Rapid Decline Research Articles

Incidence, mortality, and disability-adjusted life years due to silicosis worldwide, 1990-2019: evidence from the global burden of disease study 2019.

Silicosis is an occupational lung disease because of exposure to silica dust in the workplace. Evidence on the spatiotemporal change of silicosis burden worldwide remains limited. This study utilized data extracted from the Global Burden of Disease Study 2019 to examine the numbers and age-standardized rates of incidence (ASIR), mortality (ASMR), and disability-adjusted life years (DALYs) caused by silicosis between 1990 and 2019. Average annual percentage changes (AAPCs) were calculated to evaluate the temporal trends of age-standardized indicators by sex, region, and socio-demographic index (SDI) since 1990. Results indicated an increase in new silicosis cases globally, rising by 64.61% from 84,426 in 1990 to 138,971 in 2019, with a sustained high number of DALYs attributed to this disease. Although the global age-standardized rates of incidence, mortality, and DALYs of silicosis have decreased since 1990, the number of new cases has increased in 168 countries and territories, and the ASIR of silicosis has also risen in 118 countries and territories, primarily in developing countries. Since 1990, the burden of silicosis among the elderly has significantly increased. Countries with higher SDI experienced a more rapid decline in the silicosis burden. Silicosis remains a public health problem that requires significant attention. Programs for prevention and elimination of this public health issue need to be established in more countries and territories. Protecting young workers from silica dust exposure is crucial to prevent the onset of silicosis in their later years and to reduce the disease burden among older workers.

Trajectory patterns and influencing factors of supportive care needs in stroke patients: A longitudinal study.

To investigate the trajectory patterns and influencing factors of supportive care needs in stroke patients. A longitudinal study. In total, 207 stroke patients who received treatment at the Department of Neurology in a hospital in Xuzhou between July 2022 and July 2023 were recruited using convenience sampling. Questionnaires including supportive care needs, hospital anxiety and depression scale, and the Barthel index were investigated at baseline and at 1, 3, and 6 months. A latent class growth model was applied to identify the supportive care needs trajectories. Multiple logistic regression was used to determine the predictors for membership. This study adheres to STROBE reporting guidelines. Three patterns of supportive care needs trajectories were identified: A high needs slow decline group (20.8%), a medium needs stable group (56.5%) and a medium needs rapid decline group (22.7%). Based on further analysis, the findings indicated that age, education level, monthly income, comorbidity, activities of daily living, anxiety and depression were associated with the trajectory categories of supportive care needs with stroke patients. This study demonstrates heterogeneity in changes in supportive care needs among stroke patients. Healthcare providers need to consider these different categories of needs and develop individualized care measures based on the characteristics of different patients. Healthcare providers should be aware of the fluctuations in care needs of stroke patients at various stages. Additionally, the study aimed to identify patients' specific needs based on their circumstances, monitor the rehabilitation process and establish a more personalized and optimized care plan through multidisciplinary collaboration. The ultimate goal was to alleviate symptomatic distress and address the long-term care needs of patients. No patient or public contribution.

Deep learning model for individualized trajectory prediction of clinical outcomes in mild cognitive impairment

ObjectivesAccurately predicting when patients with mild cognitive impairment (MCI) will progress to dementia is a formidable challenge. This work aims to develop a predictive deep learning model to accurately predict future cognitive decline and magnetic resonance imaging (MRI) marker changes over time at the individual level for patients with MCI.MethodsWe recruited 657 amnestic patients with MCI from the Samsung Medical Center who underwent cognitive tests, brain MRI scans, and amyloid-β (Aβ) positron emission tomography (PET) scans. We devised a novel deep learning architecture by leveraging an attention mechanism in a recurrent neural network. We trained a predictive model by inputting age, gender, education, apolipoprotein E genotype, neuropsychological test scores, and brain MRI and amyloid PET features. Cognitive outcomes and MRI features of an MCI subject were predicted using the proposed network.ResultsThe proposed predictive model demonstrated good prediction performance (AUC = 0.814 ± 0.035) in five-fold cross-validation, along with reliable prediction in cognitive decline and MRI markers over time. Faster cognitive decline and brain atrophy in larger regions were forecasted in patients with Aβ (+) than with Aβ (−).ConclusionThe proposed method provides effective and accurate means for predicting the progression of individuals within a specific period. This model could assist clinicians in identifying subjects at a higher risk of rapid cognitive decline by predicting future cognitive decline and MRI marker changes over time for patients with MCI. Future studies should validate and refine the proposed predictive model further to improve clinical decision-making.

