Introduction: Whipple's pancreaticoduodenectomy has been refined over the years to be a safe operation though the morbidity rate still remains high (30–50%). Pancreatic fistula is the most important cause of mortality following pancreaticoduodenectomy. To prevent it, surgeons have used two anastomotic techniques: pancreaticojejunostomy and pancreaticogastrostomy. Recent studies found that pancreaticogastrostomy is associated with fewer overall complications than pancreaticojejunostomy. This is a retrospective review of patients who underwent Whipple's at Aga Khan University Hospital and had pancreaticogastrostomy as a preferred anastomosis for pancreatic stump. Methods: It is a case series collected at the Department of Surgery of Aga Khan University Hospital, Karachi from 2008 till 2016. This case series includes all adult patients who were diagnosed to have peri-ampullary mass on preoperative imaging and underwent Pancreaticoduodenectomy (Whipple procedure) with pancreaticogastrostomy as preferred anastomoses, instead of pancreatico-jejunostomy, to maintain pancreaticoenteric continuity. Beside baseline demographics postoperative 30-day mortality and morbidity were also recorded. Results: Forty four patients met the inclusion criteria, 27 were male. Our mean age was 55.5 ± 11.5 years. Ampullary Adenocarcinoma (36.4%) was the most common pathology followed by Carcinoma head of Pancreas (25%). No patient developed post-operative pancreatic fistula, 13 (31%) patients had postoperative-morbidities including delayed gastric emptying 4 (9.1%), wound infection 3 (6.8%), and haemorrhage 6 (13.6%). Mortality is reported to be five (11.4%). Conclusion: Pancreaticogastrostomy seems to be a safe and easier anastomosis to perform with less postoperative morbidity and leak rates. However more data is required to validate these results. Our mortality rate is comparable to regional low-volume centers.