This paper quantified the effects of freeway ramp spacing and auxiliary lane presence on crash frequency and crash severity. Crash frequencies were predicted with a safety performance function, and crash severities were estimated with what was termed a “severity distribution function.” The paper then demonstrated how to combine quantitative knowledge related to the effects of ramp spacing and auxiliary lane presence on both crash frequency and severity into a framework for assessing the overall crash cost for different ramp configurations. Geometric features, traffic characteristics, and crash data were collected for 404 freeway segments in California and Washington State. Negative binomial regression models and multinomial logit regression models were used to estimate the effects of ramp spacing and auxiliary lane presence on expected crash frequencies and crash severities, respectively. Results showed that expected multiple-vehicle crash frequency increased as ramp spacing decreased. Meanwhile, there was a decrease in the proportion of severe crashes (fatal, incapacitating injury) with a decrease in ramp spacing, even though the overall frequency of these severe crashes remained relatively unchanged. Providing an auxiliary lane was expected to decrease crash frequency, although this reduction appeared to be primarily in crashes that were less severe (possible injury and property damage only). The findings appeared to effectively capture the complex relationships between geometric designs and operations and the high sensitivity between speed and crash severity. The paper provided quantitative tools for making informed freeway and interchange design decisions where ramp spacing and auxiliary lanes were considerations.