This study aims to examine the relationship between crude oil price, interest rate and theunemployment rate in Nigeria using times series data for the 1991-2019 periods. Thestationarity property of the series was examined using Augmented Dickey and Fuller(1979) and Elliot, Rothenberg and Stock’s (1996) unit root test. The outcomes ofAugmented Dickey and Fuller indicated a mixture of an order of integration among theseries while Elliot et al.’s (1996) unit root test revealed that all the series are stationary atthe first difference and therefore are said to integrate of order one. The Toda andYamamoto long-run granger causality indicated that one-way causality exists flowingfrom crude oil price to unemployment rate, unemployment rate to interest rate, populationgrowth to the unemployment rate, crude oil price to interest rate and population growthto interest rate alongside two-way causality flowing from population growth to crude oilprice. Therefore, based on the empirical outcomes we recommended that labour will serveas an efficient substituting factor of production for energy and capital in the case of theNigerian economy and Nigerian government should develop both industrial and noncrude oil sectors to create employment opportunities for the unemployed teemingpopulation as well as increasing the country’s export.