In order to understand the seismic damage assessment of reinforced concrete column members, the coupling relationship between the capacity degradation and the accumulated hysteretic energy and the displacement history was considered. The energy-based damage index under the random variable amplitude loading history was proposed. On the basis of preliminary research, the corresponding relationship between the damage index and the construction member parameters and seismic parameters was established, the damage mechanism was analyzed according to the damage index, and then the performance-based design process was proposed. It was found that increase in the stirrup ratio can slow down the damage, and the slowing effect was initially fast and then slows. When the reinforcement ratio is doubled, the damage index decreased by 0.063. The longer the earthquake duration was, the more serious the damage was, and this phenomenon was more obvious when the ductility coefficient was larger. With the increase in the ductility coefficient, the damage continuously increased. Therefore, it is an effective way to decrease the damage by controlling the ductility coefficient. Among all the influencing factors, the fundamental period and seismic intensity contributed more significantly to the damage indicators. When the damage index (performance objective) was determined, the target stirrup ratio can be obtained according to the proposed performance design process, that is, this design process can be used in the performance-based design. The design method based on damage index can make up for the deficiency that the design method based on the ductility coefficient does not consider the earthquake duration.