The article deals with 2D unsteady nanofluid flow past a vertical wedge along with nonlinear mixed convection. Brownian diffusion and thermophoresis effects are considered to model nanofluid flow. Convenient transformations are assumed to change the coupled nonlinear governing PDEs into ODEs. To analyze the problem, the solutions of transformed equations are numerically achieved via ‘bvp4c’, a MATLAB approach. Graphical presentation is adopted to see the impact of various influential parameters. Results reveal that nonlinear temperature and concentration convection parameters exhibit the same impact for velocity, temperature and concentration profile, though nonlinear convection parameter for temperature is more impactful than concentration. Velocity overshoot is observed for assisting flow situations. In nonlinear mixed convection flow, skin-friction coefficient, heat and mass transfer rates prominently change for favorable and adverse pressure gradient conditions.