Reactive Proliferation Of Endothelial Cells Research Articles

Masson’s tumor of the thoracic spine: A rare cause of slowly progressive paraplegia

Introduction. Intravascular papillary endothelial hyperplasia is an unusual reactive proliferation of endothelial cells around an organized thrombus, which occurs either in a dilated blood vessel, hematoma, or preexisting vascular lesion. These tumors rarely affect the central nervous system. Symptoms depend on the localization of the process itself. Localization in the central nervous system is limited to the intracranial space. Localization in the spinal canal is extremely rare, and only a few clinical cases have been described so far in the literature. Case report. A 67- year-old female patient was examined neurologically initially due to bilateral weakness of the lower extremities, accompanied by a feeling of pain and muscle tension, dominantly in the upper legs, more to the right. The complaints were present a year ago, and before that period, the patient was in a stable state of health. Due to a severe neurological deficit and the need for detailed exploration, the patient was hospitalized. A diagnosis was performed, which showed the localization of the pathological process in the thoracic 5?6 region of the spinal column. Decompression surgery was performed, and with the ex tempore findings metastasis was ruled out. Definitive pathohistological findings proved Masson?s tumor. After the operation, the neurological weakness recovered. Conclusion. Masson?s tumor, although rarely localized in spinal canal, is curable if it is correctly diagnosed and if an adequate therapeutic approach is applied. The initially presented symptoms may resemble numerous neurological or systemic diseases, which requires the clinician to be continuously aware of such rare pathological processes.

Case Report: Intravascular Papillary Endothelial Hyperplasia In An Older Man

Masson's tumor is a benign tumor consisting of reactive proliferation of endothelial cells. It was first described by the French doctor, Pierre Masson, in 1923. A higher incidence was observed among women (1.3:1), and the average age at which it occurs is 31 years. It appears as a firm mass, with the appearance of a nodule or papule, located subcutaneously. The adjacent integument is bluish or reddish. On palpation it can be sensitive or painless. We will present the case of an 81-year-old man with Masson's tumor located at the level of the volar side of the left forearm, at the level of the flexor ulnar muscle of the carpi, which affects the ulnar artery.

A Rare Case of Intravascular Papillary Endothelial Hyperplasia (Masson's Tumor) of Vocal Cord.

Intravascular papillary endothelial hyperplasia (IPEH) also known as Masson's tumour named after Pierre Masson is a benign lesion of vascular origin which is characterized by reactive proliferation of endothelial cells with papillary formation. It is an extremely rare entity which can present anywhere in the body but is particularly found in the extremities and head and neck regions most commonly the lips, oral mucosa, tongue, gingiva, or buccal mucosa and due to its close resemblance to Angiosarcoma, it becomes important to distinguish between these two entities to avoid unnecessary aggressive treatment. Here, we describe a case of 23-year-old male who presented with change in voice since 8 months. Preoperatively, laryngoscopic examination showed right vocal cord polyp in the anterior one-third of the cord with hemorrhagic changes. He underwent micro-laryngeal surgery using suspension laryngoscope and the lesion was excised completely. Histopathological report was consistent with IPEH. Herein, we describe a rare benign case of IPEH arising from the vocal cord and we provide a brief review of relevant literature and a detailed report of this rare entity.

Masson's tumor of the ocular surface – A rare clinical entity

Masson's tumor or intravascular papillary endothelial hyperplasia (IPEH) is a benign vascular lesion usually involving the head-and-neck region. On histopathological examination, it consists of reactive proliferation of endothelial cells with papillary formations which is the key to diagnosis. This rare entity was first described in 1923 by Pierre Masson. Lesions involving orbit and eyelids have been reported before. Here, we report a case of Masson's tumor which occurred in the lid margin and later in the conjunctiva which regressed completely after excision.

Masson's Tumour: A Rare Cause of Cervical Mass.

Masson’s tumour, also known as intravascular papillary endothelial hyperplasia, is a rare non-neoplastic lesion of vascular origin, caused by an excessive reactive proliferation of endothelial cells in normal blood vessels or vascular malformations. It can affect any part of the body, presenting most frequently in the vessels of the head, neck and upper extremities. The authors describe the case of a 76-year-old female patient presenting an anterior cervical mass, measuring 2×2 cm, which was mobile, tender and slightly painful with no alteration of the overlying skin. Complementary study with ultrasound and computed tomography was inconclusive. Total excision of the lesion was performed with histology compatible with intravascular papillary endothelial hyperplasia.LEARNING POINTSMasson’s tumour is a rare and indolent non-neoplastic lesion of vascular origin, that can be easily confused with other pathological entities and misdiagnosed.Diagnosis can be a challenge; histological characterization is essential for differentiation from other lesions, such as angiosarcoma and Kaposi’s sarcoma.Masson’s tumour should be considered in patients presenting a single cervical mass.

Intravascular Papillary Endothelial Hyperplasia: The Diagnostic Challenges

Masson’s tumor or intravascular papillary endothelial hyperplasia is a benign lesion of the skin and subcutaneous tissue. It is due to reactive proliferation of endothelial cells with papillary formations related to a thrombus. It poses an interesting diagnostic differential as the clinical signs and symptoms are nonspecific. The diagnosis is based on histopathology. We report a case of Masson’s hemangioma occurring on the right ring finger.

Pyogenic granuloma of gingiva – A case report

One of the most commonly seen swiftly increasing, highly reactive proliferation of endothelial cells affecting the gingival tissue and usually happens in response to a chronic irritation is known as Pyogenic Granuloma. The current study reports a case of pyogenic granuloma located on the lingual (inner) surface of the gingiva in the left mandibular region that was managed by surgical intervention. Keywords:Pyogenic Granuloma, Pregnancy Tumor, Female Sex Hormones

Intravascular papillary endothelial hyperplasia (Masson's hemangioma) of the face.

