Reactive Saccades Research Articles

Differential Frontal Cortex Activation Before Anticipatory and Reactive Saccades in Infants

AbstractNeural correlates of anticipatory and reactive saccades were studied in 4‐month‐old infants by recording high‐density event‐related potentials. Infants were presented with a fixed sequence of stimulus presentation to which they rapidly showed anticipatory saccades, as well as continuing with some reactive (stimulus‐driven) saccades. As in a previous study, no clear evidence was found for adultlike, saccade‐related potentials, although some presaccadic differences between reactive and anticipatory saccades were observed. Infants also showed different stimulus offset‐related effects preceding the 2 types of trials with a right‐frontal positivity when an anticipatory look follows, but only left‐frontal positivity when a reactive saccade follows.

Behavioral and Cortical Measures of Infants' Visual Expectations

AbstractFeatures of the habituation paradigm were combined with the visual expectation paradigm to examine behavioral and cortical indexes of infants' visual expectations. Eight 3‐month‐old infants watched an alternating picture sequence while their eye movements were videotaped and their cortical electrophysiological activity (event‐related potential [ERP]) was recorded. Two ERP epochs were examined: a 3,000‐msec stimulus‐locked epoch included 1,000 msec before stimulus onset through 1,000 msec after stimulus offset; and a 1,200‐msec response‐locked epoch included 700 msec before saccade onset through 500 msec after the saccade. All infants anticipated upcoming pictures, and eye movement latencies for pictures that were not anticipated were comparable to saccade latencies reported in other visual expectation studies of infants at this age. Three components were identified in the stimulus‐locked ERP waveform: a slowly developing negativity prior to picture onset, a postonset negative slow wave, and a late negative deflection that peaked about 750 msec after picture onset. All stimulus‐locked components were larger for familiar than for unfamiliar pictures; prestimulus negativity was also greater before anticipated pictures. The response‐locked waveform contained 2 prominent features: a slowly increasing negative shift (NS) that began about 500 msec before saccade onset and a positive presaccadic potential that occurred about 30 to 90 msec before the saccade. Response‐locked components were larger for anticipatory saccades at the frontal scalp site; for reactive saccades, response‐locked components were larger at the vertex. Results are informative about ERPs in infants, cortical control of eye movements, and the development of visual expectations.

Functional adaptation of reactive saccades in humans: a PET study.

It is known that the saccadic system shows adaptive changes when the command sent to the extraocular muscles is inappropriate. Despite an abundance of supportive psychophysical investigations, the neurophysiological substrate of this process is still debated. The present study addresses this issue using H2(15)O positron emission tomography (PET). We contrasted three conditions in which healthy human subjects were required to perform saccadic eye movements toward peripheral visual targets. Two conditions involved a modification of the target location during the course of the initial saccade, when there is suppression of visual perception. In the RAND condition, intra-saccadic target displacement was random from trial-to-trial, precluding any systematic modification of the primary saccade amplitude. In the ADAPT condition, intra-saccadic target displacement was uniform, causing adaptive modification of the primary saccade amplitude. In the third condition (stationary, STAT), the target remained at the same location during the entire trial. Difference images reflecting regional cerebral-blood-flow changes attributable to the process of saccadic adaptation (ADAPT minus RAND; ADAPT minus STAT) showed a selective activation in the oculomotor cerebellar vermis (OCV; lobules VI and VII). This finding is consistent with neurophysiological studies in monkeys. Additional analyses indicated that the cerebellar activation was not related to kinematic factors, and that the absence of significant activation within the frontal eye fields (FEF) or the superior colliculus (SC) did not represent a false negative inference. Besides the contribution of the OCV to saccadic adaptation, we also observed, in the RAND condition, that the saccade amplitude was significantly larger when the previous trial involved a forward jump than when the previous trial involved a backward jump. This observation indicates that saccade accuracy is constantly monitored on a trial-to-trial basis. Behavioral measurements and PET observations (RAND minus STAT) suggest that this single-trial control of saccade amplitude may be functionally distinct from the process of saccadic adaptation.

An enquiry into the relationship between activation and performance using saccadic eye movement parameters

Saccadic eye movement was measured in three studies in a tracking task in which increasing stimulus jumping frequency indicates increasing difficulty. In the first study, after taking a benzodiazepine 16 subjects showed decreased saccadic velocity (activation indicator), but their reaction times and anticipatory behaviour (performance indicators) did not parallel this decline, although the saccadic amplitudes did. In the second deactivation study 23 subjects worked on somewhat boring oculomotor tasks for 2 h and showed the same decrease in saccadic velocity but showed almost no performance decline. In the third study a large sample of 254 subjects performed the same short tracking task, which offered the detailed analysis of the correspondence of the saccadic activation indicator to saccadic performance indicators. Almost all correlations were zero correlations. Thus, while performance seems to be practically independent of changing activation, the latter is dependent upon performance from one moment to the next. Stable differences were found between anticipatory and reactive saccades, which indicate an immediate change of saccadic velocity when the response mode changes. Therefore a reformulation of the relationship between performance and activation is proposed. Performance is stabilized by ‘concentration’ in a two-stage regulation process, i.e. it resists changing activation (for example through fatigue). In the second stage, the ‘effort loop’, additional brainstem activation is demanded when concentration alone fails to reach the goals that were set by the subject for his performance.