Reaction Of Precursor Research Articles

Hydrothermal vs microwave nanoarchitechtonics of carbon dots significantly affects the structure, physicochemical properties, and anti-cancer activity against a specific neuroblastoma cell line.

Carbon dots (CDs) from glucose were synthesized using two of the most common bottom-up methods, namely, microwave assisted (MW) and hydrothermal carbonization (HT). Synthetic parameters such as reaction time, temperature, and precursor concentration were changed to study the effects of each parameter on CD size, structure, surface functionalities, charge, photoluminescence behavior, quantum yield, cytotoxicity, blood-brain barrier (BBB) crossing ability and bioimaging. A detailed analysis is performed to compare the structure and properties of the CDs synthesized in ten different conditions. We show that the synthesis route drastically changes the structure, properties, and related functions of glucose-derived CDs yielding two different subtypes of CDs. Surprisingly, CDs that was synthesized via HT method showed specific anticancer activity against a neuroblastoma cell line while being non-toxic towards healthy cell lines, indicating significant potential for therapeutic applications. CDs synthesized via MW crosses the BBB in zebrafish and rat models, and accumulates in neurons. CDs synthesized via MW method showed high biocompatibility and a great potential to be used for bioimaging applications in vitro and in vivo targeting neurons. Finally, a formation mechanism of CDs is proposed for both HT and MW synthesis routes.

Dual functionalized brush copolymers as versatile antifouling coatings.

Polymer coatings containing both fouling-resistant and fouling-release components have been reported to show synergistic antifouling properties. However, it remains unclear how the polymer composition influences the antifouling performance, particularly regarding foulants of different sizes and biological natures. Herein, we prepare dual functionalized brush copolymers containing fouling-resistant poly(ethylene glycol) (PEG) and fouling-release polydimethylsiloxane (PDMS) and examine their antifouling performances against different biofoulants. We utilize poly(pentafluorophenyl acrylate) (PPFPA) as a reactive precursor polymer and graft amine-functionalized PEG and PDMS side chains to create PPFPA-g-PEG-g-PDMS brush copolymers of systematically varying compositions. The copolymer films spin-coated on silicon wafers exhibit surface heterogeneity that can be correlated well with the bulk composition of the copolymer. When the copolymer-coated surfaces are examined against protein (human serum albumin and bovine serum albumin) adsorption and cell (lung cancer cells and microalgae) adhesion, they are found to perform better than the homopolymers. The enhanced antifouling properties are attributed to the copolymers having a PEG-rich top layer and a PEG/PDMS mixed bottom layer that work synergistically to resist biofoulant attachment. Furthermore, the composition of the best-performing copolymer is different for different foulants, with PPFPA-g-PEG39-g-PDMS46 exhibiting the best antifouling properties against proteins and PPFPA-g-PEG54-g-PDMS30 exhibiting the best antifouling properties against cells. We explain this difference by considering the changes in the length scale of the surface heterogeneity in relation to the foulant sizes.

Shining light on halogen-bonding complexes: a catalyst-free activation mode of carbon-halogen bonds for the generation of carbon-centered radicals.

The discovery of new activation modes for the creation of carbon-centered radicals is a task of great interest in organic chemistry. Classical activation modes for the generation of highly reactive radical carbon-centered intermediates typically relied on thermal activation of radical initiators or irradiation with unsafe energetic UV light of adequate reaction precursors. In recent years, photoredox chemistry has emerged as a leading strategy towards the catalytic generation of C-centered radicals, which enabled their participation in novel synthetic organic transformations which is otherwise very challenging or even impossible to take place. As an alternative to these activation modes for the generation of C-centered radicals, the pursuit of greener, visible-light initiated reactions that do not necessitate a photoredox/metal catalyst has recently caught the attention of chemists. In this review, we covered recent transformations, which rely on photoactivation with low-energy light of a class of EDA complexes, known as halogen-bonding adducts, for the creation of C-centered radicals.

