Rates Of Fever Research Articles

Comparative Outcome of Wedge Excision of Perforation Site and Trimming of Perforation Margin Followed by Primary Repair in Treating Ileal Perforation

Background: Every gastrointestinal (GI) surgeon faces significant challenges when treating ileal perforation. The most common causes of ileal perforations are typhoid ulcers and trauma. The patient with an ileal perforation presents a number of challenges to the gastrointestinal surgeon, and understanding the relevant anatomy, physiology, and metabolism is required to address these challenges effectively. Aim of the Study: This study compared the results of ileal perforation management procedures including primary repair after trimming of the perforation margin and wedge excision of the perforated site. Methods: Between January 2021 and June 2022, this prospective observational study was carried out at 250 Bedded General Hospital, Naogaon & Clinic in Naogaon, Bangladesh. This study included 44 patients in total as study participants. According to how many patients there were, the total number of participants was split into two equal groups. 22 patients in Group I underwent wedge excision of the perforation site, and another 22 patients in Group II underwent perforation margin trimming followed by a primary repair procedure. All participants provided proper written consent prior to the collection of data. Patients between the ages of 15 and 70 were included in this study in accordance with the inclusion criteria. The data was gathered using a predesigned questionnaire. Results: All patients underwent primary repair after either wedge excision of the perforated site (Group I) or trimming of the perforation margin (Group II). The rates of fever, abdominal distention, constipation, and vomiting were higher in both patient groups. Both groups of patients experienced similar levels of abdominal pain, fever, abdominal distension, constipation, and vomiting. In groups I and II, post-operative fever was noted in 14 (63.5%) and 18 (81.8%) patients, respectively. The difference was statistically significant (p<0.05) in the chi square test. There were 13 cases of wound ........

Influencia del sexo en los resultados de la cirugía retrógrada intrarrenal (CRIR). Datos obtenidos del Flexible Ureteroscopy Outcomes Registry (FLEXOR)

Introduction and objectivesAs well established flexible ureteroscopy (RIRS). There is still no evidence if gender can have any influence on the outcomes and complication when performing This study aims to evaluate the role that gender has in performing flexible ureteroscopy from a large series of patients. MethodsThis study retrospectively analyzed patients who underwent RIRS for renal stones from January 2018 to August 2021 within the multicentric FLEXOR registry. Demographics, stone characteristics, perioperative findings, results and complications were analyzed and compared between gender groups. ResultsA total of 6669 patients were included, 66.1% were male and 33.9% were female. Stone characterictis was comparable between groups. Female patients had significant higher fever and positive urine culture rates (12% vs. 8% and 37% vs. 34%). Also, females had a slight longer hospital stay (3.8 vs. 3.5 days; P < 0.001) and more residual fragments after the procedure (23.03% vs. 20.97 (P = 0.032). Overall complications were slightly significantly higher in women (15.74% vs. 14% (P = 0.042)) mainly at the expense of fever rates (6.9% vs. 5.7%) whereas the risk of sepsis was similar in both groups. A multivariate analysis showed that larger stone size, multiple and lower pole stones seem to have a negative impact in the incidence of residual stones and complications. ConclusionOur real life global study reflects that female gender may have a correlation with a slightly increased residual fragment rate and overall low grade complications. However, women can safely be treated with RIRS with no increased the rate of sepsis with appropriate care.

A snapshot of pediatric inpatients and outpatients with COVID-19: a point prevalence study from Turkey.