Exploring Ca2+ dynamics in myelinating oligodendrocytes through rAAV-mediated jGCaMP8s expression in developing spinal cord organ cultures.

Oligodendrocytes, the myelin-producing glial cells of the central nervous system (CNS), crucially contribute to myelination and circuit function. An increasing amount of evidence suggests that intracellular calcium (Ca2+) dynamics in oligodendrocytes mediates activity-dependent and -independent myelination. Unraveling how myelinating oligodendrocytes orchestrate and integrate Ca2+ signals, particularly in relation to axonal firing, is crucial for gaining insights into their role in the CNS development and function, both in health and disease. In this framework, we used the recombinant adeno-associated virus (rAAV)/Olig001 capsid variant to express the genetically encoded calcium (Ca2+) indicator jGCaMP8s, under the control of the myelin basic protein (MBP) promoter. In our study, this tool exhibits excellent tropism and selectivity for myelinating and mature oligodendrocytes, and it allows monitoring Ca2+ activity in myelin forming cells, both in isolated primary cultures and organotypic spinal cord explants. By live-imaging of myelin Ca2+ events in oligodendrocytes within organ cultures, we observe a rapid decline in the amplitude and duration of Ca2+ events across different in vitro developmental stages. Active myelin sheath remodeling and growth is modulated at the level of myelin axon-interface through Ca2+ signaling and, during early myelination in organ cultures, this phase is finely tuned by the firing of axon action potentials. In the later stages of myelination, Ca2+ events in mature oligodendrocytes no longer display such a modulation, underscoring the involvement of complex Ca2+ signaling in CNS myelination.Significance Statement Determining the sources and mechanisms driving Ca2+ events in mature oligodendrocytes, typically studied through restricted transgenic lines, has proven to be challenging. To address this, we employed the rAAV/Olig001 to selectively express jGCaMP8s, under the transcriptional control of the MBP promoter, to monitor Ca2+ activity specifically in myelinating and mature oligodendrocytes in vitro and ex vivo. Our findings indicate that Ca2+ dynamics undergoes maturation-dependent modulation, and that neuronal activity can have a different impact on Ca2+ activity across developmental stages. Our research introduces a valuable genetic tool for monitoring Ca2+ signaling in myelin-forming cells to investigate how Ca2+ regulation affects oligodendrocyte function and dynamic interactions with axons.

Rapid seagrass meadow expansion in an Indian Ocean bright spot

The areal extent of seagrass meadows is in rapid global decline, yet they provide highly valuable societal benefits. However, their conservation is hindered by data gaps on current and historic spatial extents. Here, we outline an approach for national-scale seagrass mapping and monitoring using an open-source platform (Google Earth Engine) and freely available satellite data (Landsat, Sentinel-2) that can be readily applied in other countries globally. Specifically, we map contemporary (2021) and historical (2000–2021; n = 10 maps) shallow water seagrass extent across the Maldives. We found contemporary Maldivian seagrass extent was ~ 105 km2 (overall accuracy = 82.04%) and, notably, that seagrass area increased threefold between 2000 and 2021 (linear model, + 4.6 km2 year−1, r2 = 0.93, p < 0.001). There was a strongly significant association between seagrass and anthropogenic activity (p < 0.001) that we hypothesize to be driven by nutrient loading and/or altered sediment dynamics (from large scale land reclamation), which would represent a beneficial anthropogenic influence on Maldivian seagrass meadows. National-scale tropical seagrass expansion is unique against the backdrop of global seagrass decline and we therefore highlight the Maldives as a rare global seagrass ‘bright spot’ highly worthy of increased attention across scientific, commercial, and conservation policy contexts.

