Rate Of Tooth Movement Research Articles

Inhibitory effect of infliximab on orthodontic tooth movement in male rats

ObjectiveThis study aimed to investigate the effect of infliximab on orthodontic tooth movement in rats. Materials and methodsSixty male Sprague-Dawley rats were randomly divided into two groups: saline group and infliximab group. The two groups of rats received weekly intraperitoneally injection of saline or infliximab (5 mg/kg), respectively. After four weeks of injection, five rats in each group were euthanized and orthodontic appliances were placed in the other twenty-five rats each. On days 1, 3, 7, 14 and 21, five rats from each group were euthanised. Maxillae of all the rats were collected and examined by micro-computed tomography, haematoxylin and eosin staining, tartrate-resistant acid phosphatase staining, and immunohistochemical staining of tumour necrosis factor (TNF)-α, receptor activator of nuclear factor κB ligand (RANKL), receptor activator of nuclear factor κB (RANK), and osteoprotegerin (OPG). All data were analysed with Mann-Whitney test. ResultsInfliximab inhibited orthodontic tooth movement and decreased osteoclastogenesis on the compression side during orthodontic tooth movement. The elevated TNF­α level, induced by orthodontic force, was decreased by infliximab. Furthermore, infliximab reduced the expression of RANKL and RANK, while increased the expression of OPG on the compression side. ConclusionInfliximab inhibits orthodontic tooth movement by reducing levels of TNF-α, RANKL, and RANK, while increasing level of OPG, and decreasing osteoclastogenesis on the compression side of periodontium.

Age dependent treatment response to the Carriere ® Motion 3D ™ appliance for the correction of Class II malocclusion

Introduction and Purpose
 Class II malocclusion is a common anomaly. Both adults and adolescents with Class II malocclusion can be treated. One of the methods for correction is Carriere ® Motion 3D ™ appliance (CMA).
 The aim was to evaluate and compare the rate of tooth movement depending on age during treatment with Carriere ® Motion 3D ™ appliance (CMA).
 Material and method
 The retrospective study investigated medical records of 28 adult and 27 adolescent subjects who were treated with the Carriere ® Motion 3D ™ distalizer to correct Class II malocclusion. Time (in days) needed to achieve 1 mm correction was calculated for each patient, based on the quotient of days needed for Class II correction and the distance required to achieve Class I canine relationship. The difference between groups was analyzed using the Mann-Whitney-U test.
 Results
 Phase I treatment with CMA lasted on average 5,67 ± 2,01 months for adults and 4,67 ± 1,48 months for teenagers. The mean time to achieve 1 mm correction was 36,77 ± 11,01 days in the adult group and 36,59 ± 26,17 days in the adolescent group. The results showed no statistically significant difference between the two groups.
 Conclusions
 CMA can be applied to efficiently treat Class II malocclusion in adolescent as well as adult patients. No difference in age related tooth movement using the CMA was found.

Effect of vitamin D on bone morphometry and stability of orthodontic tooth movement in rats

Vitamin D (VitD) maintains bone health and may influence orthodontic tooth movement (OTM). The objective was to evaluate the VitD effect on bone morphometry and the rate and stability of OTM. Thirty-two male Sprague Dawley rats were assigned into 2 experimental groups, treated with VitD by gavage (systemic) or injection (local), and 2 respective control groups treated with phosphate-buffered saline for 47 days. OTM was performed for 7 days with a nickel-titanium coil bonded between the maxillary first molar and incisors. Microcomputed tomography scanning was performed at 5 time points: before administration of VitD, the start of OTM, the end of OTM, 7 days post-OTM, and 30 days post-OTM. The rate and stability of OTM were assessed. Bone morphometry was analyzed by bone mineral density, bone volume/total volume, total porosity, trabecular pattern factor, structure model index, and connectivity density. The systemic VitD group showed a lower OTM rate and a lower relapse than the control (P<0.05). It also demonstrated increased bone mineral density, bone volume/total volume, and a decrease in total porosity (P<0.05). The bone structure appeared more fragmented and presented a lower connectivity density than the control (P<0.05). No statistical difference was found between VitD local administration and the other groups for the rate and stability of OTM or bone morphometry. The systemic administration of VitD caused a decrease in the OTM rate by generating more bone resistance but also contributed to a lower relapse with a higher bone mineral density.

