Radon gas is known to exhale from the ground and can enter and accumulate inside buildings. Many countries set radon limit concentrations and propose mitigation techniques applied in the outdoors to prevent radon from entering buildings. However, radon can also exhale from building materials, e.g. cement, bricks, marble or tiles, contributing high concentrations indoors. Space ventilation is the most used technique to reduce the indoor radon concentration to safe limits, but sometimes, it is not enough. In these cases, it is necessary to apply alternative techniques. This work exposes a prevention technique to reduce radon concentration in indoor spaces that come from building materials or from the subsoil diffusing through basement walls, based on the use of wallpapers. The use of wallpapers is a common decorative technique in homes and buildings, which is compatible with interior finishes and is simple to apply, easily accessible, commercially available and inexpensive. Different commercial wallpapers were selected with a cellulosic and polymeric base and vinylic, cellulosic, latex or non-woven coating material. Configurations of single and double layers of wallpaper and a triple configuration by adding an intermediate layer of aluminium film have been tested. Tests to determine the reduction of radon concentration were performed, and diffusion coefficient and diffusion length were calculated following an adaptation of ISO/TS 11665–13 standard. Radon reduction of 90%, low-medium radon resistance and a diffusion coefficient around 10−11 m2/s were reached for single-layer configuration, and up to 98% of radon reduction, medium radon resistance and diffusion coefficient of 10−12 m2/s with double-layer configuration for dense non-porous base wallpapers with vinylic and non-woven coatings. Adding an aluminium foil intermediate in the double configuration improves the results of all wallpapers tested regarding radon reduction concentration, radon resistance, diffusion length and diffusion coefficient. Moreover, for the dense non-porous base made of non-woven fabric with a vinyl coating layer wallpaper, the diffusion length is shorter than the thickness of the sample in this configuration so the amount of penetrating radon will be reduced by the decay of radon in the wallpaper. Therefore, most radon would disintegrate along the sample and the concentration in the interior space would be lower. These results open a new alternative to protect indoor spaces from radon that access through walls or building materials based on a simple, easy and low-cost technique.