Radiofrequency Electromagnetic Fields Exposure Research Articles

Personal measurements of radiofrequency electromagnetic field exposure among workers of high, medium and low exposed occupations in Spain

BACKGROUND AND AIM: Novel methods for occupational exposure assessment of radiofrequency (RF) electromagnetic fields are needed to address the lack of quantitative data and reduce limitations of current methods used for epidemiological research. In the framework of an international study, we conducted an innovative measurement campaign of personal occupational RF exposure in multiple occupations in Spain in order to enhance a preliminary RF Job Exposure Matrix (RF-JEM). METHODS: Identification and prioritization of the occupations to be measured were based on exposure levels in the preliminary RF-JEM and expert judgment. Selection of participants was based on reported job titles and sources of RF exposure collected in a screening questionnaire, which was disseminated to potential participants using both broad and targeted approaches. Personal full-shift measurements were conducted following a standardized protocol. Additional data about general and occupational-specific sources of RF exposure during the measured work-shift were captured at the end of each observation day through a “worker diary”. RESULTS:Personal measurements of RF exposure were conducted and workers oversampled in occupations previously categorized as medium (n = 105) and highly-exposed (n = 26). A preliminary overview of the measurement results obtained in the campaign for various jobs as well as an initial comparison with the preliminary RF-JEM will be presented. CONCLUSIONS:We conducted the first stage of an innovative international campaign of personal occupational RF exposure measurements in Spain, gathering exposure data for workers from occupations known to be exposed to high, medium and low levels of exposure to RF fields. Further work to conduct personal measurements in the Netherlands and France will also be performed. KEYWORDS: Exposure assessment, Occupational epidemiology, Occupational exposures

Exposure to long-term evolution radiofrequency electromagnetic fields decreases neuroblastoma cell proliferation via Akt/mTOR-mediated cellular senescence

ABSTRACT The aim of this study was to examine the potential effects of long-term evolution (LTE) radiofrequency electromagnetic fields (RF-EMF) on cell proliferation using SH-SY5Y neuronal cells. The growth rate and proliferation of SH-SY5Y cells were significantly decreased upon exposure to 1760 MHz RF-EMF at 4 W/kg specific absorption rate (SAR) for 4 hr/day for 4 days. Cell cycle analysis indicated that the cell cycle was delayed in the G0/G1 phase after RF-EMF exposure. However, DNA damage or apoptosis was not involved in the reduced cellular proliferation following RF-EMF exposure because the expression levels of histone H2A.X at Ser139 (γH2AX) were not markedly altered and the apoptotic pathway was not activated. However, SH-SY5Y cells exposed to RF-EMF exhibited a significant elevation in Akt and mTOR phosphorylation levels. In addition, the total amount of p53 and phosphorylated-p53 was significantly increased. Data suggested that Akt/mTOR-mediated cellular senescence led to p53 activation via stimulation of the mTOR pathway in SH-SY5Y cells. The transcriptional activation of p53 led to a rise in expression of cyclin-dependent kinase (CDK) inhibitors p21 and p27. Further, subsequent inhibition of CDK2 and CDK4 produced a fall in phosphorylated retinoblastoma (pRb at Ser807/811), which decreased cell proliferation. Taken together, these data suggest that exposure to RF-EMF might induce Akt/mTOR-mediated cellular senescence, which may delay the cell cycle without triggering DNA damage in SH-SY5Y neuroblastoma cells.

Genotoxic Effects of Radiofrequency-Electromagnetic Fields

Genotoxic Effects of Radiofrequency-Electromagnetic Fields

Effects of 1800 MHz radiofrequency fields on signal transduction and antioxidant proteins in human A172 glioblastoma cells

