Effect of the slip boundary condition on rarefied gas flow simulations plays an important role to understand the behaviour of gas microflows in MEMS. Several second-order slip conditions were proposed by the models of the kinetic theory of gases to simulate the rarefied gas microflows, in which the so-called classical second-order slip condition was derived from the Karniadakis et al. model. In this paper, a new second-order slip condition is proposed to employ with the Navier-Stokes-Fourier equations for simulating the rarefied gas flows in microchannels. It is derived by combining the Langmuir isothermal adsorption and the Karniadakis et al. model, with the aim of achieving a more realistic physical model. The pressure-driven back-forward-step, the Couette and pressure-driven Poiseulle rarefied gas flows in microchannels are investigated to validate our new second-order slip condition. Slip velocities using our new second-order slip condition are better than those using the conventional Maxwell and the so-called classical second-order slip conditions, and are in very good agreement with the DSMC data for all cases considered.