Rapid Aging Research Articles

Expert consensus on the application of ω-3 fatty acid prescription drugs in aging-related diseases (2024 edition)

With the severe rapid aging in China, the health management system of elderly-related diseases is facing great challenges. Because of its various effects such as lipid-lowering, anti-inflammatory, and primary and sencondary prevension of atherosclerotic cardiovascular disease, etc, ω-3 fatty acids are increasingly being valued in the field of geriatric medicine. To further standardize the application of ω-3 fatty acid drugs in the field of geriatrics, initiated by the Chinese Medical Association Geriatrics Branch, based on the existing medical evidence and combined with the clinical practice of geriatrics in China, 12 recommendations were proposed, including the application of ω-3 fatty acids on cardiovascular diseases, chronic kidney disease, nervous system disease, respiratory system disease, sarcopenia, frailty, osteoporosis, tumor and autoimmune diseases, aiming to provide guidance for clinical decision-making in geriatric diseases.

Health Capacity to Work among Older Persons in Asia: Key Findings from a Regional Comparative Study

In responding to the challenge of rapid population aging in Asia, promoting healthy and active aging has become a key policy priority in many countries. There is an opportunity to realize a “silver demographic dividend” by harnessing the potential of healthy and productive older people. This paper presents the findings of a regional comparative study that quantifies the health capacity to work of older persons in seven East Asian and Southeast Asian countries. Along with improvements in the health status of older Asians over time, the additional (or untapped) working capacity of older men aged 55–64 years is estimated to have increased by 0.74 years on average over the past 15 years, with substantial variation across countries, gender, and other individual characteristics. For example, additional work capacity increased by 0.24 years in Japan and Viet Nam during the review period and by 2.24 years in the People’s Republic of China. In contrast, additional work capacity declined by 0.17 years in Indonesia. The proportion of all men aged 60–64 who are not working but are able to do so ranges from 7.8% (Viet Nam) to 21.1% in Figure 8 (Malaysia), with the proportion even higher for men in their late 60s. Older adults with higher levels of education and those living in urban areas generally have greater untapped work capacity. The potential silver demographic dividend, measured by the aggregate untapped work capacity of older workers above retirement age, is significant and has the potential to boost the gross domestic product of many countries in the region.

Challenges and solutions for discharge support of elderly people in the acute care ward: Interviews with community-based integrated care supporters and patients in Tokyo, Japan.

Japan, which has become the country with the longest-living people in the world due to rapid population aging, has an insurer function for each local government and socialized long-term care under a public system. Japan aims to build a Community-based Integrated Care System (CICS) for each municipality with the goal of integrating medical care and long-term care. However, despite the policy and management studies, the challenges and solutions for discharge support by the parties have not yet been clarified. This study aimed to obtain suggestions on challenges and solutions for discharge support in the acute care wards for the elderly for community-based integrated care support providers and patients in Kita Ward, Tokyo. Semi-structured interviews were conducted, and the obtained data were a priori analyzed by a deductive thematic analysis using a conceptual framework for integrated care based on the integrative functions of primary care. The challenges were found to include: i) disparity between medical and lifestyle perspectives, ii) competencies of medical and care workers at homes, iii) discharge support challenges related to the elderly themselves, iv) nursing care dependent on family; and v) the impact of payment of medical service in the health insurance system and payment of long-term care services. The solution that can be applied at the local government level was community connection. While aiming to build a CICS for each local government, there was a contradiction in that the challenges and solutions required examination at the national and prefectural levels.

Exploring the contribution of Japan's experience in addressing rapid aging in Asia: Focus on dementia care.

This review article explores the potential contribution of Japan's experience in addressing rapid aging in Asia with a specific focus on dementia care. As Japan is a frontrunner in terms of aging society, we consider valuable insights and lessons from Japanese policy history and reflect on its contribution. The World Health Organization, Regional Office for the Western Pacific Regional Action Plan on Healthy Ageing for the Western Pacific was compared with the Japanese "Outline for Promotion of Dementia Policies". The following five issues were discussed: i) improving awareness of dementia and community engagement in Japan from a mutual aid perspective; ii) social activities for prevention of dementia at the local level; iii) human resources for medical and long-term care; iv) local coordinators for old people care at home to evaluate the needs for care and tailor the care-plan on an individual basis; v) research and development of long-term care products. Given these factors, it is important to address the aging society through a combined cross-sectoral approach, including policy, research, development of care products, community, and education of care workers. Aging population measures in Japan do not provide a definitive answer, which prompts the consideration of better solutions derived from Japan's trial and error. The aging rate of 7%, 14%, and 21% are commonly used in international comparisons as indicators of the speed of the aging process, but before this 7% is reached, policies tailored to each country should be considered.