Evaluation of the effect of local administration of PRP vs vitamin D3 on the rate of orthodontic tooth movement and the associated external apical root resorption.

BackgroundIncreased orthodontic treatment duration is associated with iatrogenic risks such as root resorption, white spot lesions etc. Recent research using pharmacological agents to accelerate tooth movement has mostly been conducted on animals and there is no reported research conducted on humans comparing the effects of Vitamin D3 and Platelet Rich Plasma (PRP) in the same subjects using a split mouth technique.ObjectivesTo determine and compare effects of local injection of PRP and Vitamin D3 on the rate of tooth movement. Also, to assess association of external apical root resorption with the use of PRP, Vitamin D3 and compare it to a control group.Materials & methods11 subjects who diagnosed with Class I bi-maxillary malocclusion and who gave informed consent were recruited in the study. The patients were randomly divided using split mouth design and each quadrant served as either experimental or control group one. At the beginning of retraction phase, Vitamin D3 and PRP were injected to the randomly assigned quadrants while the contralateral side served as a control. The amount of space closure in 4 months was measured from distal surface of canine to mesial surface of 2nd premolar. Root resorption was assessed using CBCT taken at the beginning and at the closure of retraction phase.ResultsMean rate of tooth movement was higher in PRP and Vitamin D3 groups compared to their controls. In the PRP group, the increased rate of tooth movement was observed throughout the study interval, but in the Vitamin D3 group it was only seen in first two months. Also, the PRP group demonstrated a higher rate of tooth movement compared to Vitamin D3 group. Root resorption was lesser in both experimental groups. Among the teeth assessed, lateral incisor showed maximum root resorption and canine the least.ConclusionsPRP is a more efficient pharmacological agent compared to Vitamin D3 for accelerating tooth movement.

The effect of micro-osteoperforations on the rate of orthodontic tooth movement in animal model: A systematic review and meta-analysis.

IntroductionThe long passing time for tooth movement (TM) is one of the challenges in orthodontic. complications such as gingival recession, root resorption, and caries are common in orthodontic. To address this, there is an increased tendency to find safe and effective methods to accelerating tooth movement. A surgical method such as micro-osteoperforations (MOP) accelerating the TM. The current meta-analysis aims to investigate the outcome of MOP in accelerating TM in animal studies.MethodsIn the present meta-analysis, we evaluated 6 studies that focused on the effect of MOP on TM with the following keywords: (((MOP* OR micro-osteoperforations*) AND (("accelerating tooth movement " OR " tooth movement" AND " orthodontic tooth movement " OR " orthodontic ") until May 2021.ResultsThe results have shown there is significant difference in TM after using MOP (MD: 0.31, 95%CI: 0.20, 0.42, P < 0.00001, I2 = 76%). Subgroup analysis revealed that though experimental duration in both less than 4-week and more than 4-week, the TM were significant difference between MOP and controls. Besides, in both force subgroups including less than 100 g and more than 100g, the TM was a significant difference between MOP and controls.ConclusionThis meta-analysis found that generally MOP has a positive effect on TM.

Effect of light-emitting photobiomodulation therapy on the rate of orthodontic tooth movement : Arandomized controlled clinical trial.

