Radiographic Markers Research Articles

PATELLOFEMORAL OSTEOARTHRITIS DETECTION FROM KNEE LATERAL X-RAY USING PATELLA SHAPE AND TEXTURE RADIOMIC FEATURES

Purpose: Knee osteoarthritis (OA) has been a highly prevalent degenerative disease, that afflicts both tibiofemoral (TF) and patellofemoral (PF) joints. With the recent development of machine/deep learning techniques, a number of studies have proposed radiographic imaging markers to facilitate accurate and automated detection of the disease. Among these works, despite the high level of the clinical relevance of the OA in the PF joint, patellofemoral osteoarthritis (PFOA), most of them focus on the TF joint, where its counterpart has only received little attention.

Can Abnormal Spinopelvic Relationships be Identified by Anteroposterior Pelvic Radiographs?

Abnormal spinopelvic relationships may place patients at an increased risk for instability after primary total hip arthroplasty. The purpose of this study was to determine if radiographic markers on a standing anteroposterior (AP) pelvis radiograph could identify patients with sagittal spinopelvic imbalance or spinal stiffness. Patients undergoing primary total hip arthroplasty at a single institution from 2017 to 2020 with standing AP pelvis radiographs and sitting/standing lateral radiographs were identified. AP pelvis radiographs were assessed for the following: lumbosacral hardware, spine osteophytes, disc space narrowing, scoliosis>5°, pelvic obliquity>5°, and overlap of the sacrococcygeal junction/pubic symphysis. Patients with spinopelvic imbalance and/or spinopelvic stiffness were identified. Univariate and multivariate analyses were performed. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Four hundred eighty-six patients were included. Prevalence of isolated sagittal spinopelvic imbalance and isolated spinopelvic stiffness was 12% and 21%, respectively; 11% of patients had sagittal imbalance and stiffness. Overlap of the sacrococcygeal junction/pubic symphysis (OR= 10.2, 95% CI= 5.3-19.8) and presence of lumbosacral hardware (OR= 4.4, 95% CI= 2.0-9.4) were markers of an increased risk of combined sagittal imbalance and stiffness. Seventy-nine percent of patients with overlap of the sacrococcygeal junction and pubic symphysis and 82% of patients with lumbosacral hardware had an abnormal spinopelvic relationship. Isolated sagittal imbalance and stiffness were difficult to predict on standing AP pelvis radiographs. Overlap of the sacrococcygeal junction/pubic symphysis and presence of lumbosacral hardware associated with a higher risk of combined sagittal imbalance/stiffness and were present in ≥79% of patients with an abnormal spinopelvic relationship. IV; retrospective cohort study.

Real-world effectiveness of burosumab in children with X-linked hypophosphatemic rickets.

X-linked hypophosphatemic rickets (XLH) is the most common cause of inherited rickets. Historically, XLH was treated with oral phosphate and calcitriol (conventional treatment). Burosumab, a fibroblast growth factor 23 (FGF-23) monoclonal antibody, was approved by the United States Food and Drug Administration (FDA) in 2018 for XLH treatment. Nevertheless, conventional treatment of XLH continues to be recommended by some specialists due to lack of published experience with burosumab in the clinical setting. We compared laboratory and radiographic changes observed following transition from conventional therapy to burosumab in pediatric XLH patients as part of routine care. This retrospective single-center study identified and retroactively studied twelve patients aged 1-18years old with XLH previously treated with conventional therapy and transitioned to burosumab. Laboratory studies and radiographs were obtained routinely as standard of care during two treatment periods: (1) conventional therapy and (2) burosumab treatment. Laboratory values and radiologic rickets severity scores were compared between periods. All laboratory values demonstrated improvement following 1month of burosumab treatment, findings which were sustained over the 2-year study period. Rickets severity scores and height z-scores also improved with burosumab. There were no serious adverse events with burosumab, and adverse events overall were very infrequent and mild. One patient developed an asymptomatic mild elevation of serum phosphate while taking burosumab resulting in a temporary pause in therapy. Safety and effectiveness of burosumab in treatment of XLH were demonstrated as burosumab yielded statistically significant improvement in laboratory and radiographic markers of rickets and height compared to conventional therapy. A higher resolution version of the Graphical abstract is available as Supplementary information.