Purpose To assess the effects of 1800 MHz radiofrequency electromagnetic field (RF-EMF) exposure on the expression of signal transduction and antioxidant proteins in a human-derived A172 glioblastoma cell line. Materials and methods Adherent human-derived A172 glioblastoma cells (1.0 × 105 cells per 35 mm culture dish, containing 2 mL DMEM media) were exposed to 1800 MHz continuous-wave (CW) or GSM-modulated RF fields, in the presence or absence of serum for 5, 30 or 240 min at a specific absorption rate (SAR) of 0 (sham) or 2.0 W/kg. Concurrent negative (vehicle) and positive controls (1 µg/mL anisomycin) were included in each experiment. Cell lysates were collected immediately after exposure, stabilized by protease and phosphatase inhibitors in lysis buffer, then frozen and maintained at −80 °C until analysis. The relative expression levels of phosphorylated- and total-signal transduction proteins (CREB, JNK, NF-κB, ERK1/2, Akt, p70S6K, STAT3 and STAT5) and antioxidant proteins (SOD1, SOD2, CAT, TRX1, PRX2) were assessed using Milliplex magnetic bead array panels and a MagPix Multiplex imaging system. Results In cells exposed to 1800 MHz continuous-wave RF-EMF with the presence of serum in the culture medium, CAT expression was statistically significantly decreased after a 30 min exposure, total JNK was decreased at both 30 and 240 min of exposure, STAT3 was decreased after 240 min of exposure and phosphorylated-CREB expression was decreased after 30 min of exposure. In cells exposed to 1800 MHz GSM-modulated RF-EMF in serum-free cultures, the expression level of total STAT5 was decreased after 30 and 240 min of exposure. These observed changes were detected sporadically across time-points, culture conditions and RF-EMF exposure conditions indicating the likelihood of false positive events. When cells were treated with anisomycin for 15 min as a positive control, dramatic increases in the expression of phosphorylated signaling proteins were observed in both serum-starved and serum-fed A172 cells, with larger fold change increases in the serum-free cultures. No statistically significant differences in the expression levels of SOD1, SOD2 or TRX1 were observed under any tested conditions after exposure to RF-EMF. Conclusions The current study found no consistent evidence of changes in the expression of antioxidant proteins (SOD1, SOD2, CAT or TRX2) or a variety of signal transductions proteins (CREB, JNK, NF-κB, ERK1/2, Akt, p70S6K, STAT3, STAT5) in a human-derived glioblastoma A172 cell line in response to exposure to 1800 MHz continuous-wave or GSM-modulated RF-EMF for 5, 30 or 240 min in either serum-free or serum-containing cultures.

Exposure to RF-EMF Alters Postsynaptic Structure and Hinders Neurite Outgrowth in Developing Hippocampal Neurons of Early Postnatal Mice.

Exposure to radiofrequency electromagnetic fields (RF-EMFs) has increased rapidly in children, but information on the effects of RF-EMF exposure to the central nervous system in children is limited. In this study, pups and dams were exposed to whole-body RF-EMF at 4.0 W/kg specific absorption rate (SAR) for 5 h per day for 4 weeks (from postnatal day (P) 1 to P28). The effects of RF-EMF exposure on neurons were evaluated by using both pups’ hippocampus and primary cultured hippocampal neurons. The total number of dendritic spines showed statistically significant decreases in the dentate gyrus (DG) but was not altered in the cornu ammonis (CA1) in hippocampal neurons. In particular, the number of mushroom-type dendritic spines showed statistically significant decreases in the CA1 and DG. The expression of glutamate receptors was decreased in mushroom-type dendritic spines in the CA1 and DG of hippocampal neurons following RF-EMF exposure. The expression of brain-derived neurotrophic factor (BDNF) in the CA1 and DG was significantly lower statistically in RF-EMF-exposed mice. The number of post-synaptic density protein 95 (PSD95) puncta gradually increased over time but was significantly decreased statistically at days in vitro (DIV) 5, 7, and 9 following RF-EMF exposure. Decreased BDNF expression was restricted to the soma and was not observed in neurites of hippocampal neurons following RF-EMF exposure. The length of neurite outgrowth and number of branches showed statistically significant decreases, but no changes in the soma size of hippocampal neurons were observed. Further, the memory index showed statistically significant decreases in RF-EMF-exposed mice, suggesting that decreased synaptic density following RF-EMF exposure at early developmental stages may affect memory function. Collectively, these data suggest that hindered neuronal outgrowth following RF-EMF exposure may decrease overall synaptic density during early neurite development of hippocampal neurons.