Comparison survey on family caregivers of older persons in Japan and Thailand.

While rapid population ageing is occurring worldwide, its speed is especially prominent in Asian countries. In Asia, cultural diversity might significantly affect care burden; however, few studies have investigated the differences in care burden, and mental, physical and social conditions among Asian countries. This study aimed to clarify the situations of and differences in family caregivers (FCs) of older persons in Japan and Thailand, and evaluate the factors associated with care burden in both countries. A cross-national survey of 217 in-home FCs was conducted in Japan and Thailand and mainly included items regarding care burden and psychosocial conditions. Differences between the two countries were obtained, and the factors associated with care burden were analysed by multiple regression analyses. The FCs' and care receivers' mean ages (64.8 ± 11.1 and 84.8 ± 8.6 years, respectively) in Japan were significantly higher than the mean ages (49.1 ± 13.3 and 77.1 ± 9.5 years) in Thailand. In Japan, FCs had more severe care burden, loneliness, and stress compared to those in Thailand. In Thailand, FCs had more social connections and informal support than those in Japan. The factors associated with care burden were different in each country; thus, severe stress, low emotional care preparation, and low willingness to continue care at home were significantly associated with severe care burden in Japan, whereas poor relationships with care receivers, few social connections, low confidence in providing care, low emotional care preparation, and lack of informal support were significantly associated with severe care burden in Thailand. Despite there being a long-term care insurance system in Japan, which is absent in Thailand, care burden and psychosocial conditions of FCs might be worse in Japan. There was a clear difference in the factors associated with care burden between Japan and Thailand.

Helping the Elderly Live Better With Dementia: Recent Developments in Japan’s Adult Guardianship System and Its Role in Geriatric Social Work Practice

With the rapid aging of Japanese society and increasing concerns over the welfare of people with psychiatric disorders, intellectual disability, and dementia, a renewed adult guardianship system based on the notion of respect for self-determination, the practical use of one’s remaining abilities, and re-socialization, has now been in place for 20 years. Japanese adult guardianship practices are understudied in English language literature; thus, this article presents an overview of recent developments in Japan’s adult guardianship system and geriatric social work initiatives adopted in Japan’s adult guardianship practice. The authors found that the guardianship system not only helped the elderly live better with dementia but also contributed to the realization of “ageing in place” in the community-based integrated care system.

ADAM: a robotic companion for enhanced quality of life in aging populations.

One of the major problems of today's society is the rapid aging of its population. Life expectancy is increasing, but the quality of life is not. Faced with the growing number of people who require cognitive or physical assistance, new technological tools are emerging to help them. In this article, we present the ADAM robot, a new robot designed for domestic physical assistance. It mainly consists of a mobile base, two arms with grippers and vision systems. All this allows the performance of physical tasks that require navigation and manipulation of the environment. Among ADAM's features are its modularity, its adaptability to indoor environments and its versatility to function as an experimental platform and for service applications. In addition, it is designed to work respecting the user's personal space and is collaborative, so it can learn from experiences taught by them. We present the design of the robot as well as examples of use in domestic environments both alone and in collaboration with other domestic platforms, demonstrating its potential.

Effect of Rapid Desiccation with Ethanol Immersion on Viability and Vigor of Some Rice Seeds (Oryza sativa L.)