The ecological and biodiversity conservation values of farm dams: A systematic review.

Biodiversity is in rapid decline globally with agriculture being one of the leading causes. Within agricultural landscapes, some features provide a benefit to biodiversity that is disproportionate to their spatial area. An interesting example is artificial ponds-or farm dams-which can support a large variety of taxa. Here, we present a global review of farm dam research related to biodiversity conservation objectives to provide an overview of the topics, key research insights, and the characteristics of current research. We used a three-stage process to screen literature and identified 104 relevant papers across 27 countries encompassing studies of 13 different taxa. Most of the studies were short-term (less than 5 years) with small sample sizes (less than 20 sites). Of the 104 papers, 88 were focussed primarily on ecological outcomes, such as species richness or abundance, and 15 on primary production outcomes, such as crop and livestock yield, despite addressing or measuring ecological metrics. Only one study measured both ecological and primary production outcomes. Studies frequently examined how the features of dams (79 studies) and attributes of the surrounding landscape (47 studies) impact particular species and communities. Terrestrial mammals (1 study) were under-represented in the literature with macrophytes (28 studies), macroinvertebrates (26 studies), and amphibians (19 studies) receiving the most attention. Our results reveal a growing trend towards recognizing farm dams as habitats for various taxa, including amphibians, beetles, dragonflies, and other macroinvertebrates within agricultural environments. Significant knowledge gaps exist in understanding how dam age, invasive species, and effective management practices impact the biodiversity conservation values of farm dams. Future research should emphasize enhancing biodiversity by collaborating with landholders to increase habitat through strategic vegetation planning, minimizing runoff and nutrient inflow, and restricting stock access.

The last of the maculineans: can we save the emblematic Alcon Blue butterfly Phengaris alcon under climate change when its habitat continues to deteriorate?

AbstractIn the NW-European region of Flanders (northern Belgium), wet heathlands harbour several threatened species among which the emblematic Alcon Blue butterfly Phengaris alcon is rapidly declining. Since 1990, the number of occupied grid cells in Flanders has decreased from 61 to only six in 2023, a decline of 90%. Due to the loss of many populations, the mean distance between populations tripled from 9 km in the period 1950–1990 to 27 km now. Site-wide egg counts in one of the strongholds of the Alcon Blue in Flanders revealed a strong increase after some initial intensive care conservation measures in the 2000s, but since 2013 a steep decline of 99% has been observed. The standardised egg counts in the remaining six Flemish populations (i.e., monitoring within the framework of the Natura2000 reporting) showed a yearly decrease of 18% since 2016. Despite increased conservation attention and targeted management since the end of the 1990s, the current situation of P. alcon in Belgium is more precarious than ever. Causes of this rapid decline are manifold and they are likely to be amplified by extreme weather conditions caused by climate change. More efficient intensive care measures and more intense cooperation across national borders are now quickly required to regionally preserve this habitat specialist with a unique eco-evolutionary profile.Implications for insect conservation By analysing the causes of the decline of the threatened Alcon Blue butterfly in Flanders, we suggest management and policy measures in an attempt to conserve this and other threatened heathland species in a highly anthropogenic region.

Kidney Measurement and Glomerular Filtration Rate Evolution in Children with Polycystic Kidney Disease

