Blood transfusion can be a life-saving intervention. However,it may result in acute or delayed complications and carries the risk of transfusion transmissible infections.WHO emphasizes that blood is an expensive and scarce resource ; unnecessary transfusions may cause a shortage of blood products for patients in real need besides the risk to the recipient.A reduction in unnecessary transfusions through the appropriate clinical use of blood and blood products and the use of simple alternatives to transfusion wherever possible should be considered. Avoidance of single unit red cell transfusion is also one of the measures of rational use of blood. Some guidelines prefer single unit transfusion for it may reduce transfusion associated and dose- dependant morbidity and mortality.We follow that blood transfusion is indicated when haemoglobin(Hb) level is 10gm% in a non-bleeding patient. During the study period of two years from January 2014 to December 2015 in Regional Institute of Medical Sciences, Imphal ,single red cell units constituted 2232 out of 22546 total red cell units issued(9.9%).Based on our protocol, 480 single unit transfusions out of 2232 units were unjustified and in our context of limited resources, more demand and less supply. Group discussions and awareness sessions with clinicians will be of immense help towards rational use of blood. The study is being presented.