Considering the lack of effective solutions for multi-axis random vibration topology optimization problems, and recognizing that multi-axis random vibration excitation is the most common loading conditions experienced by structures during their operational life, this paper proposes a multi-objective topology optimization method for multi-axis random vibration. By combining Hybrid Cellular Automata (HCA) and Analytic Hierarchy Process (AHP), this method aims to enhance the vibration resistance of structures and extend their fatigue life during the topology optimization phase. To validate the effectiveness and engineering practicality of this method, two engineering cases were designed: a cantilever beam case and an automotive steering knuckle case. Multi-objective topology optimization were conducted with objectives including mass, stiffness, and vibration intensity metric (root-mean-square stress). The two cases demonstrate that the control group's topology model exhibits weaker resistance to random vibrations and shorter fatigue life. In contrast, the validation group's topology model introduces an additional load path near the excitation point, effectively dissipating the impact of vibration excitation. This enhances the structure's vibration resistance and significantly extends its fatigue life.