In Situ Assessment of 5G NR Massive MIMO Base Station Exposure in a Commercial Network in Bern, Switzerland

This paper describes the assessment of radiofrequency (RF) electromagnetic field (EMF) exposure from fifth generation (5G) new radio (NR) base stations in a commercial NR network in Bern, Switzerland. During the measurement campaign, four base station sites were investigated and the exposure induced by the NR massive multiple-input-multiple-output (MaMIMO) antennas was assessed at 22 positions, at distances from the base station between 30 m and 410 m. The NR base stations operated at 3.6 GHz and used codebook-based beamforming. While the actual field levels without inducing downlink traffic were very low (<0.05 V/m) due to a low traffic load and low antenna input powers of up to 8 W, setting up a maximum downlink traffic stream towards user equipment resulted in a time-averaged exposure level of up to 0.4 V/m, whereas the maximum extrapolated exposure level reached 0.6 V/m. Extrapolated to an antenna input power of 200 W, values of 4.3 V/m and 4.9 V/m, respectively, were obtained, which amount to 0.5–0.6% of the reference level recommended by the International Commission on Non-Ionizing Radiation Protection (ICNIRP). In Bern, it was found that the impact of the NR network on the total environmental RF exposure was very limited; with maximum downlink, it contributed 2% on average. Finally, it was also concluded that extrapolation to the maximum exposure level can be done without prior knowledge of the radiation patterns, directly based on the measurement of the Physical Downlink Shared Channel (PDSCH) resource elements.

1800 MHz Radiofrequency Electromagnetic Field Impairs Neurite Outgrowth Through Inhibiting EPHA5 Signaling.

The increasing intensity of environmental radiofrequency electromagnetic fields (RF-EMF) has increased public concern about its health effects. Of particular concern are the influences of RF-EMF exposure on the development of the brain. The mechanisms of how RF-EMF acts on the developing brain are not fully understood. Here, based on high-throughput RNA sequencing techniques, we revealed that transcripts related to neurite development were significantly influenced by 1800 MHz RF-EMF exposure during neuronal differentiation. Exposure to RF-EMF remarkably decreased the total length of neurite and the number of branch points in neural stem cells-derived neurons and retinoic acid-induced Neuro-2A cells. The expression of Eph receptors 5 (EPHA5), which is required for neurite outgrowth, was inhibited remarkably after RF-EMF exposure. Enhancing EPHA5 signaling rescued the inhibitory effects of RF-EMF on neurite outgrowth. Besides, we identified that cAMP-response element-binding protein (CREB) and RhoA were critical downstream factors of EPHA5 signaling in mediating the inhibitory effects of RF-EMF on neurite outgrowth. Together, our finding revealed that RF-EMF exposure impaired neurite outgrowth through EPHA5 signaling. This finding explored the effects and key mechanisms of how RF-EMF exposure impaired neurite outgrowth and also provided a new clue to understanding the influences of RF-EMF on brain development.

The Effect of GSM Electromagnetic Field Exposure on the Waking Electroencephalogram: Methodological Influences.

Although there is consistent evidence that exposure to radiofrequency electromagnetic fields (RF-EMF) increases the spontaneous resting alpha spectral power of the electroencephalogram (EEG), the reliability of this evidence is uncertain as some studies have also failed to observe this effect. The present study aimed to determine whether the effect of RF-EMF exposure on EEG alpha power depends on whether EEG is derived from eyes open or closed conditions and assessed earlier (<5-min) versus later (>25-min) in the exposure interval. Thirty-six adults participated in three experimental sessions, each involving one exposure: "Sham," "Low," and "High" RF-EMF corresponding to peak spatial specific absorption rates averaged over 10 g of 0, 1, and 2 W/kg, respectively. Resting EEG was recorded at baseline (no exposure), during, and after exposure. Alpha power increase was found to be greater for the eyes open than eyes closed EEG during both the High (P = 0.04) and Low (P = 0.04) RF-EMF exposures. There was also a trend towardit being larger at the end, versus the start of the "High" 30-min exposure (P < 0.01; eyes open condition). This suggests that the use of eyes closed conditions, and insufficient RF-EMF exposure durations, are likely explanations for the failure of some studies to detect an RF-EMF exposure-related increase in alpha power, as such methodological choices decrease signal-to-noise ratios and increase type II error.