Enhancing deep learning based classifiers with inpainting anatomical side markers (L/R markers) for multi-center trials

Background and objectiveThe protocol for placing anatomical side markers (L/R markers) in chest radiographs varies from one hospital or department to another. However, the markers have strong signals that can be useful for deep learning-based classifier to predict diseases. We aimed to enhance the performance of a deep learning-based classifiers in multi-center datasets by inpainting the L/R markers. MethodsThe L/R marker was detected with using the EfficientDet detection network; only the detected regions were inpainted using a generative adversarial network (GAN). To analyze the effect of the inpainting in detail, deep learning-based classifiers were trained using original images, marker-inpainted images, and original images clipped using the min-max value of the marker-inpainted images. Binary classification, multi-class classification, and multi-task learning with segmentation and classification were developed and evaluated. Furthermore, the performances of the network on internal and external validation datasets were compared using DeLong's test for two correlated receiver operating characteristic (ROC) curves in binary classification and Stuart-Maxwell test for marginal homogeneity in multi-class classification and multi-task learning. In addition, the qualitative results of activation maps were evaluated using the gradient-class activation map (Grad-CAM). ResultsMarker-inpainting preprocessing improved the classification performances. In the binary classification based on the internal validation, the area under the curves (AUCs) and accuracies were 0.950 and 0.900 for the model trained on the min-max clipped images and 0.911 and 0.850 for the model trained on the original images, respectively (P-value=0.006). In the external validation, the AUCs and accuracies were 0.858 and 0.677 for the model trained using the inpainted images and 0.723 and 0.568 for the model trained using the original images (P-value<0.001), respectively. In addition, the models trained using the marker inpainted images showed the best performance in multi-class classification and multi-task learning. Furthermore, the activation maps obtained using the Grad-CAM improved with the proposed method. The 5-fold validation results also showed improvement trend according to the preprocessing strategies. ConclusionsInpainting an L/R marker significantly enhanced the classifier's performance and robustness, especially in internal and external studies, which could be useful in developing a more robust and accurate deep learning-based classifier for multi-center trials. The code for detection is available at: https://github.com/mi2rl/MI2RLNet. And the code for inpainting is available at: https://github.com/mi2rl/L-R-marker-inpainting.

Association of Radiographic Markers of Hip Instability and Worse Outcomes 2 to 4 Years After Hip Arthroscopy for Femoroacetabular Impingement in Female Patients

