Rational Approach Research Articles

Unleashing potential: how alpha female status shape extra-role performance across life's stages and marital roles

PurposeThe present study examines the interplay between age, marital status, alpha female status and various adaptive performance dimensions among a cohort of 380 female professionals.Design/methodology/approachThis study adopts a positivist approach to collect and analyse the data, utilizing appropriate statistical techniques to explore the relationships between the variables of interest.FindingsThe study elucidates the significant role of alpha female status in predicting adaptive performance. It finds that alpha females possess distinct competencies, particularly in learning and training, indicative of proactive behaviour and self-efficacy. While older participants tend to demonstrate higher performance levels, the study reveals no significant correlation between age and alpha female status, suggesting that leadership traits may develop independently of age. Furthermore, marital status exerts a modest influence on adaptive performance. The interplay of age and marital status significantly affects adaptive performance, potentially due to the Cumulative Advantage Paradigm, which is the accumulation of advantages or disadvantages throughout an individual's life course.Originality/valueThis study contributes to the existing literature by providing a nuanced understanding of how demographic factors converge to influence adaptive performance in professional settings. It highlights the importance of recognising and nurturing alpha females in organizations and considering the interactions between age and marital status when designing career development programmes and support systems.

EcoClimate and ESG Disputes: Practice, Risks, Prospects

The ecoclimate or «green» agenda, largely constituted through the concept of «sustainable development» and the system of ESG standards, has captured the world and is changing society, generating new social patterns, and ceasing business and management models. This encourages rethinking the legal superstructure, adapting new regulatory arrays to the current legal taxonomy, which is not always possible, taking into account the positivist approach to law and a significant amount of «soft» law rules and sources of non-state regulation within the framework of «green» regulation. The ecoclimate agenda has a number of dimensions in the context of law and jurisprudence, one of which is the practice of ecoclimate and ESG disputes, often of a cross-border nature. Very little attention is paid to this issue in the Russian research space, while the volume of relevant lawsuits in the world is growing rapidly. The object of the study within the framework of this work covers the risk-oriented nature of the above-mentioned issues, the licensing risks of mainly cross-border contracts, the assessment of companies’ activities in the field of sustainable development in the context of possible judicial or arbitration proceedings. The paper provides a classification of ecoclimate and ESG disputes, gives examples of judicial and arbitration practice, and makes some conclusions regarding mitigation of litigation risks generated by the companies’ activities.

Development of Meaningful Learning from Family-School Integration

The research shows the results of a study carried out on family-school integration as a foundation for meaningful learning in secondary basic education students, belonging to the official sector in the Colombian Caribbean region. The type of research was descriptive, with a deductive rationalist approach and a mixed or complementary paradigm. The sample was made up of sixty-four (64) students in their final year of high school and twenty-four (24) parents and/or guardians, to whom a survey was applied, eleven (11) teachers and one (1) director of the educational institution, consulted through an interview. Once the information was obtained, the triangulation technique was used to cross-reference the opinions, perceptions and beliefs of the actors involved in the comprehensive training of the students. As a result, it was possible to characterize the factors that favor family-school integration, including emotionality, participation, communication, attention and motivation of parents in accompanying their children's academic activities. For their part, schools must organize spaces that promote integration relationships, which represents an alternative to face the dilemmas of the educational context and promote the development of meaningful learning.

Enhancement of interlayer exchange coupling via intercalation in 2D magnetic bilayers: towards high Curie temperature.

Two-dimensional magnetic materials are considered as promising candidates for developing next-generation spintronic devices by providing the possibility of scaling down to nanometers. However, a low Curie temperature is a crucial problem for practical applications, being intimately related to weak interlayer exchange coupling. Here, by using density functional theory calculations, we show that interlayer exchange coupling can be enhanced by intercalating 3d transition metals (Sc to Zn) into a bilayer of CrI3 and NiI2. It is found that intercalated Ni and Cr atoms exhibit strong antiferromagnetic coupling with the CrI3 and NiI2 host layers, respectively. This enhances the ferromagnetic interlayer exchange coupling between the host layers by many folds compared to pristine CrI3 and NiI2 bilayers. Moreover, both intercalated compounds show out-of-plane magnetic anisotropy with half metallic nature, which makes them ideal candidates for spintronics applications. Thereby our work provides a rational approach to raise the Curie temperature of non-metallic two-dimensional magnets by intercalation.

