Nuclear Reactions Research Articles

An experimental validation of a filtering approach for prompt gamma prediction in a research proton treatment planning system.

Prompt gamma (PG) radiation generated from nuclear reactions between protons and tissue nuclei can be employed for range verification in proton therapy. A typical clinical workflow for prompt gamma range verification compares the detected prompt gamma profile with a predicted one. Recently, a novel analytical prompt gamma prediction algorithm based on the so-called filtering formalism has been proposed and implemented in a research version of RayStation (RaySearch Laboratories AB), which is a widely adopted treatment planning system. In this work, the said algorithm is validated against experimental data and benchmarked with another well-established prompt gamma prediction algorithm implemented in a MATLAB-based software REGGUI. Furthermore, a new workflow based on several PG profile quality criteria and analytical methods is proposed for data selection. The workflow also calculates sensitivity and specificity information, which can help practitioners to decide on irradiation course interruption during treatment and monitor spot selection at the treatment planning stage. With the proposed workflow, the comparison can be performed on a limited number of selected high-quality irradiation spots without neighbouring-spot aggregation. The mean shifts between the experimental data and the simulated PG detection (PGD) profiles (ΔPGD) by the two algorithms are estimated to be 1.5~2.1 mm and -0.6~2.2 mm for the filtering and REGGUI prediction methods, respectively. The ΔPGD difference between two algorithms is observed to be consistent with the beam model difference within uncertainty. However, the filtering approach requires a much shorter computation time compared to the REGGUI approach.

Nonlinear-optical analogies in nuclear-like soliton reactions: selection rules, nonlinear tunneling and sub-barrier fusion-fission

Abstract The main goal of our article is to reveal unexpected but intriguing analogies arising between optical solitons and nuclear physics, which still remain hidden from us. We consider the main cornerstones of the concept of nonlinear optics of nuclear reactions and the well-dressed repulsive-core solitons. On the base of this model, we reveal the most intriguing properties of the nonlinear tunneling of nucleus-like solitons and the soliton selfinduced sub-barrier transparency effect. We describe novel interesting and stimulating analogies between the interaction of nucleus-like solitons on the repulsive barrier and nuclear sub-barrier reactions. The main finding of our study concerns the conservation of total number of nucleons (or the baryon number) in nuclear-like soliton reactions. We show that inelastic interactions among well-dressed repulsive-core solitons arise only when a “cloud” of “dressing” spectral side-bands appears in the frequency spectra of the solitons. This property of nucleus-like solitons is directly related to the nuclear density distribution described by the dimensionless small shape-squareness parameter. Thus the Fourier spectra of nucleus-like solitons are similar to the nuclear form factors. We show that the nuclear-like reactions between well-dressed solitons are realized by “exchange” between “particle-like” side-bands in their spectra.

New Version of the Experimental Setup for the Measurement of γ-Quantum Emission Cross Sections in Nuclear Reactions Induced by 14.1 MeV Neutrons

Within the TANGRA project framework, a new experimental setup has been constructed for the measurement of reaction cross sections (n, X, γ) in the interaction of 14.1 MeV neutrons with nuclei. The facility has a special feature: the use of the tagged neutron method. This method enables efficient separation of background and useful events, as well as accurate tracking of neutron flux. Test measurements were performed on 28Si, 12C, and 16O nuclei, and the results showed satisfactory agreement with available experimental data. This paper presents the features of the setup design and the methodology for processing the obtained experimental data

Evaluation of sodium borocaptate (BSH) and boronophenylalanine (BPA) as boron delivery agents for neutron capture therapy (NCT) of cancer: an update and a guide for the future clinical evaluation of new boron delivery agents for NCT.

