Flow Rate Ratio Research Articles

Effect of methane addition on supercritical water oxidation of poultry manure in the flow mode

The paper presents the research results of the supercritical water oxidation (SCWO) of poultry manure continuously fed into a tubular reactor both in the absence and presence of methane as an auxiliary fuel. The tests were conducted at a temperature gradient along the vertical axis of the reactor (top to bottom: 390–600 °C), a pressure of 25 MPa, and varying reagent flow rates. It is shown that due to heat generation during methane oxidation the energy consumption from external sources is reduced by 1.3–1.5 times depending on the ratio of reagent flow rates. The gas products contain CO2, N2, and trace amounts of N2O. The ash residues are predominantly composed of calcite and hydroxyapatite. The addition of methane results in a reduction in the content of phenols and polycyclic aromatic hydrocarbons present in the aqueous effluent, while content of N-bearing aromatics increases. The formation of nitrophenols was observed at elevated oxygen concentrations in the reaction mixture. It was revealed that excess oxygen plays a pivotal role in the efficacy of organic nitrogen removal. The formation of mineral acids and a high level of ammonia in the reaction mixture during the SCWO of poultry manure result in corrosion of stainless steel and copper seals, which in turn leads to an increased concentration of chromium and copper in the aqueous effluent. The results obtained indicate the potential for utilizing natural gas in an environmentally friendly and resource-saving manner for poultry manure processing by SCWO in autothermal mode.

Development of an extended action fostemsavir lipid nanoparticle

An extended action fostemsavir (FTR) lipid nanoparticle (LNP) formulation prevents human immunodeficiency virus type one (HIV-1) infection. This FTR formulation establishes a drug depot in monocyte-derived macrophages that extend the drug’s plasma residence time. The LNP’s physicochemical properties improve FTR’s antiretroviral activities, which are linked to the drug’s ability to withstand fluid flow forces and levels of drug cellular internalization. Each is, in measure, dependent on PEGylated lipid composition and flow rate ratios affecting the size, polydispersity, shape, zeta potential, stability, biodistribution, and antiretroviral efficacy. The FTR LNP physicochemical properties enable the drug-particle’s extended actions.

3D-printed microfluidics under ultrasonic cooling crystallization for nano-precipitation of ezetimibe: Effect of process parameters and PBD approach

The current research focuses on the antisolvent precipitation of Ezetimibe (EZB) via microfluidics under continuous ultrasonic cooling crystallization. One factor at a time was applied to study the effect of parameters: organic-aqueous flow rate ratio (1:2–1:5), EZB concentration (2.5–12.5, mg/mL), polymer concentration (0.025–0.3, % w/v), ultrasonic frequency (22–42, kHz), ultrasonic bath temperature (10–25, °C), ultrasonic amplitude (20–100, %), confluence angle of micromixer inlet (90°–180°) on the particle size (PS, nm), % yield, % encapsulation efficiency (% EE), and % dissolution rate (% DR). A PBD (Plackett–Burman design) was also employed for the screening studies of influencing factors for aforementioned responses. PS, Zeta potential (ZP, mv), Field Emission Gun Transmission Electron microscope (FEG-TEM), and X-ray diffraction (XRD) were analyzed for raw EZB and nano-precipitated EZB. An average EZB PS of 101 ± 1.1 nm, PDI of 0.027 ± 0.01, 80 ± 1.7 % yield, 78.83 ± 0.5 % DR, 90.67 ± 0.1 % EE, and −20 mV ZP were obtained under best parametric condition. FEG-TEM revealed the final nano EZB morphology was likely to be elongated cuboidal or rod-shaped. An approximately 5-fold increase in %DR was observed for the confluence angle of 90° (├ shaped) micromixer as compared to raw EZB. However, 94.14 % decreament in avg EZB PS was achieved for the confluence angle of 90° (├ shaped) micromixer and utilizing ultrasonic microfluidic system (USMS) under cooling crystallization as a process intesification approach.

