In this paper, we get the nuclear mass-density parameter of known mass and known charge radius by using the AME2020 nuclear mass database and the CR2013 nuclear charge radius database. For the nuclei with [Formula: see text], we obtained an empirical formula of the constant parameter equal to 0 for the difference of nuclear mass-density parameter between two neighboring isotope. That is, the nuclear mass-density parameter of the two neighboring isotopes was equal. By using this empirical formula combined with AME2020 and CR2013 databases, the calculated value of 625 nuclear charge radii was obtained. The root-mean-square deviation (RMSD) of nuclear charge radius that we have successfully obtained is [Formula: see text][Formula: see text]fm. In addition, one of the corrections is the neutron factor. This correction is the key improvement which reduces the RMSD to 0.0077[Formula: see text]fm. Considering the neutron shell effect, the different shell ranges were divided into two categories for correction, and the RMSD was reduced to 0.0056[Formula: see text]fm. Based on the revised empirical formula combined with the AME2020 database, the calculated and predicted values of nuclear charge radius were obtained with high accuracy. Some of these predictions are also very consistent with experimental values measured in recent years. In addition, we use BP neural network to study the difference of nuclear mass-density parameter on the basis of two categories. The RMSDs obtained are 0.0028[Formula: see text]fm and 0.0038[Formula: see text]fm, respectively. It can be seen that such a division has a certain degree of reliability and feasibility. These results show that the new relation proposed in this paper has simplicity and reliability, which can be compared with other local nuclear charge radius relations.
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