BACKGROUND: Motor vehicle accidents are the leading cause of death in adolescents and young adults worldwide. Road traffic fatality is high in Iran; about 28,000 individuals die from road traffic accidents annually. Previous studies on trauma care in Iran have mainly focused on pre-hospital trauma care. This paper deals with the rate of traffic injury deaths in hospitals. Objectives: The objectives of the present study were to investigate the predictors of survival rates of 2-wheel vehicle and pedestrian traffic injuries in hospitals of Tabriz, Iran. Patients and Methods: This longitudinal study reviewed 15,331 injuries in 21 hospitals in the city of Tabriz from March 2012 to March 2013. The required data on motorcycle, bicycle and pedestrian (MBP) traffic injuries were collected from hospital information systems (HISs). Operation codes were extracted according to the 2010 California Building Code and the data were analyzed using the STATA 13 statistical software package. Results: The total number of deaths due to traffic injuries was 266. Of these deaths, 184 were among inpatient traffic injuries 166 were MBP inpatients and 82 were outpatients. Young MBP patients (20 to 40 years of age) experienced a higher injury rate than older ones (48.4%, P Conclusions: Close attention to these predictors may aid officials in planning effective training programs and prevention measures. These predictors can also be used in the legislation of traffic laws and regulations and managerial plans of hospitals. Keywords: Traffic Injuries; Motorcycle; Bicycle; Pedestrian; Mortality Language: en