Working Range Research Articles

Application Prospects of Artificial Intelligence in Medical Industry

With the continuous development of the current society, the development speed of various industries is very fast, for the development of the medical industry, the application value of artificial intelligence technology is high. The development of artificial intelligence has played a certain role in promoting the development of the whole society. With the continuous progress of the current existing technology, the application scenarios of artificial intelligence have been rapidly expanded. For the development of the entire medical industry, the application of artificial intelligence technology can effectively improve the overall treatment efficiency and actual accuracy. This paper mainly starts from the basic situation of the development and application of artificial intelligence in the medical industry, understanding the basic application mode of various technologies, and does a full range of application design and research work.

THE PHENOMENON OF CYBERBULLYING: A COMPREHENSIVE LITERATURE REVIEW

This article review explores the multifaceted phenomenon of cyberbullying within the contemporary digital landscape. The research aims to provide a comprehensive understanding of cyberbullying by synthesizing key findings from a diverse range of scholarly works. The purpose of this scientific inquiry is to unravel the complex dimensions of cyberbullying, emphasizing its diverse forms, prevalence across demographics, and the profound psychological impact on victims. The research methodology involves a systematic literature review, wherein relevant articles are identified, selected, and critically evalu-ated. An extensive and systematic search for relevant articles from peer-reviewed journals prioritized publications from the last decade to analyze recent research findings on cyberbullying. The analysis provided a better understanding of the complexities associated with cyberbullying in today’s digital age. The scientific and practical significance of this work lies in its contribution to the ongoing discourse on cyberbullying. The synthesis of research findings offers a nuanced perspective on the international expe-rience of cyberbullying, recognizing the global prevalence while acknowledging cultural variations. The value of this research lies in its contribution to advancing knowledge on cyberbullying. By synthesizing diverse perspectives, the article review offers a holistic understanding of the phenomenon, guiding future research initiatives and safety policy development.

The Mediating Path of Transformational Leadership: A Cross-Sectional Study in Chinese Context

Organisations that are going through transformative processes need to make sure that they have effective change management and employee engagement. Considering the function that transformational leadership plays as a mediator, this study aims to investigate the connection between employee engagement and the change management process. This research uses a cross-sectional methodology and gathers information from a wide range of people working for various companies. Employee engagement, opinions of the change management process, and transformational leadership are all measured using a standard questionnaire. Statistically, statisticians use tools like mediation analysis and correlational testing to look into the purported links. Findings indicate a strong positive correlation between change management and the variables that inspire employee engagement. The research findings have also demonstrated that transformational leadership is an important mediator between organisational change management and employee engagement. This research suggests that transformational leaders can make employee engagement an even more powerful tool for effective change management. This study shed light on the need to develop transformational leadership skills and encourage employee participation in initiatives to bring about organisational change. Organisations should prioritise strategies that enhance employee engagement, such as communication, competition, environment, management support, innovation, job characteristics, organisational system, organisational structure, reward, and workplace well-being. Moreover, the success of change management activities can be improved by investing in leadership development programmes that aim to create transformational leadership behaviours. An empirical investigation of the function that transformational leadership plays as a mediator in the connection between the process of change management and employee engagement is the contribution that this study makes to the current body of research. Businesses can improve employee engagement and leadership practices during times of transformation if they shed light on this complex interplay and gain a more profound comprehension of the factors that drive successful change implementation.

HINGLISH TODAY: ANALYSIS OF LINGUISTIC FEATURES OF HINGLISH LANGUAGE IN CONTEMPORARY INDIAN LITERATURE

The linguistic phenomenon of Hinglish, a blend of Hindi and English, has gained widespread prevalence in India as a result of the interplay between these two languages within diverse sociocultural environments. The emergence of Hinglish, a linguistic fusion of Hindi and English, has garnered significant attention, especially within contemporary Indian literature, as it serves to portray the diverse and dynamic multicultural fabric of Indian society. The objective of this academic article is to offer a thorough examination of the linguistic characteristics of Hinglish, a fusion of Hindi and English, as manifested in present-day Indian literary works. This academic article critically examines direct quotations and references from a range of literary works to elucidate the evolution, significance, and impact of Hinglish on language, culture, and identity in India. Utilizing a wide array of empirical evidence and scholarly investigation, the present study offers significant contributions to understanding the intricate linguistic milieu of Hinglish within contemporary Indian literature. The article’s objective is to furnish a comprehensive examination of the linguistic traits of Hinglish, a linguistic amalgamation resulting from the fusion of Hindi and English in the Indian context. This research investigates the incorporation of Hinglish within contemporary Indian literature as a reflection of the diverse and multilingual characteristics of the nation. Through a comprehensive analysis, the study aims to elucidate the evolving role of Hinglish in Indian writing.