The availability of quality seeds is important in crop cultivation, so quality seeds must be available when farmers need them. Quality seeds must be able to be stored for a long time. Rapid aging through soaking with 95% ethanol within 5 minutes, can predict the shelf life of seeds. Rice seeds that were treated with rapid soaking were Inpari 45 (V1), Sunggal (V2), Memberamo (V3) and Ciherang (V4) varieties. From the results of the analysis of variance, the observation parameters of Germination Power (DB), Maximum Growth Potential (PTM) and Keserempakan Tumbuh (KST) were significantly different (1%). Of the four varieties, after the seeds were soaked in 95% ethanol for 5 minutes DB, PTM and KST decreased very drastically. The order of varieties based on their seed viability and vigor levels, from high to low, are Inpari 45 (V1), Memberamo (V3) Sunggal (V2) and Ciherang (V4). Inpari 45 (V1) has the highest germination rate (DB) of 39%, while Ciherang (V4) has the lowest germination rate (DB) of 15.67%. These results suggest that the Inpari 45 (V1) variety can be stored longer than the other three varieties. Viability and vigor of seeds are not only controlled by environmental factors but also influenced by genetic factors
 
 napid desiccatio, rice varieties, seed viability and vigor

Integrated physical and mental management for China's elderly: insights from Long-gang District, Shenzhen.

China is in a period of rapid population aging. The total population of the elderly aged 60 and above in mainland China was 264 million in 2020, and is the country with the largest elderly population in the world, which is home to 1/5 of the world's older people. The urgency of actively coping with the aging population has never been greater, and China has raised it to the height of national strategy. To this end, China has issued several plans and projects on aging work. Many of them include multiple overlapping components. The management of physical illness and mental illness in the elderly is over-differentiated and segmented. However, it is common for older adults with complex health problems. The body and mind are inherently integrated and interact with each other, and should not be separated. There is an urgent need for integrated healthcare services for the physical and mental health of the elderly population. The national basic public health services play an important role in early detection and awareness of health problems for the elderly in community health services. This paper introduces the elderly health management services, one of the national basic public health projects, and the psychological care project for the elderly in Shenzhen, Guangdong Province, China. Taking Long-gang District's exploration of the joint management of physical and mental health of the elderly as an example, this review discusses the difficulties of the elderly health work, and the feasibility of integrating the elderly mental health and physical health in medical care. We outlook to build an integrated platform for physical and mental health of the elderly in China. Focus on the needs of older population, strengthen community health services, build a integrative team, fully publicize and improve health literacy of the elderly, link up and down and work together, improve coordination between providers of medical care and social services. It is of great significance to construct a strong public health system for the elderly and promote the realization of the grand goal of Healthy China.

Integrating rehabilitation into health systems: A comparative study of nine middle-income countries using WHO's Systematic Assessment of Rehabilitation Situation (STARS).

The need for rehabilitation is growing due to health and demographic trends, especially the rise of non-communicable diseases and the rapid ageing of the global population. However, the extent to which rehabilitation is integrated into health systems is mostly unclear. Our objective is to describe and compare the nature and extent of integration of rehabilitation within health systems across nine middle-income countries using available Systematic Assessment of Rehabilitation Situation (STARS) reports. Cross-country comparative study with variable-oriented design using available rehabilitation health system assessment reports from nine middle income countries. The integration of rehabilitation into health systems is limited across countries. Governance and financing for rehabilitation are mostly established within health ministries but weakly so, while health information systems are characterized by no available data or data that is insufficient or not routinely generated. The overall numbers of rehabilitation workforce per capita are low, with frequent reports of workforce challenges. In most countries the availability of longer-stay, high-intensity rehabilitation is extremely low, the availability of rehabilitation in tertiary hospitals is modest and in government supported primary care its almost non-existent. Multiple concerns about rehabilitation quality arose but the lack of empirical data hinders formal appraisal. The study sheds light on the limited integration of rehabilitation in health systems and common areas of difficulty and challenge across nine middle income countries. All countries were found to have a basis on which to strengthen rehabilitation and there were often multiple areas within each health system building block that required action in order to improve the situation. Findings can inform governments, regional and global agencies to support future efforts to strengthen rehabilitation. Additionally, our study demonstrates the value of STARS reports for health policy and systems research and can serve as a model for further comparative studies.