This multi-center point prevalence study evaluated children who were diagnosed as having coronavirus disease 2019 (COVID-19). On February 2nd, 2022, inpatients and outpatients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were included in the study from 12 cities and 24 centers in Turkey. Of 8605 patients on February 2nd, 2022, in participating centers, 706 (8.2%) had COVID-19. The median age of the 706 patients was 92.50months, 53.4% were female, and 76.7% were inpatients. The three most common symptoms of the patients with COVID-19 were fever (56.6%), cough (41.3%), and fatigue (27.5%). The three most common underlying chronic diseases (UCDs) were asthma (3.4%), neurologic disorders (3.3%), and obesity (2.6%). The SARS-CoV-2-related pneumoniae rate was 10.7%. The COVID-19 vaccination rate was 12.5% in all patients. Among patients aged over 12years with access to the vaccine given by the Republic of Turkey Ministry of Health, the vaccination rate was 38.7%. Patients with UCDs presented with dyspnea and pneumoniae more frequently than those without UCDs (p < 0.001 for both). The rates of fever, diarrhea, and pneumoniae were higher in patients without COVID-19 vaccinations (p = 0.001, p = 0.012, and p = 0.027). Conclusion: To lessen the effects of the disease, all eligible children should receive the COVID-19 vaccine. The illness may specifically endanger children with UCDs. What is Known: • Children with COVID-19 mainly present with fever and cough, as in adults. • COVID-19 may specifically threaten children with underlying chronic diseases. What is New: • Children with obesity have a higher vaccination rate against COVID-19 than children without obesity. • Among unvaccinated children, fever and pneumoniae might be seen at a higher ratio than among vaccinated children.

Incidence and trends of 17 notifiable bacterial infectious diseases in China, 2004–2019

BackgroundCertain bacterial infectious diseases are categorized as notifiable infectious diseases in China. Understanding the time-varying epidemiology of bacterial infections diseases can provide scientific evidence to inform prevention and control measures.MethodsYearly incidence data for all 17 major notifiable bacterial infectious diseases (BIDs) at the province level were obtained from the National Notifiable Infectious Disease Reporting Information System in China between 2004 and 2019. Of them 16 BIDs are divided into four categories, respiratory transmitted diseases (RTDs, 6 diseases), direct contact/fecal-oral transmitted diseases (DCFTDs, 3 diseases), blood-borne/sexually transmitted diseases (BSTDs, 2 diseases), and zoonotic and vector-borne diseases (ZVDs, 5 diseases), and neonatal tetanus is excluded in the analysis. We characterized the demographic, temporal, and geographical features of the BIDs and examined their changing trends using a joinpoint regression analysis.ResultsDuring 2004‒2019, 28 779 thousand cases of BIDs were reported, with an annualized incidence rate of 134.00 per 100 000. RTDs were the most commonly reported BIDs, accounting for 57.02% of the cases (16 410 639/28 779 000). Average annual percent changes (AAPC) in incidence were − 1.98% for RTDs, − 11.66% for DCFTDs, 4.74% for BSTDs, and 4.46% for ZVDs. Females had a higher incidence of syphilis than males, and other BIDs were more commonly reported in males. Among 0-5-year-olds, the diseases with the largest increases in incidence were pertussis (15.17% AAPC) and scarlet fever (12.05%). Children and students had the highest incidence rates of scarlet fever, pertussis, meningococcal meningitis, and bacillary dysentery. Northwest China had the highest incidence of RTDs, while South and East China had the highest incidences of BSTDs. Laboratory confirmation of BIDs increased from 43.80 to 64.04% during the study period.ConclusionsRTDs and DCFTDs decreased from 2004 to 2019 in China, while BSTDs and ZVDs increased during the same period. Great attention should be paid to BSTDs and ZVDs, active surveillance should be strengthened, and timely control measures should be adopted to reduce the incidence.

A meta-analysis: retrograde intrarenal surgery vs. percutaneous nephrolithotomy in children.

The increasing prevalence of pediatric kidney stones worldwide makes minimally invasive lithotripsy like retrograde intrarenal surgery (RIRS) and percutaneous Nephrolithotomy (PCNL) more prevalent. However, their safety and efficacy are controversial. Consequently, a meta-analysis of the comparison between RIRS and PCNL is conducted. Clinical trials were selected from PubMed, EMBASE, Scopus, and Cochrane Library databases. The data extraction and study quality assessment were performed by two individuals independently. The data relating to therapeutic effects were extracted and analyzed by Review manager 5.4. Thirteen studies involving 1,019 patients were included. The micro-PCNL excelled in stone-free rate (P = 0.003), postoperative fever rate (P = 0.02), and Clavien-Dindo II complications (P = 0.05). Notably, the mean age of the micro-PCNL group was younger than other groups (P = 0.0005). The operation time in mini-PCNL was longer than RIRS (P < 0.00001) but with high heterogeneity (I2 = 99%). There was no difference in Clavien-Dindo I, II, and III complications between the PCNL and the RIRS, but mini-PCNL showed a higher probability than RIRS in Clavien-Dindo I (P = 0.0008) and II complications (P = 0.007). Compared with RIRS, micro-PCNL could be a better therapeutic option for kidney stones in children. Of note, more parameters should be analyzed to illustrate the efficacy of different minimally invasive surgeries for pediatric kidney stones due to poor cases in our study. https://www.crd.york.ac.uk/prospero/#recordDetails, PROSPERO CRD42022323611.