Boron neutron capture therapy (BNCT) is a cancer treatment modality based on the nuclear capture and fission reactions that occur when boron-10, a stable isotope, is irradiated with neutrons of the appropriate energy to produce boron-11 in an unstable form, which undergoes instantaneous nuclear fission to produce high-energy, tumoricidal alpha particles. The primary purpose of this review is to provide an update on the first drug used clinically, sodium borocaptate (BSH), by the Japanese neurosurgeon Hiroshi Hatanaka to treat patients with brain tumors and the second drug, boronophenylalanine (BPA), which first was used clinically by the Japanese dermatologist Yutaka Mishima to treat patients with cutaneous melanomas. Subsequently, BPA has become the primary drug used as a boron delivery agent to treat patients with several types of cancers, specifically brain tumors and recurrent tumors of the head and neck region. The focus of this review will be on the initial studies that were carried out to define the pharmacokinetics and pharmacodynamics of BSH and BPA and their biodistribution in tumor and normal tissues following administration to patients with high-grade gliomas and their subsequent clinical use to treat patients with high-grade gliomas. First, we will summarize the studies that were carried out in Japan with BSH and subsequently at our own institution, The Ohio State University, and those of several other groups. Second, we will describe studies carried out in Japan with BPA and then in the United States that have led to its use as the primary drug that is being used clinically for BNCT. Third, although there have been intense efforts to develop new and better boron delivery agents for BNCT, none of these have yet been evaluated clinically. The present report will provide a guide to the future clinical evaluation of new boron delivery agents prior to their clinical use for BNCT.

Slow 7Be and the primordial 7Li abundance

The cross sections of neutron-induced nuclear reactions are commonly large at low energies. Given this feature, the 7Be(n, p)7Li process with slow 7Be is studied in connection with the cosmological lithium problem. An idea is tested whether slow (non-Maxwellian) 7Be born in the radiative capture 3He(α, γ)7Be reaction can boost the 7Be(n, p)7Li(p, α)α mechanism of 7Li burn-up in the early universe, reducing the amount of primordial 7Li. The rate of this sequential process is examined and its effect on the 7Li abundance is clarified. In the absence of 7Be thermalization in the primordial plasma, the above mechanism can decrease 7Li/H by several percent, leaving unchanged the abundances of D and 4He which are consistent with observations. However, taking into account the 7Be thermalization due to scattering off electrons, positrons, nuclei, and photons radically suppresses the effect. It is found that the typical thermalization time of 7Be is less than 10−5 s, while the fraction of non-Maxwellian particles in the 7Be component is at most 2 × 10−7. Under this condition, the corresponding impact on 7Li/H is estimated to be no more than 10−5%.

Effect of Microstructure on Oxidation and Micro-mechanical Behavior of Arc Consolidated Mo-Ti-Si-(B) Alloys

AbstractThe present study deals with the development and characterization of Mo-35Ti-10Si and Mo-35Ti-10Si-2B (wt.%) alloy for ultra-high temperature applications beyond the temperature limit of existing super alloys. The microstructural characterization using scanning electron microscopy (SEM), energy dispersive spectrometry (EDS), electron back scattered diffraction (EBSD), x-ray diffraction (XRD) revealed that the Mo-35Ti-10Si-2B alloy was consisted of three phases, namely, (Mo, Ti)ss, (Mo, Ti)5SiB2 and (Ti, Mo)5Si3; whereas, Mo-35Ti-10Si alloy was found to be consisting of (Mo, Ti)ss, and (Mo,Ti)3Si phases. Since quantification of boron is difficult by EDS, Particle Induced Gamma-ray Emission (PIGE), a nuclear reaction analysis technique was used for chemical composition analysis of boron. The oxidation behavior of the Mo-35Ti-10Si-2B alloy in the temperature regime of 825-1250 °C was studied in detail and compared with boron-free Mo-35Ti-10Si alloy. Mo-35Ti-10Si-2B alloy exhibited superior oxidation behavior at intermediate temperatures of 825 °C, and excellent oxidation resistance at higher temperatures between 1000 and 1250 °C due to the formation of the protective borosilica and double oxide layers (TiO2 and duplex borosilica-TiO2), respectively. High-temperature oxidation mechanisms were discussed using detailed microstructural cross section analysis of the oxidized alloy samples. The micro-mechanical behavior of constitutive phases of the Mo-35Ti-10Si-2B alloy were studied by microhardness, nano-indentation and micropillar compression testing. The micropillar compression of (Mo, Ti)ss phase showed fairly ductile behavior with the evidence of activation of dislocation in the form of slip lines revealed through the post-deformation fractography. Deformation studies of (Mo, Ti)5SiB2 and (Ti, Mo)5Si3 phases were also carried out which showed large strain bursts indicating possibility of activation of dislocation activities even at room temperatures imparting low level of ductility.

