Rates Of Oral Cancer Research Articles

Enhanced laser-induced fluorescence and Raman spectroscopy with gold nanoparticles for the diagnosis of oral squamous cell carcinoma

BackgroundThe incidence, mortality, and recurrence rates of oral cancer are high worldwide. It is a common and aggressive type of tumor. Owing to the challenges associated with early illness diagnosis, squamous cell carcinoma, a kind that is prevalent of oral cancer, has an unacceptably high fatality rate. The management of the condition and the prevention of cancer, on the other hand, depend greatly on early detection. Therefore, alternative methods for the treatment and early diagnosis are essential for oral cancer. The detection of tongue squamous cell carcinoma is aided by coupled surface plasmon resonance, which can occur in gold nanoparticles (AuNPs). Compared to the currently utilized imaging contrast chemicals, AuNPs are more biocompatible and capable of targeting specific surface molecules. In the current study, AuNPs were synthesized in one step via citrate reduction and applied to tongue samples of a Caucasian man's Homo sapiens (Squamous cell carcinoma from ATCC cell-lines) in order to improve early detection using and laser-induced fluorescence and Raman spectroscopy.ResultsUV–visible spectroscopy, Zeta potential, TEM, and FTIR spectroscopic technique were used to characterize the synthesized nanoparticles. The synthesized AuNPs measured 13 ± 3 nm with uniform size distribution and high stability. Results demonstrate the significance of AuNPs in improving the identification of tongue squamous cell carcinoma.ConclusionObtained results revealed that the use of AuNPs modifies the emitted spectra in the two employed spectroscopic techniques and provides more significant receiver operating characteristic curve parameters, hence a higher detection rate of cancer.

The impact of diabetes mellitus and the hypoglycemic agent metformin on oral health: A narrative clinical review

Diabetes mellitus (DM) is a common endocrine disorder that affects more than 10% of the adult population globally, 90% of which are type 2 DM (T2DM). DM was extrapolated to affect 20.5% of adult Jordanians by 2025, and around 50% of Jordanians attending dental clinics are at a moderate to high risk of developing T2DM in 10 years. The main morbidities of DM are angiopathy, nephropathy, retinopathy, and neuropathy rendering diabetic patients at a higher risk of myocardial infarctions, chronic kidney disease, blindness, and peripheral neuropathological impairment respectively. The common oral features associated with DM include gingivitis/periodontitis, dental caries, candidosis, xerostomia, sialosis, bacterial sialadenitis, burning mouth, halitosis, and dysgeusia. DM is also accused of being a risk factor for the development of oral/head and neck cancer, potentially malignant disorders and oral lichen planus. Metformin is the first-line treatment of T2DM with versatile use. In addition to its blood glucose-lowering effect, metformin has pleiotropic effects that may influence patients' oral health and dental management. Metformin therapy has a positive impact on oral health such as decreasing the risk of gingivitis/periodontitis, ameliorating the xerostomia, accelerating the healing of periapical pathology following endodontic treatment, increasing the success rate of the dental implant and lowering the incidence and mortality rate of oral cancer, in addition to its anti-microbial activity. On the other hand, metformin has a bitter taste, may cause taste alterations, decreases the orthodontic tooth movement rate, and can induce oral lichenoid reaction. For optimum dental and medical healthcare, providers should be fully aware of the oral manifestation associated with DM and metformin therapy.

Ferroptosis induced by plasma-activated Ringer's lactate solution prevents oral cancer progression.

This study aimed to investigate the effect of plasma-activated Ringer's lactate solution (PAL) on oral squamous cell carcinoma (OSCC) cells and carcinogenic processes with a particular focus on iron and collagenous matrix formation. We used three OSCC cell lines, one keratinocyte cell line, and two fibroblast lines, and cell viability assays, immunoblotting, flow cytometry, and transmission electron microscopy were performed to evaluate the effect and type of cell death. The effect of PAL treatment on lysyl oxidase (LOX) expression was investigated invitro and invivo. Tamoxifen-inducible Mob1a/b double-knockout mice were used for the invivo experiment. PAL killed OSCC cells more effectively than the control nontumorous cells and suppressed cell migration and invasion. Ferroptosis occurred and the protein level of LOX was downregulated in cancer cells invitro and invivo. Additionally, PAL improved the survival rate of mice and suppressed collagenous matrix formation. We demonstrated that PAL specifically kills OSCC cells and that ferroptosis occurs invitro and invivo. Furthermore, PAL can prevent carcinogenesis and improve the survival rate of oral cancer, especially tongue cancer, by changing collagenous matrix formation via LOX suppression.