Adsorption behavior and mechanism of NH2-MIL-101(Cr)@COFs@SA composite adsorbent for tetracycline removal

Herein, we employed a rational approach to develop a hydrogel composite material by encapsulating NH2-MIL-101(Cr)/covalent organic frameworks (COFs) in sodium alginate (SA) to effectively capture of tetracycline (TC). Experimental tests and various characterizations (including Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron spectroscopy (SEM), Brunauer-Emmett-Teller (BET), and X-ray photoelectron spectroscopy (XPS)) confirmed that the NH2-MIL-101(Cr)@COFs@SA composite exhibited a more robust, multilayer pore structure with abundant active functional groups. Under conditions of 298 K and pH = 7, the NH2-MIL-101(Cr)@COFs@SA adsorbent demonstrated remarkable TC adsorption capability, achieving a removal rate of 96.38 % in 120 min and a qmax of 252.6 mg/g at 298 K by Langmuir model. Kinetic analysis indicated that the interaction between TC and NH2-MIL-101(Cr)@COFs@SA follows a pseudo-second-order model, suggesting that chemisoption governs the process. The Langmuir model and thermodynamic analysis suggested that TC adsorption follows a monolayer sorption pattern and is spontaneous and exothermic. Even in the presence of other ions, NH2-MIL-101(Cr)@COFs@SA maintained high efficiency for TC adsorption, demonstrating superior selectivity. NH2-MIL-101(Cr)@COFs@SA demonstrated remarkable recyclability, with only a minimal reduction in the removal efficiency (85.5 % and 142 mg/g) after 10 cycles of adsorption and regeneration. Various analytical techniques, including FTIR spectroscopy, SEM, EDX, XPS, and density functional theory (DFT) calculations of adsorption energy were used to elucidate the TC adsorption mechanisms by NH2-MIL-101(Cr)@COFs@SA. The adsorption process primarily involved π-π stacking, hydrogen bonding, electrostatic interactions, and complexation.

Tecnología financiera al servicio del cliente: percepción sobre herramientas digitales bancarias en Lima

The scientific study aims to establish the perception of banking customers in a district of Lima, Peru, regarding the effect of digital tools on the quality of service and customer care in the banking sector. It is based on a positivist approach, adopting a quantitative paradigm through a descriptive, non-experimental, and cross-sectional field method. The research employs a probabilistic random sampling method to select a representative sample of 350 banking customers in Lima, Peru. Data collection is conducted through surveys using a 21-question questionnaire. Before its implementation, the questionnaire underwent a pilot test and was evaluated by a panel of five experts. The reliability of the questionnaire was verified using Cronbach's alpha coefficient, obtaining an index of 0.87. The data were analyzed using SPSS v.27 statistical software and presented in the form of tables and graphs. The results revealed a positive perception among banking customers about the impact of digital tools applied in the banking sector on the quality of service and customer care. Additionally, the study highlights the importance of understanding individual user expectations and ensuring a regulatory framework that fosters customer trust. The research concludes by emphasizing the positive perception of banking customers regarding the impact of financial technology on the quality of service and customer care in the banking sector.

Integration of Open Metal Sites in an Amino-Functionalized Sm(III)-Organic Framework toward Enhanced Third-Order Nonlinear Optical Property.

A variety of new inorganic and organic materials have emerged to advance laser technologies and optical engineering. A rational design approach can contribute significantly to fabricating nonlinear optically active metal-organic frameworks (MOFs) by considering the underlying structure-property linkage. Here, it has been embarked on a study of novel samarium(III) MOF, ([Sm2(ata)3(DMF)4]·DMF (ata2-: 2-aminoterephthalate), abbreviated as NH2-Sm-MUM-4) with enhanced nonlinear optical (NLO) properties. The crystal structure of this MOF represents a 6-connected framework with a pcu topology and distinctive characteristics, including open metal sites, free amine groups, and great stability, making it suitable for third-order NLO activity. The nonlinear index of refraction (n2) revealed the self-focusing impacts of NH2-Sm-MUM-4 at different incident intensities. The highest value of n2 and β related to 10 mw power of incident intensity are 5.15 cm2/W and 2.65 cm/W, respectively. As far as the authors know, this is the first study examining the potential systematic structural-property associations in Sm-MOFs considering improved third-order NLO properties.