Background: Reported outcomes of patients undergoing hip arthroscopy for femoroacetabular impingement (FAI) with underlying borderline acetabular dysplasia are mixed. This may in part be the result of mixed-sex reporting. Purpose: To determine the effect of radiographic measures of acetabular dysplasia and hip instability on outcomes of female patients undergoing hip arthroscopy for FAI. Study Design: Case-control study; Level of evidence, 3. Methods: This was a retrospective study of female patients undergoing arthroscopic surgery for FAI. All patients had preoperative radiographs including a standing anteroposterior pelvic view on which lateral center-edge angle (LCEA), anterior wall index (AWI), posterior wall index (PWI), and femoroepiphyseal acetabular roof (FEAR) index were measured. Patient outcomes were quantified by preoperative and postoperative 12-Item International Hip Outcome Tool (iHOT-12) scores. All patients had follow-up at 2 to 4 years postoperatively. Published values for minimal clinically important difference (MCID), substantial clinical benefit (SCB), Patient Acceptable Symptom State (PASS), and a normal (iHOT-12 > 86 points) or abnormal (iHOT-12 < 56 points) hip were used to determine outcome, as well as the final iHOT-12 score and iHOT-12 preoperative to postoperative difference. Results: The cohort consisted of 249 female patients (83% follow-up) with iHOT-12 scores at 2 to 4 years after surgery (mean, 34.6 months). Female patients with combined LCEA ≤25° and AWI <0.35 had lower final iHOT-12 score and iHOT-12 difference and were less likely to meet MCID, SCB, and PASS and have a normal hip and were more likely to have an abnormal hip as determined by iHOT-12 cutoffs when compared with those patients who had an LCEA >25° and an AWI ≥0.35 (all P < .05). There was no effect of PWI on outcomes. Similarly, female patients with combined LCEA ≤25° and a laterally oriented (positive) FEAR index were less likely to meet MCID, SCB, and PASS and have a normal hip and were more likely to have an abnormal hip compared with those patients who had an LCEA >25° and a negative (medial) FEAR index (all P < .05). In multivariate regression, an LCEA between 18° and 25° was an independent predictor of worse outcomes. Conclusion: An LCEA of 18° to 25°, in combination with an AWI of <0.35 or a laterally opening FEAR index, was predictive of worse outcomes in female patients undergoing hip arthroscopy for FAI.

Long-term preservation of ridge dimension following tooth extraction and ridge preservation: A randomized controlled trial of healing at 4- and 12-month healing time points.

To date, the efficacy of ridge preservation in the maintenance of the residual alveolar ridge dimension beyond 6 months after treatment is unknown. The purpose of this study was to compare the differences in alveolar ridge dimensional change following ridge preservation between 4- and 12-month healing time points using cone-beam computed tomography (CBCT). Fifty seven patients planned for tooth extraction and implant placement were enrolled. Following extraction, ridge preservation was performed. CBCT scans were taken within 72hours following extraction with a customized resin stent containing a fixed radiographic marker. At either 4 months (short-term, ST group) or 12 months (long-term, LT group) after ridge preservation, patients had a second CBCT taken and an implant placed. Changes in ridge height and width were measured using the standardized radiographic marker. No significant differences were detected between the ST and LT groups in loss of buccal and lingual ridge height. Similarly, when adjusted for baseline ridge width, no significant differences were detected in ridge width loss at 3, 5, and 7mm apical to the crest between the ST and LT groups. The efficacy of ridge preservation in the maintenance of ridge width and height at the 12-month time point is similar to that of the 4-month time point. Clinicians may feel confident that a delay in implant placement for up to a year has no significant negative impact on the height and width of the healed ridge.

Applying Quantitative Radiographic Image Markers to Predict Clinical Complications After Aneurysmal Subarachnoid Hemorrhage: A Pilot Study.

Accurately predicting clinical outcome of aneurysmal subarachnoid hemorrhage (aSAH) patients is difficult. The purpose of this study was to develop and test a new fully-automated computer-aided detection (CAD) scheme of brain computed tomography (CT) images to predict prognosis of aSAH patients. A retrospective dataset of 59 aSAH patients was assembled. Each patient had 2 sets of CT images acquired at admission and prior-to-discharge. CAD scheme was applied to segment intracranial brain regions into four subregions, namely, cerebrospinal fluid (CSF), white matter (WM), gray matter (GM), and leaked extraparenchymal blood (EPB), respectively. CAD then detects sulci and computes 9 image features related to 5 volumes of the segmented sulci, EPB, CSF, WM, and GM and 4 volumetrical ratios to sulci. Subsequently, applying a leave-one-case-out cross-validation method embedded with a principal component analysis (PCA) algorithm to generate optimal feature vector, 16 support vector machine (SVM) models were built using CT images acquired either at admission or prior-to-discharge to predict each of eight clinically relevant parameters commonly used to assess patients' prognosis. Finally, a receiver operating characteristics (ROC) method was used to evaluate SVM model performance. Areas under ROC curves of 16 SVM models range from 0.62 ± 0.07 to 0.86 ± 0.07. In general, SVM models trained using CT images acquired at admission yielded higher accuracy to predict short-term clinical outcomes, while SVM models trained using CT images acquired prior-to-discharge demonstrated higher accuracy in predicting long-term clinical outcomes. This study demonstrates feasibility to predict prognosis of aSAH patients using new quantitative image markers generated by SVM models.

