We have developed a general equilibrium model that belongs to the class of real business cycle models of a small open economy exporting natural resources, which allows us to take into account the impact of investments in infrastructure projects. The model was calibrated to perform deterministic simulation of the investments project of the new railway construction and associated enterprises for the extraction and primary processing of natural resources in Siberia and the Far East. We use the information available before 2018. By 2050, the contribution of the infrastructure project, with a total size of 2.3% of GDP, to GDP growth is estimated at 4.0%, and the largest contribution of 2.7% of GDP is made by the growth of natural resource exports by 31.6 billion US dollars. 29.4 billion US dollars import increase and 7.2% consumption increase are due to the 5.4% of real ruble appreciation by 2050. The long-term equivalent consumption variation of the project is estimated as 8.36% a year. The project leads to an exacerbation of the Dutch disease of the Russian economy: the country’s specialization in the production and export of natural resources increases, imports increase, exports of other goods decrease, consumption increases, currency appreciates, and labor supply decreases.