The regulatory control structure to achieve the best product quality 1s established by utilizing the recent control configuration selection methods for the Inferential control of an industrial, multicomponent, high-purity ethylbenzene distillation column In the dual composition control, (L, V) configuration with (L-y D ;V-x B ) scheme 1s found as the best one among different schemes considering RI, RGA, JEC and RDG methods. However, in .Inferential control studies, SVD analysis revealed that high-purity end of the column cannot be utilized for temperature measurements. Thus, the possible use of single-end control is investigated within the context of Elgenstructure concept. It is found that for feed flow rate and composition disturbances column can be successfully controlled with a single-end structure. The unsteady-state simulation studies favored the [L-y D ;V=f(F)] scheme. However, for the Inferential control, [L=f(F);V-x B ] Is selected by taking into account the practical difficulties in measuring the high purity compostions. The results obtained for the existing industrial column has indicated that the control performance can be significantly improved by the proper choice of the size of the drums at an earlier stage of the design.