Case 1: A 35-year-old White man presenting an asymptomatic, lobulated, ulcerated, and pedunculated tumor, measuring 5.5 cm, in the right maxilla; radiographic examination showed areas of calcification. An excisional biopsy was performed, and the histopathologic diagnosis was peripheral ossifying fibroma (FOP). Case 2: A 49-year-old afrodescendant man presenting hyperplastic lesions along the maxillary alveolar ridge, with tumor formation of approximately 6.0 cm, asymptomatic, ulcerated, and bleeding. The histopathologic diagnosis was consistent with pyogenic granuloma (GP). FOP and GP are nonneoplastic proliferative processes, relatively common in dental practice, resulting from an exuberant organic response to different types of irritating agents, such as mechanical trauma, dental biofilm accumulation, and hormonal changes. Knowledge of these entities is essential because, despite benign reactive lesions, they can achieve large dimensions, making it challenging to establish a differential diagnosis with benign or malignant neoplasms.