Molecular epidemiology, clinical features and significance of Shiga toxin detection from routine testing of gastroenteritis specimens

After introduction of faecal multiplex PCR that includes targets for stx1 and stx2 genes, we found stx genes were detected in 120 specimens from 111 patients over a 31-month period from 2018-2020 from a total of 14,179 separate tests performed. The proportion of stx1 only vs stx2 only vs stx1 and stx2 was 35%, 22% and 42%, respectively. There were 54 specimens which were culture positive, with 33 different serotypes identified, the predominant serotype being O157:H7 (19%). Eighty-two patients had clinical data available; we found a high rate of fever (35%), bloody diarrhoea (34%), acute kidney injury (27%), hospital admission (80%) and detection of faecal co-pathogens (23%). Only one patient developed haemolytic uraemic syndrome. We found no significant association with stx genotype and any particular symptom or complication. We found a significant association of serotypes O157:H7 and O26:H11 with bloody stool, but no significant association with any other symptom or complication.

Percutaneous laser mini nephrolithotomy in the treatment of renal lithiasis: Experience within the University Hospital of Fez (about 20 cases)

Laser percutaneous mini-nephrolithotomy is a minimally invasive surgical technique, used mainly for the removal of upper renal and ureteral lithiasis The objective of our work is to test the feasibility, efficacy and safety of this technique by comparing the results with those of standard NLPC, flexible uretero-nephroscopy and extracorporeal lithotripsy. We report a retrospective study of 20 cases of laser mini-NLPC over a period from January 2022 to January 2023 in the urology department. Mini-NLPC is as safe and effective as standard NLPC for the management of small and medium-sized (10-30 mm) kidney stones, including decreasing the rate of bleeding requiring transfusion and improving the rate of eradication of multiple stones... Although its use requires a longer operating time and has a slightly higher rate of postoperative fever, some of these features such as the length of hospital stay, the dose of postoperative analgesics make it a technique of choice.

Optimising the timing of whooping cough immunisation in mums (OpTIMUM) through investigating pertussis vaccination in pregnancy: an open-label, equivalence, randomised controlled trial

Pertussis vaccination in pregnancy is recommended in many countries to provide protection to young infants. The best timing for this vaccination is uncertain. In the UK, vaccination is recommended between 16 weeks and 32 weeks of gestation. In this trial we aimed to investigate the equivalence of three time periods for pertussis vaccination in pregnancy. In this open-label, equivalence, randomised controlled trial to investigate equivalence of different time windows for pertussis vaccination in pregnancy, participants were randomly assigned (1:1:1 ratio) to receive a pertussis-containing vaccine (Boostrix-inactivated poliovirus vaccine) in one of three gestational age groups, comprising group 1 (≤23 weeks + 6 days), group 2 (24-27 weeks + 6 days), and group 3 (28-31 weeks + 6 days) using a computer-generated randomisation list. The primary outcome was concentration of pertussis-specific antibodies in the infant born at term at birth. Maternal blood sampling was done before and 2 weeks after vaccination and at delivery, together with a cord sample, and an infant sample was collected at least 4 weeks after primary vaccination. Reactogenicity was assessed for 7 days after vaccination. This trial was registered with ClinicalTrials.gov (NCT03908164). Between May 7, 2019, and Feb 13, 2020, of 1010 women assessed for eligibility, 364 women were recruited and 351 received the intervention (120 in group 1, 119 in group 2, and 112 in group 3). Equivalence of time periods was demonstrated for anti-pertussis toxin and anti-pertactin IgG concentrations. The cord blood geometric mean concentrations of anti-filamentous haemagglutinin IgG were higher with increasing gestational age at vaccination, such that for infants in group 1 (≤23 weeks + 6 days), equivalence to group 3 (28-31 weeks + 6 days) was not shown. Reported rates of fever were similar between study groups. Pertussis vaccination at three different time intervals in pregnancy resulted in equivalent concentrations of IgG antibodies in infants against two of the three pertussis antigens assessed. Overall, these findings support recommendations to vaccinate any time between 16 weeks and 32 weeks of gestation. The Thrasher Research Fund and the National Immunisation Schedule Evaluation Consortium through the National Institute for Health and Care Research policy research programme.