Abstract WP181: Statin Usage Increases White Matter Hyperintensities: A Post-hoc Analysis Of SPRINT-MIND

Introduction: White matter hyperintensity (WMH), a radiographic marker of cerebral small vessel disease, is typically treated by modification of conventional cerebrovascular risk factors. However, the influence of dyslipidemia and the impact of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitors (statins) on WMH is less certain. The goal of this study was to evaluate the influence of statins on progression of WMH over a four-year interval. Methods: We performed a post-hoc analysis of the SPRINT-MIND database for participants who had completed a baseline and a 4-year follow-up brain MRI with volumetric WMH calculations. Follow-up visits within this time window included data on medications, including statins. We defined statin usage as no therapy (0% of visits), partial therapy (1 - 99% of visits) or full therapy (100% of visits) based on this self-reported data. WMH progression was calculated as the difference in WMH volume between the two scans and then segmented into tertiles. ANOVA and chi-squared tests were used for continuous and categorical variables with adjustments made for variables known to influence WMH development. Results: 425 individuals were included in this study: 53% (226/425) without statins use, 27% (115/425) with partial use and 20% (84/425) and full use. Demographic characteristics and baseline WMH volumes were similar amongst the cohort. With increasing statin use, a significant reduction in LDL was identified. Those with full statin use were significantly more likely to be in the top tertile of worse WMH progression (adjusted OR 2.30, 95% CI 1.11 - 4.77, p = 0.025). Conclusion: SPRINT-MIND participants prescribed a statin were nearly 2.5 times more likely to be within the top tertile of WMH progression over four years, despite adjustment for synergistic risk factors and improvement in LDL.

Abstract 102: Effect Of Antihypertensives By Class On Cerebral Small Vessel Disease: A Post-hoc Analysis Of SPRINT-MIND

Introduction: Treatment of uncontrolled arterial hypertension reduces the risk of cerebral small vessel disease (CSVD) progression, though it is unclear whether this reduction occurs due to blood pressure control or antihypertensive class-specific pleotropic effects. The goal of this study was to investigate the influence of antihypertensive medication class on accumulation of white matter hyperintensities (WMH), a radiographic marker of CSVD, within a cohort with well-controlled hypertension. Methods: Using the SPRINT-MIND dataset, we completed a post-hoc analysis of participants who completed a baseline and 4-year follow-up brain MRI with volumetric WMH data. Antihypertensive medication data were recorded at follow-up visits between the MRIs. A percentage of follow-up time participants were prescribed each of the eleven classes of antihypertensive was then derived. Progression of CSVD was calculated as the difference in WMH volume between two scans and, to address skew, dichotomized into a top tertile (greatest) accumulation and combined middle and bottom tertiles (slowest) accumulation. Results: Among 448 individuals included in this study, vascular risk profiles were similar across WMH progression subgroups except age (70.1±7.9 years versus 65.7±7.3 years, p&lt;0.001) and systolic blood pressure (128.3±11.0 mmHg versus 126.2±9.4 mmHg, p=0.039). The high had a mean WMH progression of 4.7±4.3 mL compared with 0.13±1.0 mL for the slowest progressors (p&lt;0.001). Only angiotensin converting enzyme inhibitors (ACE-I) (OR 0.34, 95% CI 0.15-0.75, p=0.008) and dihydropyridine calcium channel blockers (d-CCB) (OR 0.39, 95% CI 0.19-0.81, p=0.012) were independently associated with lower odds of being in the greatest progression grouping. Conclusions: Amongst hypertensive participants in the SPRINT-MIND trial, ACE-I and d-CCB antihypertensive medications were associated with significantly lower odds of being in the highest tertile of WMH progression compared with other antihypertensive classes, independent of blood pressure control.