The State of Hope and Its Related Demographic Variables in the Elderly of Birjand City

Background: The global population is undergoing rapid aging, highlighting the importance of assessing the hope levels of the elderly to develop educational and welfare programs aimed at enhancing their quality of life. This study aimed to assess the state of hope and its associated factors among elderly individuals in Birjand city. Methods: This descriptive-correlational study included 441 elderly aged 60 and above from Birjand City, selected using a systematic stratified sampling method in 2018. Data were collected through interviews conducted by trained interviewers using the standard questionnaire “Schneider's Hope of the Elderly (SHS)." Data were analyzed using SPSS 19 software, and statistical tests, including independent T-Test, ANOVA, and Tukey's post hoc test, were applied at a significance level of α = 0.05. Results: The average age of the participants was 70.1 ± 7.3 years. The mean scores for hope, agentive thinking, and strategic thinking were 27 ± 3.3, 12.9 ± 2.1, and 14.1 ± 2.1, respectively. Men had significantly higher scores in agentive thinking (P < 0.001) and the overall hope score (P < 0.003) compared to women. Illiterate individuals had lower agentive thinking scores than other groups (P < 0.001). Additionally, married individuals had significantly higher scores in agentive thinking, strategic thinking, and overall hope scores compared to other elderly individuals. Conversely, elderly individuals without children had lower scores in these areas compared to other groups (P < 0.05). Conclusions: Based on the study's findings, it is essential to develop and implement educational and welfare interventions aimed at increasing hope among the elderly, particularly targeting women, single individuals, those who are lonely, and those with lower levels of education.

Evaluation of oral health status in the population above 50: evidence from the ardakan cohort study on aging (ACSA)

BackgroundThe global population is undergoing rapid aging, and older individuals are more susceptible to various health issues, including oral health problems. Despite the increasing attention given to healthy aging, oral health has often been overlooked in discussions related to health problems. This study aims to assess the oral health status of middle-aged and older adults in Iran.MethodsThis cross-sectional study analyzed data from 4970 men and women aged 50 years and above, who participated in the Ardakan Cohort Study on Aging (ACSA) between 2020 and 2022. Trained personnel administered a questionnaire and conducted oral health examinations to determine the oral health status and oral hygiene behaviors of the participants.ResultsThe mean value (SD) of the total Decayed, Missing, and Filled Teeth (DMFT) index was 21.3 (10.7). Approximately 46% of all participants were completely edentulous (without natural teeth). Moreover, 58.5% of the total sample wore dentures, and the mean age (SD) when they started using dentures was 48.5 (20.7) years. About 71% of participants with natural teeth reported brushing their teeth at least once a day, while about 63% of denture wearers cleaned their dentures daily. In the sample, 28% of individuals had visited a dentist in the last year. The prevalence of difficulty in biting and chewing food among the participants was 48.2% and 44.6%, respectively. Additionally, nearly 68% of all samples reported experiencing at least one difficulty in daily functioning due to oral/dental conditions. The study identified cutoff points of seven (sensitivity = 56.8 and specificity = 77.5) and 10 (sensitivity = 72.1 and specificity = 71.1) missing teeth, indicating the presence of at least one problem in daily functioning due to oral/dental conditions in middle-aged and older adults, respectively.ConclusionThe study reveals a high prevalence of edentulism and denture use among participants aged 50 years and above. The majority of samples reported difficulties in daily functioning due to oral and dental conditions, especially in biting and chewing food. These findings highlight the importance of proactive measures to address oral health issues in middle-aged and older adults, thereby enhancing their overall health and well-being.

The effect of urban-rural resident basic medical insurance on physical health of the rural older adult in China.

Urban-Rural Resident Basic Medical Insurance (URRBMI) is an important system for effectively transferring disease risks to the rural older adult. As China experiences rapid aging, maintaining the physical health of the rural older adult is key to achieving the goal of healthy aging. The study explores the impact of URRBMI on physical health of the rural older adult in China using the Chinese Longitudinal Healthy Longevity Survey (CLHLS) data in 2018. Ordinary least square models were used to analyze the relationship between URRBMI and physical health of the rural older adult, and we used instrumental variable method to address the potential endogenous problem. We find that URRBMI greatly improves physical health of the rural older adult. The heterogeneity analysis indicates that URRBMI contributes more significantly to the rural older adult in eastern areas and the advanced rural older adult. The results also suggested that URRBMI improves physical health of the rural older adult through increasing life satisfaction and enhancing the timeliness of medical services. This study implies that we need to further improve the participation rate, increase the actual reimbursement ratio and increase financial subsidies for URRBMI in central and western areas, and further integrate the distribution of medical resources to promote physical health of the rural older adult.