Intravascular papillary endothelial hyperplasia or Masson’s hemangioma is a rare vascular tumor. The reactive proliferation of endothelial cells in this disease mimics other benign or malignant vascular proliferation such as angiosarcoma or Kaposi’s sarcoma. It is important to make an accurate distinction to avoid confusion with these malignant tumors. This would facilitate a proper diagnosis, which is essential so that the patient is not subjected to unnecessarily aggressive or inappropriate treatment.

Titanium Plate Cranioplasty Induced Intravascular Papillary Endothelial Tumor: Case Report and Review of the Literature

Intravascular Papillary Endothelial Hyperplasia (IPEH) or Masson’s tumor are non-specific vascular lesions which enclose reactive proliferation of endothelial cells that arise in an organizing thrombus...

Oral Intravascular Papillary Endothelial Hyperplasia Associated with an Organizing Thrombus: Case Report and Immunohistochemical Analysis.

Intravascular papillary endothelial hyperplasia (IPEH) is a benign lesion of the skin and mucosa of vascular origin characterized by reactive proliferation of endothelial cells. A 76-year-old woman was referred presenting a painless nodule on the lip. Intraoral examination revealed bluish submucosal nodular proliferation, measuring 10 × 5 × 5 mm, affecting the lower labial mucosa. The lesion had a firm consistency and it was not fixed to the adjacent tissues. The main differential diagnoses were mucocele/mucus retention cyst, sialolith, or salivary gland neoplasia. An incisional biopsy was performed and during the intraoperative procedure an encapsulated red-bluish nodular mass was observed. Microscopic analysis revealed papillary endothelial proliferation in the center of the lesion and fibrin admixed with inflammatory cells in organization peripherally. There was no nuclear atypia, mitotic figures, or necrosis. The endothelial cells were CD34 positive, with low Ki-67 proliferation index (4%). α-SMA highlighted the vessel walls, whereas negativity for D2-40 excluded lymphatic origin. Final diagnosis was IPEH associated with an organizing thrombus. Dentists should be aware about this rare benign vascular lesion, whose final diagnosis is achieved only after histopathology analysis. Surgical removal is the treatment of choice and no recurrence is expected.

Circulation : Clinical Summaries

<i>Circulation</i> : Clinical Summaries

Reactive proliferation of endothelial cells and pericytes associated with arteriovenous malformation

Arteriovenous malformation (AVM) is a structural vascular abnormality with no proliferation of cellular components. We report on a 53-year-old man who presented with a 15-year history of a progressively enlarging nodule on his lower lip. A dark-reddish, easy-bleeding nodule diagnosed as AVM was resected to reduce the volume and troublesome bleeding. Histologically, the nodule revealed that the proliferating cellular area was composed of endothelial cells and pericytes in addition to the area of dilated vessels. We speculated that the cell proliferation developed secondary to AVM. We also discuss the histological differential diagnosis of spindle cell hemangioma and pseudo-Kaposi's sarcoma.

Intravascular Papillary Endothelial Hyperplasia: Report of 4 cases with immunohistochemical findings

Intravascular papillary endothelial hyperplasia (IPEH) is a benign endothelial proliferation, usually intravascular, that may mimic angiosarcoma. In this report, four new cases of IPEH involving the oral region are described. The affected sites were the lower lip, labial comissure and the submandibular region. After clinical evaluation, the complete removal of the lesions showed a circumscribed and soft mass. Histologically, the major feature was a reactive proliferation of endothelial cells composed of small papillary structures with hypocellular and hyalinized cores arising in an organized thrombus. Immunohistochemical staining for CD34 was strongly positive in endothelial cells. Vimentin and laminin immunolabelling were also consistent with a vascular origin. In order to verify the proliferative potential of the lesions, the Ki-67 antibody was used, revealing low percentage of labeled cells (<20%). No immunoreactivity for GLUT-1 was observed. Since the complete removal is curative, no additional treatment was necessary, and no signs of recurrence had been observed until now. Due to the particular features of IPEH, it is important for pathologists and clinicians to become familiar with this lesion. Additionally, the specific histological arrangement, including the absence of cellular pleomorphism, mitotic activity and necrosis, represents a guide to help in the differential diagnosis. Moreover, the vascular origin and the proliferative index should be assessed by immunohistochemistry in order to provide an accurate diagnosis.

Intravascular papillary endothelial hyperplasia (Masson's tumor) of the oral mucosa. Presentation of two cases and review

Intravascular papillary endothelial hyperplasia (Masson's tumor) is a benign lesion of the skin and subcutaneous tissue consisting of a reactive proliferation of endothelial cells with papillary formations related to a thrombus. The clinical picture is not specific and the diagnosis is based on histological examination. The lesion is often mistaken with angiosarcoma and a group of other benign and malignant vascular lesions. The presentation in the oral mucosa and lips is rare. Two new cases located in the lower lip and buccal mucosa are presented and a review in accessible literature is made.

Intravascular papillary endothelial hyperplasia of the mandibular mucosa

Intravascular papillary endothelial hyperplasia (IPEH) usually presents as a cutaneous lesion consisting of a reactive proliferation of endothelial cells that arise in an organizing thrombus. This lesion can easily be mistaken for an angiosarcoma. Oral presentations are rare, and when they do occur the most common site is the lip. A rare case of IPEH affecting the mandibular buccal mucosa is described.