Technological Novelties and Scientific Discoveries with the Borexino Experiment

The Borexino experiment has developed, in its 32 years of activity, techniques and methods that allow for unprecedented radiopurity levels, which continue to be the current state of the art. These pioneering techniques and methods represent a new standard for ultra-low-background physics, a legacy that Borexino leaves to future experiments studying low-energy neutrinos and searching for rare events with detectors operating deep underground. The Borexino experiment leaves an equally influential scientific legacy with its discoveries and precise measurements of the nuclear processes that cause the Sun and stars to shine. Thanks to its unparalleled low background in the energy window of ∼150 keV to ∼15 MeV, the Borexino experiment also has contributed significantly to the understanding of neutrino oscillations with the observation of the energy-dependent matter to vacuum-dominated flavor conversion probability of solar neutrinos. Along with this textbook-quality body of solar neutrino results, the Borexino experiment has contributed to the study of the Earth's mantle radioactivity with background-free measurements of geoneutrinos. This article presents an overview of the long-lasting Borexino results and of the experimental efforts required to achieve them.

China's nuclear power in the context of decarbonization of the global energy industry

The global structure of energy resource consumption is analyzed. It is shown that the total consumption of energy resources in the 20th century increased almost 15 times and amounted to about 118 PWh in 2000. Of these, more than 80% were fossil (natural) energy carriers, 13 % were renewable energy sources and more than 6 % were nuclear power. This trend has continued for many years. Renewable energy sources and nuclear power are projected to dominate the growth of global energy consumption, meeting on average more than 90 % of the additional demand. China ranks first in the world in terms of GDP and the rate of development of the electric power complex, as well as in terms of production volume and the rate of development of nuclear power. The structure of electricity generation by fuel type in countries (TOP 5, 2021) with high energy consumption has been analyzed. It is shown that the main players in this market are three countries: China (30 %), USA (13 %) and India (6 %). The volume of electricity production in China is almost three times larger than in the EU countries and almost 7 times larger than in Russia. The structure of nuclear energy and China's achievements in this field are considered. It is shown that in the context of nuclear technologies (creation of fourth-generation reactors, development of technologies close to the full closed cycle of nuclear waste processing) China is already ready to significantly expand the scope of nuclear energy. Special attention is paid to the safety of nuclear facilities operations. The main problem China will face is the absence of an insurmountable barrier between civilian and military use of such technologies. This poses a serious threat to the ecology and life safety of the country. In the long term, nuclear power must also solve the problem of safe, long-term disposal of radioactive waste. It is shown that in the future China needs to re-examine its nuclear program in the context of cooperation with International Nuclear Security Organizations.

DEM Simulation of the Idaho Calcine Simulant for Hot Isostatic Pressing Canister Filling Process: Part 2

This paper introduces a novel approach to the bulk material handling of simulated radioactive material, focusing on the challenging Idaho calcine waste. Due to the limited availability of the simulant, virtual dynamic simulations were utilized to develop technology demonstration−scale models to assess the efficacy of the discrete element method (DEM) for process development studies. The DEM model was validated using historical experimental data, demonstrating its feasibility with affordable hardware. Acknowledging the limitations of computational analysis, the presented contact model is deemed adequate for preliminary engineering studies. This research advances bulk material handling and provides valuable insights for nuclear waste treatment processes, offering a pioneering framework for researchers working with the Idaho calcine simulant.

Multiple types of nuclear localization signals in Entamoeba histolytica

Entamoeba histolytica is a protozoan parasite that belongs to the Amoebozoa supergroup whose study related to the nucleocytoplasmic transport of proteins through the nucleus is poorly studied. In this work, we have performed in silico predictions of the potential nuclear localization signals (NLS) corresponding to the proteome of 8201 proteins from Entamoeba histolytica annotated in the AmoebaDB database. We have found the presence of monopartite nuclear localization signals (MNLSs), bipartite nuclear localization signals (BNLSs), and non-canonical monopartite NLSs with lengths exceeding 20 amino acid residues. Additionally, we detected a new type of NLS consisting of multiple juxtaposed bipartite NLSs (JNLSs) that have not been described in any eukaryotic organism. Also, we have generated consensus sequences for the nuclear import of proteins with the NLSs obtained. Docking experiments between EhImportin α and an MNLS, BNLS, and JNLS outlined the interacting residues between the Importin and cargo proteins, emphasizing their putative roles in nuclear import. By transfecting HA-tagged protein constructs, we assessed the nuclear localization of MNLS (U1A and U2AF1), JMNLS (U2AF2), and non-canonical NLS (N-terminus of Pol ll) in vivo. Our data provide the basis for understanding the nuclear transport process in E. histolytica.