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder characterized by renal tubular cystic dilatations. The cysts can develop anywhere along the nephron, and over time the cystic dilatation leads to kidney enlargement. On the other hand, the cysts begin to reduce the number of functional nephrons as a consequence of cystic expansion that further contributes to the decline in renal function over the years. The pressure exerted by the dilated cysts leads to compensatory mechanisms that further contribute to the decline in renal function. These structural changes are responsible of glomerular hyperfiltration states, albuminuria, proteinuria, and hematuria. However, the presentation of ADPKD varies in children, from a completely asymptomatic child with incidental ultrasound detection of cysts to a rapidly progressive disease. There have been reports of early onset ADPKD in children younger than 2 years that showed a more rapid decline in renal function. ADPKD is caused by a mutation in PKD1 and PKD2 genes. Today, the PKD1 gene mutation seems to account for up to 85% of the cases worldwide, and it is associated with worse renal outcomes. Individuals with PKD2 gene mutation seem to present a milder form of the disease, with a more delayed onset of end-stage kidney disease. The cardinal sign of ADPKD is the presence of renal cysts during renal ultrasound. The current guidelines provide clinicians the recommendations for genetic testing in children with a positive family history. Given that the vast majority of children with ADPKD present with normal or supra-normal kidney function, we explored the glomerular filtration rates dynamics and the renal ultrasound-adjusted percentiles. In total, 14 out of 16 patients had kidney percentiles over 90%. The gene mutations were equally distributed among our cohort. In addition, we compared the modified Schwartz formula to the quadratic equation after adjusting the serum creatinine measurements. It seems that even though children with ADPKD have enlarged kidneys, the renal function is more likely normal or near normal when the quadratic estimation of glomerular filtration rate is used (qGFR tended to be lower, 111.95 ± 12.43 mL/min/1.73 m2 when compared to Schwartz eGFR 126.28 ± 33.07 mL/min/1.73 m2, p = 0.14). Also, when the quadratic equation was employed, not even a single patient reached the glomerular hyperfiltration threshold. The quadratic formula showed that glomerular filtration rates are linear or slightly decreasing after 1 year of follow-up (quadratic ΔeGFR = −0.32 ± 5.78 mL/min/1.73 m2), as opposed to the Schwartz formula that can falsely classify children in a hyperfiltration state (ΔeGFR = 7.51 ± 19.46 mL/min/1.73 m2), p = 0.019.

Management of pediatric liver failure with therapeutic plasma exchange and continuous renal replacement therapy: A retrospective observational study.

Liver failure represents a critical medical condition, marked by the rapid decline of hepatic functions. Emerging therapies, notably therapeutic plasma exchange (TPE) and continuous venovenous hemodiafiltration (CVVHDF), have demonstrated potential in mitigating these conditions through their roles in detoxification and hepatic support. The utility of these treatments, whether applied individually or in tandem, constitutes a significant area of research concerning the management of liver failure in pediatric patients. This study aims to evaluate the role and efficacy of TPE or TPE combined with CVVHDF in the treatment of liver failure among children. This retrospective study was conducted in a LTICU by reviewing the medical history of pediatric patients aged 1 month to 18 years. Patients were admitted between January 1, 2021 and December 1, 2023 due to acute liver failure or acute-chronic liver failure. The study evaluated those who received TPE or continuous renal replacement therapy combined with TPE. In statistical analyses, a P-value of <.05 was considered statistically significant. The study involved 24 patients with liver failure, comprising 13 males and 11 females. Sixteen patients (66.6%) received only TPE, while 8 patients (33.4%) were treated with TPE and CVVHDF. For patients treated only with TPE, the median INR reduced from 3.1 to 1.26, alanine aminotransferase from 1255 to 148, and aspartate aminotransferase from 2189 to 62. Similar significant reductions were observed in the TPE and CVVHDF group: INR from 3.9 to 1.26, alanine aminotransferase from 1749 to 1148, and aspartate aminotransferase from 1489 to 62. These changes were statistically significant with P-values of .01 for each parameter in both groups. Overall, 14 patients survived without requiring a liver transplant, while 4 patients underwent liver transplantation. Our study on pediatric liver failure treatment shows that both standalone TPE and its combination with CVVHDF are effective, especially as a bridge to transplantation. With 58% transplant-free survival, these therapies demonstrate significant clinical improvements. Future multicentric studies are needed for broader validation of these findings in liver failure management.