Development of a deep learning model for automatic localization of radiographic markers of proposed dental implant site locations

ObjectivesTo develop a Deep Learning Artificial Intelligence (AI) model that automatically localizes the position of radiographic stent gutta percha (GP) markers in cone beam computed tomography (CBCT) images to identify proposed implant sites within the images, and to test the performance of the newly developed AI model. Materials and MethodsThirty-four CBCT datasets were used for initial model training, validation and testing. The CBCT datasets were those of patients who had a CBCT examination performed wearing a radiographic stent for implant treatment planning. The datasets were exported in Digital Imaging and Communications in Medicine (DICOM), then imported into the software Horos ®. Each GP marker was manually labelled for object detection and recognition by the deep learning model by drawing rectangles around the GP markers in all axial images, then the labelled images were split into training, validation, and test sets. The axial sections of 30 CBCT datasets were randomly divided into training and validation sets. four CBCT datasets were used for testing the performance of the deep learning model. Descriptive statistics were calculated for the number of GP markers present, number of correct and incorrect identifications of GP markers. ResultThe AI model had an 83% true positive rate for identification of the GP markers. Of the areas labelled by the AI model as GP markers, 28 % were not truly GP markers, but the overall false positive rate was 2.8 %. ConclusionAn AI model for localization of GP markers in CBCT images was able to identify most of the GP markers, but 2.8% of the results were false positive and 17% were missed GP markers. Using only axial images for training an AI program is not enough to give an accurate AI model performance.

Outcome of treating osteomyelitis and infected non-union of long bones with antibiotic coated bone cement nails

Introduction: Nonunion in the presence of infection poses the combined dilemma of infection management and stability. The purpose of this research was to determine the function of antibiotic cement coated nailing in infection management and bony union of infected non-union of long bones.Methodology: This prospective observational study was conducted in the Department of Orthopedics, Janki Medical College, Janakpur, Nepal from August 2016 till August 2021. In this study, we included patients aged 18 years or above, who were treated with antibiotic cement coated nailing for infected non-union post-operative fractures of tibia or femur. 2 g of vancomycin and 2 g of gentamycin were put into every 40 g of bone cement. Clinical, radiographic, and haematological markers were used to assess infection control and osseous union.Results: In the present study, 50 patients were included, with a mean age of 37.3 ± 6.2 years, and 72% of the patients were males (n=36) and rest being females (28%, n=14). Tibia was involved in 60% of the cases and rest had their femur involved. Wound culture revealed staphylococcus aureus in 60% of the patients and Enterobacter in 20% of the patients. At 6 months, bone union was achieved by 92% of the patients, infection control was achieved in 94% and 90% had no complications. Reinfection was observed in four cases (4%), nail break, nail migration and malunion was observed in one patient each.Conclusions: Based on the results, it appears that antibiotic cement coated nailing in the therapy of infected non-union of long bones is a good method for achieving early infection control.

Determination of sexual dimorphism of maxillary sinus using cone-beam computed tomography in a rural population of western Maharashtra – A retrospective, cross-sectional study

Context:Radiography is used in forensics for the identification of humans, especially in cases where the body is decomposed, fragmented, or burned. In the skull bones, the zygomatic bone and maxilla including the maxillary sinus tend to remain intact even if the other bones are badly disfigured. Hence, the maxillary sinus has been considered by several authors for sex identification. The cone-beam computed tomography (CBCT) is a non-invasive, recently developed technology that has seen an exponential rise in the use for visualizing dental anatomy and pathologies. The present study chose the available CBCT records of patients who show maxillary sinus and used them for determining sexual dimorphism related to the maxillary sinus.Aims:To measure the maxillary sinuses using CBCT and determine the efficacy of these measurements for sex identification.Settings and Design:Observational, cross-sectional, retrospective study.Methods and Material:A total of 60 CBCT scans (30 males, 30 females) were selected from a rural setup, and the height, length, and width of the maxillary sinus with the highest dimension for each variable were measured and recorded.Statistical Analysis:The data were analyzed by using the paired t-test. The discriminant equations were derived for both the right and left maxillary sinus.Results:Statistically significant differences were observed between the males and females for height (right and left) and length (left) of the maxillary sinus. The accuracy rate for sex identification in the present study was found to be 71.3%.Conclusion:Maxillary sinus height can be used as a reliable radiographic marker in forensic odontology for sex identification.