Production of 5-fluorouracil-loaded PLGA nanoparticles with toroidal microfluidic system and optimization of process variables by design of experiments

In recent decades, microfluidics has presented new opportunities for the production of nanoparticles (NPs). However, to achieve rapid clinical translation, the production of PLGA NPs in a single microfluidic channel for both the pharmaceutical research and industry without the need for scaling is still limited. The aim of this study was to accomplish the production of reproducible and stable 5-FU loaded Poly(lactic-co-glycolic acid) (PLGA) NPs, using an innovative toroidal microfluidic system, for cancer therapy. The toroidal microfluidic system enabled the production of spherical NPs ranging from 100 to 150 nm by adjusting both the TFR within the range of 5–15 mL/min and FRR between 1:3 and 1:7. A systematic assessment of critical process variables (total flow rate; TFR, flow rate ratio; FRR) for the production of PLGA NPs was conducted using Design of Experiment (DoE). The NPs, which exhibit a uniform size distribution, remained stable even after centrifugation and storage for 3 months at 4 °C. The encapsulation efficiency of drug and the concentration of NPs were not affected by changing process parameters. The effective 5-FU encapsulation into NPs resulted in a controlled in vitro drug release. Due to the controlled release profile of the 5-FU loaded PLGA NPs, the formulation was a promising candidate for mitigating the toxic side effects of free 5-FU and improving cancer treatment. In conclusion, toroidal microfluidic system enables high-volume production of stable PLGA NPs, both with and without 5-FU.

In-situ biological biogas upgrading using upflow anaerobic polyfoam bioreactor: Operational and biological aspects.

A high rate upflow anaerobic polyfoam-based bioreactor (UAPB) was developed for lab-scale in-situ biogas upgrading by H2 injection. The reactor, with a volume of 440 mL, was fed with synthetic wastewater at an organic loading rate (OLR) of 3.5 g COD/L·day and a hydraulic retention time (HRT) of 7.33 h. The use of a porous diffuser, alongside high gas recirculation, led to a higher H2 liquid mass transfer, and subsequently to a better uptake for high CH4 content of 56% (starting from 26%). Our attempts to optimize both operational parameters (H2 flow rate and gas recirculation ratio, which is the total flow rate of recirculated gas over the total outlet of gas flow rate) were not initially successful, however, at a very high recirculation ratio (32) and flow rate (54 mL/h), a significant improvement of the hydrogen consumption was achieved. These operational conditions have in turn driven the methanogenic community towardthe dominance of Methanosaetaceae, which out-competed Methanosarcinaceae. Nevertheless, highly stable methane production rates of 1.4-1.9 L CH4/Lreactor.day were observed despite the methanogenic turnover. During the different applied operational conditions, the bacterial community was especially impacted, resulting in substantial shifts of taxonomic groups. Notably, Aeromonadaceae was the only bacterial group positively correlated with increasing hydrogen consumption rates. The capacity of Aeromonadaceae to extracellularly donate electrons suggests that direct interspecies electron transfer (DIET) enhanced biogas upgrading. Overall, the proposed innovative biological in-situ biogas upgrading technology using the UAPB configuration shows promising results for stable, simple, and effective biological biogas upgrading.

Scaled experiment and numerical study on the effect of a novel makeup air system on smoke control in atrium fires

In the field of fire safety engineering, makeup air systems design for atriums is always a concern for researchers and engineers. A novel makeup air system integrating breathing zone and underfloor air supply (BUMS) was applied in the investigated atrium in this study. However, the flow rates proportional relationship of makeup air required for effective smoke control on each floor remains unclear. Scaled experiments and numerical simulations were carried out to address this problem in this study. The results show that the BUMS effectively controlled temperature, followed by visibility, with minimal impact on carbon monoxide (CO) concentrations. When the flow rate of makeup air was equal on each floor, the sizes of the safe evacuation passageways created by the BUMS on the third and fourth floors were not conducive to the safe evacuation of personnel. Based on the proportion of the CO concentration of each floor under natural ventilation, distribution proportions of makeup air flow rate were obtained. The effective action area was used to help determine the upper limit flow rate ratio for each floor. Calculation results revealed that when the flow rate distribution proportion for the first to fourth floors was 15 %, 27 %, 28 % and 30 %, respectively, the smoke control effectiveness has been improved. These findings are expected are expected to provide a theoretical basis for designing makeup air systems in atrium and large-space buildings.

