Many diverse subclasses of analytic functions, q-starlike functions, and symmetric q-starlike functions have been studied and analyzed by using q-analogous values of integral and derivative operators. In this paper, we define a q-analogous value of differential operators for harmonic functions with the help of basic concepts of quantum (q-) calculus operator theory; and introduce a new subclass of harmonic functions associated with the Janowski and q-Mittag–Leffler functions. We obtain several useful properties of the new class, such as necessary and sufficient conditions, criteria for analyticity, compactness, convexity, extreme points, radii of starlikeness, radii of convexity, distortion bounds, and integral mean inequality. Furthermore, we discuss some applications of this study in the form of some results and examples and highlight some known corollaries for verifying our main results presented in this investigation. Finally, the conclusion section summarizes the fact about the (p,q)-variations.