The overuse of fertilizers in open-field tomato leads to soil deterioration through nutrient leaching and increases the risk of agricultural non-point source contamination. Currently, the combined effects of different fertilization methods on soil nitrogen leaching and tomato production are still unclear. Therefore, the most effective fertilization method for open-field tomato should be discovered by examining how different fertilization methods affected tomato yield and quality, nitrogen use efficiency (NUE), and soil nitrogen leaching. Compared with CK (no fertilization), fertilization significantly increased the yield, total sugar (TS), total soluble solids (TSS), and vitamin C (vC) contents of fruits (p < 0.05), and OPT (optimal fertilization, controlled release nitrogen application, 240 kg ha-1) had the largest effect on increasing yield, quality, and net profit. However, when the fertilizer application rate reached 375 kg ha-1, these indices decreased. Nitrogen leaching concentrations, leaching amount, and titratable acids (TAs) increased with increased nitrogen application rates. Compared with other treatments, OPT reduced the total leaching amounts of total nitrogen (TN), nitrate nitrogen (NO3--N), and ammonia nitrogen (NH4+-N) by 30.09-51.79%, 24.89-50.03%, and 30-65%, respectively. Principal component analysis (PCA) showed that OPT achieved the highest overall score in terms of yield, quality, and nitrogen leaching conditions. The partial least squares path modeling (PLS-PM) further reveals that applications of high amounts of nitorigen have a positive effect on soil nitrogen leaching. The amount of nitrogen leaching vegetatively affects tomato yield and quality, while plant uptake of nitrogen positively affects tomato production. These findings confirm the importance of using controlled-release fertilizers and reducing nitrogen inputs to control nitrogen leaching and enhance open-field tomato yields.