An urgent task for the occupational pathology service of the country is the search for objective methods for the early diagnosis of occupational diseases of the peripheral nervous system, in combination with the pathology of the musculoskeletal system, often occurring among workers of hazardous industries. Based on the analysis of electroneuromyographic and radiological research methods in 60 workers performing work with the impact of local vibration and physical overload, the degree of impairment of the peripheral nervous system and the musculoskeletal system of the upper limbs was studied in comparison with persons whose labor activity excluded contact with these labor factors. A relationship has been established between the severity of clinical and instrumental data obtained with the duration of exposure to harmful factors. Identification of lesions of the peripheral nervous system and the locomotor apparatus will ensure timely prevention and adequate therapeutic measures.