In the design of structures, stability and safety play a crucial role in serviceability. The response of the soil which influences the motion of the structure and vice versa is termed soil–structure interaction (SSI). Interaction effect is ignored to simplify the mathematical model for the analysis of problems involving soil interaction. In reality, the actual behaviour of the substructure is altered significantly if one considers the interaction among the foundations and the soil medium. In this study, a large-scale test setup (1.4 m × 0.8 m × 1.0 m) has been developed and model pile has been designed to find out the influence of SSI. Experimental tests were conducted on single pile, pile group (2 × 2), and pile-group-supported building frame subjected to an axial load. Parametric studies were conducted by varying pile spacing (3D, 4D, and 5D), aspect ratio (15, 25 and 40), and relative density of sand bed (35% and 70%). Pile cap rotation, pile head deflection, and bending moment values were measured for various configurations. The results showed that experimental findings are more useful for the evaluation of soil–structure interaction, and there is a necessity to consider the interaction effects in the calculation of design forces.