Rank-order Correlation Test Research Articles

Victimisation, Depression and Suicidal Ideation among Lesbian, Gay and Bisexual Adults in Malaysia.

BackgroundLesbian, gay and bisexual (LGB) individuals have been found to experience a high prevalence of psychological conditions. The present study aims to examine the relationship between victimisation, depression and suicidal ideation among LGB adults in Malaysia.MethodsThis study used a cross-sectional design. We distributed the questionnaire online using snowball sampling and self-identified LGB adults responded to the survey. Scales on sexual minority-specific victimisation, depression and suicidal ideation were employed. The data were analysed using Spearman rank order correlation and Kruskal-Wallis tests.ResultsThe study included 220 adults in Malaysia (156 males and 64 females; 58 lesbian, 112 gays and 50 bisexuals). Ninety-two participants (41.8%) reported experiencing sexual minority-specific victimisation; 29 participants (13.2%), 35 participants (15.9%) and 23 participants (10.5%) were mildly, moderately and severely depressed, respectively and 44.0% participants were experiencing current suicidal ideation. The correlations were fair (rs = 0.30) between victimisation and depression, poor (rs = 0.16) between victimisation and suicidal ideation, and moderate (rs = 0.60) between depression and suicidal ideation. There were no differences between homosexual and bisexual participants in victimisation, depression and suicidal ideation.ConclusionThis study contributes to a better understanding of the relationship between victimisation, depression and suicidal ideation among LGB adults in Malaysia.

Abstract 482: Early Reduction of Blood Flow in Rabbit Jugular Vein-Carotid Artery Bypass Grafts is not Caused by Anastomotic Stenosis

Background: Obstructed arteries are often treated by surgical implantation of venous bypass grafts. Vein grafts can fail for many reasons, including thrombosis, atherosclerosis, or anastomotic stenoses (narrowings where the grafts connect to the artery). In a previous study aimed at developing a hyperlipidemic rabbit model of vein-graft atherosclerosis for testing gene therapy, vein grafts used to bypass carotid arteries were widely patent. However, vein graft blood flow decreased by a mean of 5.6 mL/minute (~23%) between 8 and 16 wks after grafting, with flow at 16 wks reduced to <60% of flow in an unoperated carotid artery. We hypothesized that decreased flow was caused by anastomotic stenoses, raising concern that this might lead to graft occlusion, precluding use of the model to test gene therapy for atherosclerosis. Methods: We designed an experiment to test whether anastomotic stenoses were present and—if so—whether the stenoses were the cause of decreased blood flow. In a new set of grafted veins, we harvested the anastomoses, embedded, sectioned and stained them, and measured percent stenosis using computer-assisted image analysis. Percent stenosis was calculated by dividing intimal area by the stenosis-free lumen area (calculated from the length of the IEL, assuming circular geometry in vivo). We measured stenoses in both anastomoses of 22 patent vein grafts, harvested from 14 hyperlipidemic rabbits (44 total anastomoses). Blood flow (mL/min) in each vein graft was measured with a flow meter at 4 wks after grafting and again at 16 wks (at harvest). Results: The mean blood flow at the 4 wks measurement was 51 mL/minute (range: 28 to 90) and 36 mL/minute (range: 21 to 53) at the harvest measurement. The calculated mean change in blood flow was –16 mL/minute (range: –55 to +14). The mean anastomotic stenosis was 39% (range: 2.3% to 89%). Using Spearman’s rank-order correlation test, we found that percentage stenosis did not correlate with the change in blood flow (r=0.059; P=0.8). Conclusions: Decreased blood flow in our vein graft model is likely not caused by anastomotic stenoses. Other explanations, such as decreased cardiac output or increased downstream vascular resistance (caused by cerebral atherosclerosis or microemboli) should be considered.

Safe Working Cycle: Is It a Panacea to Combat Construction Site Safety Accidents in Hong Kong?