Explanatory models for tick-borne disease incidence (Astrakhan rickettsial fever and Crimean-Congo hemorrhagic fever)

Introduction. The study focuses on methods providing mathematical substantiation of discrepancies between actual incidence rates of Astrakhan rickettsial fever (ARF) and Crimean-Congo hemorrhagic fever (CCHF) and predicted rates due to the indirect impact of weather conditions during the current epidemic season.&#x0D; The purpose of the study was to develop explanatory models for ARF and CCHF incidence using satellite monitoring (remote sensing) data and to present the results of their practical evaluation in the Stavropol Territory and Astrakhan Region.&#x0D; Materials and methods. The materials included climate data provided by the Space Research Institute of the Russian Academy of Sciences as well as epidemiological data on CCHF and ARF incidence from 2005 to 2021. The explanatory models incorporated the Bayes theorem and Wald sequential analysis. All the calculations were completed using the Microsoft Excel 2010-based program developed by the authors.&#x0D; Results. It has been found that the greatest indirect effect on development of the CCHF epidemiological situation is produced by the normalized difference vegetation index and relative air humidity in June-July in the Stavropol Territory and by the maximum, minimum and average air temperature in October as well as the minimum air temperature in July in the Astrakhan Region. ARF incidence rates depend on the indirect effect of the annual average and average annual maximum temperature, maximum temperature and the normalized difference vegetation index in April-July. The match between explanatory model-based results and prediction model-based results ranged within 46.2-100%.&#x0D; Discussion. In addition to projecting incidence rates, which could be reached with the observed values of climatic factors in the current year, the explanatory models can be used for indirect verification of prediction models and for identification of factors causing differences in results.&#x0D; Conclusion. The practical evaluation of explanatory models confirms the prospects and benefits of the study that should be continued, involving other regions highly endemic for tick-borne infections.

MP35-06 DOES GENDER HAVE ANY INFLUENCE ON RIRS OUTCOMES? DATA FROM THE FLEXIBLE URETEROSCOPY OUTCOMES REGISTRY (FLEXOR)

MP35-06 DOES GENDER HAVE ANY INFLUENCE ON RIRS OUTCOMES? DATA FROM THE FLEXIBLE URETEROSCOPY OUTCOMES REGISTRY (FLEXOR)

The Density of Aedes aegypti Larvae Density and the Incidence of Dengue Hemorrhagic Fever in the Pesingahan Environment, Pagesangan Barat Village, Mataram

Dengue hemorrhagic fever remains a public health concern in West Nusa Tenggara Province, with the majority of cases occurring in Mataram City and the Pesinggahan Environment of West Pagesangan Village. The density of Aedes aegypti larvae as disease vectors has a strong influence on the high incidence of cases and the spread of dengue hemorrhagic fever. The objective of this study was to identify if there was a relation between the density of Aedes aegypti larvae and the rate of dengue hemorrhagic fever in the Pesinggahan Environment of Pagesangan Barat Village. This study is an analytic observational study with a cross-sectional design. This study's sample size was 56 houses. The data collected included information on the density of Aedes aegypti larvae and the incidence rate of dengue hemorrhagic fever in the Pesinggahan Environment of Pagesangan Barat Village over the previous year. Descriptive analysis was used to examine data on the density of Aedes aegypti larvae and the incidence rate of dengue hemorrhagic fever in the Pesinggahan environment. The findings revealed that the density of Aedes aegypti larvae was high (Density Figure (DF) = 6), as was the incidence rate of dengue hemorrhagic fever (0.39%). The statistical analysis between the density of A. aegypti larvae and the incidence rate of dengue hemorrhagic fever in the Pesinggahan Environment with the chi square test demonstrated indicate that p-value = 0.000 &lt; alpha = 0.05. Based on the results of the study, there was a relationship between the density of A. aegypti larvae and the incidence rate of dengue hemorrhagic fever in Pesinggahan, Pagesangan Barat Village. Further research is required regarding the detection of the dengue virus transmitted by A. aegypti mosquitoes to their offspring (transovarial).