Iron-sensitive protein conjugates formed with a Wittig reaction precursor in ionic liquid.

In this report, formation of protein conjugates with an iron-sensitive enamine linkage is demonstrated through the ionic liquid-based bioconjugation method.

Efficient doping to synthesize high-performance Co/Fe-BiOCl photocatalyst assisted by the ion release from novel CoFe2O4 nanofiber reservoir

Metal ion doping is an efficient method to achieve high photocatalytic performance of semiconductors. However, the current synthetic methods by using inorganic salts as doped sources in the precursor reaction system might suffer from ion waste and second pollution. Herein, we developed a novel method by employing electrospun nanofibers as ion reservoir to release metal ions for the synthesis of ion-doped semiconductors with high photocatalytic activity. As demonstrated, Co/Fe co-doped BiOCl photocatalyst (Co/Fe-BOC) was facilely prepared in the presence of CoFe2O4 nanofibers as Co and Fe ion reservoir via a simple solvothermal method. Compared with BiOCl, the resulted Co/Fe-BOC shows increased specific surface area, visible light response as well as separation and transportation efficiencies of photogenerated carriers. Thus, the Co/Fe-BOC exhibits significantly enhanced visible light photocatalytic activity to degrade 99.4% rhodamine B (RhB) within 4 min. This new doping approach not only avoids the ion waste and pollution during the reaction process but also facilitates the separation of the photocatalyst. Moreover, the CoFe2O4 nanofibers could be repeatedly used as ion reservoir to prepare high-performance Co/Fe-BOC. This nanofiber-based ion doping approach provides a novel, universal and promising insight to obtain doped semiconductors with high photocatalytic activity.

Evolution of Thermoelectric and Oxidation Properties in Lu-Substituted Yb14MnSb11

Yb14MnSb11 is one of the state-of-the-art high-temperature p-type thermoelectric materials with reported zTs of 1.2–1.3 at 1273 K. Site substitution of Yb14MnSb11 provides a means to control carrier concentration and impacts the oxidation kinetics. Substitution of Lu3+ for Yb2+ in Yb14MnSb11 single crystals has been shown to provide faster oxidation kinetics compared with the pristine phase, and it has been speculated that this may lead to surface passivation. Polycrystalline samples of Yb14–xLuxMnSb11 were synthesized from the elements and through a route utilizing YbH2, MnSb, and Yb4Sb3 as reactive precursors. The solubility of Lu was found to be less than x = 0.5, and at that composition and above LuSb impurities are observed in the powder X-ray diffraction. Because Lu3+ is substituting for Yb2+ in a p-type system, there is an increase in both the electrical resistivity and Seebeck coefficient with Lu substitution. As Yb14MnSb11 has been predicted to be optimally doped ∼1.5 × 1021 h+ cm–3, this reduction in carrier concentration in the solid solution of Yb14–xLuxMnSb11 decreases the peak zT. Oxidation of Yb13.7Lu0.3MnSb11 as a function of temperature was studied. At low temperatures, the Lu-substituted sample may have improved oxidation resistance through forming a passivating oxide film on the surface.

Matel complexes of schiff - base ligand; Synthesis, characterization and liquid crystalline properties

In this work a Schiff base ester derived ligand [H2L1] were synthesized in three steps, first Synthesis of the pentanoiyl chloride from reaction thionyl chloride with pentanoic acid.
 in the second step the precursosr (W1), 4-[3-(3-hydroxy-1-methyl- butylideneamino)- 4-methyl-phenylimino]-pentan-2-ol ,was prepared by the reaction of acetylaceton with tolylen2,4-diamin . In the theird step the ligands were synthesized by the reaction of precursor (W1)with pentanoiyl chloride to produce[H2L1] 1:2 mole ratio. The binuclear complexes with Cr3+, Co2+ and Zn2+, were synthesized by the reaction of the ligand with metal salts in 1:1 mole ratio. The compounds were characterized by spectroscopic methods [FT-IR, UV-Vis, CHN, 1H-NMR] elemental analysis, along with conductivity, and melting point measurements. The structure of the complexes were obtained according to the previous studies. Finally the liquid crystalline properties of the prepared compounds were studied by hot stag and DCS.