In Hong Kong, the accident statistics of the construction industry is still comparatively higher than other industries. However, accident rates within the industry have significantly decreased, starting from the implementation of diverse safety initiatives, including the Safe Working Cycle (SWC). In this study, a post-positivist philosophical stance was adopted, and a questionnaire survey was launched to gather empirical data on the application of SWC in construction projects, the effectiveness of the safety initiative, and the benefits thereof. The data gathered from 197 construction participants were analysed using descriptive statistics, mean score, Mann–Whitney U-Test, Kendall’s concordance analysis, Chi-square value, Spearman rank-order correlation test and exploratory factor analysis. The findings revealed significant adoption of SWC in the Hong Kong construction industry. Furthermore, daily, weekly, and monthly inspections and supervisions and safety committee meetings are effective items of this safety initiative. The benefits of adopting SWC can be grouped into the safety of frontline workers and increase in the organisation’s safety commitment and reputation. This study has created an excellent theoretical platform for future research work on the usefulness of the SWC in the construction industry at large.

Impact of COVID-19 on Online Interest in Urologic Conditions: An Analysis of Google Trends.

BackgroundWith COVID-19 leading to several isolation measures for preventative care, health care utilization, especially within urology, decreased substantially. The impact of COVID-19 on the population’s interests in urologic conditions remains to be established. By using the platform of Google Trends, which allows search behaviors and interest in healthcare topics to be quantified over time, we investigated the impact of COVID-19 on online search behaviors relating to common urologic conditions in the US.MethodsThe platform of Google Trends was utilized to analyze online interest in twelve common urologic conditions in the US from October 1, 2018 to August 1, 2021 (divided into “pre-COVID” and “COVID” periods at March 1, 2020). Search volume index (SVI), a measure of relative search volume on Google, data sets for the US, top queried and populated states, rising queries, and top queries were retrieved and analyzed for all conditions. Pre-COVID and COVID median SVIs were compared using the Mann Whitney U test, and correlations were analyzed using Spearman’s rank-order correlation test.ResultsFor all twelve urologic conditions, rising and top queries were often related to symptoms, treatments, and COVID-19. COVID showed higher SVIs for erectile dysfunction (p=0.04) and lower SVIs for bladder cancer (p<0.01), hematuria (p<0.01), kidney cancer (p<0.01), kidney stones (p=0.03), and prostate cancer (p<0.01). Correlations to COVID-19 searches were seen for bladder cancer (RS=-0.36, p<0.01), erectile dysfunction (RS=0.20, p=0.04), hematuria (RS=-0.31, p<0.01), overactive bladder (RS=-0.23, p=0.04), and prostate cancer (RS=-0.33, p<0.01). No correlations were found for benign prostatic hyperplasia, interstitial cystitis, low testosterone, urinary incontinence, and urinary tract infections.ConclusionsOnline interest in many urologic conditions, especially cancers, decreased during COVID. Given the internet’s increasing role in healthcare, a reduced interest could translate to delayed diagnosis and treatment of these conditions. Only erectile dysfunction showed increasing interest, potentially due to research or misinformation linking it to COVID-19.

Investigation of the Relationship between Academic Competencies and Social Information Processing of 60–72 Month-Old Children

Starting from the preschool period, children need to grow up as individuals with high academic skills, academic enablers and respond positively to their social situations. Academic skills and academic enablers together constitute academic competence. The positive reaction of children to the problems they face constitutes social information processing. This study aimed to examine the relationship between the academic competencies of 60–72-month-old children and their social information processing. The study was designed with the relational survey method. The study group consisted of 132 children aged 60–72 months with normal development who attend preschool education. The data collection tools of the study are as follows: Personal Information Form, The Social Information Processing Interview–Preschool Version, and Teacher Rating Scales of Early Academic Competence. Spearman's rank-order correlation test was used to evaluate the relationship between the scales. The findings of the study revealed that there is a relationship between the interpretation of cues and response decision, which are subdimensions of the social information processing model, academic skills (numeracy, early literacy, thinking skills, and comprehension) and academic enablers (social-emotional competence, approaches to learning, and communication).