Assessment of Knowledge and Attitude towards Oral Cancer among Healthy Individuals of Anand district, Gujarat

India has the highest incidence rate of Oral Cancer (OC) in the world and estimated 35% of all cancers in the country. Oral cancer is associated with significant morbidity, and low survival. Tobacco widely used in India and it is a major cause of cancer of the upper digestive and respiratory tract. Charotar (Anand) region, a middle Gujarat zone is well known for production and farming of Tobacco. Good Knowledge and Positive attitude towards disease condition are important for any future disease development, early prevention and detection. This study was undertaken with the aim to assess knowledge and attitude of healthy individuals of Anand region towards OCand also to establish levels of awareness regarding oral cancer. Methodology: Community based survey study was conducted using questionnaire during February 2023 to March 2023. Sociodemographic characteristic, knowledge regarding oral cancer, its risk factors, symptoms and attitude towards oral cancer were evaluated using a pre-tested structured questionnaire. Additionally, after receiving response from participants, they all were educated about OC, its risk factors and symptoms, prevention tips and their role as a contributor to society. Results: Total 140 participants were evaluated for Knowledge and attitude for Oral cancer. Majority of them had Poor knowledge, and only participants from Upper class had Good knowledge. On other hand, majority of participants had positive attitude oral cancer. Conclusion: Education level, Occupation and socioeconomic class found as a dependent factors for Knowledge and attitude towards OC. In general the awareness about the oral cancer is poor in participants. Oral Cancer awareness and screening programmes should be actively done among population of Anand district.

Assessment of salivary levels of ErbB2 in oral squamous cell carcinoma.

Oral cancer is the sixth-most common cancer globally. The survival rate of oral cancer is 5 years, depending on the stage it is diagnosed. To diagnose in the early stage, specialised tumour markers may assist and also help in improving the survival rate of oral cancer. ErbB2 is a transmembrane cell surface receptor required in signal transduction and an essential part of signalling pathways that take part in controlling the basic cellular processes like cell cycle, migration, metabolism and survival, besides cellular proliferation and differentiation. It is over-expressed in oral squamous cell carcinoma (OSCC) and is directly proportional to the poor prognosis, as it is expressed at a very low concentration in a healthy individual. Due to this, ErbB2 could be used as a diagnostic marker in OSCC. Nowadays, the search for tumour expression in the saliva with the use of salivary biomarkers could aid in the diagnosis of the OSSC. To assess the expression of ErbB2 in the saliva of patients with oral squamous cell carcinoma by correlating the ErbB2 level in the disease group with the healthy group. To determine the diagnostic significance of ErbB2 in OSCC. The study comprises 20 salivary samples from OSCC patients and 20 salivary samples from healthy individuals. The salivary level of ErbB2 was estimated using Enzyme Linked Immunosorbent Assay. To analyse the data, SPSS (IBM SPSS Statistics for Windows, Version 26.0, Armonk, NY: IBM Corp. Released 2019) is used. The significance level is fixed at 5% (α = 0.05). P value <0.05 is considered to be statistically significant. To compare the mean values of mean and concentration, an unpaired/independent sample t-test was used. The mean age of OSCC and control were found to be 57 ± 8.13 and 26.6 ± 1.51, respectively. The mean age was compared between OSCC and control by the Chi-square test, and the P value was <0.01, which was found to be statistically significant. The salivary levels of ErbB2 in the OSCC and control groups were measured by an unpaired sample t-test. The mean salivary ErbB2 level in the OSCC group is 3.20 ng/ml ± 0.57, and in the control group, it is 2.43 ng/ml ± 0.13. When a pairwise comparison of ErbB2 concentration was performed between OSCC and control, it showed a statistically significant difference with a P value of 0.007, which is P < 0.05. The present study has demonstrated an increased salivary expression of ErbB2 in OSCC patients when compared to healthy individuals. This suggests that ErbB2 could aid in the diagnosis of OSCC and could be used as a diagnostic marker in the early detection of oral cancer, a finding that has to be further established with a larger sample size.