Conventional radiological markers in rotator cuff surgery

The surgical management of a degenerative or traumatic lesion of the shoulder joint is based on anatomical, clinical, and radiologic criteria. To optimize the diagnostic and therapeutic management of patients, the use of radiological imaging must be accompanied by meticulous clinical examination first. Conventional radiography is an effective complementary exam to assess the nature of shoulder joints injuries. Many conventional radiographic markers have been described, mainly for degenerative rotator cuff lesions, and are routinely used by clinicians as a screening tool. The aim of this review was to describe these different markers and define their reliability and usefulness in avoiding more expensive imaging modalities.

Cadaveric Examination of the Radiographic Safe Zone for Open Reduction and Internal Fixation of the Calcaneus Posterior Facet.

Background:The purpose of this study is to define a safe zone for screw placement on a lateral radiograph of the calcaneus taking into account the lateral to medial convexity of the posterior facet. Such findings may serve to improve surgical quality during open reduction and internal fixation (ORIF) of the posterior facet of the calcaneus.Methods:Eleven cadaveric calcanei were harvested and the articular margins of the posterior facet were outlined with a radiopaque wire. Lateral radiographs, similar to those used for intraoperative fluoroscopy, of each specimen were obtained and calibrated to a standardized marker. The proximal-to-distal length of the posterior facet was then divided into quadrants. The greatest height difference between the superolateral and inferomedial surfaces outlined by the radiopaque marker were measured in the 2 most posterior quadrants, as screw insertion in this area would be mostly likely to risk screw penetration during ORIF.Results:The average distance from the osseous surface to the radiographic marker was 3.3 ± 1.2 mm in the most posterior quadrant (fourth quadrant) and 3.2 ± 1.6 mm in the quadrant just anterior to this (third quadrant). The range for unsafe screw placement was 1.7 to 5.6 mm below the osseous surface in the fourth quadrant and 1.1 to 6.6 mm in the third quadrant.Conclusion:Intraoperative radiographic assessment of the safety of subchondral posterior facet screws does not correlate to its osteology. Because of the superolateral to inferomedial convexity of the posterior facet of the calcaneus, overly long screws may appear to be radiographically intraosseous, though in actuality the screw may be intra-articular. On average, screws placed in the fourth quadrant of the facet are at less risk if 3.3 mm inferior to the upper margin of the osseous shadow on fluoroscopic imaging and 3.2 mm inferior in the third quadrant. Though limited by a small sample size, this study sets a foundation for future research into this complex osteology.Level of Evidence:Level V, mechanism-based reasoning.

Tracking Tag Stabilization With a Small-Diameter Implant in an Edentulous Mandible to Assist Dynamically Navigated Surgery: A Case Report

This report describes the use of a temporary dental implant to secure a radiographic fiducial marker and patient-tracking tag to an edentulous mandible for dynamically guided implant placement into a fibula microvascular free flap. A small-diameter dental implant was placed into the anterior mandible to secure a radiographic fiducial marker followed by a patient tag. The patient tag allowed for tracking of the patient's mandible during placement of endosseous dental implants. Four endosseous dental implants were successfully placed into the edentulous fibula free flap mandibular reconstruction. Dynamic navigation using a small-diameter implant to secure radiographic fiducial markers and patient tags provides a novel technique to place implants into an edentulous microvascular free flap with minimal incision and reflection of soft tissue.

