Embryo Aneuploidy Rate Research Articles

Aneuploidy rates in unfertilized oocytes, from fertile anonymous donors versus those found in young infertile patients

Objective: Aneuploidy rates in embryos of infertile patients appear to increase with maternal age. Most aneuploidies are a result of non-disjunction in the female gamete at meiosis I, so it is advantageous to evaluate oocytes, and complementary first polar bodies if at all possible, to determine the origin of chromosomal abnormalities. The purpose of this study was to compare aneuploidy rates in unfertilized oocytes from young fertile donors to those found in young infertile patients using chromosomes X, Y, 13, 18, and 21. A comparison between fertile and infertile patients helps to determine if aneuploidy is a function of increasing maternal age, or if it is a potential cause of infertility even in younger patients.

The effect of different pronuclear patterns on the aneuploidy rate of cleavage stage embryos and subsequent blastocyst formation

The effect of different pronuclear patterns on the aneuploidy rate of cleavage stage embryos and subsequent blastocyst formation

O-49. High aneuploidy rate in preimplantation embryos developed from macrocephalic sperm injection

O-49. High aneuploidy rate in preimplantation embryos developed from macrocephalic sperm injection

Human embryos derived from in vitro and in vivo matured oocytes: analysis for chromosomal abnormalities and nuclear morphology.

To determine whether embryos resulting from oocytes matured in vitro have a higher incidence of nuclear and/or genetic abnormalities compared to embryos resulting from oocytes matured in vivo. Fluorescence in situ hybridization analysis for chromosomes X, Y, and 18 was used to compare the rates of aneuploidy, mosaicism, and nuclear abnormalities in embryos derived from oocytes that were prophase I at aspiration (immature group) to that observed in embryos resulting from oocytes that were metaphase I or II at aspiration (mature group). Based on nuclear morphology, significantly more embryos in the mature group (23%) were classified as normal compared to embryos in the immature group (3%). No difference was found in the rate of aneuploidy or in the incidence of mosaicism involving these chromosomes. These findings suggest that few embryos derived from prophase I oocytes collected following ovarian stimulation are morphologically normal.