Non-Nucleon Metastable Excitations in Nuclear Matter and e– Catalysis As a Quark-Cumulative Mechanism for Initiating Low-Energy Nuclear Chemical Processes: Phenomenology

Non-Nucleon Metastable Excitations in Nuclear Matter and e– Catalysis As a Quark-Cumulative Mechanism for Initiating Low-Energy Nuclear Chemical Processes: Phenomenology

Exploring asymmetric fission in 180Hg⁎ compound nucleus using dynamical cluster-decay model

The observed asymmetric fission of the 180Hg⁎ compound nucleus challenges conventional expectations of symmetric fission, which are attributed to the presence of shell closures at Z=40 (semi-magic) and N=50 (magic). To comprehend this novel phenomenon, the dynamical cluster-decay model has been employed. For the first time, this model incorporates the bulk and neutron-proton asymmetry coefficients of the nuclear shape-dependent mass excess formula which are tuned recently to the ground state mass excess data of AME2020 and/or FRDM(2012) along with the temperature dependence for the nuclear shape and the surface energy coefficient of the nuclear proximity potential. The calculations have considered nuclear shapes as both spherical and deformed (quadrupole), with and without temperature dependence for the quadrupole deformation. A new minimum appears in the symmetric mass region of the fragmentation potential for masses (80, 100), when the fragments are deformed and optimally oriented, at an energy lower than that obtained for masses (90, 90) where the fragments are assumed to be spherical or nearly spherical at higher temperatures. This new minimum seems equivalent to the appearance of a new shell gap with deformation and is responsible for the asymmetric fission of 180Hg⁎. The most probable fission channel and the transition from asymmetric to symmetric mass distribution at higher excitation energies are consistent with experiments for the current temperature dependence assigned to the quadrupole deformation parameter.

In Plasma ion beam analysis of polymer layer and adsorbed H monolayer etching

We present two experiments where a layer is plasma-etched while monitoring its evolution by in plasma ion beam analysis. First, we etch a photoresist with a diffuse O2 plasma at low pressure. Using a 4.335 MeV He beam, Rutherford Backscattering Spectrometry and Elastic Recoil Detection spectra are acquired every minute during 8 h. Etching of most elements follows a linear trend, but H desorbs faster at the beginning of the plasma process, which we ascribe to the ion beam-induced desorption. In addition, we observe a thin Mo layer building up at the surface, likely due to the sputtering of an electrode in the plasma source. Secondly, we etch in HF a crystalline Si (c-Si) sample with <100> surface orientation, which should leave 14 H/nm2 bonded to the c-Si surface. The sample is then introduced in the chamber and exposed to a diffuse Ar plasma at low pressure. During plasma processing, the H surface concentration is monitored using a resonant nuclear reaction with a 15N beam at 6.385 MeV. The initial H concentration is 11.7±1.1 H/nm2, and it decreases over a 3-minute timescale to an equilibrium concentration of 6.0±0.8 H/nm2. Over the range of experimental conditions investigated, the diffuse Ar plasma is therefore not able to entirely sputter the H from the c-Si surface.