Combination anlotinib and toripalimab for an advanced biliary tract cancer patient with high Eastern Cooperative Oncology Group performance status: a case report.

Up to 80% of biliary tract cancer (BTC) patients relapse within 3 years after surgery and the efficacy of second-line treatment remains dismal for patients who progressed on gemcitabine and cisplatin chemotherapy. Median overall survival of patients with palliative chemotherapy is less than 1 year. The feasibility and safety of targeted therapies plus immunotherapies remain scanty currently, and patients with recurrent or advanced BTCs often experience a rapid decline in Eastern Cooperative Oncology Group (ECOG) performance status. This case report is the first report suggesting a 17-month progression-free survival (PFS), partial response, and another 11-month PFS after progressive disease of anlotinib plus toripalimab in advanced BTC with high ECOG performance status. We report a 67-year-old Chinese male with BTC. He was observed with progressive disease after surgical resection, adjuvant chemotherapy, palliative chemotherapy, and diagnosed with American Joint Committee on Cancer clinical stage IV (cT3N0M1) extrahepatic BTC. The patient experienced a rapid decline in performance status, and he received oral anlotinib and toripalimab with informed consent. MRI scans showed partial response on 22 June 2022. PET-CT showed that tumor activity has been inhibited on 8 March 2023. He achieved 17 months of PFS. Although the patient developed solitary lung metastasis, he had a continuous survival benefit from treatment of anlotinib plus toripalimab after lung radiotherapy. Until the writing of the case draft, he had achieved another 11 months of PFS. The present case suggests that anlotinib plus toripalimab might be a potential effective treatment for advanced BTCs patients with high ECOG performance status.

The developmental trajectories of teacher autonomy support and adolescent mental well-being and academic stress

AbstractThis study investigated the developmental impact of teacher autonomy support on changes in students’ mental well-being and academic stress throughout upper secondary school. The sample consisted of 1453 Norwegian students (baseline Mage = 17.00; 60.6% girls; 80.9% Norwegian-born). The unconditional latent growth curve model results showed that perceived teacher autonomy support and mental well-being decreased during the three-year-long education. Academic stress, on the other hand, increased during this period. Findings from the parallel process latent growth curve model indicated that the initial status and change in teacher autonomy support were positively and negatively related to the initial levels and trajectories of mental well-being and academic stress, respectively. Girls experienced a higher level of academic stress and lower mental well-being and teacher autonomy support at the beginning of upper secondary school. Students with a higher socioeconomic status reported higher initial mental well-being and teacher autonomy support than others but also a more rapid decline in teacher autonomy support throughout upper secondary school. This study provides new insights into academic, psychological, and affective processes and their interrelationships during upper secondary school.

Review of Shale Oil and Gas Refracturing: Techniques and Field Applications

Shale oil and gas wells usually experience a rapid decline in production due to their extremely low permeability and strong heterogeneity. As a crucial technique to harness potential and elevate extraction rates in aged wells (formations), refracturing is increasingly employed within oil and gas reservoirs globally. At present, the selection processes for refracturing, both of wells and layers, are somewhat subjective and necessitate considerable field data. However, the status of fracturing technology is difficult to control precisely, and the difference in construction effects is large. In this paper, well selection, formation selection, and the fracturing technology of shale oil and gas refracturing are deeply analyzed, and the technological status and main technical direction of refracturing technology at home and abroad are analyzed and summarized. The applicability, application potential, and main technical challenges of existing technology for different wells are discussed, combined with the field production dynamics. The results show that well and layer selection is the key to the successful application of refracturing technology, and the geological engineering parameters closely related to the remaining reservoir reserves and formation energy should be considered as the screening parameters. General temporary plugging refracturing technology has a low cost and a simple process, but it is difficult to accurately control the location of temporary plugging, and the construction effect is very different. Mechanical isolation refracturing technology permits the exact refurbishment of regions untouched by the initial fracturing. However, it is costly and complex in terms of construction. Consequently, cutting the costs of mechanical isolation refracturing technology stands as a pivotal research direction.

