Background: Rare diseases are often complex, multisystem disorders requiring specialized, lifelong care. These diseases share significant challenges in healthcare delivery, including diagnostic delays, limited access to specialists, and lack of effective treatments. Objectives: To aggregate and critically examine innovative health services interventions for rare diseases, with the goal of identifying potentially scalable strategies to improve care. Eligibility criteria: Peer-reviewed original research published in English reporting results of interventions to improve guideline-concordant care, care coordination, and care transitions in rare disease populations. Using Covidence software, two researchers independently screened all texts against preestablished inclusion and exclusion criteria, with conflicts resolved through consensus discussion with a third researcher. Sources of evidence: Comprehensive searches were conducted in April 2022 in Ovid MEDLINE, Embase.com, Web of Science Core Collection, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov. Charting methods: Two researchers independently extracted study characteristics and results from eligible full texts using Covidence software, with any conflicts resolved through consensus discussion with a third researcher. Results: Our search identified 2899 articles. After screening for eligibility criteria, 12 articles describing health services interventions in rare diseases were identified. Most studies were conducted in Europe and involved adult participants. Three main intervention targets were identified: (1) increasing patients’ access to multidisciplinary expertise (e.g. using expert panels/tumor boards, integrating additional disciplines into care teams, and creating a hotline for specialist advice); (2) using technology to give point-of-care physicians access to information (e.g. electronic medical record templates/decision-support); and (3) standardizing care through clinical care pathways. Conclusion: This review identified several efficacious interventions to improve healthcare delivery for individuals with a single rare disease. Testing these strategies across broader groups of rare disease patients could more efficiently improve healthcare delivery for the rare disease community, facilitating patients’ timely access to treatments, improving their health outcomes, and potentially reducing healthcare costs with economies of scale.