Activation of matrix metalloproteinases and FoxO3a in HaCaT keratinocytes by radiofrequency electromagnetic field exposure

As the skin is the largest body organ and critically serves as a barrier, it is frequently exposed and could be physiologically affected by radiofrequency electromagnetic field (RF-EMF) exposure. In this study, we found that 1760 MHz RF-EMF (4.0 W/kg specific absorption rate for 2 h/day during 4 days) exposure could induce intracellular reactive oxygen species (ROS) production in HaCaT human keratinocytes using 2′,7′-dichlorofluorescin diacetate fluorescent probe analysis. However, cell growth and viability were unaffected by RF-EMF exposure. Since oxidative stress in the skin greatly influences the skin-aging process, we analyzed the skin senescence-related factors activated by ROS generation. Matrix metalloproteinases 1, 3, and 7 (MMP1, MMP3, and MMP7), the main skin wrinkle-related proteins, were significantly increased in HaCaT cells after RF-EMF exposure. Additionally, the gelatinolytic activities of secreted MMP2 and MMP9 were also increased by RF-EMF exposure. FoxO3a (Ser318/321) and ERK1/2 (Thr 202/Tyr 204) phosphorylation levels were significantly increased by RF-EMF exposure. However, Bcl2 and Bax expression levels were not significantly changed, indicating that the apoptotic pathway was not activated in keratinocytes following RF-EMF exposure. In summary, our findings show that exposure to 1760 MHz RF-EMF induces ROS generation, leading to MMP activation and FoxO3a and ERK1/2 phosphorylation. These data suggest that RF-EMF exposure induces cellular senescence of skin cells through ROS induction in HaCaT human keratinocytes.

Protocol for personal RF-EMF exposure measurement studies in 5th generation telecommunication networks

BackgroundThe general population is exposed to Radio-Frequency Electromagnetic Fields (RF-EMFs) used by telecommunication networks. Previous studies developed methods to assess this exposure. These methods will be inadequate to accurately assess exposure in 5G technologies or other wireless technologies using adaptive antennas. This is due to the fact that 5G NR (new radio) base stations will focus actively on connected users, resulting in a high spatio-temporal variations in the RF-EMFs. This increases the measurement uncertainty in personal measurements of RF-EMF exposure. Furthermore, a user’s exposure from base stations will be dependent on the amount of data usage, adding a new component to the auto-induced exposure, which is often omitted in current studies.GoalsThe objective of this paper is to develop a general study protocol for future personal RF-EMF exposure research adapted to 5G technologies. This protocol will include the assessment of auto-induced exposure of both a user’s own devices and the networks’ base stations.MethodThis study draws from lessons learned from previous RF-EMF exposure research and current knowledge on 5G technologies, including studies simulating 5G NR base stations and measurements around 5G NR test sites.ResultsTo account for auto-induced exposure, an activity-based approach is introduced. In survey studies, an RF-EMF sensor is fixed on the participants’ mobile device(s). Based on the measured power density, GPS data and movement and proximity sensors, different activities can be clustered and the exposure during each activity is evaluated. In microenvironmental measurements, a trained researcher performs measurements in predefined microenvironments with a mobile device equipped with the RF-EMF sensor. The mobile device is programmed to repeat a sequence of data transmission scenarios (different amounts of uplink and downlink data transmissions). Based on simulations, the amount of exposure induced in the body when the user device is at a certain location relative to the body, can be evaluated.ConclusionOur protocol addresses the main challenges to personal exposure measurement introduced by 5G NR. A systematic method to evaluate a user’s auto-induced exposure is introduced.

Wi-fi related radiofrequency electromagnetic fields (RF-EMF): a pilot experimental study of personal exposure and risk perception

The impact of providing people with an objectively measured personal radiofrequency electromagnetic fields (RF-EMF) exposure information on the risk perception of people is not well understood. We conducted an experimental study, among three groups of participants, to investigate the risk perception of people towards RF-EMF from Wi-Fi sources (ISM 2.4 GHz) by providing participants with either basic text, precautionary information, or a summary of their personal RF-EMF exposure measurement levels. Participants provided with personal RF-EMF exposure measurement information were more confident in protecting themselves from RF-EMF exposure, compared to those provided with only basic information. Nonetheless, neither the exposure perception nor the risk perception of people to Wi-Fi related RF-EMF differed by the type of information provided. The measured Wi-Fi signal levels were far below international exposure limits. Furthermore, self-rated levels of personal RF-EMF exposure perception were not associated with objectively measured RF-EMF exposure levels. Providing people with objectively measured information may help them build confidence in protecting themselves from Wi-Fi related RF-EMF exposure.