Investigation of Xinomavro Red Wine Aging with Various Wood Chips Using Pulsed Electric Field

This study explored the potential of pulsed electric field (PEF) as an alternative wine-aging method in four Xinomavro red wines with the implementation of several wood chips (apricot, peach, apple, cherry, acacia, and oak trees). The evolution of total polyphenol content (TPC) and sensory properties of the wines were investigated. Sensory evaluation revealed that PEF treatment increased volatile compound extraction from each wood chip, thereby enhancing the overall quality of the wines. The utilization of acacia tree wood chips in Goumenissa wine led to a notable increase of 10.84% in TPC from the control sample, reaching 2334.74 mg gallic acid equivalents/L. A notable outcome was that PEF decreased TPC, a trend that was also verified through correlation analyses. The highest positive impact of PEF was observed in peach tree wood chips in Goumenissa wine, with a significant increase of 11.05% in TPC. The results from the volatile compound analysis revealed an increase in alcohols and esters from 0.24% to 23.82%, with the highest proportion found in 2-phenylethanol (16.92 mg/L) when utilizing peach tree wood chips in the production of Amyndeo wine. This study could provide a benchmark for rapid, efficient, and cost-effective wine aging through the implementation of the PEF process.

Research on the relationship between sleep and aging

With the in-depth development of population aging, the level of health reduction of the elderly groups sharply increased, the rapid aging of the population brought health problems became a major challenge of 21st-century Chinese society, how to healthy aging, continuously improve the health level of older people, improve the quality of life in old age, there is no doubt more holistic, targeted and innovative thinking. Several studies have proved that a healthy lifestyle can effectively improve the health of the elderly. However, a series of factors, such as poor sleep quality, continue to harm the health of the elderly, resulting in reduced quality of life. With the large scale and rapid aging, the proportion of the elderly in the population is also increasing. In an aging society, the biggest problems plaguing the elderly are the loss of sleep quality and the loss of memory and concentration. People may have sleep disorders as they get older, and sleep problems will affect memory. This study used literature research to summarize the relationship between population aging and sleep. Compared with previous studies, this paper is more targeted and comprehensive in explaining the relationship between the three from micro and macro perspectives: aging leads to changes in sleep structure and duration, which further affects memory ability.

Heat-induced risks of road crashes among older motorcyclists: Evidence from three motorcycle-dominant cities in Taiwan

IntroductionRoad crashes pose significant public health concerns worldwide, with vulnerable road users like motorcyclists accounting for 23% of global road deaths. Recently, heat exposure has been identified as a risk factor for road crashes by reducing driver performance. Given the rapid aging, many Asian cities face challenges regarding heat-induced road crashes among older motorcyclists, a significant segment of the road user population with lower motor abilities and thermal tolerance. In this study, I aim to investigate varying impacts of heat on road crashes across road users in different age groups using different transportation modes in three major Taiwanese cities characterized by motorcycle-dominant traffic cultures and (sub)tropical climates. MethodsTemperature data and records of road crashes involving motorcycles and car drivers from 2018 to 2021 were collected, merged based on the dates, and processed into a year-round dataset and a summer-time dataset. The generalized linear regression model with a Generalized Poisson link function was employed to estimate the association between temperature and road crash frequency, with the analysis stratified by two age groups (i.e., older and younger) and two transportation modes (i.e., car and motorcycle). Results and conclusionIn total, 24 models were built for four driver groups (i.e., older motorcycle, younger motorcycle, older car, and younger car drivers) across three cities using year-round and summer-time datasets. Findings reveal higher vulnerabilities to heat-induced road crashes among older road users, especially those driving motorcycles. Heat-induced road risks among motorcycle drivers significantly increased during the summer, while this pattern was not found for car drivers. Policymakers should develop targeted interventions aimed at mitigating heat-related road crashes among older motorcyclists. In the context of climate change and ageing, this research holds broader implications for the development of policies integrating heat mitigation strategies and traffic safety measures, particularly in Southeast Asian cities with similar demographics and tropical climates.

