The purpose of this report is to present some of the special radiological problems which arise when a nuclear reactor or atomic pile is used in medical research and experimental radiation therapy. While there are many and various ways in which this new tool can be used, the principal emphasis here will be toward the means and the devices which are utilized in order to control the energy spectrum of the external neutron stream and to direct it selectively to the treatment site. It has become possible to investigate these problems under practical conditions of use now that a nuclear reactor has been built expressly for and as an integral part of a Medical Research Center (1). Figure 1 shows the general external aspect of the Medical Research Center at Brookhaven National Laboratory, with the reactor housed in the cylindrical building in the background. The initial exploratory phase of its operation has turned up the acute problem of extracting from the machine the kinds and the numbers of neutrons required for experimental therapy, and the concurrent problem of keeping the gamma-ray contamination down to an acceptable level. Except for some pertinent details of power level and neutron fluxes, the nuclear engineering aspects of the machine are not related here. The emphasis is instead placed on the machine as a device for studies on man and the diseases of man. Its design began with the establishing of criteria for the treatment situation in terms of human convenience as well as of radiation. The beginning point was the patient and a suitable radiation exposure room around him. The neutron aperture was stipulated to be at the appropriate location and to have the desired flow of neutrons controlled by a shutter. The situation is thus entirely medical in nature; the reactor was designed to provide the factors demanded. Other conveniences were, of course, included, and flexibility of application was built in at every possible point. Other kinds of investigation are planned and still others—as yet not imagined—must surely present themselves. The reactor will run typically at a power of 1,000,000 watts (1 megawatt). Performance of the reactor has actually been satisfactory in terms of its internal and operational characteristics. Its pattern of control, heat transfer, and other engineering attributes have been good enough that permission has been granted to run at power levels up to 3 megawatts. For the typical operating condition at the 1-MW power level, central core flux figures are greater than 1013 n/cm.2·sec., as predicted. On the other hand, the primary reason for building this reactor is to use streams of neutrons external to the reactor shield. To provide for this, the design includes specialized shielding components to minimize the delivery distance. The channel combines elements arranged for best neutron optics, planned from studies made during the criticality experiments.
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