Comparison of Digital OPG and CBCT in Assessment of Risk Factors Associated with Inferior Nerve Injury during Mandibular Third Molar Surgery.

Background: Pre-operative radiographic assessment of the anatomical relationship between the roots of the mandibular third molar and the inferior alveolar nerve (IAN) is a must to minimize the risk of IAN injury during surgery. Objectives: To compare the radiographic signs of digital orthopantomogram (OPG) and cone-beam computed tomography (CBCT). An additional objective was to assess the cortex status between the mandibular canal and third molar on CBCT images in relation to the demographic characteristics, region (right or left side), and angulation of mandibular molar. Methodology: In this retrospective study, a total of 350 impacted mandibular third molars with a close relationship between the inferior alveolar canal (IAC) and impacted mandibular third molars on digital OPG were further referred for CBCT imaging for assessment of the position of the mandibular canal. The study was conducted between August 2018 and February 2020. Digital OPGs were evaluated for radiographic signs like interruption of the mandibular canal wall, darkening of the roots, diversion of the mandibular canal, and narrowing of the mandibular canal. The age and sex of patients, site of impacted third molar, Winter’s classification of mandibular third molar, position of IAC relative to impacted molar, and the radiographic markers of OPG were assessed for cortical integrity using CBCT. Chi square testing was applied to study the values of difference and binomial logistic regression was done to assess the factors associated with cortication. Statistical significance was set at p ≤ 0.05. Results: Among 350 patients, 207 (59.1%) were male and 143 (40.9%) were female with a mean age of 36.8 years. The most common OPG sign was interruption of white line, seen in 179 (51.1%) cases. In total, 246 cases (70.3%) showed an absence of canal cortication between the mandibular canal and the impacted third molar on CBCT images. Cortication was observed in all cases with a combination of panoramic signs which was statistically significant (p = 0.047). Cortication was observed in 85 (50.6%) cases where IAC was positioned on the buccal side, 11 (16.9%) in cases of inferiorly positioned IAC, and just 8 (7.6%) for cases of lingually positioned IAC which was statistically significant (p = 0.003). Statistically insignificant (p > 0.05) results were noted for cortex status in CBCT images with regards to the age, sex, site, and angulation of impacted third molars. Conclusion: CBCT imaging is highly recommended for those cases where diversion of the mandibular canal is observed on OPG and when the roots are present between canals.

Femoroacetabular translation in female athletes and dancers assessed by dynamic hip ultrasonography

ObjectiveTo compare femoroacetabular (FA) translation between dancers and athletes with hip pain and between dancers with and without hip pain.MethodsIn this cross-sectional study, 171 female athletes and dancers with hip...

Pelvic and sacral morphology and their correlation with pelvic incidence, lumbar lordosis, and lumbar alignment changes between standing and sitting postures

Study designRetrospective Cross-Sectional Radiographic Study. ObjectiveThis study aims to describe novel radiographic markers of sacropelvic morphology to further define the static and dynamic relationship between the pelvis and the spine, via the analysis of two postures - standing and sitting. Summary of background dataThere is increasing evidence underlining the importance of spinopelvic radiographic parameters in the holistic management of sagittal spinal deformity given the close relationship between pelvic morphology and spinal profile. MethodsThis is a retrospective radiographic study of patients who presented with the first episode of isolated mechanical, low back pain of fewer than 3 months’ duration. All patients underwent whole spine radiographs using EOS technology in both standing and relaxed sitting postures. Six novel distance measurements (H1, H2, H3, V1, V2, DD) to determine pelvic dimensions, and 3 novel angles (A, B, C) to determine sacral morphology were described. ResultsA total of 64 males (58.2%) and 46 females (41.8%) with a mean age of 42.8 ± 18.6 (range:17–81) years old was studied. Between standing and relaxed sitting postures, differences were observed in all sagittal radiographic parameters.Multivariate analysis showed that standing LL< 500 (p = 0.008), standing V1 > 13 cm(p = 0.040), and angle B> 800(p = 0.002) are predictive of PI< 500, standing TK< 300 (p = 0.003) and PI< 500 (p = 0.006) are predictive of LL< 500, and standing PT< 170(p = 0.034), standing H3 ≥ 4 cm (p = 0.030), standing angle C< 420 (p = 0.003), sitting SS≥ 60 (p = 0.002), and sitting PT < 450 (p = 0.013) are predictive of change in LL below mean difference of 420 between standing and relaxed sitting. ConclusionsApart from the known correlation between TK, LL and PI, low PI was found to be associated with a tall pelvis and a straight sacrum (angle B). Association between a small coccygeal inclination angle (angle C) and smaller change in LL between standing and relaxed sitting may have clinical relevance.