Vegetative propagation of Phytolacca acinosa Roxb. by rhizome cuttings: a step towards conservation and cultivation approach

IntroductionPhytolacca acinosa Roxb. is a highly valuable multipurpose herb native to the Himalayan region. Unsustainable harvesting of this species due to its diverse uses has resulted in a rapid decline in its population across natural habitats, thereby necessitating its propagation and conservation. To overcome this challenge, the potential of P. acinosa rhizomes for ex situ regeneration was evaluated.MethodsThe current study aims to develop a standard propagation protocol for P. acinosa. Rhizome cuttings derived by splitting whole rhizomes were used to study the effect of various hormones and soil compositions on their sprouting and growth performance.ResultsSoil compositions SC10 and SC5 consisting of soil, sand, pebbles, and vermicompost (1:1:1:1) and soil, sand, and vermicompost (1:1:1), respectively, were the most suitable compositions for the optimum growth of this species. The rhizome segments treated with GA3 (150ppm) induced the highest sprouting percentage (91.67%), with a minimum sprouting time of 23.25 days. The maximum root length (9.25 cm), shoot length (16.5 cm), and leaf number (11.25) were recorded for GA3 (150ppm) treated rhizome cuttings.ConclutionsOverall, the results of the present study helped in establishing a cost-effective, rapid, efficient, and simple mass propagation method for the target species. The results of this study will serve as a guide for the large-scale cultivation, effective conservation, and sustainable utilization of this economically valuable medicinal herb.

Impacts of High-Concentration Turbid Water on the Groundwater Environment of the Tedori River Alluvial Fan in Japan

The occurrence of high-concentration turbid water due to a large landslide in the upper reaches of the Tedori River Basin in Japan in May 2015 led to a rapid decline in the groundwater levels within the alluvial fan. However, factors other than turbid water, such as changes in precipitation patterns, can have a significant impact on groundwater levels but have not been thoroughly investigated. By analyzing the relationship between river water and groundwater levels, we found that by 2018, conditions had returned to those observed prior to the turbidity events. Regarding seepage, we found that approximately 24% of the Tedori River’s discharge contributed to seepage before the turbidity event. In contrast, during the post-turbidity years, seepage decreased between 2015 and 2017 and returned to the pre-turbidity levels by 2018. Furthermore, by constructing a hydrological model and examining the contributions of turbidity and precipitation, we found that in 2015, turbidity contributed to 76% of the groundwater level changes, whereas precipitation accounted for 24%. In contrast, in 2016, turbidity contributed to 67%, while precipitation contributed to 33%. In essence, the first year was characterized by a significant contribution from turbidity, while precipitation also played a significant role in groundwater level fluctuations in the second year.

ИНДИКАТОРЫ СОСТОЯНИЯ ПРОДОВОЛЬСТВЕННОГО ОБЕСПЕЧЕНИЯ И УРОВНЯ ЖИЗНИ НАСЕЛЕНИЯ ДАЛЬНЕВОСТОЧНОГО ФЕДЕРАЛЬНОГО ОКРУГА

In developed countries of the world, human capital is recognized as the main most valuable resource, which is the principal factor in the development of any territory. The life and health of people is the most important asset of any nation. The population of Russia has been steadily decreasing in recent decades due to natural and migration decline. In the Far Eastern Federal District (FEFD), the demographic situation is especially acute: over the last three decades, the population has decreased by 22,3 %. The main reason is the rapid decline in the standard of living of the population. In turn, the demographic situation is significantly influenced by housing conditions, the level of food supply and the quality of nutrition. The population of the Far Eastern regions eats irrationally: people compensate for the energy and nutrients not received in protein foods and vegetable and melon products by excessive consumption of baked goods, pasta and cereals. This diet contributes to an increase in morbidity and a reduction in life expectancy. These problems are especially acute in regions with high poverty, low living standards and low social productivity. The most problematic in terms of the standard of living of the population are the Jewish Autonomous Region, the Trans-Baikal Region and the Republic of Buryatia: the median per capita cash income of residents of these regions allows them to buy no more than 4 minimum sets of food per month (in Russia as a whole – 5,7 sets), housing conditions are the worst in the Far Eastern Federal District. To improve the quality of food supply and living standards of the population in the regions, it was proposed to strengthen the social responsibility of the state and take comprehensive measures to increase real cash incomes; development of social entrepreneurship and social partnership; restoration and development of production in the regions of necessary products - milk, eggs, melons and vegetables. This will require significant investment in the rural economy of the Far Eastern regions to ensure growth in production volumes and development of human capital.