Radio-frequency electromagnetic field exposure and contribution of sources in the general population: an organ-specific integrative exposure assessment

In order to achieve an integrated radio-frequency electromagnetic fields (RF-EMF) dose assessment, detailed information about source-specific exposure duration and output power is needed. We developed an Integrated Exposure Model (IEM) to combine energy absorbed due to use of and exposure to RF-EMF sources and applied it to a sample of the general population to derive population RF-EMF estimates. The IEM used specific absorption rate transfer algorithms to provide RF-EMF daily dose estimates (mJ/kg/day) using source-specific attributes (e.g. output power, distance), personal characteristics and usage patterns. Information was obtained from an international survey performed in four European countries with 1755 participants. We obtained median whole-body and whole-brain doses of 183.7 and 204.4 mJ/kg/day. Main contributors to whole-brain dose were mobile phone near the head for calling (2G networks) and far-field sources, whereas the latter together with multiple other RF-EMF sources were main contributors for whole-body dose. For other anatomical sites, 2G phone calls, mobile data and far-field exposure were important contributors. The IEM provides insight into main contributors to total RF-EMF dose and, applied to an international survey, provides an estimate of population RF-dose. The IEM can be used in future epidemiological studies, risk assessments and exposure reduction strategies.

A case study on electromagnetic field assessment and uncertainty evaluation

This paper presents a radiofrequency electromagnetic field exposure assessment carried out in an observatory open for general public, where there are multiple radio and television transmitters in the surrounding area. An uncertainty evaluation is presented, considering that the main broadcast stations reduced their transmitted power to comply with the regulatory limits throughout the observatory area. A discussion is done about uncertainty of measurement result and its use or not in both precautionary measure and sanctioning process applied by regulatory authority.

Stochastic Dosimetry Assessment of the Human RF-EMF Exposure to 3D Beamforming Antennas in indoor 5G Networks

The deployment of near future 5G networks will introduce modifications in the population’s exposure levels to radio-frequency electromagnetic fields (RF-EMFs). The present work aimed to face the challenge of studying the exposure variability in the presence of an access point (AP) at 3.7 GHz with 64 patch elements uniform planar array antenna and 3D beamforming capability. The novelty introduced in the methodology of the exposure’s evaluation was the combining of traditional computational methods with a new approach based on stochastic dosimetry, called polynomial chaos kriging method, in order to estimate the exposure levels for 1000 different antenna beamforming patterns with low computational efforts. The simulations were evaluated considering a child model and computing the specific absorption rate (SAR) in different tissues. The analysis of the results highlighted a high exposure variability scenario depending on the beamforming patterns of the array antenna and identified the ranges of elevation and azimuth angles of the main antenna beam that may cause the highest levels of exposure.

Biological Effects of Exposure to a Radiofrequency Electromagnetic Field on the Placental Barrier in Pregnant Rats.

The placenta protects the fetus against excessive stress‐associated maternal cortisol during pregnancy. We studied whether exposure to radiofrequency electromagnetic field (RF‐EMF) radiation during pregnancy can cause changes in dams and their placentas. Pregnant Sprague–Dawley rats were divided into cage‐control, sham‐exposed, and RF‐exposed groups. They were exposed to RF‐EMF signals at a whole‐body specific absorption rate of 4 W/kg for 8 h/day from gestational Day 1 to 19. Levels of cortisol in the blood, adrenal gland, and placenta were measured by enzyme‐linked immunosorbent assay. Levels of adrenocorticotropic hormone and corticotropin‐releasing hormone were monitored in maternal blood. Expression levels of placental 11β‐hydroxysteroid dehydrogenase type 2 (11β‐HSD2) messenger RNA (mRNA) were measured by reverse transcription polymerase chain reaction. Morphological changes in the placenta were analyzed using hematoxylin and eosin staining. Fetal parts of the placenta were measured using Zen 2.3 blue edition software. Maternal cortisol in circulating blood (RF: 230 ± 24.6 ng/ml and Sham: 156 ± 8.3 ng/ml) and the adrenal gland (RF: 58.3 ± 4.5 ng/ml and Sham: 30 ± 3.8 ng/ml) was significantly increased in the RF‐exposed group (P < 0.05). Placental cortisol was stably maintained, and the level of placental 11β‐HSD2 mRNA expression was not changed in the RF‐exposed group. RF‐EMF exposure during pregnancy caused a significant elevation of cortisol levels in circulating blood; however, no changes in the placental barrier were observed in pregnant rats. Bioelectromagnetics. © 2021 Bioelectromagnetics Society

