantly. Process improvements developed for data acquisition, credentialing, and data management have provided the necessary infrastructure for uniform data. With continued improvement in the technology and delivery of RT, evaluation processes for target definition, RT planning, and execution undergo constant review. As we move to multimodality image-based definitions of target volumes for protocols, future clinical trials will require near real-time image analysis and feedback to field investigators. The ability of quality assurance centers to meet these real-time challenges with robust electronic interaction platforms for imaging acquisition, review, archiving, and quantitative review of volumetric RT plans will be the primary challenge for future successful clinical trials.

Adhesion of endothelial cells using self-assembly peptides under precise deformation control of tissue-engineered vessels

The objective of this study was to anchor endothelial cells using self-assembly peptides under precise deformation control of tissue-engineered vessels. An acelluarized vascular matrix was used as the control group to examine the function of self-assembly peptides. In the experiment group, the self-assembly peptides were added to the inner surface of tissue-engineered vessels to form a monolayer. Then the endothelial cells were injected into the vascular lumen. A deformation control system was developed which was based on real-time image analysis and feedback control system. After dynamic culture by different deformation (set points 1, 5, and 10 per cent), the endothelial cell densities of experimental and control groups were compared. Both the self-assembly peptides and the extent of deformation affected the endothelial cell density on the inner surface of tissue-engineered vessels. The construct with self-assembly peptides under 5 per cent deformation gained the highest endothelial cell density. It was concluded that the deformation of assembled peptides contributes to the development and adhesion of endothelial cells in the inner surface of tissue-engineered vessels.

A parallelizable real-time motion tracking algorithm with applications to ultrasonic strain imaging

Ultrasound-based mechanical strain imaging systems utilize signals from conventional diagnostic ultrasound systems to image tissue elasticity contrast that provides new diagnostically valuable information. Previous works (Hall et al 2003 Ultrasound Med. Biol. 29 427, Zhu and Hall 2002 Ultrason. Imaging 24 161) demonstrated that uniaxial deformation with minimal elevation motion is preferred for breast strain imaging and real-time strain image feedback to operators is important to accomplish this goal. The work reported here enhances the real-time speckle tracking algorithm with two significant modifications. One fundamental change is that the proposed algorithm is a column-based algorithm (a column is defined by a line of data parallel to the ultrasound beam direction, i.e. an A-line), as opposed to a row-based algorithm (a row is defined by a line of data perpendicular to the ultrasound beam direction). Then, displacement estimates from its adjacent columns provide good guidance for motion tracking in a significantly reduced search region to reduce computational cost. Consequently, the process of displacement estimation can be naturally split into at least two separated tasks, computed in parallel, propagating outward from the center of the region of interest (ROI). The proposed algorithm has been implemented and optimized in a Windows® system as a stand-alone ANSI C++ program. Results of preliminary tests, using numerical and tissue-mimicking phantoms, and in vivo tissue data, suggest that high contrast strain images can be consistently obtained with frame rates (10 frames s−1) that exceed our previous methods.

Advanced Surgical Guidance Technology: A Review

To maximize the outcome of implant placement, the use of advanced radiographic procedures such as computerized tomography, along with fabrication of surgical guides, has been advocated to inform surgeons of ideal implant location. More recently, simulation computer software has been introduced to view radiographic images and test potential implant locations. Yet, surgical guides are processed based on ideal tooth position, with little consideration for underlying anatomical limitations, which creates a disconnection between diagnostic planning and surgical restrictions. In response to this "missing link," computer-assisted design and computer-assisted manufacturing, as well as real-time surgical navigation were recently developed to obtain fully integrated surgical and prosthetic planning. Today, there are several technologies available, but, to our knowledge, a systematic assessment of surgical guidance has not yet been performed. Therefore, the aims of this review are to introduce advanced radiographic and software modalities, and present a detailed assessment of computer-assisted design and computer-assisted manufacturing methods and surgical navigation.

시각기반 원격로봇 제어를 위한 적응 영상전송기법

In remote control of telerobotics equipment, the real-time visual feedback is necessary in order to facilitate real-time control. Because of the network congestion and the associated delays, the real-time image feedback is generally difficult in the public networks like internet. If the remote user is not able to receive the image feedback within a certain time, the work performance may tend to decrease, and it makes difficulties to control of the telerobotics equipment. In this paper, we propose an improved visual feedback scheme over the internet for telerobotics system. The size of a remote site image and its quality are adjusted for efficient transmission. The constructed system has a better real-time update characteristics, and shows a potential for the real-time visual control of the telerobotics system.br/

A modified block matching method for real-time freehand strain imaging.

