The Material Extrusion (ME) technique in 3D printing facilitates the production of thermoplastic materials with diverse cellular or lattice-like infill geometries, enabling the creation of lightweight, high-performance materials. This study investigates the influence of infill geometry and relative density on the fracture behavior of 3D-printed thermoplastics produced through ME. Polylactic acid (PLA) is used as the model material, with unit cell geometries-square, triangle, and Kagome-and relative densities ranging from 0.4 to 0.8 explored. Tensile tests are first conducted to determine in-plane elastic moduli in two orthogonal directions, accounting for unit cell anisotropy. These results are employed in effective fracture energy calculations. Compact tension fracture tests follow, quantitatively characterize crack growth characteristics in both directions. In both tests, digital image correlation method is used to measure full field strain distributions. Three significant findings emerge. First, there is a power scaling relationship between Elastic Modulus and relative density across all unit cells, with Kagome exhibiting the highest correlation constant. Triangle and Kagome unit cells show negligible orthotropic responses in perpendicular directions for varying relative densities. Second, the relationship between nondimensional fracture toughness and relative density follows a similar scaling law, with minor variations depending on unit cell type. The correlation factor slightly dependens on unit cell geometry but remains around 3 across the the examined relative density range. Third, considering the dissipation of inelastic fracture energy, both triangle and Kagome unit cell geometries demonstrate an order of magnitude higher effective fracture energy (i.e., crack growth resistance) compared to the square unit cell. This is associated with toughening mechanisms such as crack deflection and bifurcation. These findings highlight the disparity between fracture toughness and effective fracture energy in assessing the fracture resistance of 3D-printed thermoplastics, clearly demonstrating that fracture toughness alone is insufficient for a comprehensive assessment. The proposed scaling laws provide predictive insights into the fracture toughness of polymeric materials produced via the ME method.