Minichromosome maintenance protein 5 - a promising prognostic marker of oral epithelial dysplasias and oral squamous cell carcinomas.

Early diagnosis is the single most effective means of reducing the mortality rate of oral cancer. This study was undertaken to assess the expression of minichromosome maintenance protein 5 (MCM5) in oral epithelial dysplasias and oral squamous cell carcinomas (OSCCs) and to evaluate their possible role as a biomarker for early diagnosis and prognosis of OSCC. A retrospective cross-sectional study. The study was conducted to assess the expression of MCM5 immunohistochemically in the tissue samples of oral epithelial dysplasias (n = 27) and OSCCs (n = 30) diagnosed between 2014 and 2019. The difference in the mean nuclear labelling index (LI) between the groups and the subgroups was analysed statistically using the Kruskal-Wallis test and the post hoc test, and the Dunn-Bonferroni multiple comparison analysis was conducted for pairwise comparison between the four main groups and the subgroups. The association between mean MCM5 LI and clinicopathological parameters was analysed using Spearman's rank correlation coefficient. A progressive increase in the nuclear expression of MCM5 protein (P-value <0.001) was noticed from normal oral mucosa through oral epithelial hyperplasia and oral epithelial dysplasia to OSCC. A significant correlation was also observed between the mean nuclear MCM5 LI of OSCC and TNM staging (R2 = 0.268, P = 0.029). Our findings suggest that MCM5 may be of great value in assessing the malignant potential of dysplastic lesions and may serve as biomarker of utility in the early diagnosis and prognosis of OSCC.

Exploring olfactory receptor family 7 subfamily C member 1 as a novel oral cancer stem cell target for immunotherapy.

The mortality rate of oral cancer has not improved over the past three decades despite remarkable advances in cancer therapies. Oral cancers contain a subpopulation of cancer stem cells (CSCs) that share characteristics associated with normal stem cells, including self-renewal and multi-differentiation potential. CSCs are tumorigenic, play a critical role in cancer infiltration, recurrence, and distant metastasis, and significantly contribute to drug resistance to current therapeutic strategies, including immunotherapy. Cytotoxic CD8+ T lymphocytes (CTLs) are key immune cells that effectively recognize peptide antigens presented by the major histocompatibility complex class I molecules. Increasing evidence suggests that cancer antigen-specific targeting by CTLs effectively regulates CSCs that drive cancer progression. In this study, we utilized data from public domains and performed various bioassays on human oral squamous cell carcinoma clinical samples and cell lines, including HSC-2 and HSC-3, to investigate the potential role of olfactory receptor family 7 subfamily C member 1 (OR7C1), a seven transmembrane G-protein-coupled olfactory receptor that is also expressed in nonolfactory tissues and was previously reported as a novel marker and target of colon cancer initiating cell-targeted immunotherapy, in CSC-targeted treatment against oral cancer. We found that the OR7C1 gene was expressed only in oral CSCs, and that CTLs reacted with human leukocyte antigen-A24-restricted OR7C1 oral CSC-specific peptides. Taken together, our findings suggest that OR7C1 represents a novel target for potent CSC-targeted immunotherapy in oral cancer.