Probing chromatin condensation dynamics in live cells using interferometric scattering correlation spectroscopy

Chromatin organization and dynamics play important roles in governing the regulation of nuclear processes of biological cells. However, due to the constant diffusive motion of chromatin, examining chromatin nanostructures in living cells has been challenging. In this study, we introduce interferometric scattering correlation spectroscopy (iSCORS) to spatially map nanoscopic chromatin configurations within unlabeled live cell nuclei. This label-free technique captures time-varying linear scattering signals generated by the motion of native chromatin on a millisecond timescale, allowing us to deduce chromatin condensation states. Using iSCORS imaging, we quantitatively examine chromatin dynamics over extended periods, revealing spontaneous fluctuations in chromatin condensation and heterogeneous compaction levels in interphase cells, independent of cell phases. Moreover, we observe changes in iSCORS signals of chromatin upon transcription inhibition, indicating that iSCORS can probe nanoscopic chromatin structures and dynamics associated with transcriptional activities. Our scattering-based optical microscopy, which does not require labeling, serves as a powerful tool for visualizing dynamic chromatin nano-arrangements in live cells. This advancement holds promise for studying chromatin remodeling in various crucial cellular processes, such as stem cell differentiation, mechanotransduction, and DNA repair.

Efficient production and purification of 32P radioisotope from sulfur by dry distillation: A practical approach with high radiochemical purity

The 32P radioisotope, with a half-life of 14.3 days and an energy level of 1.71 MeV, has diverse applications in medicine and research. Consequently, producing a carrier-free 32P radioisotope characterized by high radiochemical and radionuclide purity is imperative. Two primary methods for generating 32P radioisotopes exist: irradiating phosphorus through the nuclear reaction (n,γ) or irradiating sulfur through the nuclear reaction (n,p). Using sulfur as a target material provides several advantages. Besides the fact that the chemical element produced after irradiation (32P) differs from the irradiated element (32S), it also produces a32P radioisotope with a higher specific activity than using 31P as the target. The production of the radioisotope 32P from sulfur employs the dry distillation method, capitalizing on sulfur's easily sublimated nature. The volatility of sulfur when heated makes it easy to separate the resulting sulfur and radioisotope 32P without the need for additional reagents. This research aims to establish a practical method for producing the 32P radioisotope using the dry distillation technique. The dry distillation method utilizes a quartz ampoule containing a mixture of 32P and 35S radionuclides, a distillation tube wrapped with heating tape, and a condenser to collect the distilled sulfur. Sulfur, serving as the target material, undergoes irradiation in the reactor at the Central Irradiation Position (CIP) through the 32S(n,p)32P nuclear reaction with a fast neutron flux of 5.380 × 1013 n/cm2.sec. Separation is achieved through distillation at a temperature of 440 °C. The residual separation products are then dissolved in a 0.1 N HCl solution. The purification process involves using an AG50 WX8 cation exchange resin column, which is pre-conditioned with 0.1 N HCl. The resulting eluate contains the 32P radioisotope. The radiochemical purity of the 32P radioisotope is analyzed using thin-layer chromatography (TLC). In this analysis, a PEI Cellulose plate serves as the stationary phase, and a KH2PO4 solution acts as the mobile phase. This vacuum-free distillation method successfully separates the 32P radioisotope from sulfur, achieving a separation efficiency of 55.1 ± 9.9% (n = 7). The average activity produced after the purification process is 5.690E+10 Bq. Purifying the 32P radioisotope results in a radiochemical purity of 99.97% at Rf 0.7110, as orthophosphate, the radionuclide purity exceeds 99%.

Deuterium loading of redeposited-like W coatings present in tokamaks by ion implantation

Pulsed Laser deposition (PLD) is a suitable technique to reproduce W, W–O and W–N–O coatings resembling those present in tokamaks walls, as protective W coatings covering plasma facing components (PFCs) or W-based layers redeposited in PFCs during reactor operation. Nevertheless, difficulties still exist to codeposit deuterium in all such layers, and parallel methods need to be implemented to load it. W-based coatings with porous and columnar microstructures grown by PLD where loaded with flat depth contents of deuterium down to 0.4–0.6 μm using multiple ion implantation steps at distinct incident energies and fluences. Deuterium amounts close to 7 at.% were easily achieved. Similar deuterium contents are commonly observed in deposits in now-a-days tokamaks. Microstructural characterization of the coatings was carried out by scanning electron microscopy (SEM). Quantitative elemental analysis of as-deposited and as-implanted materials was accessed by elastic backscattering spectroscopy (EBS), nuclear reaction analysis (NRA) and by time-of-flight elastic recoil detection (ToF-ERDA). Secondary ion mass spectrometry (SIMS) revealed the depth profiles of the existing isotopes and, particularly, of retained deuterium. Beyond their use in ex-situ experiments, the production is useful to calibrate laser induced breakdown spectroscopy (LIBS) and SIMS setups, aiming a standard free depth-quantification of deuterium in W-based coatings.

