ABSTRACT This study investigated insecticide usage and associated acute health hazards in rice farming in Odisha, India. A retrospective cross-sectional study design was used to collect data from 139 participants, in the post-monsoon period, 2023. The participants were overwhelmingly male, mostly aged 30 and over, with basic literacy and a range of educational attainment, three-quarters ceasing education by 10th grade and a significant number never attending school. Most farmers/farmworkers used low or moderately toxic insecticides in low doses, typically 3 times/year. However, uptake of appropriate PPE was poor when mixing and applying insecticides. Almost two-thirds (63.4%) of participants reported discomfort/illness after insecticide exposure. Over 90% reported up to 3 symptoms, most experiencing skin irritation. The reported health symptoms were significantly higher among those who ate and drank during insecticide application, compared to those who did not. The number of symptoms reported was also significantly higher in participants who had seen or heard of community insecticide poisoning cases in the previous 12 months, compared with those who had not. Further research is needed on barriers to using effective PPE and on information and training on risks and controls of insecticide exposure that are appropriate for rice farmers in Odisha, India.