The aim of this study was to evaluate the effect of light-emitting photobiomodulation therapy (LPT) on the rate of canine distalization. This study was performed on 60extraction spaces formed by extraction of the upper first premolars of 30patients (15 in the LPT group and 15in the control group). Paul Gjessing (PG)-segmented canine retraction springs were used for canine distalization. In the LPT group, the Biolux OrthoPulse™ (Biolux Research Ltd, Vancouver, Canada) intraoral device (wavelength 850 nm LED light and an energy density of 63 mW/cm2 [±13 mW/cm2]) was used for 5min per day over a period of 84days. For each patient, the diagnosis was based on standard orthodontic documentation with photographs, digital model casts, and cephalometric and panoramic radiographs. The anchorage loss, canine rotations, canine inclinations, and molar inclinations were also evaluated on plaster models obtained on days 0, 21, 42, 63, and 84. The models were measured by using 3Shape OrthoAnalyzer software (3Shape, Copenhagen, Denmark). Measurements were made by a researcher and a blinded clinician. For statistical comparison, a paired-samples t‑test and one-way analysis of variance (ANOVA) were used at the p < 0.05 level. The mean canine distalization rates were 1.36 mm/21days and 1.02 mm/21days in the LPT and control groups, respectively, and were statistically greater in the LPT group (p < 0.001). The amount of anchorage loss, canine rotations, canine inclinations and molar inclinations were not significantly different between the LPT and control groups at any of the timepoints. LPT has the potential to accelerate orthodontic tooth movement by 33%.

May alcoholic and non-alcoholic drinks affect the rate of orthodontic tooth movement? A systematic review of animal studies.

Humans may consume various beverages in everyday life. Previous research has shown that the administration of different substances (medicinal or not) may affect bone turnover and, thus, orthodontic tooth movement. It would be anticipated that the substances contained in beverages could have an impact on tooth movement, as well. To investigate in a systematic way and appraise the quality of the available evidence from animal studies regarding the impact of various drinks or the main ingredients included in beverages on the rate of orthodontic tooth movement. Search without restriction in six databases (including grey literature) and hand searching were performed until March 2022. We looked for controlled animal studies investigating the effect of drinks, or the main ingredients included in beverages, on the rate of orthodontic tooth movement. After study retrieval and selection, relevant data was extracted, and the risk of bias was assessed using the SYRCLE's Risk of Bias Tool. The quality of available evidence was assessed with the Grades of Recommendation, Assessment, Development, and Evaluation. The initially identified records were finally reduced to nine studies conducted on animals. Carbonated soft drinks were shown to decrease the rate of tooth movement, but alcohol consumption did not have an impact. Exploratory meta-analysis showed that caffeine exhibited an acceleratory effect after 3 weeks of force application. Exploratory meta-regression results indicated that high dosages of caffeine reduced the rate of tooth movement. The located animal experiments reported that caffeine accelerates, carbonated drinks decelerate, while alcohol does not affect the rate of orthodontic tooth movement. However, due to various limitations it remains unclear whether caffeine, alcohol, or carbonated drinks finally influence tooth movement in animal studies. Open Science Framework (https://osf.io/jyhbd/).

Effectiveness of platelet-rich concentrates on the rate of orthodontic tooth movement: a systematic review and meta-analysis.

Autologous platelet-rich concentrates (PRCs) are recently used as a local biological substance in orthodontics to accelerate the rate of tooth movement. This systematic review aimed to evaluate the effects of PRCs on the rate of orthodontic tooth movement (OTM). Unrestricted search of five electronic databases supplemented by the manual and gray literature search were undertaken in March 2022. Randomized controlled trials (RCTs) evaluating the effect of PRCs on the rate of OTM with their side effect were included in this systematic review. Data items were extracted by two authors using a pre-piloted extraction form. Similar outcomes within a comparable time frame were synthesized in a meta-analysis. Fourteen studies were deemed eligible for inclusion and seven RCTs were pooled in a meta-analysis. Canine retraction rate was higher in the side of PRCs injection than the control side by 0.28 mm/month (95% CI: 0.16-0.40, I2 = 95.6 per cent, P < 0.001, 345 patients) in the first 4 months after PRCs injection. There was no statistically significant difference between the PRCs side and the control side regarding molar anchorage loss (MAL) (MD = 0.03 mm, 95% CI: -0.18 to 0.24, I2 = 46.3 per cent, P = 0.78, 44 patients), canine rotation (MD = -0.19o, 95% CI: -1.95 to 1.57, I2 = 45.4 per cent, P = 0.96, 48 patients), or en-masse retraction. Likewise, there was no difference between both groups in terms of the duration of de-crowding. The mandibular canine retraction was statistically higher on the PRCs side than on the control side by 0.17 mm/month (P < 0.001, one trial). Regarding root resorption, there was no statistically significant difference between the experimental and control sides within the follow-up time. Mild pain scores were reported by the patients in the first 24 hours after injections. Low-level evidence indicates that the effect of PRCs on OTM is minor and clinically insignificant. The findings should be interpreted with caution due to the inherent limitations in the included RCTs. PROSPERO (CRD42022300026).