Individual Effects of Flux Species as a Reaction Field on Coprecipitation Precursor toward the Design of Fine, Mono-Dispersed LiNi0.5Co0.2Mn0.3O2 Single Crystals

High-output lithium-ion batteries that have excellent high-rate capacity and durability are indispensable for high-energy devices. LiNi0.5Co0.2Mn0.3O2 (NCM523) is a representative active material and is typically used as a secondary particle. However, the practical use of NCM523 in high-output applications remains challenging, owing to insufficient capacity and cycle durability resulting from grain boundary resistance and cracks. Mono-disperse, fine particle characteristics are used for crystal designs for high-output performance. The single-crystal growth of NCM523 has been introduced using various methods; however, these methods primarily focused on NCM523 itself. Therefore, a guideline for crystal control, focusing on particle size and aggregation nature, is still necessary to achieve the optimal NCM523 design for an electrode structure. Precursor choice and reaction field design are important factors to consider to achieve mono-dispersed fine crystals. In this study, we focused on coprecipitation hydroxides as a precursor and molten flux as a reaction field and we studied the effect of fluxes on NCM523 crystal growth. We observed that flux species provide a unique contribution to the growth manner of NCM523. For example, borate-based flux disaggregated secondary particles, whereas chloride-based flux developed the crystal face in primary particles. Some fluxes provided mono-disperse NCM523 crystal particles with a size of less than 1 μm, which exhibited a 1st capacity over 110 mAh·g–1@5C and 100th capacity over 120 mAh·g–1@1C as high-output characteristics. The synergistic effect of the coprecipitate and flux on crystal growth was interpreted based on the growth manner observations. The results show that the size of NCM523 single crystals can be finely controlled in the submicron to several micron range. Coprecipitates can be made at many metal ions, including Mn, Co, and Ni; therefore, our suggested flux guideline for crystal design can be applied to other battery materials, such as NCM and LiCoO2. This insight contributes to the development of high-power battery electrodes based on particle-morphologic design.

PCET-Mediated Ring-Opening Alkenylation of Cycloalkanols via Dual Photoredox and Cobalt Catalysis.

The construction of molecular skeletons and modification of molecules using widely available and easily prepared alcohols as radical precursors for coupling reactions are significant and challenging subjects. We herein report a straightforward strategy for the dehydrogenative ring-opening alkenylation of cycloalkanols with alkenes by combining a proton-coupled electron transfer strategy and a dual photoredox and cobalt catalysis system. With this approach, a series of distally unsaturated ketones were obtained in 17-83% yields with high E selectivity.

RAGE-Dependent Effect of Exogenous Methylglyoxal Intake on Lung Biomechanics in Mice

Methylglyoxal (MG) is a known highly reactive dicarbonyl and precursor to free radicals and advanced glycation end-products (AGEs). It is discussed to be involved in tissue aging and in the pathogenesis of different degenerative diseases. The effect of long-term oral administration of MG, simulating dietary MG intake, on the lung biomechanics of wild type (WT) and receptor for advanced glycation end-products knockout (RAGE-KO) mice was studied using an ex vivo ventilation system starting at the age of 6 months and after feeding for 6 and 12 months with MG. Our results showed that MG was taken up in the circulation and efficiently excreted with urine. The amount of free urinary MG measured after 12 months of feeding was lowered. After 12 months feeding, a significant airway resistance increase accompanied by a decrease of the maximal inspiratory airflow was observed in WT animals. No effect of MG in lung function of RAGE-KO mice could be detected. Despite the evidence that MG entered the systemic circulation, no MG-derived AGE accumulation was detected in the lung lysates in dependency on MG-feeding. Our data indicate that the short-term feeding of MG has little effect in vivo. Only after long-term treatment was MG secretion reduced, leading to tissue impairment.