Unlocking Success: Strategies for Preventing and Managing Complications in Chronic Total Occlusion Percutaneous Coronary Intervention Procedures

Complications in percutaneous coronary intervention (PCI), particularly in chronic total occlusion (CTO) cases, pose notable challenges, with a mortality rate of approximately 0.4% during hospitalization, mainly due to issues like perforation and tamponade. While risk assessment tools can aid in evaluating periprocedural complication risk, prevention and preparedness take precedence. Guided by the "3 Ps" framework—prevention, preparedness, and planning—we navigate the complexities of managing complications in CTO PCI procedures. This emphasizes the importance of comprehensive patient discussions, adherence to appropriateness use criteria, and ensuring a well-trained team equipped with standardized equipment. Furthermore, it is crucial to extract valuable insights from encountered complications, turning potential setbacks into invaluable learning opportunities. This positive approach not only fosters individual growth but also contributes to the advancement of CTO PCI practices. Various complications specific to CTO PCI are addressed, including donor vessel injury, equipment loss/entrapment, radiation injury and coronary perforation.

Mouse cursor trajectories capture the flexible adaptivity of predictive sentence processing.

Recent psycholinguistic findings raise fundamental questions about comprehenders' ability to rationally adapt their predictions during sentence processing. Two mouse cursor tracking experiments (each N = 85) assessed this adaptivity by manipulating the reliability of verb-based semantic cues. In Experiment 1, predictive mouse cursor movements to targets (e.g., bike) versus distractors (e.g., kite) were measured while participants heard equal proportions of nonpredictive (e.g., "spot … the bike"), predictive (e.g., "ride … the bike"), and antipredictive (e.g., "fly … the bike") sentences. In Experiment 2, participants heard equal proportions of nonpredictive and antipredictive sentences. Participants were observed to flexibly adapt their predictions, such that they disengaged prediction in Experiment 1 when verb-based cues were unreliable and as likely to be disconfirmed as confirmed, while they generated adapted predictions in Experiment 2 when verb-based cues were reliably disconfirmed. However, links to individual differences in cognitive control were not observed. These results are interpreted as supporting rational theoretical approaches. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Characterization of DNA damage repair pathway utilization in high-grade serous ovarian cancers yields rational therapeutic approaches

While poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have improved the prognosis of ovarian high-grade serous carcinoma (HGSC) tumors that are homologous recombination (HR) deficient (HRD), new therapeutic strategies are needed for tumors that are HR proficient (HRP) because they demonstrate greater resistance to current treatments and thus have poorer clinical outcomes. Additionally, clinical precautionary statements regarding potential risks associated with PARPi, such as myelodysplastic syndrome, highlight the need for combinatorial approaches that can lessen the dose and duration of PARPi treatment to reduce toxicities. Here, we evaluated DNA double-strand damage repair pathways in HRD and HRP ovarian cancer cell lines and found that in HRD cell lines, PARPi therapy reduced non-homologous end joining (NHEJ)-mediated repair, specifically due to decreased theta-mediated end-joining. The combination of PARPi with ATM serine/threonine kinase inhibitor (ATMi) suppressed both NHEJ and HR pathways in HRD and HRP cell lines, with synergistic increases in apoptosis and decreases in cell viability and colony formation. Interestingly, PARPi plus ATMi also decreased NF-κB p65 phosphorylation, which was not observed when PARPi was combined with inhibition of the ATR kinase (ATRi). These findings indicate that PARPi plus ATMi is a promising strategy for HGSC independent of underlying tumor HR status.

Computational Strategies to Enhance Cell-Free Protein Synthesis Efficiency

Cell-free protein synthesis (CFPS) has emerged as a powerful tool for protein production, with applications ranging from basic research to biotechnology and pharmaceutical development. However, enhancing the efficiency of CFPS systems remains a crucial challenge for realizing their full potential. Computational strategies offer promising avenues for optimizing CFPS efficiency by providing insights into complex biological processes and enabling rational design approaches. This review provides a comprehensive overview of the computational approaches aimed at enhancing CFPS efficiency. The introduction outlines the significance of CFPS and the role of computational methods in addressing efficiency limitations. It discusses mathematical modeling and simulation-based approaches for predicting protein synthesis kinetics and optimizing CFPS reactions. The review also delves into the design of DNA templates, including codon optimization strategies and mRNA secondary structure prediction tools, to improve protein synthesis efficiency. Furthermore, it explores computational techniques for engineering cell-free transcription and translation machinery, such as the rational design of expression systems and the predictive modeling of ribosome dynamics. The predictive modeling of metabolic pathways and the energy utilization in CFPS systems is also discussed, highlighting metabolic flux analysis and resource allocation strategies. Machine learning and artificial intelligence approaches are being increasingly employed for CFPS optimization, including neural network models, deep learning algorithms, and reinforcement learning for adaptive control. This review presents case studies showcasing successful CFPS optimization using computational methods and discusses applications in synthetic biology, biotechnology, and pharmaceuticals. The challenges and limitations of current computational approaches are addressed, along with future perspectives and emerging trends, such as the integration of multi-omics data and advances in high-throughput screening. The conclusion summarizes key findings, discusses implications for future research directions and applications, and emphasizes opportunities for interdisciplinary collaboration. This review offers valuable insights and prospects regarding computational strategies to enhance CFPS efficiency. It serves as a comprehensive resource, consolidating current knowledge in the field and guiding further advancements.