Effect of Extending Corticotomy Depth to Trabecular Bone on Accelerating Orthodontic Tooth Movement in Rats.

Corticotomy is a surgical procedure that induces injury to the cortical bone to accelerate tooth movement. This study aimed to increase the depth of corticotomy to the trabecular bone and to evaluate the amount and rate of tooth movement and alveolar bone changes in response to various degrees of cortical and trabecular bone injury. Seventy-eight male Wistar rats were randomly divided into four groups based on procedure used: (1) baseline control group of orthodontic tooth movement (OTM) only; (2) OTM + 4 corticotomies (CO); (3) OTM + 4 osteotomies (OS); and (4) OTM + 16 CO. A closed-coil nickel–titanium spring was placed to move the maxillary first molar mesially with a 10 g force. On days 0, 7, 14, and 21, alveolar bone alteration and tooth movement were measured using microcomputed tomography. Significant tooth movement was related to the number and the depth of the perforations. The OTM + 16 CO group showed a greater amount and rate of tooth movement than the OTM + 4 CO group. When osteotomy and corticotomy were compared with the same volume of bone removed, the OTM + 4 OS group had a faster rate of tooth movement than the OTM + 16 CO group during the first week, with significantly reduced bone volume. However, no significant difference was observed in the amount of tooth movement between the OTM + 4 OS and OTM + 16 CO groups at the end of the study. Extending the depth of corticotomy to trabecular bone increased the amount of tooth movement by accelerating the induction and completion of bone remodeling, which accelerated the rate of tooth movement during the initial stage.

Influence of ibuprofen combined with corticotomy on tooth movement and alveolar bone remodeling in rats.

To investigate the effects of corticotomy-assisted orthodontic tooth movement and administration of ibuprofen on tooth movement rate and alveolar bone response. A total of 78 adult male Wistar rats were randomly assigned to five groups: one baseline group (no treatment) and four experimental groups including orthodontic tooth movement only (OTM), orthodontic tooth movement with ibuprofen (OTMI), corticotomy-assisted orthodontic tooth movement (COTM), and corticotomy-assisted orthodontic tooth movement with ibuprofen (COTMI). Corticotomy was performed on a maxillary molar unilaterally. Nickel-titanium closed-coil springs generated a 10-gram force for maxillary first molar movement. The experimental drug groups received 15 mg/kg of ibuprofen, and the other groups received reverse osmosis water. Tooth movement and bone volume fraction were evaluated by micro-computed tomography on days 0, 7, 14, and 21. The corticotomy groups had statistically significantly higher tooth movement and lower bone volume fraction than the orthodontic groups (P &lt; .05). The amount and rate of tooth movement were statistically significantly different between the OTM and OTMI groups, but not statistically significantly different in bone volume fraction. However, statistically significant differences were not observed in any measurements between the COTM and COTMI groups. Ibuprofen during orthodontic tooth movement inhibited tooth movement and alveolar bone remodeling but had no effect on corticotomy-assisted orthodontic treatment.

Effect of masseter muscle mass on the rate of experimental tooth movement in rats.