Variation of groundwater level due to land use, precipitation, and earthquake in Yogyakarta City from 2005 to 2020

Yogyakarta City not only experiences rapid land use conversion and precipitation decline but also experiences frequent earthquake events. These factors can have a significant impact on groundwater variation dynamics in this city. Therefore, the aim of this research is to analyze the factors that can influence groundwater oscillation based on precipitation, land use, earthquake, and river discharge changes. The method used to analyze spatio-temporal groundwater level and precipitation are by applying space-time Bayesian statistics since Bayesian has lower root mean square error compared to the space-time variogram and inverse distance methods. Land use is classified with false color composite for Landsat ETM and infrared color composite for Landsat 8 since these color composites well classify built-up and non-built-up areas. River discharge is analyzed as a primary indication of earthquake event impact on groundwater level variation.There is no significant variation of groundwater level from 2005 to 2020. Groundwater fluctuation is classified as stable since the magnitude of change is approximately less than 1.5 m from dry to wet period. It is also probably because there is abundances of groundwater resources in Yogyakarta City that shallow aquifer have very high hydraulic conductivity. The conversion speed from non-built-up area into built-up area is 26% from 2005 to 2015, while 8% from 2015 to 2020. At least 78% of Yogyakarta City is built-up areas in 2020. Abrupt changes in groundwater level is due to: a) declining trends of precipitation on May 2009 to July 2016 with average accumulative monthly residual rainfall ranging from 500 mm month−1 to 1300 mm month−1, and b) high magnitude earthquake occurrences on May 2006, November 2010 and 2015 when groundwater patterns and levels including discharge rivers showed distinct behavior. This study shows that precipitation and earthquake are the major contribution to groundwater level variation compared to land use.

The impact of desertification on soil health stability in Semi-Arid alpine Regions: A case study of the Qilian Mountains in the northeastern Tibetan Plateau, China

Desertification poses a serious threat to ecosystem health, and with global changes, the variability and uncertainty of ecological functions in semi-arid alpine regions are increasing. A pressing issue is quantifying how desertification affects the soil system functions in these areas. However, empirical evidence is still lacking in exploring the interaction between desertification degradation gradients and soil functions under natural conditions by coupling soil physicochemical properties, soil microbiota, and vegetation. For this purpose, we conducted a survey sampling of soil and vegetation at five sites with no, light, moderate, severe and extremely severe desertification in Qinghai Area of Qilian Mountains National Park, China. We introduced a new concept soil health stability (SHS) to represent the actual health status of soil systems in semi-arid alpine regions and assessed the impact of desertification on this stability. We observed that the intensification of desertification has led to a significant decrease in soil organic matter, relative abundance of soil microorganisms, and plant factors. The contributions of plant factors and soil microbiota to SHS showed a negative correlation with the degradation gradient. SHS varied across different degradation gradients, rather than following a single linear relationship, with a relatively rapid decline in the transition from non-desertification to moderate desertification. Our work emphasizes that the coupled contributions of soil physicochemical properties, soil microbiota, and vegetation to SHS. It calls for intensified prevention and treatment of mild and moderate desertification, while providing new methods and deeper scientific understanding for accurately evaluating soil system functions in semi-arid alpine regions.