Scalable microfluidic method for tunable liposomal production by a design of experiment approach

Liposomes constitute a widespread drug delivery platform, gaining more and more attention from the pharmaceutical industry and process development scientists. Their large-scale production as medicinal products for human use is all but trivial, especially when parenteral administration is required. In this study an off-the-shelf microfluidic system and a methodological approach are presented for the optimization, validation and scale-up of highly monodisperse liposomes manufacturing. Starting from a Doxil®-like formulation (HSPC, MPEG-DSPE and cholesterol), a rational approach (Design of Experiments, DoE) was applied for the screening of the process parameters affecting the quality attributes of the product (mainly size and polydispersity). Additional DoEs were conducted to determine the effect of critical process parameters “CPPs” (cholesterol concentration, total flow rate “TFR” and flow rate ratio “FRR”), thus assessing the formulation and process robustness. A scale-up was then successfully accomplished. The procedure was applied to a Marqibo®-like formulation as well (sphingomyelin and cholesterol) to show the generality of the proposed formulation, process development and scale-up approach. The application of the system and method herein presented enables the large-scale manufacturing of liposomes, in compliance with the internationally recognized regulatory standards for pharmaceutical development (Quality by Design).

Flow field analysis and performance evaluation of a mini-hydrocyclone for ultra-low inlet flow rate

It is difficult for hydrocyclone to separate oil-water under the condition of ultra-low inlet flow rate, which commonly exist in the field of energy engineering. Mini-hydrocyclone is an effective technology to solve this problem. The flow field characteristics and oil droplet migration trajectory in the mini-hydrocyclone are the key to guide its efficient work. An innovative mini-hydrocyclone are studied via computational fluid dynamics (CFD) and experiment method. The good separation performance of mini-hydrocyclone for ultra-low inlet flow rate and tiny particle size of oil droplets is verified and analyzed. Furthermore, The distribution of velocity, oil volume fraction and oil migration trajectories in the mini-hydrocyclone are analyzed systematically. The effects of oil droplet size, inlet flow rate and split ratio on the separation performance of mini-hydrocyclone are investigated. The results show that the maximum separation efficiency of the mini-hydrocyclone for 1.0 L/min ultra-low inlet flow rate is 99.98 %, when the split ratio is 30 %, the oil phase volume fraction is 2 %. Moreover, the morphological and distribution of oil core in mini-hydrocyclone are basically consistent between simulation and experiment results, under the conditions of different operating parameters. The minimum error of numerical simulation and experiment results is less than 2.23 %, the accuracy of the numerical simulation method is verified.

Mass transfer of gas–liquid two‐phase flow in asymmetric parallel microchannels with liquid feed splitting

AbstractDue to size limitations, the gas–liquid absorption capacity of a single microchannel is limited, making it difficult to achieve large‐scale CO2 capture. Therefore, the parallel microchannels combining the advantages of high efficiency and large throughput stand out. However, when the operating condition is high gas–liquid flow rate ratio, the liquid phase between bubbles almost disappears after multiple distributions, which affects the amount of gas–liquid absorption. In this study, the numbering‐up of the asymmetric parallel microchannels in the gas–liquid absorption process was investigated by splitting the liquid feed stream in two. The flow patterns under different operating conditions were obtained. The flow and distribution of gas–liquid two‐phase flow were investigated, and the reason of the distribution deterioration caused by appearance of long slug bubbles was explained by the pressure drop distribution. The total liquid mass transfer coefficient and bubble residence time were derived and obtained, and the mass transfer was further discussed.

High performance symmetric supercapacitors based on Au incorporated CrN thin films fabricated by reactive magnetron sputtering

Recently, transition metal nitrides are being investigated extensively as potential supercapacitor material. In the present study, Au incorporated CrN (Au_CrN) thin films have been synthesized using reactive magnetron co-sputtering technique for application as supercapacitor electrode material. Films have been prepared at different Ar to N2 flow rates keeping total deposition pressure constant to achieve the required structural phase in the sample. Electrochemical properties of the deposited materials have been investigated with a three-electrode system in 0.5 M H2SO4 aqueous electrolyte. The CrN thin film deposited under 3:1 Ar: N2 partial pressure or flow rate ratio shows the highest specific capacitance. Upon Au incorporation, the film shows an areal capacitance of 56.8 mFcm−2 at 1.0 mAcm−2discharge current density which is an almost nine-fold enhancement in specific capacitance value compared to pristine CrN sample. Symmetric supercapacitors have also been developed by sandwiching two identical Au_CrN thin film electrodes, which have found to deliver excellent specific capacitance of 86.03 mFcm−2at 1.0 mAcm−2 discharge current density with no decline in capacitance value till 20,000 cycles. Furthermore, it can deliver a high energy density of 52.02mWhcm−2and a power density of 0.12mWcm−2. The electrochemical properties of the supercapacitors fabricated with the Au_CrN thin film electrodes are found to be better than most of the results reported so far in the literature with CrN electrodes. Results of the present study clearly demonstrate that these Au enhanced CrN films prepared by easily scalable and highly reproducible magnetron sputtering technique have great potential as a high capacitance supercapacitor electrode material.