Enhancing energy storage capabilities of MoS2 nanoflowers through designing nanoarchitecture by controlling synthesis growth parameters

Among transition metal dichalcogenides, molybdenum disulfide (MoS2) is considered as the most cost-effective electrode material for energy storage applications such as supercapacitors and supercapatteries. The layered morphology, intrinsic high surface area and edge sites favour the enhanced energy storage performance of MoS2 nanostructures. Low-cost, solution based hydrothermal synthesis has been considered as the most attractive route for the growth of exotic MoS2 nanostructures for their potential applications in energy storage devices. Yet, the performance of an electrode in a supercapacitor is related to the structural aspects such as morphology, crystallinity and phase which in turn can be tailored suitably by altering the synthesis conditions. Here in, we report a detailed study on the role of synthesis parameters such as reaction time, temperature and precursor amount on the capacitive performance of MoS2 nanoflowers by one-step hydrothermal synthesis. The morphological and structural analysis of the samples were carried out using various characterization techniques including electron microscopy, X-ray diffraction, Raman, UV–Visible and X-ray photoelectron spectroscopy. Tuning the inter-layer spacing by altering the synthesis conditions of MoS2 nanoflowers resulted in the enhanced charge storage performance. A superior value of specific capacitance ~215 F/g with high power density of ~1 kW/kg with an energy density of ~30 Wh/kg, respectively, have been achieved for bare MoS2 nanoflowers, simply by tailoring the synthesis conditions.

Secured Nanosynthesis–Deposition Aerosol Process for Composite Thin Films Incorporating Highly Dispersed Nanoparticles

Application of nanocomposites in daily life requires not only small nanoparticles (NPs) well dispersed in a matrix, but also a manufacturing process that is mindful of the operator and the environment. Avoiding any exposure to NPs is one such way, and direct liquid reaction-injection (DLRI) aims to fulfill this need. DLRI is based on the controlled insitu synthesis of NPs from the decomposition of suitable organometallic precursors in conditions that are compatible with a pulsed injection mode of an aerosol into a downstream process. Coupled with low-pressure plasma, DLRI produces nanocomposite with homogeneously well-dispersed small nanoparticles that in the particular case of ZnO-DLC nanocomposite exhibit unique properties. DLRI favorably compares with the direct liquid injection of exsitu formed NPs. The exothermic hydrolysis reaction of the organometallic precursor at the droplet-gas interface leads to the injection of small and highly dispersed NPs and, consequently, the deposition of fine and controlled distribution in the nanocomposite. The scope of DLRI nanosynthesis has been extended to several metal oxides such as zinc, tin, tungsten, and copper to generalize the concept. Hence, DLRI is an attractive method to synthesize, inject, and deposit nanoparticles and meets the prevention and atom economy requirements of green chemistry.

Zn-Doped P-Type InAs Nanocrystal Quantum Dots.

Doped heavy metal-free III-V semiconductor nanocrystal quantum dots (QDs) are of great interest both from the fundamental aspects of doping in highly confined structures, and from the applicative side of utilizing such building blocks in the fabrication of p-n homojunction devices. InAs nanocrystals (NCs), that are of particular relevance for short-wave IR detection and emission applications, manifest heavy n-type character poising a challenge for their transition to p-type behavior. The p-type doping of InAs NCs is presented with Zn - enabling control over the charge carrier type in InAs QDs field effect transistors. The post-synthesis doping reaction mechanism is studied for Zn precursors with varying reactivity. Successful p-type doping is achieved by the more reactive precursor, diethylzinc. Substitutional doping by Zn2+ replacing In3+ is established by X-ray absorption spectroscopy analysis. Furthermore, enhanced near infraredphotoluminescence is observed due to surface passivation by Zn as indicated from elemental mapping utilizing high-resolution electron microscopy corroborated by X-ray photoelectron spectroscopy study. The demonstrated ability to control the carrier type, along with the improved emission characteristics, paves the way towards fabrication of optoelectronic devices active in the short-wave infrared region utilizing heavy-metal free nanocrystal building blocks.