A Study to Compare Spirometric Observations in Smokers and Non Smokers in Age Group between 25-55 Years

In India, smoking is a common habit prevalent in both urban and rural areas irrespective of mode of smoking i.e beedis, cigarettes, cigars etc. Tobacco smoke contains 400 chemicals out of which 60 are known carcinogens, which can lead to lung cancer. Smoking leads to rapid decline in pulmonary function test. Cigarette smokers have a high annual rate of decline in FEV1 of about 50ml, which is nearly double the average value in non smokers.

Improving Irrigation Management of Cotton with Small Unmanned Aerial Vehicle (UAV) in Texas High Plains

The rapid decline in water availability for irrigation on the Texas High Plains (THP) is a significant problem affecting crop production and the viability of a large regional economy worth approximately USD 7 billion annually. This region is the largest continuous cotton-producing area in the United States, and the timely delivery and efficient use of irrigation water are critical to the sustainability and profitability of cotton production in this region. Current irrigation scheduling must be improved to reduce water consumption without compromising crop production. Presently, irrigation scheduling based on reference evapotranspiration (ETo) is limited due to the lack of reliable and readily available in-field weather data and updated crop coefficients. Additionally, in-field variability in crop water demand is often overlooked, leading to lower irrigation efficiency. To address these challenges, we explored the potential use of an unmanned aerial vehicle (UAV)-based crop monitoring system to support irrigation management decisions. This study was conducted in Lubbock, Texas, in 2022, where high temporal and spatial resolution images were acquired using a UAV from a cotton field experiment with four irrigation levels. Soil moisture and canopy temperature sensors were deployed to monitor crop response to irrigation and rainfall. The results indicated a significant effect of water stress on crop growth (revealed by UAV-based canopy cover (CC) measurements), yield, and fiber quality. Strong correlations between multi-temporal CC and lint yield (R2 = 0.68 to 0.88) emphasized a clear trend: rainfed treatments with lower yields exhibited reduced CC, while irrigated plots with higher CC displayed increased yields. Furthermore, irrigated plots produced more mature and uniform fibers. This study also explored various evapotranspiration calculation approaches indicating that site-specific CC measurements obtained from a UAV could significantly reduce irrigation application. A regression model linking evapotranspiration to canopy cover demonstrated promising potential for estimating water demand in crops with an R2 as high as 0.68. The findings highlight the efficacy of UAV-based canopy features in assessing drought effects and managing irrigation water in water-limited production regions like the THP.

Endoscopic reflux esophagitis and decline in pulmonary function in nonsmokers: A retrospective cohort study

BackgroundThe association between reflux esophagitis and pulmonary function remains controversial. Thus, evaluating the relationship between endoscopic reflux esophagitis and changes in pulmonary function over time in a nonsmoking population is an important clinical issue. MethodsIn this single-center retrospective cohort study, a medical examination database at Kameda Medical Center Makuhari was employed to identify nonsmokers who underwent upper gastrointestinal endoscopy and spirometry in 2010 and were followed up in 2015. Gastroenterologists carefully double-checked the diagnosis of reflux esophagitis. Multiple linear regression analyses were performed to compare the decline in the percentage of predicted vital capacity (%VC), forced vital capacity (%FVC), and forced expiratory volume in 1 s (%FEV1) between participants with reflux esophagitis and those without. Furthermore, using multivariable logistic regression analyses, we evaluated the factors associated with rapid decline in %VC, %FVC, and %FEV1, which is defined as a decrease of >10% in each parameter over the 5-year observation period. ResultsWe identified 3098 eligible subjects, including 72 and 44 participants who had a Los Angeles classification grade A and B–C (severe) reflux esophagitis in 2010, respectively. The decline in %VC was significantly larger in the participants with severe reflux esophagitis than in the control subjects (standardized coefficient, −0.037; 95% confidence interval, −0.071 to −0.004). Moreover, reflux esophagitis was significantly associated with a rapid decline in %VC and %FVC but not in %FEV1 (P for trend: 0.009, 0.009, and 0.276, respectively). ConclusionsSevere reflux esophagitis among nonsmokers had clinical disadvantages in terms of a decline in %VC.