The Model for Prediction Across Scales-Atmosphere (MPAS) was used to simulate meteorological conditions for a two-week winter episode during 10–23 January 2013, and a two-week summer episode during 18–31 July 2016, using both as a global model and a regional model with a focus on California. The results of both global and regional applications of MPAS were compared against the surface and upper air rawinsonde observations while the variations of characteristic meteorological variables and modeling errors were evaluated in space, time, and statistical sense. The results of the Advanced Weather Research and Forecast (WRF-ARW, hereafter WRF) model simulations for the same episodes were also used to evaluate the results of both applications of MPAS. The temporal analyses performed at surface stations indicate that both global and regional applications of MPAS and WRF model predict the diurnal evolution of characteristic meteorological parameters reasonably well in both winter and summer episodes studied here. The average diurnal bias in predicting 2 m temperature by MPAS and WRF are about the same with a maximum of 2 °C in winter and 1 °C in summer while that of 2 m mixing ratio is within 1 g/kg for all three modeling applications. The rawinsonde profiles of temperature, dew point temperature, and wind direction agree reasonably well with observations while wind speed is underestimated by all three applications. The comparisons of the spatial distribution of anomaly correlation and mean bias errors calculated from each model results for 2 m temperature, 2 m water vapor mixing ratio, 10 m wind speed and wind direction indicate that all three models have similar magnitudes of agreement with observations as well as errors away from observations throughout California.