Climate Factors and DHF Cases in Padang During the COVID-19 Pandemic

Background: Dengue Hemorrhagic Fever is transmitted within regions characterised by tropical weather. The present study reports the incidence rate of Dengue Hemorrhagic Fever (DHF) in Padang City during the year 2021, which is estimated to be 37.2 cases per 100,000 individuals in the community.Purpose: The objective of this study is to examine the correlation between specific components of the physical environment, specifically the climate, and the occurrence of Dengue Hemorrhagic Fever (DHF) in Padang City amidst the Covid-19 Pandemic.Method: The present study employs ecological research methodologies. The study utilised a sample consisting of all instances of dengue hemorrhagic fever (DHF) that were documented at the Padang City Health Service, along with climatic data obtained from the BMKG for the period spanning from March 2020 to March 2022. The findings of the study indicate a temporal increase in cases of dengue hemorrhagic fever (DHF) in Padang City throughout the period from July to December 2021.Result: The findings from the examination of incidences of dengue hemorrhagic fever (DHF) in relation to climate factors during the Covid-19 pandemic revealed a statistically significant association with wind speed (p = 0.018). Wind speed emerged as the prevailing environmental determinant in instances of dengue hemorrhagic fever (DHF) within the Covid-19 pandemic. The wind speed was identified as a climate variable that exerted influence on the occurrence of Dengue Hemorrhagic Fever (DHF) in Padang amongst the Covid-19 pandemic.

Kırım Kongo Kanamalı Ateşi Virüsünün Tokat/Türkiye’de PCR Tanısı, Epidemiyolojik ve Klinik Verileri

Objectives: To contribute to case management algorithms and guidelines by evaluating the clinical symptoms, laboratory data, risk factors and mortality rates of patients admitted to health institutions with tick bite in Tokat. &#x0D; &#x0D; Methods: The virus determination was made from the blood by conventional PCR in 141 patient. Epidemiological data such as socio-demographic variables and risk factors were compared with clinical &#x0D; symptoms, biochemical and hematological parameters. &#x0D; &#x0D; Results: Of the patients, 83 (58.9%) were male, 84(59.6%) were positive. Five patients (5.95%) died in the PCR-positive group. Fever and tick contact history rates was found to be significantly higher in the PCR &#x0D; positive patients than the PCR negative group. Thrombocytopenia, leukopenia, aspartate transaminase (AST) elevation were found to be significantly higher in PCR positive patients. Despite the mean alanine transferase (ALT) was not significantly higher, the increase in the number of patients exceeding the reference range was found to be significantly higher in PCR-positive group (p

In-Depth Analysis of the Re-Emergence of Respiratory Syncytial Virus at a Tertiary Care Hospital in Germany in the Summer of 2021 after the Alleviation of Non-Pharmaceutical Interventions Due to the SARS-CoV-2 Pandemic.

Following the extensive non-pharmaceutical interventions (NPIs) and behavioral changes in the wake of the SARS-CoV-2 pandemic, an interseasonal rise in respiratory syncytial virus (RSV) cases was observed in Germany in 2021. The aim of this study was to characterize the local molecular epidemiology of RSV infections in comparison to the three pre-pandemic seasons. Additionally, clinical data were retrieved from patient charts to determine the clinical significance of RSV infections. RSV detections peaked in calendar week 40 of 2021, 18 weeks earlier than the usual peak observed in the three pre-pandemic seasons. Sequence analysis revealed a close phylogenetic relatedness regardless of the season of origin. A significantly higher amount of pediatric cases (88.9% of all cases, p < 0.001) was observed for season 2021/2022. For the pediatric cases, significant differences were observed for an increased number of siblings in the household (p = 0.004), a lower rate of fever (p = 0.007), and a reduced amount of co-infections (p = 0.001). Although the mean age of the adult patients was significantly younger (47.1 vs. 64.7, p < 0.001), high rates of comorbidities, lower respiratory tract infections and intensive care unit admissions prevailed. The NPIs in the wake of the SARS-CoV-2 pandemic had a tremendous impact on the epidemiologic characteristics and seasonality of RSV and warrant further epidemiologic studies of this important pathogen.