Analysis of thiol/disulphide homeostasis and oxidant-antioxidant status as a result of exposure to radio-frequency electromagnetic fields

ABSTRACT The aim of the current study is to investigate the effect of daily long-term radio-frequency electromagnetic field (RF-EMFs) exposure on thiol/disulphide homeostasis and oxidant-antioxidant status in the serum of rats. Fourteen male Sprague Dawley rats were divided into two equal groups (n = 7). They were grouped as group 1 (sham-control) and group 2 (2100 MHz exposed). Group 2 rats were exposed to GSM-like signals for 5 h/day, 7 days per week for 14 days. In serum of blood samples, the native, total and native/total thiol levels and antioxidant-oxidant parameters were analyzed. The study revealed that the mean serum total thiol levels of GSM exposure group was rather higher than sham-control group (p = 0,219); the mean serum native thiol levels of GSM exposure group was rather higher than sham-control group (p = 0,416), and the mean serum disulphide levels of GSM exposure group was rather higher than sham-control group (p = 0,566). On the other hand, the mean serum total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) of GSM exposure group were higher than sham-control group. There are no data in the literature, that examine the effects of RF-EMFs on thiol/disulphide homeostasis. The results of this study, indicate that RF-EMFs did not cause oxidative stress and statistically changes in thiol/disulphide homeostasis. More sample sizes and longer-term exposures are needed to confirm the results of this study.

Empirical and Modeling Approach for Environmental Indoor RF-EMF Assessment in Complex High-Node Density Scenarios: Public Shopping Malls Case Study

This work provides an intensive and comprehensive in-depth study from an empirical and modeling approach of the environmental radiofrequency electromagnetic fields (RF-EMF) radiation exposure in public shopping malls, as an example of an indoor high-node user density context aware environment, where multiple wireless communication systems coexist. For that purpose, current personal mobile communications (2G-5G FR 1) as well as Wi-Fi services (IEEE 802.11n/ac) have been precisely analyzed in order to provide clear RF-EMF assessment insight and to verify compliance with established regulation limits. In this sense, a complete measurements campaign has been performed in different countries, with frequency-selective exposimeters (PEMs), providing real empirical datasets for statistical analysis and allowing discussion and comparison regarding current health effects and safety issues between some of the most common RF-EMF exposure safety standards: ICNIRP 2020 (Spain), IEEE 2019 (Mexico) and a more restrictive regulation (Poland). In addition, environmental RF-EMF exposure assessment simulation results, in terms of spatial E-field characterization and Cumulative Distribution Function (CDF) probabilities, have been provided for challenging incremental high-node user dense scenarios in worst case conditions, by means of a deterministic in-house 3D Ray-Launching (3D-RL) RF-EMF safety simulation technique, showing good agreement with the experimental measurements. Finally, discussion highlighting the contribution and effects of the coexistence of multiple heterogenous networks and services for the environmental RF-EMF radiation exposure assessment has been included, showing that for all measured results and simulated cases, the obtained E-Field levels are well below the exposure limits established in the internationally accepted standards and guidelines. In consequence, the obtained results and the presented methodology could become a starting point to stablish the RF-EMF assessment basis of future complex heterogeneous 5G FR 2 developments on the millimeter wave (mmWave) frequency range, where massive high-node user density networks are expected.