Spatial and Temporal Distribution Characteristics of Precipitation in Different Seasons in Heilongjiang Province from 1954 to 2013

This paper intends to provide data as reference basis for Heilongjiang Provinces’ optimization of precipitation forecast and the resource allocation. The precipitation characteristics of Heilongjiang Province from 1954-2013 (60 years) were studied by Mann-Kendall rank order correlation test, mutation test, linear trend analysis, and Kriging interpolation combined with GIS analysis. The results show that the overall trend of precipitation in Heilongjiang Province from 1954 to 2013 was decreasing, but the results of segmental analysis show that the trend has been increasing since 1980, and the spatial distribution was characterized by high in the east and low in the west, with the precipitation center in the middle; the seasonal average precipitation gradually increased from east to west, and the precipitation was mainly concentrated in summer, accounting for 63.47% of the year. The annual precipitation was mainly light rainfall, but the difference with the medium rain was not large, both about 35%.

Expression of CXCR4 and CXCR7 in papillary thyroid carcinoma and adjacent tissues and their relationship with pathologic indicators of tumor aggressiveness

The receptors of chemokines play a significance role in the aggressiveness of tumor. CXCR4/CXCR7 promote metastasis of papillary thyroid carcinoma (PTC). This study examined the expresssion of chemokine receptors CXCR4/CXCR7 in human tissue specimens of PTC and peritumoral nonmalignant tissues. The correlation between CXCR4/CXCR7 and the clinicopathological factors in PTC was also determined. CXCR4/CXCR7 were examined in 115 PTC tissues from 115 patients using immunohistochemistry. Staining intensity was compared with patients and tumor characteristics including gender, age, tumor size, capsule invasion, multifocality, lymph node metastasis, and nature of paracancerous tissue. [Statistics: rank sum test, Spearman rank order correlation test; p < 0.05]. Higher expression rates of CXCR4/CXCR7 exhibited in PTC compared with peritumoral nonmalignant tissues. The expression of them was correlated in cancer and paracancerous specimens. A trend toward higher CXCR4/CXCR7 expression was found among tumors showing positive lymph nodes and capsule invasion, while no association with sex, age, tumor size, and nature of paracancerous tissue. Number of lymph nodes was associated with higher intensity IHC staining for CXCR4/CXCR7. Intense staining for CXCR4 was also associated with multifocality. Expression of CXCR4/CXCR7 by PTCs was correlated with lymph node metastasis and capsule invasion. Although multiple bias, they were thought to play a significance role in the aggressiveness of PTC, which provides potential targets for therapeutic interventions.

Social Information Processing in Preschool Children: Relations to Social Interaction

The Social Information Processing Process Model consists of organizing the social adaptation and behavior of children in line with their responses to the social situations they encounter with their peers in their daily lives. The Social Information Processing Model affects children's ability to interact with their peers, their level of interaction, and provides information about the structure of interaction. In this direction, it was aimed to examine the relationship between social information processing and social interaction skills of 60-72 month-old children. The study was designed in relational screening model. The study group of the research consisted of 250 children, between 60 - 72 months, with normal development in the fall semester of the 2020-2021 academic year. The Social Information Processing Interview–Preschool Version and Children's Interaction Rating Scale were used as data collection tools in the study. The data were collected by reading stories with children, asking questions about the story and observation. Since no normal distribution was observed in the analysis of the data, Spearman's Rank-Order Correlation Test was used. As a result of the study, there was a statistically significant and positive relationship between "interpretation, response diversification, response decision", which were sub-dimensions of Social Information Processing Interview and "cooperation, self-control, assertiveness”, sub-dimensions of the Interaction Rating Scale for Children. This situation can be evaluated as children who make positive comments in social situations they encounter, who create positive reactions and react positively, are more cooperative in the context of social interaction, have a strong sense of self-control, and their assertiveness skills are high.