Morphology-dependent solvothermal synthesis of spinel NiCo2O4 nanostructures for enhanced energy storage device application

Spinel NiCo2O4 is a remarkable electrode material for enhanced energy storage devices due to its unique tunable structure and shape. Herein, we have demonstrated a facile solvothermal approach to synthesize various nanostructures such as nanoparticles, nanoflowers self-assembled with nanoflakes, nanorods, and nanosheets of spinel NiCo2O4. The influence of solvents (such as water, ethanol, water-ethanol, and ethylene glycol etc.), urea, the molar concentration of reactant precursors Ni(NO3)2·6H2O and Co(NO3)2·6H2O, and calcination temperatures are varied for designing the various nanostructures of NiCo2O4. Further all electrode materials are tested for supercapacitor application. Among all as-synthesized nickel cobaltites, NiCo2O4 nanoflowers (NC-2) is found to be the best electrode materials for supercapacitor application with a high specific capacitance (415 F/g at 2 mV/s scan rate and 144.3 F/g at 1 A/g current density) under 1 M Na2SO4 electrolyte using three-electrode system. The higher specific capacitance of NiCo2O4 nanoflowers is attributed to its larger surface area, the higher number of active sites, and lower charge transfer resistance. Moreover, the NiCo2O4 nanoflowers electrodes were further fabricated for a two-electrode symmetric supercapacitor device and showed a specific capacitance of 80.2 F/g at 1 A/g current density and exhibit higher energy density of 17.4 Wh/kg with a power density of 329.7 W/kg. The fabricated symmetric device of NiCo2O4 nanoflowers displays outstanding durability upto 10,000 continuous charge-discharge cycles at 5 A/g.

Role of dose optimization in Ru atomic layer deposition for low resistivity films

Ruthenium (Ru) is an alternative to copper (Cu) and cobalt (Co) interconnect layers in sub 20 nm features due to its low resistivity in scaled wires and low diffusion into porous low-K dielectrics (SiCOH). Two goals for a successful Ru atomic layer deposition (ALD) process are to enable films with resistivity values as close as possible to that of bulk Ru and to enable selective deposition to achieve bottom-up fill of vias. In this work, the effects of dose variation on resistivity and selectivity of the Ru ALD process using a dicarbonyl-bis(5-methyl-2, 4-hexanediketonato) Ru(II) precursor, Ru(IHD)2(CO)2 (“Carish”), and O2/He coreactant were investigated. Instead of varying the Carish precursor dose to optimize the growth rate per cycle, the precursor dose was optimized to reduce the film resistivity from 18.5 to 10.2 μΩ cm. By varying the O2/He coreactant dose, the substrate selectivity of the ALD process was successfully enhanced as evidenced by the increased nucleation delay on bis(N,N-dimethylamino)dimethylsilane passivated SiO2 over hydrofluoric acid-cleaned SiO2. These findings highlight the importance of dose optimization beyond the ALD saturation point in developing a selective and low resistivity Ru ALD process. Density functional theory calculations were performed to provide a mechanistic understanding of the underlying surface reactions of the Carish precursor and the roles of CH3 passivation and O2 coreactants.