Human RF-EMF Exposure Assessment Due to Access Point in Incoming 5G Indoor Scenario

The study aimed at expanding the knowledge about the assessment of radio-frequency electromagnetic fields (RF-EMF) exposure, considering the novelties introduced by the incoming 5G networks. Specifically, a possible future case of indoor exposure scenario is investigated, where the presence of a 5G access point (AP) in a room is simulated. The AP was modelled by two different indoor uniform planar array (UPA) antennas at 3.7 GHz and at 14 GHz, to evaluate how the beamforming and the higher frequency use could impact the exposure levels. Different scenarios were evaluated, considering the maximum antenna gain, two different human computational models, an adult model and a child one, and by varying the distance and the orientation between the UPA antenna and the two models head. All the simulations were conducted using the Sim4Life platform and in particular the exposure levels were expressed by the specific absorption rate averaged on 10 g of tissue (SAR <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10g</sub> ), which was analyzed for the skin and for some specific tissues. The work underlined that the highest SAR <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10g</sub> values were obtained in the head area for all scenarios, with the skin SAR <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10g</sub> highest peaks when the UPA is placed laterally to the human model (195.73 mW/kg and 223.29 mW/kg for the adult and child model, respectively, for 100 mW input power). Furthermore, the work permitted to highlight that the SAR <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10g</sub> exposure levels are slightly higher for the child model, compared to the adult one and that the distance between the UPA antenna and the human models could greatly lower the SAR <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10g</sub> levels. At last, it was found that the SAR <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10g</sub> exposure levels obtained with the UPA antenna at 14 GHz were lower than the ones at 3.7 GHz, although further investigations will be necessary.

Prioritizing health outcomes when assessing the effects of exposure to radiofrequency electromagnetic fields: A survey among experts

Exposure to radiofrequency (RF) electromagnetic fields (EMF) (frequencies of 100 kHz to 300 GHz) has been steadily increasing. In addition to heat-related effects of RF EMF, other yet-unspecified biological effects, might exist which could possibly lead to health effects. Given the large number of health endpoints that have been studied, we wanted to prioritize those that would merit systematic reviews.We developed a survey listing of all health endpoints reported in the literature and we asked 300 RF EMF experts and researchers to prioritize these health effects for systematic review as critical, important or unimportant. We also asked the experts to provide the rationale for their prioritization.Of the 300 RF EMF experts queried, 164 (54%) responded. They rated cancer, heat-related effects, adverse birth outcomes, electromagnetic hypersensitivity, cognitive impairment, adverse pregnancy outcomes and oxidative stress as outcomes most critical regarding RF EMF exposure. For these outcomes, systematic reviews are needed. For heat-related outcomes, the experts based their ranking of the critical outcomes on what is known from human or animal studies, and for cancer and other outcomes, they based their rating also on public concern.To assess health risks of an exposure in a robust manner, it is important to prioritize the health outcomes that should be systematically reviewed. Here we have shown that it feasible to do so in an inclusive and transparent way.

Health disturbances and exposure to radiofrequency electromagnetic fields from mobile-phone base stations in French urban areas

The effects of radiofrequency exposure on the health of people living near mobile-phone base stations (MPBSs) have been the subject of several studies since the mid-2000s, with contradictory results.We aimed to investigate the association between measured exposure to radiofrequency electromagnetic fields (RF-EMF) from MPBSs and the presence of self-reported non-specific and insomnia-like symptoms.A cross-sectional survey conducted between 2015 and 2017 in five large cities in France involved 354 people living in buildings located at a distance of 250 m or less from an MPBS and in the main transmit beam of the antennas. Information on environmental concerns, anxiety, and non-specific and insomnia-like symptoms was collected with a questionnaire administrated by telephone. A complete broadband field-meter measurement [100 kHz - 6 GHz] was then made at five points of each dwelling, followed by a spectral analysis at the point of highest exposure, detailing the contribution of each service, including MPBS.The median exposure from MPBS was 0.27 V/m (0.44 V/m for global field), ranging from 0.03 V/m to 3.58 V/m, MPBSs being the main source of exposure for 64% of the dwellings. In this study population, the measured exposure from MPBSs was not associated with self-reported non-specific or insomnia-like symptoms. However, for insomnia-like symptoms, a significant interaction was found between RF-EMF exposure from MPBSs and environmental concerns.These findings do not support the hypothesis of an effect of RF-EMF from MPBSs on non-specific or insomnia-like symptoms in the overall population. Studies are needed to further investigate the positive association observed between exposure from MPBSs and insomnia-like symptoms among people reporting environmental concerns.