Development and validation of Dementia Solat Score for detecting cognitive impairment among Muslim patients: A pilot study

Background &amp; Objective: Low education and simplicity of lifestyle of Malaysian older adults may mask the early signs of dementia and lead to late presentation with various complications and neglect. From clinical observation, decline in prayer performance in older Muslims might be a sign of cognitive impairment. This study aim to develop and validate an objective assessment tool for dementia based on Muslim routine prayer performance status. Methods: This was a pilot study which involved Muslim participants aged 50 and above. They were divided into normal cognitive control group and cognitive impaired group. Clinical Dementia Rating (CDR) was done on all participants upon recruitment, and Dementia Solat Score (DSS) was done by another group of assessors which were blinded to CDR findings. All the statistical analyses was performed using R statistical software, Version 3.5.2. Results: There were total of 36 participants, 16 from normal cognitive control group and 20 from cognitive impaired group. DSS score was significantly lower in cognitive normal control (median=0, IQR=0) compared to cognitive impaired group (median=4, IQR=9.0), Z=-4.54, p&lt;0.001. Spearman’s rank-order correlation test between CDR and DSS revealed a positive correlation between the two assessment tools, r= 0.920, p&lt;0.001. The cut-off point of 1 and above in DSS showed a sensitivity of 85.0%, specificity of 93.8%, positive predictive value of 94.4% and negative predictive value of 83.3%. Conclusions: This pilot study showed that DSS has high sensitivity and specificity in detecting cognitive impairment among Muslim patients. A higher score in DSS may indicate more severe stage of disease.

The Unintended Consequence of Novel Coronavirus (COVID-19) Pandemic on Racial Inequities Associated With Adverse Childhood Experiences (ACEs): Findings From a Population-Based Study.

A rising concern is the COVID-19 pandemic effect on adverse childhood experiences (ACEs) due to increased parental stress and social/physical isolation. These pandemic effects are likely to be higher in already marginalized communities. The objective of this ecological study was to examine the relationship between COVID-19 cases and deaths, race/ethnicity, and the estimated number of adults with ACEs using data from South Carolina (SC). COVID-19 reported cases and death data were obtained from the SC Department of Health and Environmental Control. ACE data was used from the 2014–2016 SC Behavioral Risk Factor Surveillance System. Census data were used to obtain county population data. To measure the relationship between these variables, the Spearman rank-order correlation test was used because the data distribution was non-normal. There was a moderate relationship between the estimated number of adults with one or more ACEs and deaths (ρ = 0.89) and race/ethnicity-specific COVID-19 case counts by county (Black: ρ = 0.76; =White: ρ = 0.96; Hispanic: ρ = 0.89). Further, the Spearman correlation test showed the strongest relationship between COVID-19 deaths and race-ethnicity-specific county populations was with the Black adult population (ρ = 0.90). Given the known link between existing health inequities and exposure to COVID-19, these results demonstrate that the current pandemic could have unintended consequences on the well-being of children and caregivers. Response efforts should consider promoting protective factors for children and families and advocating for equitable policies and systems that serve children.

Job Satisfaction and Organizational Commitment Among Teachers of the Bohol Association of Catholic Schools, Diocese of Tagbilaran

Job Satisfaction is an attitude the employees have about their jobs, while organizational commitment refers to a widely recognized theory covering normative, affective, and continuance aspects. The study aimed to assess the level of job satisfaction and organizational commitment among teachers in BACS. Furthermore, it examined the correlation between job satisfaction and organizational commitment. It also looked into the significant difference in job satisfaction between the respondents’ years of service. The study used the quantitative descriptive-normative survey method to gather data through standardized questionnaires. From 311 teachers, a random sample of 291 respondents was selected with a +/-1.46% margin of error at a 95% confidence interval. Results revealed that teachers were highly satisfied with their jobs, while having a moderate organizational commitment (rs = 0.524, p = 0.000). Moreover, Spearman’s rank-order correlation test revealed a positive correlation between job satisfaction and organizational commitment. Furthermore, a Kruskal-Wallis H test showed a statistically significant difference in job satisfaction between the respondents’ years of service, = 10.124, p=0.018, with a mean rank job satisfaction of 170.36 for one year and below, 137.76 for more than one year – three years, 124.70 for more than three years – five years, and 148.75 for more than five years. A Dunn-Bonferroni test showed that teachers employed for one year and below significantly had higher job satisfaction than those who stayed for more than three years – five years.

