A series of cyclic loading tests were conducted on steel frames incorporating RC walls with large openings. The RC walls of these specimens were designed reflecting the design of the walls in an existing 14 story-condominium building, which mostly consist of spandrel and mid-span walls. Despite the large openings, the RC walls showed brittle behavior, but gave large initial stiffness and maximum strength to the system. The spandrel walls maintained substantial resisting capacity to large drift level. This force acting on the column lead to shear failure in one specimen designed in the Weak-column manner, but in the Weak-beam frame system, the spandrel wall increased the overall shear capacity, without causing any undesirable effect.