Experimental investigation and performance analysis of a spray-type ionic liquid desiccant dehumidifier

Ionic liquid desiccants (ILDs) have vapor pressures similar to lithium chloride and no corrosion and crystallization problems, so they are considered a promising alternative to halide salt desiccant solutions. However, the cost of ILDs is more expensive than conventional halide salts, which limits their practical application. Thus, this study developed a spray-type dehumidifier using an ionic liquid desiccant to increase dehumidification performance and reduce the required amount of ILDs. The presented dehumidifier was tested at various operating conditions. Also, a theoretical model was established to analyze heat and mass transfer coefficients of the dehumidifier. Results indicate that the increase in the flow rate ratio of solution to air benefits absorption performance, and the mass flux of solution is suggested to exceed 170 mL s−1 to avoid the occurrence of air bypass. Moreover, compared with the packed bed type, the spray type can reduce the required solution flow rate by 35 % and save power consumption by 19 % under the same moisture removal rates. The dehumidification effectiveness of the presented dehumidifier was up to 0.64 and comparable to the conventional packed bed dehumidifier using lithium chloride solutions.

Boiling induced atomization of liquid film produced by oblique jet impingement on superheated wall

For the thermal management of industrial devices, a reduction in the net coolant flow rate by droplet dispersion from a liquid film is important because it can cause unexpected thermal failure. To understand the process of droplet dispersion from a liquid film better, we experimentally and theoretically evaluated the characteristics of boiling-induced atomization in a liquid film formed by oblique jet impingement on a superheated wall. Atomization processes were visualized using magnified high-speed imaging using a backlight technique. In this study, two types of droplets were observed using high-speed-magnification imaging. These were large droplets that disintegrated from the ligament formed on a relatively high-temperature wall, and small droplets from the ligament formed via bubble bursting in the nucleate boiling regime. For the atomization induced by nucleate boiling, larger droplets were produced via bubble bursting further downstream from the impingement point because the bubble size and liquid film thickness increased. Finally, the total volume of the droplets produced by nucleate boiling was estimated from the frequency of bubble bursting and droplet size measured from the visualization results. The estimation results suggest that the ratio of the total volume flow rate of the ejected droplets to the injection flow rate of the liquid was negligible (2%). Thus, most of the injected liquid eventually reached the wetting front of the sheet, separating it from the wall before drying out.

DoE-Aided Optimization of RP-HPLC Method for Simultaneous Estimation of Amoxicillin and Tinidazole Loaded Mucoadhesive GRDDS Formulation for the Treatment of H. pylori

Helicobacter pylori (H. pylori) infection is one of the primary risk factors of peptic ulcer disease worldwide. Treatment of H. pylori with the conventional dosage form is often challenging due to the ineffective reach of the antibiotics to the inner layers of gastric mucosa, where the organism resides. This study developed an eco-friendly, stability-indicating RP-HPLC method to simultaneously estimate amoxicillin and tinidazole from mucoadhesive formulation targeting H. pylori infection. The mucoadhesive GRDDS formulation of antibiotics was developed with a goal of improving bioavailability at the gastric mucosa. The multivariate Box–Behnken design (BBD) was utilized to optimize chromatographic parameters. Independent variable such as ratio of mobile phase, flow rate, pH and injections volume were optimized using DoE, and analyzed using perturbation plots. A desirability of 0.981 was achieved for the optimized variables. The optimized method utilized methanol and phosphate buffer (25:75) at pH 6.3 as the mobile phase in an isocratic elution mode on a Luna ODS C18 column kept at 25 °C as the stationary phase. The method was linear from 0.25 to 20 µg/mL, for both the drugs with R2 values of 0.9993 and 0.9997 for amoxicillin and tinidazole, respectively. This validated RP-HPLC technique demonstrated selectivity in the presence of possible degradation products and excipients present in the mucoadhesive GRDDS beads. The method was used for the determination of entrapment efficiency and in vitro release profile for tinidazole and amoxicillin in the mucoadhesive GRDDS formulation.Graphical