Towards a rational approach for multi-axial experimental campaigns for rubberlike material

This work takes up the developments around the logarithmic strain tensor and uses the invariants of this tensor to propose a new approach to multi-axiality of fatigue experiments for elastomers. This study leads to the introduction of a new notion, modality, which is intended as the microscopic counterpart of uni- and multi-axiality. This notion is quantified by the K3 invariant (mode of deformation) of the logarithmic strain tensor, and is used to rationalize tension–torsion experimental campaigns. It is illustrated using two examples: the perfect cylinder and the AE2 “diabolo” sample. We then propose a methodology for building a test campaign based on this new definition.

Validity and reliability of the Checklist for Habitual Physical Activity for people 75 years and older in Japan.

Despite health benefits, many older adults struggle to meet physical activity guidelines, leading to stagnant activity levels. While integrating physical activity into daily routines has been proposed as a promising strategy for older adults, fit-for-purpose measurement tools to assess such routines are lacking. The Checklist for Habitual Physical Activity (CHaPA) was developed based on the positive deviance approach and socio-ecological model to assess daily behaviours encouraging physical activity among adults aged 75 and older. It has been confirmed for its content and face validity. However, to ensure its broader applicability and usefulness, assessing its construct validity and reliability is necessary. Therefore, this study aims to assess the construct validity and reliability of the CHaPA and accordingly update the tool. To validate the construct validity of the CHaPA 22-item version, we conducted item analysis and exploratory and confirmatory factor analyses. We removed inappropriate items based on predefined criteria. Then, we assessed the reliability, internal consistency, test-retest reliability, and measurement errors of the CHaPA final version. Item analyses and factor analyses resulted in the deletion of 11 items. The results of confirmatory factor analysis validated the CHaPA 11-item version with the three-factor structure based on model fit index with χ2/degree of freedom = 1.25, comparative fit index = 0.965, Tucker-Lewis index = 0.952, and root-mean-square error of approximation = 0.038. Omega coefficient (0.90) showed excellent internal consistency. Intraclass correlation coefficient (ICC) demonstrated good test-retest reliability (ICC (1, 2) = 0.77, 95% CI = 0.34-0.89, standard error of measurement = 1.75). We finalised the CHaPA 11-item version as a valid and reliable instrument for assessing daily behaviours conducive to physical activity among individuals aged 75 years and older. We need to examine the methods and effectiveness of disseminating this checklist to ensure its utilisation as a resource for promoting healthy ageing and aiding older adults in maintaining active lifestyles.

Positive Deviance Theory: Leveraging Compliments Data to Guide Strategic Planning for Patient Experience Improvement in a Large Rural Health Care System.

Patient-centered care (PCC) has been called for as a solution to improving care quality and patient outcomes. Patient experience, termed care experience, is a measurable aspect of PCC and aligns with coproduction. Identifying patterns of positivity and high performers is a Positive Deviance approach that can inform strategic improvement of the care experience. To identify the characteristics of positive deviances from voluntary, unsolicited compliments from patients and family members about their care experiences. The authors conducted a mixed-method analysis, including content and a thematic analysis of unsolicited comments from patients and families, submitted between January 2021 and January 2022. After removing duplicates and miscategorized comments, 213 compliments were included in the analysis using a single, blinded inductive coding to synthesize thematic statements. The main campus received the most compliments by location (89%); the most widely used patient sentiment was thankful (36.8%). Compassionate (26.8%), together with six others: competent (11.6%), communication (10.6%), cared for (8.5%), care team (8.0%), and supportive (8.0%), made up approximately 80% of drivers of care quality. Physicians (37.3%) and nurses (34.2%) were the most complimented personnel, although surgery (17.0%) were the most complimented services team. Similar characteristics were reported for exemplary individuals and their associated care teams. The results align with previously reported work by the Beryl Institute and CMS 5-star rating on key drivers of patient experience. This approach provides a method by which exemplars can be identified within health systems, and that information is used to guide improvement and organizational planning.