Unionist Screws: Depictions of Northern Irish Unionists in British and Irish Cinema

This article explores the representation of Northern Irish unionists in British and Irish cinema by investigating a dominant way that the community has been portrayed in fiction films: as prison officers and orderlies. Specifically, Northern Irish unionists have been portrayed as prison officers and orderlies employed in the Maze and Armagh prisons during the period of republican unrest which culminated in hunger strikes in 1981, and a mass prison escape in 1983. The films that depict, to varying degrees, these characters as belonging to the Northern Irish unionist community include Some Mother’s Son (1996), H3 (2001), Silent Grace (2001), Hunger (2008) and Maze (2017). In these films, the typical representation of Northern Irish unionists reflects both the community’s general ‘othering’ in cinema and the film-makers’ primary interest in Irish nationalism when depicting Northern Ireland. Thus, unionist characters are usually depicted abjectly and feature only as adjuncts to narratives that are principally about Irish nationalists. This study aims to build upon a range of critical work in this area and to add to broader debates that have identified this cinematic deficit whereby Northern Irish unionists are depicted more critically and less frequently than Irish nationalists.

Doubling matter (notes on architectural motifs in the lyrics of F. I. Tyutchev)

The paper focuses on the range of lyrical works by F. I. Tyutchev, which involve architectural images and motifs. Tyutchev’s interest in these motifs and images — from the “ruins of Ilion” to the “Tsarskoe Selo palaces” and Moscow churches — has been observed for more than half a century. Tyutchev’s poems discussed in the paper are studied taking into account their connections with the “architectural” poetry of their predecessors. First of all, the connections with G. R. Derzhavin and P. A. Vyazemsky are traced. Among the heirs of this tradition, the author singles out O. E. Mandelstam. A special place in the work is given to the comparison of architectural images and motifs in Tyutchev’s lyrics with those of A. S. Pushkin, possible Pushkin sources of a number of Tyutchev’s works are found. The author’s special attention is devoted to a group of poems (“Dream at Sea”, “Morning in the Mountains”, “Unexpectedly and Brightly...”), in which the presence of architectural images is involved in solving completely different lyrical and philosophical issues that are not related to direct poet’s impressions from works of architectural art. The specific Tyutchev’s distrust towards the plastic arts (architecture, sculpture), in contrast to the poet’s always benevolent attention to music, is associated with the most profound, fundamental features of Tyutchev’s personality and worldview. The author argues that the distrust of the plastic arts is caused by the poet’s more general skeptical attitude towards the objects of the man-made world (in this respect, Tyutchev is close to N. V. Gogol).

Japan practices in the preservation of cultural heritage. Nara Research Center

The article deals with the history, structure and methods of work of the Nara Research Center, as well as the socio-cultural context of its establishment. Compared to many countries, the experience of preserving cultural heritage in Japan began to take shape relatively recently, but over the past period, original forms of working with heritage unique to Japan have been developed, which have expanded the world experience in this area. Familiarity with the Japanese experience can be useful for the Russian museum community and can contribute to the emergence of new forms in the domestic practice of dealing with heritage. One of the striking manifestations of the organization of cultural heritage conservation in Japan is the activity of the National Research Institute in Nara. There are currently no works in the domestic literature devoted to the analysis. Since the 50s of the 20th century, the Japanese government has actively begun to work in the field of preserving and protecting universal cultural values. The Nara National Research Institute is an excellent example of a government organization that is engaged in a wide range of work to preserve the country’s cultural assets, as well as scientific education and international activities. The work of the National Research Center is a striking example of a well-functioning system for the protection of cultural property operating in Japan at the state level. The competence of the center includes not only conducting excavations, but also analyzing the extracted materials, extensive educational, educational and international security activities. The data obtained during the research is carefully structured and digitized and will be made publicly available through several public databases created for a detailed study of issues related to archeology and related sciences.

