The viscosity ratio of polymer and oil is a crucial factor for polymer flooding, which can affect the water–oil mobility ratio and oil recovery. However, for high-temperature and high-salinity reservoirs, the reasonable viscosity ratio limit of polymer flooding under the condition of medium–high permeability and low oil viscosity is not clear. Thus, the heterogeneous sand-pack flooding experiments were carried out to analyze the influence of polymer–oil viscosity ratio on the enhanced oil recovery (EOR) performance of anti-hydrolyzed polymer to establish a reasonable viscosity ratio limit. Then the three-dimensional heterogeneous model flooding experiments were performed to clarify the mechanism. The results showed that when the permeability ratio was the same, as the viscosity ratio increased from 0.15 to 2.0, the incremental oil recovery increased from 3.2% to 27.2%. When the viscosity ratio was the same, the incremental oil recovery decreased with the increase in the permeability ratio. The reasonable viscosity ratio ranges from 1.0 to 1.5. For three-dimensional heterogeneous model flooding experiments, as the polymer–oil viscosity ratio increased from 0.45 to 1.0, the swept area of high and low permeability area was expanded and the oil saturation near the injection well in the mainstream channel was greatly reduced. Moreover, when the polymer–oil viscosity ratio was 1, the difference in the width of the mainstream channels between high and low permeability layers in the saturation field decreased, and the degree of utilization in low permeability layers increased significantly. As the polymer–oil viscosity ratio increased from 0.45 to 1.0, the incremental oil recovery increased from 16.2% to 24%.