Mechanism of temporal interface evolution and internal circulations during the droplet formation in a planar slit T-microchannel

The present study has numerically explored the mechanism of interface evolution and internal flow circulations during the droplet formation in two-phase flow through a planar T-microchannel. The two-dimensional unsteady form of the conservative level set equation coupled with Navier–Stokes equations has been solved using the finite element method. The range of parameters include the contact angle (θ) from 120° to 180°, and the flow rate ratio (Qr) from 0.1 to 10 for the low capillary number (Cac≤10−2). The present study indicates that surface wettability plays a crucial role in influencing the temporal evolution of the interface. The internal flow circulation in the droplet is controlled by the axial and radial velocities primarily influenced by shear stress. The newly introduced novel “interface-to-neck ratio” parameter has provided another platform to investigate the pinch-off dynamics of droplets. Moreover, the phenomenon of droplet pinch-off is primarily initiated and driven by the Laplace pressure, defined by three distinct approaches: the pressure difference method, the determination of the minimum local radius of curvature on the rear side, and a calculation of the neck width. The predictive correlations have been established to estimate the droplet characteristics as a function of the flow rate ratio and contact angle. The findings reported have significant implications for the design of droplet dispensing systems that depend on surface wettability as a critical regulating parameter.

DEVELOPMENT OF AN ALGORITHM FOR CALCULATING COMPONENT COMPOSITION TO IMPROVE THE DEVELOPMENT OF OFFSHORE OIL FIELDS IN THE NORTH CASPIAN BASIN

The paper presents an algorithm to reconstruct the component composition of the mixture based on the results of production modeling in the black oil format and a fixed set of tables with the results of phase equilibrium calculations in a given pressure range. The approach is based on analyzing the ratio of flow rates for each phase and the ratio between average reservoir pressure and saturation pressure. The algorithm takes into account the possibility of oil degassing when saturation pressure decreases, as well as gas breakthrough of gas caps to the bottoms of producing wells.Implementation of the method is based on a unified thermodynamic model of multilayer reservoir, built on the principles of a single set of HC mixture components and uniform parameters of the equation of state on a set of fluid samples for all modeling stages: reservoir model, model of the gathering system and site facilities. In addition to steady-state flow calculations performed together with reservoir modeling, the unified model is planned to be used for dynamic flow calculations in the corresponding simulator (well start/stop), which will allow solving production problems in the process of operation of wells with complex completions.The conversion algorithm is automated using modern high-level tools: Python and data automation components from MS Excel, which eliminates the need for manual data input at all stages and makes it possible to obtain the estimated component composition of produced fluid for any set of wells and for any time step within the forecasting horizon.The obtained compositions are used to verify the reproduction of the main controlled parameters (oil density and gas oil ratio) and can be used for subsequent calculations of fluid transportation and treatment systems.The implemented algorithm has been tested for stability at different ratios of gas and oil flow rates by wells and meets the practical requirements of engineering calculations — the error of oil density is not higher than 2 % and gas factor is not higher than 10 %.

Double protection of probiotics in alginate hydrogel through emulsification incorporated with freeze drying and coaxial wet-electrospraying: Survivability and targeted delivery

Two probiotic strains were co-encapsulated in water in oil emulsion by two methods: (1) coaxial wet electrospraying and (2) freeze-drying methods. Optimization of the wet electrospray technique for maximum yield, minimum sphericity factor, and size resulted in an alginate concentration of 2.99% w/v, flow rates ratio of alginate to the emulsion of 4.81, and applied voltage of 10 kV. The cell viability of Lactobacillus plantarum PTCC 1896 was the same after both encapsulation techniques, while the freeze-drying method was more impressive (97.25%) than the coaxial electrospraying (86.46%) in maintaining the viability of Bifidobacterium animalis subsp. Lactis. Exposing electrospray-encapsulated probiotics to simulated gastrointestinal conditions for 4 h resulted in only a one logarithmic cycle decrease in the viability of both bacteria. The number of live cells remained at more than 108 CFU g−1. In contrast, the viability of freeze-dried probiotics was reduced to about 107 CFU g−1. The freeze-dried B. lactis was the most sensitive probiotic to simulated gastric conditions. Monitoring the viability of bacteria during storage at −18 °C for both wet electrospraying and freeze-drying methods showed that the number of living microorganisms was more than 6 Log CFU g−1 after 5 and 4 months, respectively.