Perancangan Dan Implementasi Sistem Informasi Manajemen Proyek Berbasis Web Dengan Metode WATERFALL

CV Winman Konstruksi is a company that focuses on the building construction sector. The portfolio of projects that CV Winman Konstruksi has successfully undertaken covers a wide range of work, from the planning stage to the implementation of building construction and repair projects. In conducting the project management process, CV Winman Konstruksi has been using personal short messages as a means of communication between employees, but it needs to be recognized that this method may have limitations in terms of progress tracking, project documentation, and building a formal framework that can provide more systematic and structured guidance for the entire project team. The result of this research is a computerized system as a means of project management which is realized in the form of a project management information system website. In developing this system, researchers use the waterfall method which consists of the stages of needs analysis, design, design, implementation and testing. Later it is hoped that with this system, the management process at the CV Winman Konstruksi company can be monitored easily anywhere and anytime.

Study on the Construction of Educational Management System to Integrate the Elements of Civic and Political Programs with the Employment and Precision Support for Poor College Students in Colleges and Universities under the Learning Migration Theory

Abstract Facing the complex and changing job market, poor students in colleges and universities face severe challenges. This study explores how to construct an educational management system for precise employment support for poor college students in colleges and universities by integrating elements of the Civics and Political Science program under the guidance of the learning transfer theory to enhance employment ability and increase employment opportunities. The entropy weight-TOPSIS method is used in the study to assess the quality of employment help for poor college students in a comprehensive manner. Among the 10 colleges and universities, the evaluation scores of the quality of employment assistance work range from 0.25 to 0.7567, and the average score is 0.4432, which concludes that there is a significant difference between different colleges and universities in the quality of employment assistance work. Through the analysis of the multiple linear regression model, it is found that individual career level, school guidance level, and ability development level are the key factors affecting the satisfaction of employsment precision help for poor college students, and the influence of ability development level is the most significant. To improve the employment quality of poor college students, colleges and universities should prioritize individualized guidance and ability development when providing employment assistance.

A flexible, stretchable and wearable strain sensor based on physical eutectogels for deep learning-assisted motion identification.

Physical eutectogels as a newly emerging type of conductive gel have gained extensive interest for the next generation multifunctional electronic devices. Nevertheless, some obstacles, including weak mechanical performance, low self-adhesive strength, lack of self-healing capacity, and low conductivity, hinder their practical use in wearable strain sensors. Herein, lignin as a green filler and a multifunctional hydrogen bond donor was directly dissolved in a deep eutectic solvent (DES) composed of acrylic acid (AA) and choline chloride, and lignin-reinforced physical eutectogels (DESL) were obtained by the polymerization of AA. Due to the unique features of lignin and DES, the prepared DESL eutectogels exhibit good transparency, UV shielding capacity, excellent mechanical performance, outstanding self-adhesiveness, superior self-healing properties, and high conductivity. Based on the aforementioned integrated functions, a wearable strain sensor displaying a wide working range (0-1500%), high sensitivity (GF = 18.15), rapid responsiveness, and excellent stability and durability (1000 cycles) and capable of detecting diverse human motions was fabricated. Additionally, by combining DESL sensors with a deep learning technique, a gesture recognition system with accuracy as high as 98.8% was achieved. Overall, this work provides an innovative idea for constructing multifunction-integrated physical eutectogels for application in wearable electronics.

A new strategy for the determination of dinobuton fungicide by square wave stripping voltammetry on the multi-walled carbon nanotube electrode