Thermal spray coatings for molten salt facing structural parts and enabling opportunities for thermochemical cycle electrolysis

AbstractThermochemical water splitting stands out as the most efficient techniques to produce hydrogen through electrolysis at a high temperature, relying on a series of chemical reactions within a loop. However, achieving a durable thermochemical cycle system poses a significant challenge, particularly in manufacturing suitable coating materials for reaction vessels and pipes capable of enduring highly corrosive conditions created by high‐temperature molten salts. The review summarizes thermally sprayed coatings (deposited on structural materials) that can withstand thermochemical cycle corrosive environments, geared towards nuclear thermochemical copper–chlorine (CuCl) cycles. An assessment was conducted to explore material composition and selection (structure–property relations), single and multi‐layer coating manufacturing, as well as corrosion environment and testing methods. The aim was to identify the critical areas for research and development in utilizing the feedstock materials and thermal spray coating techniques for applications in molten salt thermochemical applications, as well as use lessons learnt from other application areas (e.g., nuclear reaction vessels, boilers, waste incinerators, and aero engine gas‐turbine) where other types of molten salt and temperature are expected. Assessment indicated that very limited sets of coating‐substrate system with metallic interlayer is likely to survive high temperature corrosive environment for extended period of testing. However, within the known means and methods, as well as application of advanced thermal spray manufacturing processes could be a way forward to have sustainable coating‐substrate assembly with extended lifetime. Spraying multi‐layered coating (nano‐structured or micro‐structured powder materials) along with the application of modern suspension or solution based thermal spray techniques are considered to result in dense microstructures with improved resistance to high temperature thermochemical environment.

Comprehensive Overview of Recent Research and Industrial Advancements in Nuclear Hydrogen Production

As new sources of energy and advanced technologies are used, there is a continuous evolution in energy supply, demand, and distribution. Advanced nuclear reactors and clean hydrogen have the opportunity to scale together and diversify the hydrogen production market away from fossil fuel-based production. Nevertheless, the technical uncertainties surrounding nuclear hydrogen processes necessitate thorough research and a solid development effort. This paper aims to position pink hydrogen for nuclear hydrogen production at the forefront of sustainable energy-related solutions by offering a comprehensive review of recent advancements in nuclear hydrogen production, covering both research endeavors and industrial applications. It delves into various pink hydrogen generation methodologies, elucidating their respective merits and challenges. Furthermore, this paper analyzes the evolving landscape of pink hydrogen in terms of its levelized cost by comparatively assessing different production pathways. By synthesizing insights from academic research and industrial practices, this paper provides valuable perspectives for stakeholders involved in shaping the future of nuclear hydrogen production.

Development of a plastic scintillator based and SiPM readout detector for high-precision fast-timing measurements at rosphere array

We report on the development of a custom particle detection system that aims to improve the detection capabilities of the ROSPHERE array. The detector is designed specifically for lifetime measurements using the in-beam Fast-timing method for nuclear states in nuclides produced in nuclear transfer reactions. An 80 x 3.6 mm disc of BC400 plastic scintillator was coupled to a sparse SiPM array readout connected to a dedicated Front End Electronics board. The detector was tested versus a conical LaBr3(Ce) coupled to a Hamamatsu PMT readout. The timing measurements resulted in a resolution of 896(5) ps. The detector design, characteristics, and performances are presented in this paper along with future improvements.

Progenitor Stars Calculated with Small Reaction Networks should not be Used as Initial Conditions for Core Collapse

Core collapse initial conditions are a bottleneck in understanding the explosion mechanism(s) of massive stars. Stellar evolution codes struggle after carbon burning, and either stop or adopt numerical simplifications missing crucial physics. The use of small nuclear reaction networks (NRN) that account for energy production but bypass weak reactions is typical, but insufficient to study the dynamics of the collapse. We advise against the use of progenitors computed with small NRN in expensive multidimensional simulations of core collapse, bounce, (jet formation), and explosion.