Previous clinical observational studies have suggested that orthodontic tooth movement (OTM) is related, at least partly, to the mass and/or capabilities of the masticatory muscles. Our study aimed to examine the influence of masticatory muscle mass on the OTM in an animal experimental model in which the masseter muscle was modulated by botulinum neurotoxin type A (BTX) injection. Eighteen Wistar rats were equally divided into two groups: BTX injection and control. BTX was injected bilaterally into the masseter muscles. Three days after the injection, the maxillary left first molars were orthodontically moved for 14 days. At the end of the experiment, micro-computed tomography was performed to evaluate the rate of OTM and bone morphometry. The masseter muscles were weighed and prepared for histological analyses. The masseter muscle mass in the BTX group was less than that in the control group, and histological findings showed atrophy of muscle fibres. The rate of OTM was significantly higher in the BTX group than in the control group. Furthermore, a negative correlation was detected between masseter muscle mass and OTM in the BTX group. Bone morphometry showed no difference between the control and BTX groups. Decreased masseter muscle mass was found to be closely related to an increase in the rate of OTM in rats using BTX injection to modify the masseter muscle mass. Masseter muscle mass could be a predictive factor for OTM in rats injected with BTX.

Monitoring orthodontic tooth movement in rats after piezocision by bone scintigraphy.

Piezocision, corticocision of mineralized tissue by ultrasound showed promising results in accelerating tooth movement induced by orthodontic appliances although the biologic effects of this procedure are not well-understood so far. The aim of this study was to investigate the impact of piezocision on bone remodeling in rats by bone SPECT imaging. Ten male Wistar rats underwent surgical placement of orthodontic appliances on each side of the maxilla followed by piezocision on one side only. Each rat underwent 99mTc-MDP bone SPECT/CT imaging before surgery (T0), and 2 (T1) and 4 weeks (T2) after surgery. Bone uptake is expressed as median [IQR] min-max in percentage of the injected activity per ml computed from the 10 voxels with the highest uptake (%IAmax10/ml). Pooled data regardless of the piezocision showed a significant increase in bone uptake from T0 (3.2 [2.8-3.9] 2.6-4.9) to T1 (4.4 [3.8-4.6] 3.4-4.8; p = 0.001). Thereafter, the uptake decreased to T2 (3.8 [3.1-4.4] 2.8-4.8; p = 0.116). No significant differences in bone uptake were found between the maxilla sides without and with piezocision: T1: without (4.3 [3.8-4.5] 3.4-4.8) vs. with (4.5 [3.7-4.6] 3.5-4.7; p=0.285), T2: without (4.0 [3.1-4.5] 2.8-4.8) vs. with (3.7 [3.0-4.4] 2.8-4.8; p=0.062). 99mTc-MDP bone SPECT imaging in rats was able to reproduce changes in bone uptake in the maxilla after placement of orthodontic appliances inducing measurable tooth movement. An additional effect of piezocision on bone remodeling in terms of bone uptake was not detectable which is probably due to the pronounced and significant effects induced by the orthodontic appliances per se, which may mask the potential effects of additional piezocision.

Association of Orthodontic Tooth Movement with Leptin Concentration in Gingival Crevicular Fluid.

Objectives:This study aims to evaluate the association of orthodontic tooth movement with the concentration of leptin in gingival crevicular fluid (GCF).Materials and Methods:In thirty orthodontic patients, the concentration of leptin was assessed at baseline, 1 h, 24 h, 7 days, and 1 month after application of orthodontic force. Distalized tooth movement was evaluated by measuring the difference on dental casts at baseline and 1 month after force application.Results:Average concentration of leptin in GCF raises from baseline (T0) to 1 h after application of force (T1). There was a significant association of the overall average concentration of leptin with the degree of tooth movement (correlation coefficient = 0.625).Conclusion:There was a biphasic change in GCF leptin concentration and significant association between rates of tooth movement with GCF leptin concentration.