Dinobuton is a fungicide with a dinitrophenol group pesticide, and its electrochemical behavior was investigated by cyclic voltammetry (CV) and square wave stripping voltammetry (SWSV) on a multi-walled carbon nanotube paste electrode (MWCNTPE). First of all, optimum parameters such as pH, step potential, frequency, puls amplitude, deposition time and, deposition potential were specified by using SWSV on the MWCNTPE. In the negative potential scans, two cathodic peaks appeared at nearly −480 mV and –760 mV due to the nitro groups on the molecule and the second sharp one appeared at −760 mV (versus Ag/AgCl) was used for analytical purposes. The linear working range was found to be within 3.74–25.8 μM on the MWCNTPE by SWSV in pH 7.0 Britton Robinson (BR) buffer solution. The limit of detection (LOD) and limit of quantification (LOQ) values were found to be 0.73 μM and 2.43 μM, respectively. The interference study was conducted in the presence of some pesticides such as triasulfuron, azinphos-methyl, bromoxynil-octanoate, dialifos, fipronil, vinclozolin, iprodione, procymidone, and some selected metal ions withal. Furthermore, the proposed method was also applied to apple juice, tap water, and grape juice, and percent recoveries (%) were detected as 105.9 ± 4.3; 98.3 ± 0.9; 103.7 ± 2.5% with relative standard deviations of 4.0, 1.0, and 2.4%, respectively. On the other hand, percent relative errors were calculated as 5.90, 1.65, and 3.74%, respectively. High recoveries and low relative standard deviations indicate that the applicability of the proposed method in both matrix and real samples is satisfying.

An electrochemically synthesized molecularly imprinted polymer for highly selective detection of breast cancer biomarker CA 15-3: a promising point-of-care biosensor.

In this study, a molecularly imprinted polymer film (MIP) was prepared on the surface of a disposable carbon screen-printed electrode (C-SPE) using (3-acrylamidopropyl)trimethylammonium chloride (AMPTMA) as a functional monomer and the cancer biomarker carbohydrate antigen 15-3 (CA 15-3) as a template. The MIP was synthesized by in situ electropolymerization (ELP) of the AMPTMA monomer in the presence of the CA 15-3 protein on the C-SPE surface. The target was subsequently removed from the polymer matrix by the action of proteinase K, resulting in imprinted cavities with a high affinity for CA 15-3. Electrochemical techniques such as cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to characterize the different phases of the sensor assembly. Chemical and morphological analysis was performed using RAMAN and scanning electron microscopy (SEM). CA 15-3 was successfully detected in a wide working range from 0.001 U mL-1 to 100 U mL-1 with a correlation coefficient (R2) of 0.994 in 20 min. The MIP sensor showed minimal interference with other cancer proteins (CEA and CA 125). Overall, the developed device provides a rapid, sensitive, and cost-effective response in the detection of CA 15-3. Importantly, this comprehensive approach appears suitable for point-of-care (PoC) use, particularly in a clinical context.

Electrochemical aptasensor based on DNA-templated copper nanoparticles and RecJf exonuclease-assisted target recycling for lipopolysaccharide detection.

An electrochemical aptasensor for detecting lipopolysaccharides (LPS) was fabricated based on DNA-templated copper nanoparticles (DNA-CuNPs) and RecJf exonuclease-assisted target recycling. The DNA-CuNPs were synthesized on a double-stranded DNA template generated through the hybridization of the LPS aptamer and its complementary chain (cDNA). In the absence of LPS, the CuNPs were synthesized on DNA double-strands, and a strong readout corresponding to the CuNPs was achieved at 0.10 V (vs. SCE). In the presence of LPS, the fabricated aptamer could detach from the DNA double-strand to form a complex with LPS, disrupting the template for the synthesis of CuNPs on the electrode. Meanwhile, RecJf exonuclease could hydrolyze the cDNA together with this single-stranded aptamer, releasing the LPS for the next round of aptamer binding, thereby enabling target recycling amplification. As a result, the electrochemical signal decreased and could be used to indicate the LPS content. The fabricated electrochemical aptasensor exhibited an extensive dynamic working range of 0.01 pg mL-1 to 100 ng mL-1, and its detection limit was 6.8 fg mL-1. The aptasensor also exhibited high selectivity and excellent reproducibility. Moreover, the proposed aptasensor could be used in practical applications for the detection of LPS in human serum samples.

A double-crack structure for bionic wearable strain sensors with ultra-high sensitivity and a wide sensing range.