Neutropenic Fever–Associated Admissions Among Patients With Solid Tumors Receiving Chemotherapy During the COVID-19 Pandemic

This cohort study examines the rates of neutropenic fever–associated admissions and outpatient antibiotic use among patients with cancer receiving chemotherapy before and during the COVID-19 pandemic.

A Clinicopathological, Etiological Analysis of 136 Cases of Erythroderma: A Single-Center Retrospective Study

Objective: Erythroderma is an uncommon and severe skin disorder with many underlying causes and identifying its etiology can facilitate further treatments. This study was performed to evaluate the clinical profile and etiology of erythroderma. Methods: We collected the data on 136 patients diagnosed with erythroderma with respect to the epidemiological, clinical, biological, and histological data, treatments, and outcomes in The First Affiliated Hospital of Ningbo University from 2011 to 2021. The analyses of qualitative data were performed with the chi-square test or Fisher’s exact test. The groups of quantitative data were compared using a t-test or analysis of variance. Results: The patients’ mean age in this study was 65.00 ± 16.51 years, with a male:female ratio of 5.8:1.0. Acute onset occurred in 27 patients (19.9%) and was associated with drug reactions (P = 0.002). The mean length of stay was 19.18 ± 9.75 days. Clinical characteristics were dominated by pruritus (135, 99.3%), fever (44, 32.4%), edema (82, 60.3%), nail changes (14, 10.3%), arrhythmia (16, 11.8%), and superficial lymphadenopathy (57, 41.9%). Combined with biopsy, history inquiry and laboratory testing, this study found that most common causative factor was pre-existing dermatoses (107, 78.7%), followed by drug reactions (15, 11.0%), malignancies (8, 5.9%), and undetermined etiology (6, 4.4%). Among the pre-existing dermatoses, eczema was the most common etiology (33.9%). We also found that psoriasis, solar dermatitis, hypereosinophilic syndrome, atopic dermatitis, scabies, pemphigus foliaceus, and pityriasis rubra pilaris were causes of erythroderma. In the drug-induced group, anticonvulsants were the most frequently implicated drug. Compared to other cause diseases, patients with psoriasis had a significant higher rate of fever (P = 0.022), nail changes (P &lt; 0.001), arthralgia (P &lt; 0.001), and infection (P = 0.007). Eosinophilia and an increased immunoglobulin E concentration were associated with hypereosinophilic syndrome (P = 0.005) and eczema (P = 0.032), respectively compared to other cause diseases. The infection rate was significantly higher in patients with abnormal liver function compared to the patients with normal liver function (P &lt; 0.001). Conclusion: Most of the clinical features of erythroderma are unspecific with the exception of fever, nail changes, and arthralgia, which were mostly found in patients with psoriasis. Clinicohistopathological examination helps to establish the etiology of erythroderma and reminder doctors to focus on high-risk populations.

Analysis of the epidemiological characteristics of scarlet fever in Yantai City, Shandong Province from 2015 to 2019

From 2015 to 2019, the annual average incidence rate of scarlet fever was 7.80/100 000 in Yantai City, which showed an increasing trend since 2017 (χ2trend=233.59, P<0.001). The peak period of this disease was from April to July and November to January of the next year. The ratio of male to female was 1.49∶1, with a higher prevalence among cases aged 3 to 9 years (2 357/2 552, 92.36%). Children in kindergartens, primary and middle school students, and scattered children were the high risk population, with the incidence rate of 159.86/100 000, 25.57/100 000 and 26.77/100 000, respectively. The global spatial auto-correlation analysis showed that the global Moran's I index of the reported incidence rate of scarlet fever in Yantai from 2015 to 2019 was 0.28, 0.29, 0.44, 0.48, and 0.22, respectively (all P values<0.05), suggesting that the incidence rate of scarlet fever in Yantai from 2015 to 2019 was spatial clustering. The local spatial auto-correlation analysis showed that the "high-high" clustering areas were mainly located in Laizhou City, Zhifu District, Haiyang City, Fushan District and Kaifa District, while the "low-high" clustering areas were mainly located in Haiyang City and Fushan District.

