The objective of this study is to identify cost-optimal efficiency packages at several levels of building energy savings. A two-story residential building located in Jordan is selected as a case study. DesignBuilder software is used to predict the annual energy usage of a two-story residence in Irbid, Jordan. Real-time experimental data from a single isolated controlled room was used to verify the proposed model. In addition to energy analysis, the economic, environmental, and social benefits of the proposed design have been investigated. The sequential search optimization approach is used to estimate the minimum cost of the building while considering various design scenarios. In addition, the impact of various energy conservation techniques on residential buildings is assessed, and the payback period for each program is calculated. Ultimately, the optimal combination of design to achieve energy efficiency measures has been identified in several climate regions. The simulations results predict that the annual electricity consumption can be reduced up to 50% if the proper combinations of energy conservation measures are selected at the lowest cost. The payback period is 9.3 years. Finally, energy efficiency measures can lead to a total of 9470 jobs/year job opportunities.The study provide practical framework to link between energy performance criteria and economic goals of building. Linking the energy performance requirements to economic targets provides guidelines for homeowners, contractors, and policymakers for making a suitable decision regarding the retrofitting of existing residential buildings. The study focuses on developing new methodologies that support minimizing costs during a building's lifecycle while maximizing environmental benefits which can not be identified by a series of parametric analyses using individual energy-efficient measures.