Global white matter structural integrity mediates the effect of age on ischemic stroke outcomes.

The relationship of global white matter microstructural integrity and ischemic stroke outcomes is not well understood. To investigate the relationship of global white matter microstructural integrity with clinical variables and functional outcomes after acute ischemic stroke. A retrospective analysis of neuroimaging data from 300 acute ischemic stroke patients with magnetic resonance imaging brain obtained within 48 hours of stroke onset and long-term functional outcomes (modified Rankin, mRS) was performed. Peak width of skeletonized mean diffusivity (PSMD), as a measure of global white matter microstructural injury, was calculated in the hemisphere contralateral to the acute infarct. Multivariable linear and logistic regression analyses were performed to identify variables associated with PSMD and excellent functional outcome (mRS < 2) at 90 days, respectively. Mediation analysis was then pursued to characterize how PSMD mediates the effect of age on acute ischemic stroke functional outcomes. White matter hyperintensity volume, age, pre-stroke disability, and normal-appearing white matter mean diffusivity were independently associated with increased PSMD. In logistic regression analysis, increased infarct volume and PSMD were independent predictors of excellent functional outcome. Additionally, the effect of age on functional outcomes was indirectly mediated by PSMD (P < 0.001). As a marker of global white matter microstructural injury, increased PSMD mediates the effect of increased age to contribute to poor acute ischemic stroke functional outcomes. PSMD could serve as a putative radiographic marker of brain age for stroke outcomes prognostication.

Pathophysiological and diagnostic importance of fatty acid-binding protein 1 in heart failure with preserved ejection fraction

Elevated intracardiac pressure at rest and/or exercise is a fundamental abnormality in heart failure with preserved ejection fraction (HFpEF). Fatty acid-binding protein 1 (FABP1) is proposed to be a sensitive biomarker for liver injury. We sought to determine whether FABP1 at rest would be elevated in HFpEF and would correlate with echocardiographic markers of intracardiac pressures at rest and during exercise. In this prospective study, subjects with HFpEF (n = 22) and control subjects without HF (n = 23) underwent resting FABP1 measurements and supine bicycle exercise echocardiography. Although levels of conventional hepatic enzymes were similar between groups, FABP1 levels were elevated in HFpEF compared to controls (45 [25–68] vs. 18 [14–24] ng/mL, p = 0.0008). FABP1 levels were correlated with radiographic and blood-based markers of congestion, hemodynamic derangements during peak exercise (E/e’, r = 0.50; right atrial pressure, r = 0.35; pulmonary artery systolic pressure, r = 0.46), reduced exercise cardiac output (r = − 0.49), and poor exercise workload achieved (r = − 0.40, all p < 0.05). FABP1 distinguished HFpEF from controls with an area under the curve of 0.79 (p = 0.003) and had an incremental diagnostic value over the H2FPEF score (p = 0.007). In conclusion, FABP1 could be a novel hepatic biomarker that associates with hemodynamic derangements, reduced cardiac output, and poor exercise capacity in HFpEF.