Effects of 3S business intelligence systems for nursing students: a repeated-measures randomized control trial

BackgroundThe growing need for healthcare services as a result of a consistently rising prevalence of chronic diseases and rapid population aging calls for a new set of activities and practices. Therefore, we developed a program—3S (Simple, Smart, and Speed) Business Intelligence Systems (3S-BIS), which is an ERP software system that helps nursing business to support nursing entrepreneurship —and analyzed its effects on nursing students.MethodsA repeated-measures randomized controlled trial was performed with two groups: experimental (n = 29) and control (n = 30) groups. The former group underwent the five-day 3S-BIS education program. Each session comprised four components: lectures 1 and 2, simulation case study, and debriefing. Post-tests were performed immediately post-intervention and four and eight weeks later. The effectiveness was measured using the following variables: simulation design assessment, evaluation of educational practices in simulation, education satisfaction, self-efficacy for learning, and entrepreneurship. The differences before and after intervention between the experimental and control groups were analyzed using the Friedman test. The Mann–Whitney U test was used for comparisons between groups at each time point, and the Wilcoxon signed-rank test was used for comparisons within groups at each time point.ResultsPost-intervention (8 weeks after intervention), the experimental group demonstrated higher simulation design assessment (z = -3.88, p = < .001), evaluation of educational practices in simulation (z = -3.34, p = .001), education satisfaction (z = -3.11, p = .002), self-efficacy for learning (z = -3.04, p = .002), and entrepreneurship (z = -2.15, p = .031) compared to controls. Furthermore, simulation design assessment score in the experimental group significantly differed between T1 (immediately after intervention) and T0 (baseline), and between T3 (8 weeks after intervention) and T0. Evaluation of educational practices in the simulation, education satisfaction, and self-efficacy also significantly differed between T1 and T0, and between T3 and T0. Entrepreneurship significantly differed between T3 and T2 (4 weeks after intervention), and between T3 and T0.ConclusionsThe 3S-BIS program contributes to enhancing nursing start-up competency. Subsequent studies should evaluate the effects of the program on nurses who work in home healthcare services.

Transcriptome profiling and RXR gene family identification reveals the molecular mechanism of rapid aging after spawning of cuttlefish Sepiella japonica

Transcriptome profiling and RXR gene family identification reveals the molecular mechanism of rapid aging after spawning of cuttlefish Sepiella japonica

Toward adapting the UN's healthy aging agenda for India: tailoring to unique historical context and traditions.

India is known for its rich cultural heritage with different cultures and customs. Indian historical traditions and cultures were molded in a manner that most older adults were cared for at home by their children. However, India is being urbanized and developing swiftly changing its socio-cultural scenarios. With globalization and the increased popularity of social media, the youth is more ambitious than ever and is ready to migrate and explore. Fueled by the rapid aging of the global population, demand is escalating for robust programs, policies, and activities to improve the lives of older adults. However, most of these schemes have not yet been fully implemented nationwide; several state governments have yet to realize their full potential due to the lack of resources and competing priorities. Aligning with the UN's healthy aging agenda, several programs and policies in India are contributing toward ensuring quality aged care services. This paper explores the challenges and opportunities for effective ground-level translation from precepts to practice.

Maternal exposure to zinc oxide nanoparticles causes cochlear dysfunction in the offspring.

Introduction: Zinc oxide nanoparticles (ZnO NPs) have been engineered and are largely used in material science and industry. This large and increasing use justifies a careful study about the toxicity of this material for human subjects. The concerns regard also the reproductive toxicity and the fetotoxicity. Materials and methods: The effect of the exposure to ZnO NPs on the cochlear function was studied in a group of pregnant CD1 mice and in their offspring. This study is part of a larger toxicological study about the toxicity of ZnO NPs during pregnancy. Four groups were analyzed and compared, exposed and non-exposed dams and their offspring. The cochlear function was quantitatively assessed by means of Distortion Product Otoacoustic Emissions (DPOAEs). Results and discussion: A large statistically significant difference was found between the non-exposed dams offspring and the exposed dams offspring (p = 1.6 · 10-3), whose DPOAE levels were significantly lower than those of non-exposed dams offspring and comparable to those of the adults. The DPOAE levels of the exposed and non-exposed dams were very low and not significantly different. This occurrence is related to the fact that these mice encounter a rapid aging process. Conclusion: Our findings show that maternal exposure to ZnO NPs does not reflect in overt toxicity on fetal development nor impair offspring birth, however it may damage the nervous tissue of the inner ear in the offspring. Other studies should confirm this result and identify the mechanisms through which ZnO NPs may affect ear development.