Use of Hydrogels to Regulate Orthodontic Tooth Movement in Animal Models: A Systematic Review

The objective of this article is to conduct a systematic review of the literature to contrast the existing evidence regarding the use of hydrogels during and after experimental orthodontic treatment in animals. An extensive search was performed through the electronic databases, Medline, Web of Science and Scopus, from December 2020 to April 2021 for in vivo animal studies. A total of 282 studies were reviewed. Eight studies were included for final revision; four studies were conducted in rats, two in rabbits, one study in mice and one study in guinea pigs. The quality assessment of the eight included studies was performed according to the ARRIVE guidelines and the risk of bias was assessed using the Center for Systematic Review of Laboratory Animal Experimentation tool; in four of the eight articles evaluated, a high risk-of-bias rating was obtained in 40% of the criteria evaluated. In the studies reviewed, the hydrogel acted as a carrier, and inhibition (post-treatment retention) or acceleration of orthodontic tooth movement was assessed according to the active substance used in each of the articles. The uses of hydrogels for transporting active substances to regulate the rate of orthodontic tooth movement remains debatable. Future studies are suggested to evaluate the feasibility of hydrogel as a transport method in humans.

Linking leptin in GCF with tooth movement among Indians.

It is of interest to evaluate the association of orthodontic tooth movement with concentration of leptin in Gingival Crevicular Fluid (GCF).Thirty orthodontic patients of both genders with equal sample size were included for the present study. Concentration of leptin was assessed at baseline (T0), 1 hr after application of force (T1), 24 hours later (T2), 7 days after application of force (T3), and 1 month after application of orthodontic force (T4). Using strips of filter paper, GCF was collected from the gingival sulcus on distal aspect of the right maxillary canine. Distalized tooth movement was evaluated by measuring the difference on dental casts, at baseline and one month after force application. One-way ANOVA with Bonferroni correction and Pearson's correlation test were used to analyze the data. Average concentration of leptin in GCF raises from baseline (T0) to 1 hours after application of force (T1), then increased to peak after 24 hours (T2), and declined to a minimum value after 7 days (T3) and again raises after 1 month (T4), closer to the base line value (T0), and this was statistically significant (P < 0.05). There was significant association of the overall average concentration of leptin to degree of tooth movement (correlation coefficient = 0.625). There was a biphasic change in GCF leptin concentration during one cycle of orthodontic force application, thus, a significant association between rates of tooth movement with GCF leptin concentration is noted.

Straight wire and segmented technique in canine retraction-case reports

Correct positioning of the canines after their retraction is of great importance for the function, stability and esthetics. Aim: Two case reports were presented to compare the efficiency of two techniques for canine retraction, segmented mechanics using 0.017 x 0.025 TMA T-loop vs sliding straight-wire mechanics usingelastomeric chains. Material and methods: The first case describes orthodontic treatment with 0.017 x 0.025 TMA T-loop whereas the second case describes a 9 mm canine retraction using elastomeric chains. Results: Depending on the type of malocclusion both techniques for canine retraction can be used. Post treatment results showed canine retraction with good anchorage control and no mesial movement of the molars.Conclusion: Both techniques provide an optimum rate of tooth movement and none of the methods can be considered superior in terms of tooth movement or side effects, including rotation, tipping, root resorption, anchorage loss, as well as associated pain.

Platelet-rich derivatives for accelerating the rate of orthodontic tooth movement - a systematic review and meta-analysis

Objective: The aim of this systematic review and meta-analysis was to report on the effects of using platelet-rich derivatives on the rate of tooth movement. Material and Methods: Both electronic and manual searches were performed with specific eligibility criteria based on population, intervention, comparison, outcome, and study design. Risk of bias (RoB) assessment was done using the Cochrane RoB tool 2, the data were pooled and analyzed using review manager 4.5, and certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation approach. Two independent reviewers performed the study selection, data extraction, and analysis. Nine studies were included for qualitative analysis and two of them were subjected to meta-analysis. Results: The standard mean difference for the rate of canine distal movement with platelet-rich derivatives was not significantly higher than controls at any of the time intervals (P &gt; 0.0001). Rotation of canines, molar mesialization, and pain scores were not affected by the administration of platelet-rich derivatives for accelerating tooth movement. A moderate to high RoB was noted in the included studies and the certainty of the available evidence as assessed by the GRADE approach was moderate. Conclusion: The included studies presented with high heterogeneity and more high-quality studies with strict protocols are needed. Even though individual studies report significant acceleration of tooth movement following administration of PR derivatives, moderate certainty of evidence suggests no acceleratory effect on tooth movement.

