The TOPAZ-II thermionic space reactor system, which was designed by the Soviet Union, is characterized by its high degree of nonlinearity and positive temperature reactivity feedback. The thermionic space reactor exhibits characteristics of high inertia and significant delay in controlling its electrical power and outlet temperature. The simple PID controller is difficult to achieve good performance. To carry out controller design for thermionic space reactor, the simulation platform for thermionic space reactor is developed based on coupling between reactor system thermal-hydraulic code RESYS and control system simulator in this study. After that, based on the cascade control strategy and gain-scheduling, the reactor thermal controller, electric power controller, outlet temperature controller applicable for the full power range is designed with transfer function model and frequency domain analysis method. To validate the nonlinear electric power controller performance, the continuous minor step disturbances, major step disturbances, and ramp variation of electric power setpoint is simulated. The performance of outlet temperature controller is verified with the simulation result of step and ramp variation of outlet temperature setpoint. Thereafter, the start-up process of the thermionic space reactor TOPAZ-II is simulated and analyzed. The simulation result reveals that the controller designed in this paper can overcome the nonlinearity of the thermionic space reactor system and has good performance throughout the entire power range. Compared to traditional simple PID controller, the cascade controller has better performance and can achieve good control performance even in situations where simple PID controllers cannot function properly.