You have accessJournal of UrologyCME1 May 2022MP51-04 P-SCORE IN PREOPERATIVE BIOPSIES ACCURATELY PREDICTS P-SCORE IN FINAL PATHOLOGY AT RADICAL PROSTATECTOMY Pontus Röbeck, Li-Di Xu, Dilruba Ahmed, Anca Dragomir, Pär Dahlman, Sam Ladjevardi, and Michael Häggman Pontus RöbeckPontus Röbeck More articles by this author , Li-Di XuLi-Di Xu More articles by this author , Dilruba AhmedDilruba Ahmed More articles by this author , Anca DragomirAnca Dragomir More articles by this author , Pär DahlmanPär Dahlman More articles by this author , Sam LadjevardiSam Ladjevardi More articles by this author , and Michael HäggmanMichael Häggman More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002626.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Prostatype RT-qPCR kit analyses the expression of 3 genes (IGFBP3, F3, and VGLL3) in formalin-fixed paraffin-embedded prostate cancer (PCa) tissues. The gene parameter is combined with patient-specific clinical parameters in a pre-defined algorithm to calculate the P-score, which has previously been shown to improve prediction performance of PCa-specific death as compared to clinical parameters only. To establish the prognostic accuracy of P-score in MRI/TRUS fusion-guided diagnostic biopsies as compared to P-score in the paired radical prostatectomy specimens and to elucidate the concordance of P-score in the paired index- and concomitant non-index tumour foci. METHODS: 98 men with localized PCa, all diagnosed by MRI/TRUS fusion-guided biopsies, underwent robot-assisted radical prostatectomy. All prostatectomies were whole-mounted and tumour maps were drawn. From all biopsies and from index and non-index tumour foci of the corresponding prostatectomies, gene expression was assessed with Prostatype and P-score was computed. This P-score was calculated in a range of 0-15 with one as the smallest unit and categorised into three risk groups by using previously defined cut-offs. RESULTS: Preoperative biopsies yielded sufficient and technically analysable materials for comparison with the prostatectomy in 71 men. Biopsy P-score significantly correlated with P-score in corresponding prostatectomy with a Pearson correlation of 0.84 (95% CI: 0.75-0.89, p<0.0001). P-score in paired biopsy and prostatectomy were also in substantial agreement (weighted kappa score 0.68). P-score in index tumour significantly correlated with P-score in the paired concomitant foci (Pearson correlation: 0.83, 95% CI: 0.74-0.90, p<0.0001). P-score in the paired index tumour and the concomitant foci were also in agreement (weighted kappa score: 0.68). CONCLUSIONS: P-score in preoperative fusion-guided biopsies accurately predicts the P-score in the prostatectomy. P-score in index tumour and concomitant foci also show substantial concordance. Thus, biopsy P-score is adequate for assisting with predicting prostate cancer progression. Source of Funding: Uppsala University Hospital © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e876 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Pontus Röbeck More articles by this author Li-Di Xu More articles by this author Dilruba Ahmed More articles by this author Anca Dragomir More articles by this author Pär Dahlman More articles by this author Sam Ladjevardi More articles by this author Michael Häggman More articles by this author Expand All Advertisement PDF DownloadLoading ...