Assessment of precipitation trends and its implications in the semi-arid region of Southern India

Rainfall is a complex meteorological phenomenon with high spatio-temporal variability. These variations in hydrologic time series can be better analyzed using homogeneity and trend tests. In this paper, three homogeneity tests were applied to the annual rainfall series of 1980–2013 from 30 raingauge stations over the study area. The rainfall stations with homogeneous time series were subjected to cluster analysis (Agglomerative Hierarchical Clustering technique) and thereafter traditional trend tests (Mann-Kendall test and Spearman Rank-order Correlation test) and one emerging trend test (called ‘Innovative Trend test’) were applied to individual clusters. Based on the homogeneity test results, 27 rainfall stations with homogeneous time series were classified under six clusters. The results of the trend analysis revealed that a distinct pattern of increasing (decreasing) rainfall trend exists in the northern (southern) part of the study area. Although the traditional tests detected insignificant trends, the Innovative Trend (IT) test indicated the trends to be significant in all the clusters. However, the magnitude of trends detected by the traditional trend tests and non-traditional trend tests is similar for all the clusters. It is concluded that the emerging IT test is highly sensitive to the changes in the rainfall time series. The findings of this study suggest that the orography, population density, industrialization and agricultural intensity lead to a precipitation gradient in the study area.

Elements of Innovation Culture Influencing Individual Research and Development (R&amp;D) Performance in Public Higher Education Institutions in the Philippines

This study explored the elements of innovation culture influencing individual performance of research and development (R&amp;D) personnel. It employed quantitative research wherein innovation culture and R&amp;D performance assessment tools were developed and administered to 115 R&amp;D personnel in public higher education institutions (HEIs). Individual performance in terms of quantity of R&amp;D outputs such as inventions, utility models, other intellectual property (IP) and creations, and scientific publications were assessed. Spearman’s rank-order correlation test showed significant association between inclusivity, continuous improvement, creativity, learning organization, innovativeness, communication system, innovation process, and the innovative teams and groups and performance of R&amp;D personnel. Furthermore, the ordinal logistic regression analysis showed that freedom, orientation to technological innovation, innovation process, creativity, flexibility, openness, continuous improvement, learning organization, innovative teams/groups and individuals can influence individual performance of R&amp;D personnel in public HEIs. This study added to our understanding of innovation culture in public or government organizations by providing empirical information on its validity and applicability, which can help analyse its elements in relation to individual performance. It gave insights on how each element of innovation culture can influence individual performance, particularly the production of R&amp;D outputs in public HEIs.

Using the Best Value Approach to Improve Project Performance in the Vietnam Construction Industry

The Vietnam Construction Industry (VCI) has been facing risks that cause delays, budget overrun, and low customer satisfaction that required continuous research efforts on solutions. This paper focuses on how the Best Value Approach (BVA), a procurement and project management philosophy, could be utilized in VCI projects to improve overall performance. Analysis from six industry experts determined how current VCI conditions, namely risk and success factors, are related to the BVA. Sixteen BVA success principles were identified and ranked based on their perceived impact to project performance by an industry survey with 98 VCI practitioners. The results show high agreement rate with all sixteen BVA principles. Spearman’s rank-order correlation test determined relatively high agreement between owners and contractors, and lower agreement between owners and consultants on the ranking. The majority of participants agreed that the BVA would improve project performance and were interested in learning more about the BVA. The results encourage further BVA testing and education in the VCI. This approach is not limited to the VCI but could be followed by other developing nations.