This manuscript reports a technical innovation that has been developed for real-time, freehand strain imaging. This work is based on a well-known block-matching algorithm with two significant modifications. First, since displacements are estimated row-by-row, displacement estimates from the previous row are used to predict the displacement estimates in the current row, thereby drastically reducing the search-region size and increasing computational efficiency. Second, a displacement error detection and correction method is developed to overcome the local tracking errors that may be more severe with freehand scanning and thereby improve the robustness of the algorithm. This algorithm has been implemented on a clinical ultrasound imaging system, and with real-time imaging feedback, long sequences of high quality strain images are observed using freehand compression. Displacement estimation errors with this method are experimentally measured and compared with results from simulation. We report only a specific implementation, with no comparison to other displacement estimators in the literature and no optimization of this specific technique. Images of tissue-mimicking phantoms with small spherical targets are used to test the ability to detect small lesions using the strain imaging technique. In vivo strain images of breast and thyroid are also shown.

Spatiotemporal addressing of surface activity.

We have modified surface catalytic activity in real time and space by focusing an addressable laser beam to differentially heat a platinum (110) single-crystal surface. Ellipsomicroscopy imaging of local conditions (such as reactant and product local coverages) enabled us to close the loop between sensing and actuation (both spatiotemporally resolved). Pulses and fronts, the basic building blocks of patterns, could be formed, accelerated, modified, guided, and destroyed at will. Real-time image processing and feedback allow the design and implementation of new classes of nonlocal evolution rules.

Interactive magnetic resonance imaging-guided management of intracranial cystic lesions by using an open magnetic resonance imaging system.

The authors present their experience with neurosurgical procedures requiring real-time imaging feedback such as aspiration of a cystic structure or abscess cavity, decompression of hydrocephalic ventricles, management of arachnoid cysts, and installation of permanent or temporary drainage conduits, in which interactive magnetic resonance (MR) imaging guidance was used to monitor structural alterations associated with the procedure. Drainage of eight intraparenchymal brain abscesses in seven patients, decompression of space-occupying cystic or necrotic brain tumors in four patients, and endoscopic management of hydrocephalus associated with arachnoid cysts in three patients were performed using MR imaging-guided frameless stereotaxy in an open-configuration 0.5-tesla superconducting MR imaging system. Intraoperative MR imaging guidance provided accurate information on the course of the surgical procedure and associated intraoperative changes in tissue position, such as the degree of cyst aspiration, the presence or absence of hemorrhage or induced swelling, and changes associated with decompression of adjacent brain parenchyma and the ventricular system. No clinically significant complications were encountered in any patient. There were no targeting errors, and procedural objectives were accomplished in all cases. Drainage of brain abscesses, punctures of cystic or necrotic intracranial lesions with subsequent aspiration, and management of hydrocephalus can be performed safely and accurately by monitoring the procedure using real-time MR imaging to obtain immediate feedback on associated dynamic tissue changes.

Two-dimensional fine particle positioning under an optical microscope using a piezoresistive cantilever as a manipulator

In this paper, a fine particle manipulation system using a piezoresistive microcantilever, which is normally utilized in Atomic Force Microscopy, as the manipulator and force sensor, and a top-view Optical Microscope (OM) as the vision sensor is proposed. Modeling and control of the interaction forces among the manipulator, particle and surface have been realized for moving particles with sizes less than 3 μm on a silicon substrate in 2D. The microcantilever behaves also as a force sensor which enables contact point detection, real-time force measurements, and surface alignment sensing. A 2D OM real-time image feedback constitutes the main user interface, where the operator uses mouse cursor and keyboard for defining the tasks for the cantilever motion controller. Preliminary particle manipulation experiments are demonstrated for 2.02 and 1 μm gold-coated latex particles, and it is shown that the system can be utilized in 2D micro particle assembling.

Brain tumor surgery with the Toronto open magnetic resonance imaging system: preliminary results for 36 patients and analysis of advantages, disadvantages, and future prospects.

Frameless navigation systems represent a huge step forward in the surgical treatment of intracranial pathological conditions but lack the ability to provide real-time imaging feedback for assessment of postoperative results, such as catheter positions and the extent of tumor resections. An open magnetic resonance imaging system for intracranial surgery was developed in Toronto, by a multidisciplinary team, to provide real-time intraoperative imaging. The preliminary experience with a 0.2-T, vertical-gap, magnetic resonance imaging system for intraoperative imaging, which was developed at the University of Toronto for the surgical treatment of patients with intracranial lesions, is described. The system is known as the image-guided minimally invasive therapy unit. Between February 1998 and March 1999, 36 procedures were performed, including 21 tumor resections, 12 biopsies, 1 transsphenoidal endoscopic resection, and 2 catheter placements for Ommaya reservoirs. Three complications were observed. All biopsies were successful, and the surgical goals were achieved for all resections. Problems included restricted access resulting from the confines of the magnet and the imaging coil design, difficulties in working in an operating room that is less spacious and familiar, inconsistent image quality, and a lack of nonmagnetic tools that are as effective as standard neurosurgical tools. Advantages included real-time imaging to facilitate surgical planning, to confirm entry into lesions, and to assess the extent of resection and intraoperative and immediate postoperative imaging to confirm the extent of resections, catheter placement, and the absence of postoperative complications. Intraoperative magnetic resonance imaging has great potential as an aid for intracranial surgery, but a number of logistic problems require resolution.