Differential cardiopulmonary effects of isoprene-versus toluene-generated photochemically-Aged smog in rats

Photochemical smog is a complex mixture of primary and secondary air pollutants including secondary organic aerosols (SOA), ozone and reactive aldehydes which has been linked to increased risk of adverse cardiovascular and pulmonary responses. The components and related health effects of smog are thought to be determined both by the precursor chemicals and reaction conditions. Here we examined the difference between isoprene- (IS-) and toluene- (TL) generated smog in causing cardiopulmonary effects in rats. Wistar-Kyoto rats were exposed to either filtered air (FA) or smog for 4 h. IS-smog contained 660 ppb NO2, 335 ppb O3, and 178 μg/m3 SOA while TL-smog had 380 ppb NO2, 250 ppb O3, and 1,250 μg/m3 SOA. Whole-body plethysmography was performed at baseline and after each exposure and left ventricular function was measured using a Millar probe and arrhythmic sensitivity to aconitine. Tidal volume decreased only after IS-smog while inspiratory time and nasal injury increased following both smog atmospheres. Only TL-smog caused an increase in PenH, which is an indicator of airway irritation. On the other hand, only IS-smog caused left ventricular pressure to decrease, while only TL-smog increased sensitivity to cardiac arrhythmia. These data indicate that the source of smog atmosphere plays a large role in the types of responses it elicits and that its relative SOA and gaseous composition determine the extent of cardiovascular versus respiratory effects.

Spontaneous Hetero-attachment of Single-Component Colloidal Precursors for the Synthesis of Asymmetric Au-Ag2X (X = S, Se) Heterodimers.

Finding simple, easily controlled, and flexible synthetic routes for the preparation of ternary and hybrid nanostructured semiconductors is always highly desirable, especially to fulfill the requirements for mass production to enable application to many fields such as optoelectronics, thermoelectricity, and catalysis. Moreover, understanding the underlying reaction mechanisms is equally important, offering a starting point for its extrapolation from one system to another. In this work, we developed a new and more straightforward colloidal synthetic way to form hybrid Au-Ag2X (X = S, Se) nanoparticles under mild conditions through the reaction of Au and Ag2X nanostructured precursors in solution. At the solid-solid interface between metallic domains and the binary chalcogenide domains, a small fraction of a ternary AuAg3X2 phase was observed to have grown as a consequence of a solid-state electrochemical reaction, as confirmed by computational studies. Thus, the formation of stable ternary phases drives the selective hetero-attachment of Au and Ag2X nanoparticles in solution, consolidates the interface between their domains, and stabilizes the whole hybrid Au-Ag2X systems.

Reactivity and Structure of a Bis-phenolate Niobium NHC Complex.

We report the facile synthesis of a rare niobium(V) imido NHC complex with a dianionic OCO-pincer benzimidazolylidene ligand (L 1 ) with the general formula [NbL 1 (N t Bu)PyCl] 1-Py. We achieved this by in situ deprotonation of the corresponding azolium salt [H 3 L 1 ][Cl] and subsequent reaction with [Nb(N t Bu)Py 2 Cl 3 ]. The pyridine ligand in 1-Py can be removed by the addition of B(C6F5)3 as a strong Lewis acid leading to the formation of the pyridine-free complex 1. In contrast to similar vanadium(V) complexes, complex 1-Py was found to be a good precursor for various salt metathesis reactions, yielding a series of chalcogenido and pnictogenido complexes with the general formula [ NbL 1 (N t Bu)Py(EMes)] (E = O (2), S (3), NH (4), and PH (5)). Furthermore, complex 1-Py can be converted to alkyl complex (6) with 1equiv of neosilyl lithium as a transmetallation agent. Addition of a second equivalent yields a new trianionic supporting ligand on the niobium center (7) in which the benzimidazolylidene ligand is alkylated at the former carbene carbon atom. The latter is an interesting chemically "noninnocent" feature of the benzimidazolylidene ligand potentially useful in catalysis and atom transfer reactions. Addition of mesityl lithium to 1-Py gives the pyridine-free aryl complex 8, which is stable toward "overarylation" by an additional equivalent of mesityl lithium. Electrochemical investigation revealed that complexes 1-Py and 1 are inert toward reduction in dichloromethane but show two irreversible reduction processes in tetrahydrofuran as a solvent. However, using standard reduction agents, e.g., KC8, K-mirror, and Na/Napht, no reduced products could be isolated. All complexes have been thoroughly studied by various techniques, including 1H-, 13C{1H}-, and 1H-15N HMBC NMR spectroscopy, IR spectroscopy, and X-ray diffraction analysis.