Impaired Exercise Tolerance in Repaired Tetralogy of Fallot Is Associated With Impaired Biventricular Contractile Reserve: An Exercise-Stress Real-Time Cardiovascular Magnetic Resonance Study.

Correction of tetralogy of Fallot (cTOF) often results in pulmonary valve pathology and right ventricular (RV) dysfunction. Reduced exercise capacity in cTOF patients cannot be explained by these findings alone. We aimed to explore why cTOF patients exhibit impaired exercise capacity with the aid of a comprehensive cardiopulmonary exercise testing (CPET) and real-time cardiovascular magnetic resonance exercise testing (CMR-ET) protocol. Thirty three cTOF patients and 35 matched healthy controls underwent CPET and CMR-ET in a prospective case-control study. Real-time steady-state free precession cine and phase-contrast sequences were obtained during incremental supine in-scanner cycling at 50, 70, and 90 W. RV and left ventricle (LV) volumes and pulmonary blood flow (Qp) were calculated. Differences of CPET and CMR-ET between cTOF versus controls and correlations between CPET and CMR-ET parameters in cTOF were evaluated statistically for all CMR exercise levels using Mann-Whitney U and Spearman rank-order correlation tests. CPET capacity was significantly lower in cTOF than in controls. cTOF patients exhibited not only significantly reduced Qp and RV function but also lower LV function on CMR-ET. Higher CPET values in cTOF correlated with higher Qp (Qp 90 W versus carbon dioxide ventilatory equivalent %: R=-0.519, P<0.05), higher LV-end-diastolic volume indexed to body surface area (LV-end-diastolic volume indexed to body surface area at 50 W versus oxygen uptake in % at maximum exercise on CPET R=0.452, P<0.05), and change in LV ejection fraction (EF; LV-EF at 90 W versus Watt %: r=-0.463, P<0.05). No correlation was found with regard to RV-EF. Significant RV-LV interaction was observed during CMR-ET (RV-EF versus LV-EF at 50 W and 70 W: r=0.66, P<0.02 and r=0.52, P<0.05, respectively). Impaired exercise capacity in cTOF resulted from a reduction in not only RV, but also LV function. cTOF with good exercise capacity on CPET demonstrated higher LV reserve and pulmonary blood flow during incremental CMR-ET. Apart from RV parameters, CMR-ET-derived LV function could be a valuable tool to stratify cTOF patients for pulmonary valve replacement.

The relatively higher concentrations of trace elements to arsenic may have influenced on methylation process of inorg- As in humans

The relatively higher concentrations of trace elements to arsenic may have influenced on methylation process of inorg- As in humans

A Modified CRITIC Method to Estimate the Objective Weights of Decision Criteria

In this study, we developed a modified version of the CRiteria Importance Through Inter-criteria Correlation (CRITIC) method, namely the Distance Correlation-based CRITIC (D-CRITIC) method. The usage of the method was illustrated by evaluating the weights of five smartphone criteria. The same evaluation was repeated using four other objective weighting methods, including the original CRITIC method. The results from all the methods were further analyzed based on three different tests (i.e., the distance correlation test, the Spearman rank-order correlation test, and the symmetric mean absolute percentage error test) to validate D-CRITIC. The tests revealed that D-CRITIC could produce more valid criteria weights and ranks than the original CRITIC method since D-CRITIC yielded a higher average distance correlation, a higher average Spearman rank-order correlation, and a lower symmetric mean absolute percentage error. Besides, additional sensitivity analysis indicated that D-CRITIC has the tendency to deliver more stable criteria weights and ranks with a larger decision matrix. The research has contributed an alternative objective weighting method to the area of multi-criteria decision-making through a unique extension of distance correlation. This study is also the first to propose the idea of a distance correlation test to compare the performance of different criteria weighting methods.