Mass Transfer Performance of a Rotating Spiral: Comparison with Conventional Contacting Methods

Previous work by the authors develops a novel technology for counter-current contacting of immiscible fluid phases based on a rotating spiral channel. The work has established theoretical modelling allowing prediction of mass transfer rates for physical absorption and desorption of dilute solute species and has verified the main hydrodynamic elements of the theory, with experimental measurements over a wide range of flow rates and liquid viscosity. A key feature of rotating spiral contacting is that the relative thicknesses of the phase layers is constant throughout the contacting process and, along with the relative phase flow rates, can be varied regardless of phase and solute properties to produce optimum conditions for the contacting. It has been shown that there are two criteria that determine the optimum. First, the flow rate ratio of the phases is matched to the equilibrium distribution of the solute between the two phases, so that sufficient solvent phase flows to allow full removal of solute from the processed stream. Second, the relative layer thicknesses should maximise specific throughput, i.e. the flow rate of the processed stream per device volume. These ideas of optimum contacting guide a comparison here of recent mass transfer data for the spiral with corresponding literature data for the packed column and rotating packed bed.

Microwave plasma-assisted hydrogen production via conversion of CO2–CH4 mixture

A method concerning re-use of the main greenhouse gases: CO2 and CH4 at the same time producing value-added chemicals (H2 + CO) is presented in this paper. The method involves the methane dry reforming using an atmospheric pressure operated 915 MHz microwave plasma source with a swirl gas flow. The effect of the CO2 to CH4 flow rates ratio, the total gas flow rate and the absorbed microwave power on the volume concentration of the gaseous plasma component in the outlet gas (%), CO2 and CH4 conversion rate (%), hydrogen production rate (g h−1) and energy yield of hydrogen production (g kWh−1) was investigated experimentally. The recorded results of the CO2 and CH4 conversion rate were about 82% and 88%, respectively. The best results in terms of the hydrogen production rate and energy yield of hydrogen production were equal to 156 g h−1 and 24 g kWh−1, respectively.

Anti-fogging properties of amphiphilic copolymer films deposited by chemical vapor deposition (CVD)

This study demonstrates the deposition of an amphiphilic copolymer as an anti-fogging coating on the glass and mirror surfaces. For this purpose, copolymer films of 2,2,2,3,4,4,4,4 hexafluorobutyl acrylate (HFBA) with 2-(dimethylamino)ethyl methacrylate (DMAEMA) were synthesized using initiated chemical vapor deposition (iCVD). During the iCVD process by adjusting the flow rate ratio of the monomers, the amount of fluorinated moiety in the P(HFBA-DMAEMA) was systematically tuned, which was confirmed through FTIR and XPS analyses. According to the water contact angle measurements, coatings were shown to be more hydrophobic with increasing fraction of fluorine atoms in their structures. The P(HFBA-DMAEMA)-deposited surfaces showed outstanding and long-lasting anti-fogging performance while maintaining high optical transmissivity. Films were observed to be functional in terms of anti-fogging behavior even after 1-year from the initial coating process, which confirms the durability of the films.

Cavitation-on-a-Chip Enabled Size-Specific Liposomal Drugs for Selective Pharmacokinetics and Pharmacodynamics.

The size of liposomal drugs has been demonstrated to strongly correlate with their pharmacokinetics and pharmacodynamics. While the microfluidic method successfully achieves the production of liposomes with well-controlled sizes across various buffer/lipid flow rate ratio (FRR) settings, any adjustments to the FRR inevitably influence the concentration, encapsulation efficiency (EE), and stability of liposomal drugs. Here we describe a controllable cavitation-on-a-chip (CCC) strategy that facilitates the precise regulation of liposomal drug size at any desired FRR. The CCC-enabled size-specific liposomes exhibited striking differences in uptake and biodistribution behaviors, thereby demonstrating distinct antitumor efficacy in both tumor-bearing animal and melanoma patient-derived organoid (PDO) models. Intriguingly, as the liposome size decreased to approximately 80 nm, the preferential accumulation of liposomal drugs in the liver transitioned to a predominant enrichment in the kidneys. These findings underscore the considerable potential of our CCC approach in influencing the pharmacokinetics and pharmacodynamics of liposomal nanomedicines.