Sensitivity of Ozone Formation in Summer in Jinan Using Observation-Based Model

According to online monitoring data on atmospheric ozone and the pollution characteristics of its precursors obtained in Jinan in June 2021, we analyzed different sites: urban sites (city monitoring station, Quancheng Square), an industrial park site (oil refinery), and a suburban site (Paomaling). The relative incremental reactivity of different precursors was calculated using a photochemical observation-based model to explore the sensitivity of O3 generation at each site and to draw a curve using the empirical kinetics modeling approach. The PMF model was used to analyze the origin of volatile organic compounds (VOCs) pollution in Jinan. The results showed that the concentration of O3 at the industrial park was higher than that in the urban area in Jinan, which may be related to the fact that ozone precursor concentrations in the industrial park were significantly higher than those in the urban area (the AVOCs concentration at the industrial park site was 56.9 ppbv, approximately twice that of the urban site), and there are emission peaks at night; alkanes, oxygenated compounds, and halogenated hydrocarbons were the main components of the AVOCs, and olefins, alkanes, and aromatic hydrocarbons were the main active components in Jinan. The O3 generation in urban areas generally occurred in the VOCs-sensitive zones, while the O3 generation in the other areas occurred in the VOCs-NOx transition zone; there was a clear diurnal variation in the sensitivity of the industrial park, with the site being in the obvious VOCs-sensitive zone from nighttime to morning hours and shifting to the VOCs-NOx transition zone in the afternoon hours; the relative incremental reactivity (RIR) value of AVOCs for O3 generation in Jinan was the largest, and olefins were the most sensitive component of O3. The AVOCs in Jinan mainly originated from motor vehicle exhaust, oil and gas volatilization, industrial emissions, and solvent use, and ozone prevention and control in summer should strengthen the control of these sources.

Habitual intake of dietary methylglyoxal is associated with less low-grade inflammation: the Maastricht Study

Dicarbonyls are major reactive precursors of advanced glycation endproducts (AGEs). Dicarbonyls are formed endogenously and also during food processing. Circulating dicarbonyls and AGEs are associated with inflammation and microvascular complications of diabetes, but for dicarbonyls from the diet these associations are currently unknown. We sought to examine the associations of dietary dicarbonyl intake with low-grade inflammation and microvascular function. In 2792 participants (mean ± SD age: 60±8 y; 50% men; 26% type 2 diabetes) of the population-based cohort the Maastricht Study, we estimated the habitual intake of the dicarbonyls methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG) by linking FFQ outcome data to our food composition database of the MGO, GO, and 3-DG content of>200 foods. Low-grade inflammation was assessed as six plasma biomarkers, which were compiled in a z score. Microvascular function was assessed as four plasma biomarkers, compiled in a zscore; as diameters and flicker light-induced dilation in retinal microvessels; as heat-induced skin hyperemic response; and as urinary albumin excretion. Cross-sectional associations of dietary dicarbonyls with low-grade inflammation and microvascular function were investigated using linear regression with adjustments for age, sex, potential confounders related to cardiometabolic risk factors, and lifestyle and dietary factors. Fully adjusted analyses revealed that higher intake of MGO was associated with a lower z score for inflammation [standardized β coefficient (STD β): -0.05; 95% CI: -0.09 to -0.01, with strongest inverse associations for hsCRP and TNF-α: both -0.05; -0.10 to -0.01]. In contrast, higher dietary MGO intake was associated with impaired retinal venular dilation after full adjustment (STD β: -0.07; 95% CI: -0.12 to -0.01), but not with the other features of microvascular function. GO and 3-DG intakes were not consistently associated with any of the outcomes. Higher habitual intake of MGO was associated with less low-grade inflammation. This novel, presumably beneficial, association is the first observation of an association between MGO intake and health outcomes in humans and warrants further investigation.