Genotype-phenotype correlation in Jordanian children with genetically-proven familial Mediterranean fever: The effect of R202Q mutation

<h3>Background</h3> Familial Mediterranean fever (FMF) is a hereditary periodic fever syndrome inherited as an autosomal recessive pattern; nonetheless, patients with symptomatic heterozygous variants exist. This study aimed to review children with genetically-proven FMF, to describe their mutation maps and clinical characteristics, and to explore the genotype–phenotype correlation. <h3>Methods</h3> Medical charts of pediatric FMF patients who were diagnosed by both genetic mutation and clinical criteria and followed up at our hospital were reviewed. Demographic and clinical data, results of <i>MEFV</i> genetic testing, procedures, concomitant medical conditions, disease severity, and treatment response were recorded and analyzed. <h3>Results</h3> A total of 132 patients (71 females [54%]) were included in the final analysis. The average ages at presentation and diagnosis were 6.2 ± 3.1 and 7.6 ± 4.4 years, respectively. The most common clinical features were abdominal pain (n = 120, 91%), fever (n = 97, 73.5%), and arthritis (n = 75, 56.2%). Gastrointestinal endoscopy was the most frequently reported procedure (n = 27, 20.45%). The most common mutation was R202Q (n = 71, 53.8%), followed by E148Q (n = 36, 27.3%), M694V (n = 30, 22.7%), and V726A (n = 22, 16.7%). Two rare variants with potential pathogenicity were identified—namely, c.-15 and c.-330. A novel <i>MEFV</i> mutation (p. Lys629 Met) was noted. Abdominal pain, arthritis, arthralgia, and skin rashes were more common with the R202Q mutation. Patients with compound heterozygous mutations showed a higher rate of abdominal pain (94.1%) and exhibited the best response to colchicine (67.6%). Patients with complex alleles had the highest rate of fever (80%) and arthritis/arthralgia (70%). <h3>Conclusion</h3> FMF is endemic in Jordan. Genetic testing is important in FMF evaluation; however, the genotype–phenotype correlation needs further study. The R202Q mutation is possibly pathogenic and is associated with the manifestation of the full spectrum of FMF features; hence, it needs to be considered in the diagnosis of FMF patients in Jordan.

Stronger Neo‐Minophagen C (SNMC): A stronger adjuvant for TACE?

Stronger <scp>Neo‐Minophagen</scp> C (<scp>SNMC</scp>): A stronger adjuvant for <scp>TACE</scp>?

Clinical characteristics of primary atrial tumor and their diagnostic value: A retrospective study of 10 years.

Primary atrial tumors are relatively rare and predominantly benign. However, some atrial tumors may be malignant and are associated with poor outcome. Currently, it is hard to determine the malignance of atrial tumors by preoperative clinical presentation or by echocardiography. We aimed to report the difference in the clinical characteristics of patients with benign and malignant atrial tumor. This was a single-center retrospective study. A total of 194 patients with primary atrial tumor admitted to our center between 2012 and 2021 were included. The clinical characteristics of patients with benign and malignant tumor were compared. Benign and malignant tumor accounted for 93% (n = 180) and 7% (n = 14) of the total patients, respectively. Malignant atrial tumor tended to occur in younger patients (P < 0.05), was more likely to be located at the right atrium (P < 0.05), and tended to attach to the atrial wall or valve instead of the atrial septum. Fever symptoms were more common in patients with malignant tumors than in patients with benign tumors (P < 0.05). Compared to benign tumor, patients with malignant atrial tumor also demonstrated higher rates of fever, lower rates of increasing fibrinogen, increased blood glucose (P < 0.05), significantly longer prothrombin time, and lower prothrombin activity (P < 0.05). Patients with malignant primary atrial tumor had higher mortality rate, tumor metastasis rate, and tumor recurrence rate than patients with benign primary atrial tumor (P < 0.05). We compared the clinical characteristics of patients with benign and malignant atrial tumor. These findings provide valuable information to preoperatively determine the malignance of atrial tumor and thus guide surgical treatment.