Systematic review of the role of genomic salivary biomarkers in the early detection of oral cancer

Cancer is a large group of diseases that can start in almost any organ or tissue of the body when abnormal cells grow uncontrollably, and metastasize to any other part of the body. India reports approximately one-fourth of global incidences of oral cancer annually, that is, around 77,000 new cases and 52,000 deaths. While cancer is the second leading cause of death worldwide, oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers with a global incidence of more than 350,000 new cases and 177,000 deaths every year. Since the average 5-year survival rate of oral cancer on early diagnosis is 77.3% in stages I and II along with a better prognosis, but only 32.2% in stages III and IV, early detection of oral cancer is pertinent for prompt treatment of the problem at its grassroot level to decrease the subsequent morbidity and mortality associated with the disease. This article has been written as a compilation of the various genomic salivary biomarkers that have been detected in the saliva of cancer patients to inculcate a better understanding of these biomarkers and the role they play in the early detection of oral cancer. This will provide adequate knowledge to general and oral surgeons, as well as cancer biologists about the salivary diagnostic markers which will act as an adjunct to the traditional methods of cancer detection. The articles were selected from PubMed/Medline and Google Scholar. The articles with higher academic relevance were selected.

A Genome-Wide Association Study Identified Novel Genetic Susceptibility Loci for Oral Cancer in Taiwan.

Taiwan has the highest incidence rate of oral cancer in the world. Although oral cancer is mostly an environmentally induced cancer, genetic factors also play an important role in its etiology. Genome-wide association studies (GWAS) have identified nine susceptibility regions for oral cancers in populations of European descent. In this study, we performed the first GWAS of oral cancer in Taiwan with 1529 cases and 44,572 controls. We confirmed two previously reported loci on the 6p21.33 (HLA-B) and 6p21.32 (HLA-DQ gene cluster) loci, highlighting the importance of the human leukocyte antigen and, hence, the immunologic mechanisms in oral carcinogenesis. The TERT-CLMPT1L locus on 5p15.33, the 4q23 ADH1B locus, and the LAMC3 locus on 9q34.12 were also consistent in the Taiwanese. We found two new independent loci on 6p21.32, rs401775 in SKIV2L gene and rs9267798 in TNXB gene. We also found two suggestive novel Taiwanese-specific loci near the TPRS1 gene on 8q23.3 and in the TMED3 gene on 15q25.1. This study identified both common and unique oral cancer susceptibility loci in the Taiwanese as compared to populations of European descent and shed significant light on the etiology of oral cancer in Taiwan.

A Systematic Review On The Prevalence Of Oral Cancer Among Tobacco And Non-Tobacco Users In Tamil Nadu

Background: Oral Cancer Is One Of The World's Most Common Types Of Cancer, With Delayed Diagnosis And Poor Prognosis. IndiaIs Among The Leading Countries With A High Rate Of Oral Cancer Due To Its Increased Tobacco Use Rate.Aim: This Study Aims To Assess The Prevalence Of Oral Cancer Among Tobacco And Non-Tobacco Users In Tamil Nadu.Materials And Method: A Systematic Review Of Cross-Sectional Studies Were Performed. The Data Was Searched Using ElectronicDatabases, And 376 Articles Were Screened. The Intervention And Outcomes Were Assessed In The Studies Included In TheSystematic Review. The Bias Assessment Done For The Article Was Based On The Newcastle-Ottawa Scale.Results: Overall Analysis Of The Studies Shows That The Prevalence Of Oral Cancer In Tamil Nadu Has Been Significantly IncreasingAnd That Smokeless Tobacco Causes Oral Cancer Compared With Other Forms Of Tobacco.Conclusion: The Prevalence Of Oral Cancer In Tamil Nadu Is Increasing Significantly With The Usage Of The Increased Amount OfTobacco, And Awareness Of The Ill Effects Of Tobacco Usage May Considerably Decrease The Rates.

Molecular Crosstalk between the Immunological Mechanism of the Tumor Microenvironment and Epithelial-Mesenchymal Transition in Oral Cancer.

Oral cancer is a significant non-communicable disease affecting both emergent nations and developed countries. Squamous cell carcinoma of the head and neck represent the eight major familiar cancer types worldwide, accounting for more than 350,000 established cases every year. Oral cancer is one of the most exigent tumors to control and treat. The survival rate of oral cancer is poor due to local invasion along with recurrent lymph node metastasis. The tumor microenvironment contains a different population of cells, such as fibroblasts associated with cancer, immune-infiltrating cells, and other extracellular matrix non-components. Metastasis in a primary site is mainly due to multifaceted progression known as epithelial-to-mesenchymal transition (EMT). For the period of EMT, epithelial cells acquire mesenchymal cell functional and structural characteristics, which lead to cell migration enhancement and promotion of the dissemination of tumor cells. The present review links the tumor microenvironment and the role of EMT in inflammation, transcriptional factors, receptor involvement, microRNA, and other signaling events. It would, in turn, help to better understand the mechanism behind the tumor microenvironment and EMT during oral cancer.

