Abstract Introduction Cardiovascular disease (CVD) is a problem facing governments around the world. Early detection saves the healthcare system thousands of dollars by allowing prevention and avoiding costly treatments when the disease has progressed to advanced stages. According to the World Health Organization (WHO), cardiovascular diseases represent the leading cause of mortality worldwide (WHO, 2019). That is why, we have decided to develop novel artificial intelligence models for the detection of heart disease, with accuracies that allow us to put the obtained algorithms into production. The revolution of artificial intelligence allows the application Deep Learning techniques of two-dimensional images in the domain of both real numbers and complex value numbers, as classifiers of heart sounds, for the detection of normality or abnormality in the functioning of the heart. Purpose In the present work, we propose the comparison of a novel 2D convolutional neural network (CNN) algorithm in the domain of complex value numbers with its counterpart in the domain of real numbers for the automatic classification of heart sounds into normal or abnormal. Material The database we decided to use for our research is Pascal, which has audio files of cardiac activity, distributed in 351 normal sounds and 129 pathological sounds. Methods The following steps were applied to get the objectives of our work: 1) automatic segmentation of a single heartbeat, 2) conversion of the segmented sound into its associated image scalogram using the Hilbert transform, 3) classification of the sounds into normal and abnormal using the proposed algorithms, and 4) measurement and comparison of the results obtained by performing a two-tailed t-student hypothesis test and cross-validation. Results We present a comparative table between the two proposed models, finding that Accuracy, F1 Score, Precision and Recall metrics obtained using complex-valued convolution networks present significant improvements compared with the real valued one. The following table show us the obtained numbers. For all cases, the t-student test shows us p-values less than 0.05%, giving statistical evidence that the means are significantly different between the two proposed models. Besides, in all cases, the performance of the Complex-valued model is better compared with the Real-valued one. Conclusion Complex-valued neural networks propose a significant advance around Deep learning, since they present a better performance than the traditional counterparts based on real numbers. This proposes an experimental basis for the construction of a new Deep learning paradigm, where information in another numerical domain, is better exploited with the help of mathematical transforms. The latter is a significant advance in health sciences, where the demand is higher, in terms of performance of the proposed models. Funding Acknowledgement Type of funding sources: Other. Main funding source(s): eVIDA research Group
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