Flexible strain sensors are crucial in fully monitoring human motion, and they should have a wide sensing range and ultra-high sensitivity. Herein, inspired by lyriform organs, a flexible strain sensor based on the double-crack structure is designed. An MXene layer and an Au layer with cracks are constructed on both sides of the insulated polydimethylsiloxane (PDMS) film, forming an equivalent parallel circuit that guarantees the integrity of the conductive path under a large strain. The rapid disconnection of the crack junctions causes a significant change in the resistance value. Due to the effect of cracks on the conductive path, the sensitivity of the sensor is largely improved. Benefiting from the double-crack structure, the as-obtained sensor shows ultra-high sensitivity (maximum gauge factor of up to 14 373.6), a wide working range (up to 21%), a fast response time (183 ms) and excellent dynamical stability (almost no performance loss after 1000 stretching cycles and different frequency cycles). In practical applications, the sensor is applied to different parts of the human body to sense the deformation of the skin, demonstrating its great potential application value in human physiological detection and the human-machine interaction. This study can provide new ideas for preparing high-performance flexible strain sensors.

Degradation and detection of organophosphorus pesticides based on peptides and MXene-peptide composite materials.

Safety problems caused by organophosphorus pesticide (OP) residues are constantly occurring, so the development of new methods for the degradation and detection of OPs is of great scientific significance. In the present study, β-sheet peptides and β-hairpin peptides for catalyzing the hydrolysis of OPs were designed and synthesized. The peptide sequences with the highest hydrolytic activity (EHSGGVTVDPPLTVEHSAG) were screened by investigating the effect of the location of the active sites of the peptide and the peptide's structure on the degradation of OPs. In addition, the relationship between the peptides' conformation and hydrolytic activity was further analyzed based on density functional theory calculations. The noncovalent interactions of the peptides with the OPs and the electrostatic potential on the molecular surface and molecular docking properties were also investigated. It was found that peptides with approximate active amino acids consisting of the catalytic triad and with the hairpin structure had enhanced hydrolytic activity toward the hydrolysis of OPs. To develop an electrochemical sensor technique to detect OPs, the conductive MXene (Ti3C2) material was first immobilized with a caffeic acid monolayer via enediol-metal complex chemistry and then bound with the β-hairpin peptide (EHSGGVTVDPPLTVEHSAG) via carboxy-amine condensation chemistry between the -COOH of caffeic acid and the -NH2 of the peptide to prepare a MXene-peptide composite. Then, the prepared composite was modified on the surface of a glassy carbon electrode to construct an electrochemical sensor for the detection of OPs. The developed technique could be used to monitor OPs within 15 min with a two orders of linear working range and with a detection limit of 0.15 μM. Meanwhile, the sensor showed good reliability for the detection of OPs in real vegetables.

Lab-made CO2 laser-engraved electrochemical sensors for ivermectin determination.

The ivermectin (IVM), as a broad-spectrum antiparasitic drug, was widely prescribed to treat COVID-19 during the pandemic, despite lacking proven efficacy in combating this disease. Therefore, it is important to establish affordable devices in laboratories with minimal infrastructure. The laser engraving technology has been revolutionary in sensor manufacturing, primarily attributed to the diversity of substrates that can be employed and the freedom it provides in creating sensor models. In this work, electrochemical sensors based on graphene were developed using the laser engraving technology for IVM sensing. Through, the studies that used the techniques of cyclic voltammetry and differential pulse voltammetry, following parameter optimization, for the laser-induced graphene electrode demonstrated a mass transport governed by adsorption of the species and exhibited a linear working range of 10-100 (μmol L-1), a limit of detection (LOD) of 1.6 × 10-6 (mol L-1), a limit of quantification (LOQ) of 4.8 × 10-6 (mol L-1), and a sensitivity of 0.139 (μA μmol L-1). The developed method was successfully applied to direct analysis of pharmaceutical tablets, tap water (recovery of 94%) and synthetic urine samples (recovery between 97% and 113%). These results demonstrate the feasibility of the method for routine analyses involving environmental samples.

Development of a facile electrochemical sensor based on GCE modified with one-step prepared PNMA-CeO2-fMWCNTs composite for simultaneous detection of UA and 5-FU.