Effects of various analgesics on pain perception and rate of tooth movement: a randomized controlled clinical study

Background: Pain is one of the most reported side effects of orthodontic treatment despite the advanced technology in orthodontics. Many analgesics have been introduced to control orthodontic pain including acetaminophen and selective and nonselective nonsteroidal anti-inflammatory drugs. The great concern about these drugs is their adverse effect on rate of teeth movement. Aims: The purpose of this study was to evaluate and compare the effect of acetaminophen, ibuprofen and etoricoxib on pain perception and their influence on the rate of teeth movement during leveling and alignment stage. Methods: Forty patients were evenly and randomly distributed in a blinded way to one of four groups: placebo (starch capsules), acetaminophen 500mg thrice daily, ibuprofen 400mg thrice daily, and etoricoxib 60mg once daily. The drugs were given one hour before bonding and archwire placement and continued for three days. A visual analogue scale was used to express pain levels before and after archwire placement, on the first, second, third, and seventh day. Little’s irregularity index was measured before bonding and at every activation visit until the end of the alignment and leveling stage. Results: All three drugs showed a lower pain level than placebo at the bonding and first activation visits. Etoricoxib showed the least pain level among other drugs followed by ibuprofen. No statistically significant differences were found between the drug groups and the placebo at the second and third activation visits. No statistically significant differences were detected between the 4 experimental groups concerning the rate of teeth movement. Conclusions: The three drugs were only effective in controlling pain during the first two visits of orthodontic treatment; and etoricoxib 60mg/day was the best. All three drugs had no influence on rate of teeth movement when used in their least recommended dose.

The number of osteoblasts and osteoclasts in hypofunctional teeth during orthodontic tooth movement in rats

Background: When moved orthodontically, hypofunctional teeth will have a decreased tooth movement rate compared to normal teeth. Hypofunctional teeth would have less VEGF expression and decreased heparan sulfate proteoglycan production during orthodontic tooth movement. This study aimed to determine the number of osteoblasts in the tension side and the number of osteoclasts in the pressure side of the hypofunctional teeth during orthodontic tooth movement. Method: 18 male Wistar rats were given a palatal coil spring application on the maxillary incisors. Rats were divided into two groups, the orthodontic group with normal occlusion (NO) and hypofunctional occlusion (HO). The number of osteoblasts on the tension side and osteoclasts on the pressure side on days zero (D0), five (D5), and 10 (D10) were tested with two-way ANOVA. Observations were made by hematoxylin eosin staining. Result: The results showed that the number of osteoblasts on the tension side of the HO group was the same at the NO group (p&gt; 0.05). The number of osteoblasts on the tension side in the NO and HO groups at D5 was the same at D10 (p = 0.99), but significantly higher (p = 0.002), than D0. The number of osteoclasts on the pressure side in the HO group was significantly lower than the NO group (p &lt;0.05). The number of osteoclasts in the NO D5 group was significantly higher than the other groups (p &lt;0.05). Conclusions: The number of osteoblasts on the tension side was not affected by the hypofunctional state but decreased the number of osteoclasts on the pressure side during orthodontic tooth movement.

Effect of various biological ways on the orthodontic tooth movement

The duration of orthodontic treatment is the primary concern of utmost patients. Unfortunately, long orthodontic treatment time poses several disadvantages like an advanced predilection to dental caries, gingival recession, and root resorption. Thus, there is an increase in the demand to find the best method of faster tooth movement. Orthodontic treatment is formed on the premise that when force is delivered to a tooth and thereby transmitted to the adjacent investing tissues, certain mechanical, chemical, and cellular events take place within these tissues, which allow for the structural difference that contributes to the tooth movement. Conventionally, this process is slow, and orthodontic treatment time can range anywhere from 36-48 months. The body's responses to these forces are the crucial controllers of inflammation and tissue turnover. So, in this article, various pharmacological means are discussed that can enhance the rate of tooth movement.