Factors associated with mothers' knowledge of children with congenital heart disease in Bangkok, Thailand

PurposeThis study aimed to determine mothers' knowledge of children with congenital heart disease (CHD) and to examine the relationship between types of CHD, the duration of treatments, the perception of the severity of illness and the mothers' knowledge.Design/methodology/approachA correlation study was conducted among 84 mothers of children (from infancy to six years old) with CHD who had attended pediatric cardiology clinics and pediatric units in three tertiary hospitals in Bangkok, Thailand. The two questionnaires aimed to evaluate the mothers' knowledge and perceptions of the severity of illness. Descriptive statistics, Spearman's rank-order correlation and Fisher's exact test were used to analyze the data.FindingsKnowledge levels of mothers of children with CHD were at a high level with a mean score of 34.79 (SD = 8.23), but the knowledge domain of preventing complications was at a low level with a mean score of 14.95 (SD = 5.28). The types of CHD and the perceptions of illness were not correlated with the mothers' knowledge, but the duration of treatments was significantly correlated (r = 0.271, p &lt; 0.05).Originality/valueHealthcare professionals, especially nurses, should emphasize proper health education on complication prevention and the duration of treatments for children. Moreover, mothers should be supported to nurture children with CHD to reduce possible complications and prepare for cardiac surgery where needed.

The prognostic value of cyclin D1 in breast cancer patients treated with hormonal therapy: A pilot study

The aimof the study was to determine the clinical relevance of cyclin D1 (cD1) and its association with clinicopathological parameters in breast cancer patients treated with hormonal therapy. Material and methodsThe study included 96 primary breast cancer patients with known clinicopathological parameters. In adjuvant setting, 44 patients were tamoxifen-treated and 52 were treated with ovarian irradiation/ablation. The cD1 status (gene amplified/nonamplified) was determined on formalin-fixed paraffin-embedded tumor tissue sections by chromogenic in situ hybridization. Associations between parameters were analyzed by Chi-square and Spearman’s rank order correlation tests. Cox proportional hazards regression test was performed. Survival curves for relapse-free survival were constructed according to the Kaplan-Meier method. ResultsThere were no significant associations between cyclin D1 and clinicopathological parameters in either patient group. Amplified cyclin D1 associated significantly with the actual relapse incidence in the ovarian ablation patient group (p = 0.01, HR = 3.1), but not in the tamoxifen-treated patient group. Estrogen receptor and cyclin D1 have proven to be independent parameters of poor outcome in the ovarian ablation patient group (p = 0.03, HR = 2.9; and p = 0.009, HR = 2.5; respectively). ConclusionsCyclin D1 might be a candidate biomarker of poor outcome in breast cancer patients treated with ovarian ablation, suggesting its possible involvement in acquirement of hormonal resistance. The role of cyclin D1 as potential parameter of response to tamoxifen was not as pronounced.

The Fisher Separation Theorem And Capital Budgeting Decisions Of Quoted Firms In Nigeria

This study explored the Fisher separation theorem and capital budgeting decisions of quoted firms on the Nigerian stock exchange. A sample of 60 questionnaires were filled and returned by staffs from particular sectors like manufacturing, health and agriculture. Descriptive statistics was employed to illustrate the data while the Spearman rank order correlation test was used to determine if a significant relationship exist among the variables. From the estimates, the Net Present Value and Modified Internal Rate of Return are regularly employed by firms in making capital budgeting decisions. Also, when firms employ capital budgeting tools, it creates wealth for both managers and shareholders, providing support for the Fisher’s separation theorem. Finally, a correlation coefficient of 0.827 reflect a positive and linear relationship between capital budgeting decision and Shareholders’ value creation. Thus, an increase in capital budgeting decisions result to an increase in value creation. This outcome is consistent with findings from other economies and previous studies. It thus recommends that firms in the Nigerian environment should ensure they play down on shareholders’ desire for dividends and instead redirect their funds to more investments by employing suitable capital budgeting decisions.