Role of Calmodulin in Cardiac Disease: Insights on Genotype and Phenotype.

Calmodulin, a protein critically important for the regulation of all major cardiac ion channels, is the quintessential cellular calcium sensor and plays a key role in preserving cardiac electrical stability. Its unique importance is highlighted by the presence of 3 genes in 3 different chromosomes encoding for the same protein and by their extreme conservation. Indeed, all 3 calmodulin (CALM) genes are among the most constrained genes in the human genome, that is, the observed variants are much less than expected by chance. Not surprisingly, CALM variants are poorly tolerated and accompany significant clinical phenotypes, of which the most important are those associated with increased risk for life-threatening arrhythmias. Here, we review the current knowledge about calmodulin, its specific physiological, structural, and functional characteristics, and its importance for cardiovascular disease. Given our role in the development of this knowledge, we also share some of our views about currently unanswered questions, including the rational approaches to the clinical management of the affected patients. Specifically, we present some of the most critical information emerging from the International Calmodulinopathy Registry, which we established 10 years ago. It appears growingly evident as further progress requires the collection of deep phenotypic information through international contributions to the registry as the best way to expand our knowledge about Calmodulinopathies with the goal of acquiring the information necessary to guide clinical management.

Pharmacognostical study of stem and bark of bauhinia vahlii (wight & arn)

Bauhinia is known by its medicinal effect in the body system as because it is used in many disease for their initial treatment with no such sevier side effect. This research based on the testing of the plant Bauhinia vahlii and its wide analysis. Plant was collected mainly from threeregions of India Uttarakhand (Pithoragarh, Kathgodam, Gathiya). Stem and Bark part of the plant is taken for research. The research elaborates transverse and longitudinal section of this plant. Research include analysis and testing of the plant with addition of it chromatography by the HPTLC. The complete research done by study of steam and bark of the plant Bauhinia vahlii. The result obtain by the research in the constituents of steam and bark clearly shows all the characterization and positive approach towards the health benefit of it. As traditionally it is seen to usage of its leaf in the covering of some edible sweets like singauri because of its extraordinary pharmaceutical benefits which seems in the result came by this research. This creeper like medicinal plant with structurally wide leaf is widely grows in the hilly areas of Uttarakhand by itself.

Influence of Hippocrates on the development of modern medicine

Introduction: Hippocratic thought is not simply an echo of the past, but an eternal link that connects the historical roots of medicine with its contemporary evolution, being a fundamental guide for doctors in the search for technical excellence and ethical practice. Objective: Analyze the influence of Hippocrates on the development of modern medicine.Methods: A bibliographic review was carried out by consulting academic databases PubMed, Scopus and Google Scholar, and using specific keywords to identify and select relevant studies on the topic. High-quality and current sources were evaluated and synthesized, organizing the information into thematic categories for analysis.Results: The history of medicine is deeply intertwined with the scientific method, and in this context, Hippocrates stands out as a pioneer who paved the way towards evidence-based medicine. His scientific legacy, reflected in his teachings and practices, has endured through the centuries, shaping the way doctors approach the diagnosis and treatment of diseases.Conclusions: Although some of Hippocrates' theories have been surpassed, his contribution to establishing medicine as a respected and responsible profession remains essential in current medical care. His rational approach, medical ethics, preventive and comprehensive vision, and methods of diagnosis and treatment maintain the validity of his thinking.

Evidence that extracellular HSPB1 contributes to inflammation in alcohol-associated hepatitis.

