Objective To analyze the clinical efficacies of repairing nasal tissue defect. Methods The 17 cases of nasal defects were repaired. According to the difference of nasal tissue defect, different treatments were used, which included total nose reconstruction or partial nose reconstruction with forehead flap, transplantation of auricle composite flap, medpor framework implantation, nasolabial flap transferring, full-thickness skin graft, skin expander embedded in the forehead or cheek, extraction of costal cartilage or nasal septal cartilage and columella lengthening. Results The follow-up was from 2 months to 6 years. Four cases with nose reconstruction had a good appearance, but exposure of framework was found in two of them, which was healed after repairing. Auricle composite flaps were completely survived in three cases and necrosis was found in one case. Six of seven cases had a completely survived nasolabial flaps, and the remaining one had a partial necrosis. The full-thickness skins were survived in the two cases. The four cases who received expander embedded had a expectant result. Random flaps were completely survived in five cases. Columella lengthening in two cases had a stable result. Five cases had received two or more than two times operations. During the follow-up period, the 17 cases were satisfied with the operative results. Conclusions The nasal tissue defect not only presents in a single nasal subunit, but also happens in multi-subunits. Flap transferring, graft of auricle composite tissue, medpor framework implantation and nose reconstruction could be used in the repairing procedures. Key words: Nose; Tissue defect; Subunit