ADVANCED DIAGNOSTIC AIDS IN ORAL PATHOLOGY

Oral cancers are one of the most common cancers worldwide today. They are usually neglected by the common population when compared to systemic cancers such as the lung cancer, colon cancer etc. However, they also may be extremely fatal if left untreated even at a very initial stage of the lesion. Early detection and treatment gives the best chance for its cure. The five-year survival rate of oral cancer still remains low and delayed diagnosis is suggested to be one of the major reasons. The detection and diagnosis are currently based on clinical examination, histopathological evaluation of the biopsy material and molecular methods. Several diagnostic aids have been developed over the years for early detection of oral cancer. The purpose of this article is to review the advanced available diagnostic adjuncts for the detection of oral cancer.

Nano-diagnostics as an emerging platform for oral cancer detection: Current and emerging trends.

Globally, oral cancer kills an estimated 150,000 individuals per year, with 300,000 new cases being diagnosed annually. The high incidence rate of oral cancer among the South-Asian and American populations is majorly due to overuse of tobacco, alcohol, and poor dental hygiene. Additionally, socio-economic issues and lack of general awareness delay the primary screening of the disease. The availability of early screening techniques for oral cancer can help in carving out a niche for accurate disease prognosis and also its prevention. However, conventional diagnostic approaches and therapeutics are still far from optimal. Thus, enhancing the analytical performance of diagnostic platforms in terms of specificity and precision can help in understanding the disease progression paradigm. Fabrication of efficient nanoprobes that are sensitive, noninvasive, cost-effective, and less labor-intensive can reduce the global cancer burden. Recent advances in optical, electrochemical, and spectroscopy-based nano biosensors that employ noble and superparamagnetic nanoparticles, have been proven to be extremely efficient. Further, these sensitive nanoprobes can also be employed for predicting disease relapse after chemotherapy, when the majority of the biomarker load is eliminated. Herein, we provide the readers with a brief summary of conventional and new-age oral cancer detection techniques. A comprehensive understanding of the inherent challenges associated with conventional oral cancer detection techniques is discussed. We also elaborate on how nanoparticles have shown tremendous promise and effectiveness in radically transforming the approach toward oral cancer detection. This article is categorized under: Diagnostic Tools > Biosensing Diagnostic Tools > Diagnostic Nanodevices Diagnostic Tools > In Vitro Nanoparticle-Based Sensing.

EE88 Cost-Effectiveness Analysis of Risk Scoring Model in Population-Based Oral Cancer Screening Program of Taiwan

Age-standardized incidence rate of oral cancer (OC) in Taiwanese males remains high globally. Although free population-based oral mucosa examination (OME) is provided in Taiwan, late diagnoses and low survival rates of OC are still critical public health concerns. This study aimed to estimate the potential lifetime cost-effectiveness of the risk scoring model (RSM), a novel prediction strategy additional with OME simultaneously or consequently, in the OC screening program of Taiwan.

Forecast of peak attainment and imminent decline after 2017 of oral cancer incidence in men in Taiwan

Oral cancer is the fourth most common cancer among men in Taiwan. The age-standardized incidence rate of oral cancer among men in Taiwan has increased since 1980 and became six times greater in 2014. To enable effective public health planning for oral cancer, research on the projection of oral cancer burden is essential. We conducted an age-period-cohort analysis on the incidence of oral cancer among men in Taiwan from 1997 to 2017 and extrapolated the trend to 2025. We found that the period trends for young adults aged between 25 and 44 have already peaked before 2017; the younger, the earlier, and then the trends declined. The cohort trends have peaked roughly at the 1972 birth cohort and then declined for all ages. Despite the increasing trend in the age-standardized incidence rate for oral cancer among men in Taiwan from 1997 to 2017, we forecast a peak attained, an imminent decline after 2017, and a decrease of 8.4% in age-standardized incidence rate from 2017 to 2025. The findings of this study contribute to developing efficient and comprehensive strategies for oral cancer prevention and control.