Alcohol-associated hepatitis (AH) is the most life-threatening form of alcohol-associated liver disease (ALD). AH is characterized by severe inflammation attributed to increased levels of ethanol, microbes or microbial components, and damage-associated molecular pattern (DAMP) molecules in the liver. HSPB1 (Heat Shock Protein Family B (Small) Member 1; also known as Hsp25/27) is a DAMP that is rapidly increased in and released from cells experiencing stress, including hepatocytes. The goal of this study was to define the role of HSPB1 in AH pathophysiology. Serum HSPB1 was measured in a retrospective study of 184 heathy controls (HC), heavy alcohol consumers (HA), patients with alcohol-associated cirrhosis (AC), and patients with AH recruited from major hospital centers. HSPB1 was also retrospectively evaluated in liver tissue from 10 HC and AH patients and an existing liver RNA-seq dataset. Finally, HSPB1 was investigated in a murine Lieber-DeCarli diet model of early ALD as well as cellular models of ethanol stress in hepatocytes and hepatocyte-macrophage communication during ethanol stress. Circulating HSPB1 was significantly increased in AH patients and levels positively correlated with disease-severity scores. Likewise, HSPB1 was increased in the liver of patients with severe AH and in the liver of ethanol-fed mice. In vitro , ethanol-stressed hepatocytes released HSPB1, which then triggered TNFα-mediated inflammation in macrophages. Anti-HSPB1 antibody prevented TNFα release from macrophages exposed to media conditioned by ethanol-stressed hepatocytes. Our findings support investigation of HSPB1 as both a biomarker and therapeutic target in ALD. Furthermore, this work demonstrates that anti-HSPB1 antibody is a rational approach to targeting HSPB1 with the potential to block inflammation and protect hepatocytes, without inactivating host defense. HSPB1 is significantly increased in serum and liver of patients with alcohol-associated hepatitis.Ethanol consumption leads to early increases in HSPB1 in the mouse liver.Hepatocytes subjected to ethanol stress release HSPB1 into the extracellular environment where it activates TNFα-mediated inflammation in macrophages.Anti-HSPB1 antibody blocks hepatocyte-triggered TNFα in a model of hepatocyte-macrophage communication during ethanol stress.

The Relationship Between Students' Attitudes Towards Violence Against Women And Their Depression

Background: Violence against women, especially by an intimate partner in its various forms (sexual, physical, or stalking), and childhood violence (sexual or physical) are common and are associated with depressive symptoms. Method: The sample of this descriptive-analytic research was consisted of 895 students attending to the Faculty of Health Sciences of a public university in the East of Turkey. Data were collected between October and November 2021 via the "Personal Description Form", "ISKEBE Attitudes Towards Violence Against Women Scale" and "Beck Depression Scale". Descriptive statistics, independent group t-test, Pearson correlation analysis, Chi-square, and ANOVA tests were used for statistical analysis. Results: More than half of the students (56.1%) stated that they were exposed to violence. Verbal violence was reported to come from mothers (24.5%), fathers (20.0%) and sibling (20.2%). In addition, 23.2% of the students experienced emotional violence from their friends and 14.7% from their partners. The majority of participants indicated that an apology typically follows an act of violence as a means of restoring peace and order (28.3%). Attitude towards the body sub-dimension of ISKEBE was significantly related with the exposure to violence in general, experience of emotional and sexual violence, gender, grade and mother's educational level. Beck Depression Scale scores were significantly higher in students exposed to violence, were married, were in first grade and those under the18 years of age Conclusion: In this study, we found that as the age of the students increased, their attitudes towards violence against women became increasingly positive. The depression score of the students who had been exposed to violence at any point in their lives was found to be higher than those who had not experienced violence. Furthermore, it was observed that while students' depression scores increased, ISKEBE scores decreased. This indicates that individuals with elevated depression scores tend to adopt a positive approach to the issue of "violence against women". Nurse educators and nurses should plan interventions to protect the mental health of nursing students and to increase their awareness of violence against women.

Update on Antisocial Personality Disorder.

Antisocial personality disorder (ASPD) is a characterized by lifelong or recurrent behavioral problems that begin in childhood or early adolescence. This communication provides an overview on ASPD including findings from recent reviews and new research. With regard to DSM-5's Section III Alternative Model of Personality Disorder criteria for ASPD, advocates point to the broader symptom coverage and harmonization with ICD-11; yet critics point to the lack of evidence for improved outcomes. A new report shows that antisocial individuals age faster than non-antisocial peers. ASPD has high heritability and newer molecular studies have found intriguing linkages to genes associated with crucial brain regions. A mentalization-based therapy model has been developed and early work shows promise. ASPD is common, widespread, and disruptive to individuals, families, and society. Chronic and lifelong, ASPD typically lessens in severity with advancing age. Assessment rests on the individual's history because there are no diagnostic tests. ASPD likely results from an interplay ofgenetic and environmental factors. Brain imaging studies have linked cortical dysfunction to antisocial behavior in crucial brain regions. Medication is sometimes targeted at the individual's aggression and irritability, but a more rational approach is to target co-occurring disorders. Cognitive-behavioral therapy and mentalization-based therapy models have been developed and are being studied.