Grape processing generates residues rich in bioactive compounds with potential application in the meat industry. However, these substances are unstable and needs to be treated to allow their action during the processing and storage of meat products. In this sense, a phenolic-rich extract from grape pomace was microencapsulated and evaluated for its potential to inhibit the oxidative process in raw and precooked beef burgers during cold storage. Three hamburger formulations containing lyophilized extract (LEB), microencapsulated extract (MEB) and synthetic antioxidant sodium erythorbate (SEB) were prepared, pre-cooked, and evaluated for lipid and protein oxidation. The microencapsulation, with 95.0% efficiency, provided a material with a crystalline structure, rich in phenolics and with high antioxidant potential, showing 377.4 ± 0.01, 1768.1 ± 0.07 and 1185.0 ± 0.20 μmol TEAC.100 g−1 for DPPH, ABTS and FRAP, respectively. Lower values of malonaldehyde were found in LEB and MEB (2.9 ± 0.3 and 1.4 ± 0.5 mg MDA.kg−1, respectively) at the end of storage, with emphasis on for the hamburgers that received the microencapsulated extract. Similar behavior was observed for the analysis of carbonyl compounds, with values of 11.1 ± 1.1, 8.7 ± 1.4 and 6.8 ± 1.0 nM carbonyl.mg−1 in SEB, LEB and MEB, respectively. Thus, the freeze-dried and microencapsulated grape extracts showed superior results when compared to the synthetic antioxidant, increasing the oxidative stability of hamburgers, and avoiding significant color changes during the cold storage. The results indicate the high potential of the microencapsulated material to be used as a natural antioxidant in the meat industry.