BIOMARKERS IN ORAL CANCER-A REVIEW

The incidence and mortality rate of oral cancer have increased throught out the world. Early detection through different investigatory methods and newer screening approaches are very important to reduce the mortality of this disease. Sensitive and specic Biomarkers for oral cancer are not only used for effective screening but also the use extends in diagnosing, and even for staging. . Advancement in technology in genomics, proteomics and molecular pathology have increased the clinical value of biomarkers. Clinical signicance of biomarkers can be used to combat oral cancer. Hence, we have reviewed the importance of biomarkers for oral cancer.

Using Intervention Mapping to Develop ISAC, a Comprehensive Intervention for Early Detection and Prevention of Oral Cancer in Saudi Arabia

Oral cancer forms a major public health issue. In Saudi Arabia, Jazan region has the highest rate of oral cancer; > 35% of total cases. Furthermore, dentists’ engagement in oral cancer screening and patient education in Jazan region is limited. This paper aimed to describe the process used to develop a comprehensive oral cancer (OC) practice intervention to be implemented in dental clinics. The intervention was informed by the six steps of intervention mapping (IM). Steps 1–3 included mixed methods approach of reviewing relevant existing literature, focus group discussions, observations, one-on-one interviews, and questionnaires utilizing the community participatory approach. Step 4 used information form steps 1–3 to develop the intervention components and its associated tools to facilitate its delivery. Steps 5 and 6 specified the prospective plans for implementation and evaluation. ISAC is the developed intervention that comprises the following: Informing dental patients about performing routine OC screenings, Screenings for OC, Advising patients, and Connecting patients to the required services. ISAC practical applications were clustered into two components: (a) didactical session covering aspects related to OC practices and introducing ISAC and (b) practical session that included a step-by-step modeling of the intervention. Using IM facilitated the systematic planning of the ISAC intervention that covers the main issues revealed by the need’s assessments. Working towards developing the ISAC required extensive work in assessing dental public health issues in a specific context with limited data — and this constituted a great challenge. The development of the ISAC was a lesson that casts light on the advantages of engaging multidisciplinary expertise to tackle serious public health issue like OC.

How Do Adolescents Assess and Rank the Risk of Areca Nut Use? Findings from a Study in Mumbai, India.

Objective:Areca nut use, along with tobacco, is a contributor to India’s high rates of oral cancer. Areca nut use is culturally accepted, often initiated early in adolescence, and said to lead to later tobacco use. Unlike tobacco prevention, there are scarce prevention or harm-reduction programmes or campaigns specifically targeted at areca nut. Methods:A participative ranking method was used to understand adolescents’ assessment of risks of areca nut. Five focus group discussions were conducted with 31 adolescents, 19 fe-male and 12 male, non-users and users of chewing tobacco, water-pipe (hookah) and areca nut. Participants categorized and ranked the risk of 16 activities, including the use of areca nut and various tobacco-products, and discussed reasons for these risk-rankings. Results:Despite differences between groups on the assessment of risks associated with the 16 different activities, all the groups, user and non-user, rated cigarette smoking as having the highest risk, chewing fennel and using mouth fresheners as no risk, and areca nut as low risk. The other activities were ranked differently by each group. Adolescents’ perceptions of smoking or online games as risky was influenced by greater exposure to messaging on harmful consequences of the activity through multiple channels such as mass media, interpersonal networks including parents, and classroom health-education sessions. Inadequate knowledge about the harmful consequences of areca nut use, greater social and cultural acceptability, and the sweet taste of commercially packaged areca nut influenced low-risk perceptions. Conclusion:Perceptions of risk from an activity often determines preventive behaviors. Presently, adolescents do not perceive areca use as risky. In comparison to smoking they con-sider it less harmful. More research is required to better understand areca nut use and its cul-tural determinants. However, targeted health communication messages and prevention poli-cies and programmes have to be initiated to reduce areca nut use and associated burden of oral cancer.

