The study was about effectiveness of radio agricultural programmes in scaling up farming activities of smallholder farmers in Bushenyi district. The specific objective was to; determine the factors associated with radio listenership and application of the knowledge gained through agricultural radio messages. The study was a descriptive-cross sectional survey employing both quantitative and qualitative approaches to data collection and analysis. Data was gathered from a sample of 360 respondents across 18 listener groups of agricultural extension programs using questionnaire and interview guide. Data was analyzed using SPSS version 20.0 to generate both descriptive and inferential statistics. The study concluded that that age bracket (39 – 48), radio ownership, place of residence, negative attitudes and perceptions, limited agricultural spaces, media exposure and investment capital were some of the factors associated with radio listenership and application of the knowledge gained through agricultural radio messages in the area. The study concluded that agricultural extension radio programmes have a wider coverage and have been so pertinent to smallholder farmer’s activities, however listenership and application of the knowledge gained through agricultural radio messages is still hampered by certain impediments that call for urgent address. This study therefore recommends that the programme should be changed to evening when most farmers are available in their houses. Radio producers and program hosts should do this through programme planning which informs the selection of topics, presentation of the topics on radio with interviews from selected experts and farmers.