In this study, a poly(N-methyl aniline)-cerium oxide-functionalized MWCNTs (PNMA-CeO2-fMWCNTs) composite was synthesized in a one-step preparation technique. As a highly efficient modifier, the composite was used to modify the glassy carbon electrode surface for simultaneous detection of uric acid (UA) and 5-fluorouracil (5-FU). Morphological characterization of the GCE/PNMA-CeO2-fMWCNTs was studied using scanning electron microscopy. Structural characterization of the composite was performed using X-ray diffraction and Fourier-transformed infrared spectroscopy. Electron transfer properties of the prepared electrodes were carried out with electrochemical impedance spectroscopy and cyclic voltammetry. The linear working range for UA and 5-FU was found to be 0.25-50 μM and 0.5-750 μM, respectively. The limit of detection values for UA and 5-FU were 0.04 μM and 0.19 μM, respectively. The effects of various interfering substances on the electrochemical response of UA and 5-FU were investigated. The GCE/PNMA-CeO2-fMWCNTs sensor has excellent stability, reproducibility, anti-interference ability, and reproducibility. To demonstrate the practical application of the sensing platform, fetal bovine serum was selected and tested in the spiked samples, and satisfactory results were obtained. The prepared composite proved to be a promising platform for simple, rapid, and simultaneous analysis of UA and 5-FU.

A rigid–soft hybrid paper-based flexible pressure sensor with an ultrawide working range and frequency bandwidth

A rigid–soft hybrid design strategy to fabricate paper-based pressure sensor with ultrawide working range and frequency bandwidth.

SEQUENTIAL DETERMINATION OF Zn, Fe, Mg, Ca, Na AND K IN SYNTHETIZED BABASSU FAME BY HIGH RESOLUTION CONTINUUM SOURCE FLAME ATOMIC ABSORPTION SPECTROMETRY

In this work, babassu FAME samples were synthesized by transesterification reaction under alkaline catalysis with sodium glyceroxide and by two steps process with KOH followed by H2SO4 as catalysts. A sequential multi-element method for determination of Zn, Fe, Mg, Ca, Na and K in synthesized babassu FAME by high resolution continuum source flame atomic absorption spectrometry (HR-CS FAAS) was developed. The proposed method is based on a microemulsion formation by mixing the babassu FAME samples with 1-propanol and aqueous phase. The mass proportion of the added components was evaluated through a ternary diagram. External and matrix-matching calibration techniques with inorganic and organic standard were investigated. In the five-level spike-recovery test, satisfactory results were obtained by performing the matrix-matching calibration along with inorganic standard solutions. By using the optimized conditions, limits of detection in the range of 0.002-0.12 mg kg-1 were obtained. Accuracy was attested by the agreement of the results obtained in the analysis of three certified reference materials. By applying the microemulsion system and HR-CS FAAS, the sequential determination of six elements was achieved. Therefore, the proposed method was a suitable alternative for metal determination in babassu FAME samples, with good sensitivities, accuracy, and a wide linear working range.

Design of a Novel Electrochemical Immunosensor for Toxoplasma gondii Detection Based on Gold Nanoparticle/Chitosan Decorated Screen Printed Electrode

Toxoplasma gondii is an intracellular parasite that primarily utilizes cats as its definitive host. This parasite, which is spread through cat feces, can be transmitted to other animals and, from there, to humans through various routes. In healthy individuals, this parasite may not cause severe illness, but it can be fatal, especially in individuals with weakened immune systems due to factors like chemotherapy or organ transplantation, as well as in fetuses developing in the womb. Given its relatively common occurrence worldwide, controlling the spread of this parasite is imperative. In this study, an antibody-based electrochemical biosensor was developed to directly detect Toxoplasma, offering potential applications in disease surveillance and management. The biosensor was designed using screen-printed electrodes, and the electrode surface was modified with chitosan and gold nanoparticles. Anti-Toxoplasma gondii antibodies were immobilized onto the modified electrode surface using glutaraldehyde as a cross-linking agent. Changes in surface properties were investigated using various techniques, including differential pulse voltammetry, cyclic voltammetry, and electrochemical impedance spectroscopy. The surface morphology of the developed immunosensor was visualized using scanning electron microscopy. Subsequently, the biosensor's linear working range and detection limit were determined, followed by its application in the detection of Toxoplasma gondii in synthetic serum samples. This innovative approach holds promise for the development of sensitive and specific diagnostic tools for Toxoplasma gondii infection, which is crucial for effective disease management and prevention, particularly in vulnerable populations.