This study focuses on optimizing the lateral jet efficiency of THAAD-like (Terminal High Altitude Area Defense) missiles operating under hypersonic rarefied flow conditions. We employ the DSMC-QK algorithm to simulate the three-dimensional lateral jet flow field, accounting for thermochemical non-equilibrium effects. The analysis investigates how the force/momentum amplification coefficient varies with the angle of attack, jet pressure ratio, jet Mach number, and jet gas composition. Subsequently, we develop an artificial neural network (ANN) proxy model using the pyrenn toolbox, achieving an average prediction error of 0.866% and a maximum error of 1.60%. Utilizing this ANN model, we perform single- and multi-objective optimizations with a genetic algorithm to determine the optimal jet parameters. The results reveal that in multi-objective optimization, the proportion of helium in the jet gas composition increases, leading to a slight reduction in the force amplification coefficient but a substantial 61.4% decrease in the mass flow rate. This demonstrates that a judicious selection of jet gas composition can significantly reduce mass flow while maintaining high jet efficiency, thus achieving efficient lateral jet control.