Abstract PO-089: Racial/ethnic disparities in oral cancer screening between low-income Asian Americans aged 18-50 and their White counterparts

Abstract Background. Asian Americans (AAs) aged 18-50 have higher incidence and mortality rates of oral cancer. However, scant attention has been focusing on oral cancer disparities among this population. Although oral cancer screening is not recommended for asymptomatic adults, it's effective in oral cancer early detection among high-risk populations. The study aimed at assessing the racial/ethnic disparities in oral cancer screening experienced by Asian Americans aged 18-50 living federal poverty level, comparing with their White counterparts. Method. The sample consists of 1540 low-income adults (478 AAs and 1062 Whites) aged 18-50 from the 2011-2018 National Health and Nutrition Examination Survey (NHANES) combined datasets. Weighting was applied since NHANES oversampled Asian Americans. We conducted bivariate analysis such as t-test and chi-square test to examine the association between demographic and behavioral factors =and oral cancer screening among high-risk populations. Multiple logistic regressions were used to identify the risk factors of oral cancer screening disparities. All data analyses were conducted in Stata 16. A p value smaller than 0.05 was considered statistically significant, while a p value between 0.05-0.1 was taken as marginally significant criteria. Results. AAs are predominately foreign-born (79.13%), about half of them only spoke their native languages at home (47.69%), and 27.31% of them did not have health insurance. Overall, AAs had significantly lower oral cancer screening rate than Whites (7.33% vs. 16.69%, p=0.006). Specifically, within those who were not covered with health insurance, AAs were less likely to receive oral cancer screening than Whites (3.5% vs.13.73%, p=0.060); among those who did not receive any HPV vaccine shots, Asians had lower oral cancer screening rate than Whites (7.64% vs.14.72%, p=0.058); among those who were not self-motivated to visit their dentists, Asians reported extremely low oral cancer screening rate (2.24%), which was significantly (p=0.016) lower than that of Whites (10.27%). Although Asians had higher self-motivation to do dental visit than Whites (62.96% vs. 52.72%, p=0.009), among self-motivated patients, AAs were less likely to be told the importance of checking for oral cancer by their dentists (12.94% vs. 23.54%, p=0.063), compared with Whites. Logistic regressions also showed that the negative impacts of less-frequent dental visits on oral cancer screening was stronger among AAs (OR=0.45, p=0.042) than in Whites (OR=0.75, p=0.005), controlling for other variables. Conclusion. AAs experience oral cancer screening disparities among multiple high-risk/vulnerable populations. There is an urgent need of educational intervention to promote oral cancer screening for AAs, especially among high-risk subpopulations, and to improve dentists' awareness of AAs' oral cancer screening needs. Citation Format: Wenyue Lu, Lin Zhu, Bohui Wang, Di Zhu, Ming-chin Yeh, Grace X. Ma. Racial/ethnic disparities in oral cancer screening between low-income Asian Americans aged 18-50 and their White counterparts [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-089.

The Potential Role of Telemedicine in Early Detection of Oral Cancer: A Literature Review.

The 5-year survival rates of oral cancer have not improved significantly since many decades. It is believed that “diagnostic delay” plays a critical role in determining the prognostic outcomes. At present, the coronavirus disease (COVID-19) pandemic has led to drastic changes within a short period of time and has resulted in many serious consequences at different levels worldwide. Although it is evident that COVID-19 is a major concern when it comes to people's health, it carries with it a message of hope, a desire to survive, and an opportunity to address many unprecedented challenges. This has left the doors wide open to use “telemedicine” as an essential tool to counter the rapid shift in health-care services and to meet the high demands in different health specialties including oral medicine. The aim of this review is to explore the potential roles of telemedicine in early detection of oral cancer and to highlight both the benefits and the limitations of the available applications and technologies. The clinical applications of telemedicine show a great potential in early detection of oral cancer, but the evidence of their effectiveness is still not conclusive. This needs to be investigated, especially in the developing countries where “telemedicine” may prove to be highly valuable in the future.